ATE373466T1 - Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung - Google Patents

Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung

Info

Publication number
ATE373466T1
ATE373466T1 AT02774211T AT02774211T ATE373466T1 AT E373466 T1 ATE373466 T1 AT E373466T1 AT 02774211 T AT02774211 T AT 02774211T AT 02774211 T AT02774211 T AT 02774211T AT E373466 T1 ATE373466 T1 AT E373466T1
Authority
AT
Austria
Prior art keywords
methods
lipid carrier
carrier compositions
improved active
active retention
Prior art date
Application number
AT02774211T
Other languages
English (en)
Inventor
Murray Webb
Paul Tardi
Original Assignee
Celator Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celator Pharmaceuticals Inc filed Critical Celator Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE373466T1 publication Critical patent/ATE373466T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT02774211T 2001-11-13 2002-11-13 Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung ATE373466T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33124901P 2001-11-13 2001-11-13

Publications (1)

Publication Number Publication Date
ATE373466T1 true ATE373466T1 (de) 2007-10-15

Family

ID=23293193

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02774211T ATE373466T1 (de) 2001-11-13 2002-11-13 Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung

Country Status (7)

Country Link
US (1) US20050118249A1 (de)
EP (1) EP1448165B1 (de)
AT (1) ATE373466T1 (de)
AU (1) AU2002340670A1 (de)
DE (1) DE60222580T2 (de)
ES (1) ES2290333T3 (de)
WO (1) WO2003041682A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003298738A1 (en) * 2002-11-26 2004-06-18 Su-Ming Chiang Liposomal formulations
JP2007522085A (ja) * 2003-06-27 2007-08-09 スミスクライン・ビーチャム・コーポレイション 安定化されたトポテカンリポソーム組成物および方法
US20070224255A1 (en) * 2004-04-02 2007-09-27 Italfarmaco, S.A. Liposomal Formulations
KR100889139B1 (ko) 2004-06-01 2009-03-17 테루모 가부시키가이샤 이리노테칸 제제
WO2007076117A2 (en) * 2005-12-22 2007-07-05 Celator Pharmaceuticals, Inc. Liposomal formulations comprising secondary and tertiary amines and methods for preparing thereof
WO2009059449A1 (en) * 2007-11-05 2009-05-14 Celsion Corporation Novel thermosensitive liposomes containing therapeutic agents
EP2123258A1 (de) * 2008-05-23 2009-11-25 Liplasome Pharma A/S Liposomen zur Arzneimittelverabreichung
CN102369008B (zh) 2009-03-30 2014-10-29 卫材R&D管理有限公司 脂质体组合物
WO2010113983A1 (ja) * 2009-03-30 2010-10-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 リポソーム組成物の製造方法
DK177532B1 (en) * 2009-09-17 2013-09-08 Bio Bedst Aps Medical use of sPLA2 hydrolysable liposomes
JP5947807B2 (ja) 2010-12-14 2016-07-06 テクニカル ユニバーシティ オブ デンマークＴｅｃｈｎｉｃａｌ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｄｅｎｍａｒｋ ナノ粒子組成物への放射性核種の封入
SI2768484T1 (sl) 2011-10-21 2019-12-31 Jazz Pharmaceuticals Research Llc Liofilizirani liposomi
WO2014047116A1 (en) * 2012-09-18 2014-03-27 Comfort Care For Animals Llc Encapsulating liposomes
US10039716B2 (en) 2013-03-13 2018-08-07 Mallinckrodt Llc Liposomal cisplatin compositions for cancer therapy
US9993427B2 (en) * 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
AU2016256979B2 (en) * 2015-05-04 2021-01-28 Genfit Method for preparing transmembrane pH-gradient vesicles
WO2017188350A1 (ja) 2016-04-28 2017-11-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍の成長を抑制する方法
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US859494A (en) * 1905-10-17 1907-07-09 Walter C Hardesty Trousers-press.
US2202857A (en) * 1939-07-26 1940-06-04 Henney Motor Co Footrest for vehicles
US5736155A (en) * 1984-08-08 1998-04-07 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
US5622713A (en) * 1985-09-17 1997-04-22 The Regents Of The University Of California Method of detoxifying animal suffering from overdose
EP0225130B1 (de) * 1985-11-22 1991-10-30 Takeda Chemical Industries, Ltd. Liposomzusammensetzung
JPH0617309B2 (ja) * 1985-11-29 1994-03-09 株式会社ビタミン研究所 アドリアマイシン包埋リポソ−ム製剤
IL81264A (en) * 1986-01-30 1990-11-05 Takeda Chemical Industries Ltd Quinone derivatives,their production and pharmaceutical compositions containing them
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
DE3718581C1 (de) * 1987-06-03 1988-12-29 Helmut Steinhilber Vorrichtung zum Schonen der Schuhe des Fahrers eines Kraftfahrzeugs
US4915951A (en) * 1987-12-03 1990-04-10 California Institute Of Technology Cryoprotective reagent
JP2880800B2 (ja) * 1989-06-22 1999-04-12 ネクスター・フアーマシユーテイカルズ・インコーポレイテツド カプセル化方法
AU6428890A (en) * 1989-09-12 1991-04-18 Regents Of The University Of California, The Therapeutic peptides and proteins
US5225212A (en) * 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
IS1685B (is) * 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
US5683714A (en) * 1991-04-19 1997-11-04 Nexstar Pharmaceuticals, Inc. Liposomal cyclosporin pharmaceutical formulation
PT101422B (pt) * 1993-12-06 1997-06-30 Ineti Inst Biotec Q F E Tecnol Formulacoes lipossomicas contendo vidarabina e/ou derivados, com indice terapeutico elevado e processo para a sua preparacao
US5993850A (en) * 1994-09-13 1999-11-30 Skyepharma Inc. Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
EP0784470B1 (de) * 1994-10-03 2003-08-13 INFECTIO RECHERCHE Inc. Liposomenzubereitungen zur behandlung von viruserkrankungen
US6331289B1 (en) * 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
US5827532A (en) * 1997-01-31 1998-10-27 The Reagents Of The University Of California Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations
US5827533A (en) * 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
US5962015A (en) * 1997-05-02 1999-10-05 Kobo Products S.A.R.L. Stabilized liposomes
US6306432B1 (en) * 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
US6106858A (en) * 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
US5967602A (en) * 1998-01-08 1999-10-19 Hoover Universal, Inc. Extending cargo shelf for vehicle seat
US6200598B1 (en) * 1998-06-18 2001-03-13 Duke University Temperature-sensitive liposomal formulation
US6270806B1 (en) * 1999-03-03 2001-08-07 Elan Pharma International Limited Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions
US6145931A (en) * 1999-03-18 2000-11-14 Subotic; Slobodan Article for use in putting on and removing shoes
HUP0202475A3 (en) * 1999-07-16 2004-06-28 Alza Corp A liposome composition having resistance to freeze/thaw damage
US6390547B1 (en) * 2000-01-07 2002-05-21 Johnson Controls Technology Company Seat assembly

Also Published As

Publication number Publication date
WO2003041682A2 (en) 2003-05-22
DE60222580T2 (de) 2008-06-12
AU2002340670A1 (en) 2003-05-26
DE60222580D1 (de) 2007-10-31
ES2290333T3 (es) 2008-02-16
EP1448165B1 (de) 2007-09-19
US20050118249A1 (en) 2005-06-02
WO2003041682A3 (en) 2003-09-18
EP1448165A2 (de) 2004-08-25

Similar Documents

Publication Publication Date Title
ATE373466T1 (de) Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung
ATE295347T1 (de) Stoffe und zusammensetzungen für die verabreichung aktiver substanzen
ATE383169T1 (de) Komponente und zusammensetzungen zur verabreichung von wirkstoffen
DE69401204D1 (de) Gonadotropin enthaltende gefriergetrocknete troepfen
DE60104206D1 (de) Halbfeste arzneizubereitung enthaltend isotretinoin
DK0478686T3 (da) Flour- og phosphorholdige amphiphile molekyler med overfladeaktive egenskaber
EA199700197A1 (ru) Стабильные белково-фосфолипидные составы и способы их получения
CY1119742T1 (el) Βιολογικα συστηματα μεταφορας πολλαπλου-συστατικου
WO2002069949A3 (en) Combination therapy for reduction of toxycity of chemotherapeutic agents
TWI256891B (en) 17alpha-alkyl-17beta-oxy-estratrienes and intermediate products for their production, use of the 17alpha-alkyl-17beta-oxy-estratrienes for the production of pharmaceutical agents as well as pharmaceutical preparations
BRPI0415409A (pt) uso de efetuadores de ciclases de glutaminila e glutamato
ATE329897T1 (de) Verbindungen und zusammensetzungen zur verabreichung aktiven substanzen
EA200300337A1 (ru) Полиарилкарбоксамиды, применимые в качестве агентов, снижающих содержание липидов
RU95112465A (ru) Пирановые соединения, фармацевтическая композиция, способ получения и промежуточные соединения
DK0783297T3 (da) Polyethylenglycol-modificerede ceramid-lipider og liposomer
ATE453380T1 (de) Verabreichung von in lipidvesikeln verpackten kleinen hydrophilen molekülen
DK1009385T3 (da) Kolesterolsænkende komposition
WO2003099830A3 (en) Cardiolipin compositions, methods of preparation and use
DE60017341D1 (de) Emulsion, und Verfahren zur Herstellung von Emulsionen und öligen Zusammensetzungen
PT1135193E (pt) Agentes para o tratamento de tumores a base de lipossomas e compreendendo tamoxifeno
DE59912159D1 (de) Phospholipide mit ungesattigten alkyl- und acylketten
ES2108698T3 (es) Liposomas exentos de sustancias activas, para el tratamiento de aterosclerosis.
SE0003476D0 (sv) Compounds
ATE311403T1 (de) Derivate des streptogramins, ihre herstellung und sie enthaltende zubereitungen
DE602004005821D1 (de) Enteralpräparat zur vorbeugung gegen bzw. behandlung von sepsis

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties