DK1501828T3 - Piperazinbenzothiazoler som midler til behandling af cerebrale iskæmiske lidelser eller CNS-lidelser - Google Patents

Piperazinbenzothiazoler som midler til behandling af cerebrale iskæmiske lidelser eller CNS-lidelser

Info

Publication number: DK1501828T3
Authority: DK; Denmark
Prior art keywords: piperazine; treatment; benzothiazoles; agents; cerebral ischemic
Prior art date: 2002-04-25

Application number

DK03727365T

Other languages

Danish (da)

English (en)

Inventor

Jean-Pierre Gotteland

Pierre-Alain Vitte

P Gaillard

Original Assignee

Serono Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-25

Filing date

2003-04-25

Publication date

2008-03-10

2003-04-25 Application filed by Serono Lab filed Critical Serono Lab

2008-03-10 Application granted granted Critical

2008-03-10 Publication of DK1501828T3 publication Critical patent/DK1501828T3/da

Links

208000015114 central nervous system disease Diseases 0.000 title abstract 2
230000002490 cerebral effect Effects 0.000 title abstract 2
230000000302 ischemic effect Effects 0.000 title abstract 2
238000011282 treatment Methods 0.000 title abstract 2
NZORAUGSDRBBBH-UHFFFAOYSA-N 1,3-benzothiazole;piperazine Chemical class C1CNCCN1.C1=CC=C2SC=NC2=C1 NZORAUGSDRBBBH-UHFFFAOYSA-N 0.000 title 1
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK03727365T 2002-04-25 2003-04-25 Piperazinbenzothiazoler som midler til behandling af cerebrale iskæmiske lidelser eller CNS-lidelser DK1501828T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02100417		2002-04-25
PCT/EP2003/004323 WO2003091249A1 (en)	2002-04-25	2003-04-25	Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or cns disorders

Publications (1)

Publication Number	Publication Date
DK1501828T3 true DK1501828T3 (da)	2008-03-10

Family

ID=29265991

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03727365T DK1501828T3 (da)	2002-04-25	2003-04-25	Piperazinbenzothiazoler som midler til behandling af cerebrale iskæmiske lidelser eller CNS-lidelser

Country Status (22)

Country	Link
US (1)	US7314878B2 (de)
EP (1)	EP1501828B1 (de)
JP (1)	JP4523289B2 (de)
KR (1)	KR100948469B1 (de)
CN (1)	CN1310911C (de)
AT (1)	ATE383356T1 (de)
AU (1)	AU2003233067B2 (de)
BR (1)	BRPI0309594A8 (de)
CA (1)	CA2481763C (de)
CY (1)	CY1107204T1 (de)
DE (1)	DE60318567T2 (de)
DK (1)	DK1501828T3 (de)
EA (1)	EA009682B1 (de)
ES (1)	ES2297165T3 (de)
IL (2)	IL164796A0 (de)
MX (1)	MXPA04010474A (de)
PT (1)	PT1501828E (de)
RS (1)	RS51407B (de)
SI (1)	SI1501828T1 (de)
UA (1)	UA78035C2 (de)
WO (1)	WO2003091249A1 (de)
ZA (1)	ZA200408023B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003091249A1 (en)	2002-04-25	2003-11-06	Applied Research Systems Ars Holding N.V.	Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or cns disorders
JP5021307B2 (ja) *	2003-09-12	2012-09-05	メルクセローノソシエテアノニム	糖尿病治療のためのベンゾチアゾール誘導体
WO2005118543A1 (ja) *	2004-06-03	2005-12-15	Ono Pharmaceutical Co., Ltd.	キナーゼ阻害薬およびその用途
US7838522B2 (en)	2004-11-17	2010-11-23	Ares Trading S.A.	Benzothiazole formulations and use thereof
JP5144271B2 (ja) *	2004-11-17	2013-02-13	アレストレーディングソシエテアノニム	ベンゾチアゾ−ル製剤、及びそれらの使用
KR20080044836A (ko)	2005-07-15	2008-05-21	라보라뚜와르 세로노 에스. 에이.	자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt)	2005-07-15	2010-12-14	Serono Lab	inibidores de jnk para o tratamento de endometriose
US20100121057A1 (en) *	2007-04-17	2010-05-13	Merck Serono Sa	Process for the Preparation of Piperazine Benzothiazoles
EP2283009B1 (de) *	2008-05-16	2012-08-29	F. Hoffmann-La Roche AG	Jnk-hemmer
JP5916719B2 (ja) *	2010-06-04	2016-05-11	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	Ｊｎｋの阻害剤として有用な２−アミノ−ピリミジン誘導体
US8471027B2 (en) *	2011-04-06	2013-06-25	Hoffmann-La Roche Inc.	Adamantyl compounds
WO2014114186A1 (zh) *	2013-01-24	2014-07-31	山东亨利医药科技有限责任公司	Jnk抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4153574B2 (ja)	1997-09-10	2008-09-24	トーアエイヨー株式会社	新規なピペリジン誘導体、その製造法およびそれを含有する循環器官用剤
EP1110957A1 (de) *	1999-12-24	2001-06-27	Applied Research Systems ARS Holding N.V.	Benzazolderivate und ihre Verwendung als JNK Modulatoren
EP1193256A1 (de)	2000-09-27	2002-04-03	Applied Research Systems ARS Holding N.V.	Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren
WO2003091249A1 (en)	2002-04-25	2003-11-06	Applied Research Systems Ars Holding N.V.	Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or cns disorders

2003
- 2003-04-25 WO PCT/EP2003/004323 patent/WO2003091249A1/en not_active Ceased
- 2003-04-25 KR KR1020047016871A patent/KR100948469B1/ko not_active Expired - Fee Related
- 2003-04-25 EP EP03727365A patent/EP1501828B1/de not_active Expired - Lifetime
- 2003-04-25 US US10/511,438 patent/US7314878B2/en not_active Expired - Lifetime
- 2003-04-25 EA EA200401423A patent/EA009682B1/ru not_active IP Right Cessation
- 2003-04-25 IL IL16479603A patent/IL164796A0/xx unknown
- 2003-04-25 IL IL164796A patent/IL164796A/en not_active IP Right Cessation
- 2003-04-25 CN CNB03814493XA patent/CN1310911C/zh not_active Expired - Fee Related
- 2003-04-25 DK DK03727365T patent/DK1501828T3/da active
- 2003-04-25 AU AU2003233067A patent/AU2003233067B2/en not_active Ceased
- 2003-04-25 RS YUP-928/04A patent/RS51407B/sr unknown
- 2003-04-25 AT AT03727365T patent/ATE383356T1/de active
- 2003-04-25 SI SI200331114T patent/SI1501828T1/sl unknown
- 2003-04-25 MX MXPA04010474A patent/MXPA04010474A/es active IP Right Grant
- 2003-04-25 PT PT03727365T patent/PT1501828E/pt unknown
- 2003-04-25 JP JP2003587807A patent/JP4523289B2/ja not_active Expired - Fee Related
- 2003-04-25 UA UA20041008647A patent/UA78035C2/uk unknown
- 2003-04-25 ES ES03727365T patent/ES2297165T3/es not_active Expired - Lifetime
- 2003-04-25 CA CA2481763A patent/CA2481763C/en not_active Expired - Fee Related
- 2003-04-25 BR BRPI0309594A patent/BRPI0309594A8/pt not_active IP Right Cessation
- 2003-04-25 DE DE60318567T patent/DE60318567T2/de not_active Expired - Lifetime
2004
- 2004-10-05 ZA ZA2004/08023A patent/ZA200408023B/en unknown
2008
- 2008-02-18 CY CY20081100199T patent/CY1107204T1/el unknown

Also Published As

Publication number	Publication date
US7314878B2 (en)	2008-01-01
SI1501828T1 (sl)	2008-04-30
EA009682B1 (ru)	2008-02-28
WO2003091249A1 (en)	2003-11-06
JP4523289B2 (ja)	2010-08-11
UA78035C2 (en)	2007-02-15
MXPA04010474A (es)	2004-12-13
PT1501828E (pt)	2008-02-11
EA200401423A1 (ru)	2005-04-28
ES2297165T3 (es)	2008-05-01
IL164796A (en)	2013-02-28
KR20040104572A (ko)	2004-12-10
CA2481763A1 (en)	2003-11-06
IL164796A0 (en)	2005-12-18
BRPI0309594A8 (pt)	2017-04-11
HK1075664A1 (en)	2005-12-23
AU2003233067B2 (en)	2009-01-08
ATE383356T1 (de)	2008-01-15
RS51407B (sr)	2011-02-28
CY1107204T1 (el)	2012-11-21
ZA200408023B (en)	2005-11-30
DE60318567D1 (de)	2008-02-21
CA2481763C (en)	2011-06-14
AU2003233067A1 (en)	2003-11-10
CN1310911C (zh)	2007-04-18
EP1501828A1 (de)	2005-02-02
EP1501828B1 (de)	2008-01-09
CN1662528A (zh)	2005-08-31
DE60318567T2 (de)	2009-02-19
BRPI0309594A2 (pt)	2016-11-16
RS92804A (sr)	2006-12-15
KR100948469B1 (ko)	2010-03-17
US20050261304A1 (en)	2005-11-24
JP2006504631A (ja)	2006-02-09

Publication	Publication Date	Title
CY1107204T1 (el)	2012-11-21	Πιπεραζινοβενζοθειαζολια ως ουσιες για την θεραπευτικη αντιμετωπιση εγκεφαλικων ισχαιμικων διαταραχων ή διαταραχων του κνς
DE60332433D1 (de)	2010-06-17	Azolylaminoazine als proteinkinasehemmer
DE60332604D1 (de)	2010-07-01	Azolylaminoazine als proteinkinasehemmer
DE60314603D1 (de)	2007-08-09	Zusammensetzungen brauchbar als protein-kinase- inhibitoren
NO20052595L (no)	2005-06-27	Sammensetninger anvendelige som inhibitorer av ROCK- og andre proteinkinaser.
DE60327999D1 (de)	2009-07-30	Azolylaminoazine als inhibitoren von proteinkinasen
DE602004014117D1 (de)	2008-07-10	Thiazole zur verwendung als inhibitoren von protein-kinasen
NO20082673L (no)	2008-07-23	Nye 2-amino-imidazol-4-on forbindelser og deres anvendelse i fremstilling av et medikament som skal brukes til behandling av kognitiv svekkelse, Alzheimers sykdom, neurodegenerasjon og demens
DE602004024572D1 (de)	2010-01-21	Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen
DK1487444T3 (da)	2010-04-12	Anvendelse af pyridylamider som angiogeneseinhibitorer
NO20051726L (no)	2005-04-07	Pyrimidinonderivaer som terapeutiske midler ovenfor akutte og kroniske inflammasjons-, iskemiske og remodeleringsprosesser
NO20064599L (no)	2006-12-08	Substituerte morfolin- og tiomorfolinderivater
NO20062020L (no)	2006-07-10	1-amino-2-oksysubstituerte tetrahydronaftalenderivater, fremgangsmate for fremstilling derav, og deres anvendelse som antiflogistika
DK1789398T3 (da)	2011-01-24	2-amino-quinazolin derivater anvendelige som inhibitorer af B-sekretase (BACE)
NO20050514L (no)	2005-03-18	Sammensetning og antiviral aktivitet til substituerte azaindoloksoeddikpiperazinderivater
UY30025A1 (es)	2007-07-31	Derivados sustituidos de las 2-amino-5,6-dihidro pirimidin-4(3h)-onas y sus sales farmacéuticamente aceptables, composiciones farmacéuticas conteniéndolos y aplicaciones.
NO20054848L (no)	2005-10-20	Substituerte p-diaminobenzenderivater
NO20050701L (no)	2005-03-02	4-pyrrolidino-fenyl-benzyleter derivater
DE602004012578D1 (de)	2008-04-30	Als inhibitoren von c-met geeignete pyrrolzusammensetzungen
NO20082679L (no)	2008-06-10	Sammensetning og fremgangsmate for a behandle CNS lidelser
ECSP055844A (es)	2005-09-20	Nuevos compuestos triciclicos
DK1658062T3 (da)	2010-05-31	Alfa-aminoamid-derivater anvendelige som anti-inflammatoriske midler
ATE440836T1 (de)	2009-09-15	Verbindungen
EA200200750A1 (ru)	2003-02-27	Новое терапевтическое применение еноксапарина
DK1751105T3 (da)	2009-03-09	Piperazinderivater af alkyloxindoler