ATE386722T1 - Ein verbessertes verfahren für die synthese von methylphenidaten und zwischenprodukten - Google Patents
Ein verbessertes verfahren für die synthese von methylphenidaten und zwischenproduktenInfo
- Publication number
- ATE386722T1 ATE386722T1 AT05253597T AT05253597T ATE386722T1 AT E386722 T1 ATE386722 T1 AT E386722T1 AT 05253597 T AT05253597 T AT 05253597T AT 05253597 T AT05253597 T AT 05253597T AT E386722 T1 ATE386722 T1 AT E386722T1
- Authority
- AT
- Austria
- Prior art keywords
- methylphenidates
- synthesis
- improved method
- intermediate products
- substituted
- Prior art date
Links
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 239000002269 analeptic agent Substances 0.000 abstract 1
- 150000001555 benzenes Chemical class 0.000 abstract 1
- 125000005841 biaryl group Chemical group 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960001344 methylphenidate Drugs 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN651MU2004 | 2004-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE386722T1 true ATE386722T1 (de) | 2008-03-15 |
Family
ID=34978625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05253597T ATE386722T1 (de) | 2004-06-15 | 2005-06-10 | Ein verbessertes verfahren für die synthese von methylphenidaten und zwischenprodukten |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7459467B2 (de) |
| EP (1) | EP1607388B1 (de) |
| AT (1) | ATE386722T1 (de) |
| DE (1) | DE602005004834T2 (de) |
| ES (1) | ES2302145T3 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7897777B2 (en) * | 2007-01-05 | 2011-03-01 | Archimica, Inc. | Process of enantiomeric resolution of D,L-(±)-threo-methylphenidate |
| US9512077B2 (en) * | 2013-08-14 | 2016-12-06 | Zcl Chemicals Ltd. | Process for the preparation of methylphenidate hydrochloride and its intermediates thereof |
| KR101969407B1 (ko) | 2017-09-12 | 2019-08-20 | 한국화학연구원 | 선택적 수소화용 촉매 및 그것을 이용하는 선택적 수소화법 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2507631A (en) | 1944-01-19 | 1950-05-16 | Ciba Pharm Prod Inc | Pyridine and piperidine compounds and process of making same |
| US2957880A (en) | 1953-12-23 | 1960-10-25 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
-
2005
- 2005-06-10 DE DE602005004834T patent/DE602005004834T2/de not_active Expired - Fee Related
- 2005-06-10 ES ES05253597T patent/ES2302145T3/es not_active Expired - Lifetime
- 2005-06-10 US US11/150,737 patent/US7459467B2/en not_active Expired - Fee Related
- 2005-06-10 EP EP05253597A patent/EP1607388B1/de not_active Expired - Lifetime
- 2005-06-10 AT AT05253597T patent/ATE386722T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US7459467B2 (en) | 2008-12-02 |
| US20050277667A1 (en) | 2005-12-15 |
| EP1607388A1 (de) | 2005-12-21 |
| ES2302145T3 (es) | 2008-07-01 |
| EP1607388B1 (de) | 2008-02-20 |
| DE602005004834D1 (de) | 2008-04-03 |
| DE602005004834T2 (de) | 2009-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |