ATE456801T1 - Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe - Google Patents

Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe

Info

Publication number: ATE456801T1
Authority: AT; Austria
Prior art keywords: sirolimus; tacrolimus; complexes; immunosupressive; cyclosporin
Prior art date: 2005-04-06

Application number

AT06740696T

Other languages

English (en)

Inventor

Susan Drengler

Bennet Baugher

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-04-06

Filing date

2006-04-05

Publication date

2010-02-15

2006-04-05 Application filed by Abbott Lab filed Critical Abbott Lab

2010-02-15 Application granted granted Critical

2010-02-15 Publication of ATE456801T1 publication Critical patent/ATE456801T1/de

Links

238000000034 method Methods 0.000 title abstract 4
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 title abstract 2
239000008280 blood Substances 0.000 title abstract 2
210000004369 blood Anatomy 0.000 title abstract 2
230000001506 immunosuppresive effect Effects 0.000 title abstract 2
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 2
229960002930 sirolimus Drugs 0.000 title abstract 2
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 2
229960001967 tacrolimus Drugs 0.000 title abstract 2
QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 title abstract 2
238000003556 assay Methods 0.000 abstract 2
239000003018 immunosuppressive agent Substances 0.000 abstract 2
229940124589 immunosuppressive drug Drugs 0.000 abstract 2
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
238000009007 Diagnostic Kit Methods 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000002651 drug therapy Methods 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9493—Immunosupressants
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Analytical Chemistry (AREA)
Cell Biology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT06740696T 2005-04-06 2006-04-05 Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe ATE456801T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US66871405P	2005-04-06	2005-04-06
PCT/US2006/012988 WO2006108130A2 (en)	2005-04-06	2006-04-05	Methods to measure immunosuppressive tacrolimus, sirolimus, and cyclosporin a complexes in a blood sample

Publications (1)

Publication Number	Publication Date
ATE456801T1 true ATE456801T1 (de)	2010-02-15

Family

ID=36888889

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT06740696T ATE456801T1 (de)	2005-04-06	2006-04-05	Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe
AT10151541T ATE544073T1 (de)	2005-04-06	2006-04-05	Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT10151541T ATE544073T1 (de)	2005-04-06	2006-04-05	Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe

Country Status (9)

Country	Link
US (2)	US7592186B2 (de)
EP (2)	EP2180323B1 (de)
JP (1)	JP4862038B2 (de)
AT (2)	ATE456801T1 (de)
CA (1)	CA2602732A1 (de)
DE (1)	DE602006012033D1 (de)
ES (1)	ES2380207T3 (de)
MX (1)	MX2007012447A (de)
WO (1)	WO2006108130A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8022188B2 (en) *	2006-04-24	2011-09-20	Abbott Laboratories	Immunosuppressant binding antibodies and methods of obtaining and using same
US20080081379A1 (en) *	2006-07-13	2008-04-03	Sigler Gerald F	Homogeneous double receptor agglutination assay for immunosuppressant drugs
US7883855B2 (en) *	2006-07-21	2011-02-08	Abbott Laboratories	Immunosuppressant drug extraction reagent for immunoassays
ES2405364T3 (es)	2006-12-29	2013-05-30	Abbott Laboratories	Ensayo diagnóstico para la detección de una molécula o fármaco en sangre entera
WO2008082984A2 (en)	2006-12-29	2008-07-10	Abbott Laboratories	Non-denaturing lysis reagent for use with capture-in-solution immunoassay
ES2393135T3 (es) *	2006-12-29	2012-12-18	Abbott Laboratories	Ensayo mejorado para fármacos inmunosupresores
US7914999B2 (en)	2006-12-29	2011-03-29	Abbott Laboratories	Non-denaturing lysis reagent
US8288111B2 (en) *	2007-05-24	2012-10-16	Abbott Laboratories	Immunoassays exhibiting reduced cross-reactivity with hydrophobic drug analyte metabolites
US9164090B2 (en) *	2007-08-17	2015-10-20	Korea Advanced Institute Of Science And Technology	Methods for detecting molecular interactions
WO2012054639A2 (en)	2010-10-22	2012-04-26	T2 Biosystems, Inc.	Nmr systems and methods for the rapid detection of analytes
US8409807B2 (en)	2010-10-22	2013-04-02	T2 Biosystems, Inc.	NMR systems and methods for the rapid detection of analytes
US8563298B2 (en)	2010-10-22	2013-10-22	T2 Biosystems, Inc.	NMR systems and methods for the rapid detection of analytes
US8586322B2 (en) *	2012-03-07	2013-11-19	Siemens Healthcare Diagnostics, Inc	Sandwich assay for immunosuppressant drugs
WO2013158281A1 (en)	2012-04-20	2013-10-24	T2 Biosystems, Inc.	Compositions and methods for detection of candida species
JP6879496B2 (ja) *	2015-10-29	2021-06-02	シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓＨｅａｌｔｈｃａｒｅＤｉａｇｎｏｓｔｉｃｓＩｎｃ．	小分子のためのサンドイッチアッセイ
US11519016B2 (en)	2016-01-21	2022-12-06	T2 Biosystems, Inc.	NMR methods and systems for the rapid detection of bacteria

Family Cites Families (8)

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US5525461A (en)	1991-11-01	1996-06-11	T Cell Diagnostics, Inc.	Therapeutic and diagnostic methods using total leukocyte surface antigens
CA2140661A1 (en)	1992-07-20	1994-02-03	Sharat Singh	Novel chemiluminescent compounds and methods of use
KR100243536B1 (ko)	1992-08-12	2000-02-01	후지야마 아키라	Fk506-결합 단백질을 인식하는 모노클로날 항체, fk506-결합 단백질의 농도를 분석하는 방법 및 이를 위한 키트
US5756301A (en)	1993-03-03	1998-05-26	The Trustees Of Columbia University In The City Of New York	Endogenous taxol-like substance in human serum, monoclonal antibodies directed thereto and methods of assaying therefor
CN1147853A (zh) *	1994-03-10	1997-04-16	藤泽药品工业株式会社	免疫抑制剂的定量法
WO1996018102A1 (en) *	1994-12-07	1996-06-13	Fujisawa Pharmaceutical Co., Ltd.	Method of measuring the concentration of fk506-binding protein
DE69840586D1 (de) *	1997-10-08	2009-04-02	Isotechnika Inc	Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien
US20060014677A1 (en) *	2004-07-19	2006-01-19	Isotechnika International Inc.	Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds

2006
- 2006-04-05 JP JP2008505563A patent/JP4862038B2/ja not_active Expired - Fee Related
- 2006-04-05 EP EP10151541A patent/EP2180323B1/de not_active Not-in-force
- 2006-04-05 ES ES10151541T patent/ES2380207T3/es active Active
- 2006-04-05 CA CA002602732A patent/CA2602732A1/en not_active Abandoned
- 2006-04-05 DE DE602006012033T patent/DE602006012033D1/de active Active
- 2006-04-05 MX MXMX07012447A patent/MX2007012447A/es active IP Right Grant
- 2006-04-05 WO PCT/US2006/012988 patent/WO2006108130A2/en not_active Ceased
- 2006-04-05 AT AT06740696T patent/ATE456801T1/de not_active IP Right Cessation
- 2006-04-05 EP EP06740696A patent/EP1875250B1/de active Active
- 2006-04-05 AT AT10151541T patent/ATE544073T1/de active
- 2006-04-06 US US11/398,997 patent/US7592186B2/en not_active Expired - Fee Related
2009
- 2009-08-12 US US12/539,825 patent/US7923210B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2602732A1 (en)	2006-10-12
EP2180323B1 (de)	2012-02-01
WO2006108130A2 (en)	2006-10-12
US20060257957A1 (en)	2006-11-16
US7592186B2 (en)	2009-09-22
US7923210B2 (en)	2011-04-12
EP2180323A1 (de)	2010-04-28
DE602006012033D1 (de)	2010-03-18
WO2006108130A3 (en)	2006-11-23
US20090298090A1 (en)	2009-12-03
ATE544073T1 (de)	2012-02-15
MX2007012447A (es)	2007-10-19
EP1875250A2 (de)	2008-01-09
JP2008536126A (ja)	2008-09-04
JP4862038B2 (ja)	2012-01-25
ES2380207T3 (es)	2012-05-09
EP1875250B1 (de)	2010-01-27

Legal Events

Date	Code	Title	Description
2010-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE544073T1 (de)	2012-02-15	Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a- komplexe in einer blutprobe
CA2465800A1 (en)	2003-05-15	Instrument
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ATE540319T1 (de)	2012-01-15	Verfahren für die bestimmung von fk506
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