ATE482977T1 - Insulinderivate - Google Patents
InsulinderivateInfo
- Publication number
- ATE482977T1 ATE482977T1 AT07712327T AT07712327T ATE482977T1 AT E482977 T1 ATE482977 T1 AT E482977T1 AT 07712327 T AT07712327 T AT 07712327T AT 07712327 T AT07712327 T AT 07712327T AT E482977 T1 ATE482977 T1 AT E482977T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin derivatives
- chain
- amino group
- present
- lys residue
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06110441 | 2006-02-27 | ||
| EP06118253 | 2006-08-01 | ||
| PCT/EP2007/051835 WO2007096431A1 (en) | 2006-02-27 | 2007-02-27 | Insulin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE482977T1 true ATE482977T1 (de) | 2010-10-15 |
Family
ID=38001155
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT10168840T ATE557037T1 (de) | 2006-02-27 | 2007-02-27 | Insulin derivate |
| AT07712327T ATE482977T1 (de) | 2006-02-27 | 2007-02-27 | Insulinderivate |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT10168840T ATE557037T1 (de) | 2006-02-27 | 2007-02-27 | Insulin derivate |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8722620B2 (de) |
| EP (2) | EP1991576B1 (de) |
| JP (2) | JP5202338B2 (de) |
| AT (2) | ATE557037T1 (de) |
| DE (1) | DE602007009496D1 (de) |
| ES (1) | ES2387955T3 (de) |
| WO (1) | WO2007096431A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004261353B2 (en) * | 2003-08-05 | 2009-12-10 | Novo Nordisk A/S | Novel insulin derivatives |
| ES2435522T3 (es) | 2005-02-02 | 2013-12-20 | Novo Nordisk A/S | Derivados de insulina |
| WO2006082204A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
| EP1969004B1 (de) | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen |
| JP5202338B2 (ja) | 2006-02-27 | 2013-06-05 | ノボ・ノルデイスク・エー／エス | 新規インシュリン誘導体 |
| AU2007247109B2 (en) * | 2006-05-09 | 2012-03-15 | Novo Nordisk A/S | Insulin derivative |
| WO2007128815A1 (en) * | 2006-05-09 | 2007-11-15 | Novo Nordisk A/S | Insulin derivative |
| CN101541830A (zh) | 2006-09-22 | 2009-09-23 | 诺沃-诺迪斯克有限公司 | 蛋白酶抗性的胰岛素类似物 |
| WO2008132224A2 (en) | 2007-04-30 | 2008-11-06 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
| JP5552046B2 (ja) | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー／エス | インスリン誘導体を含有する薬学的製剤 |
| AU2008288413B2 (en) | 2007-08-15 | 2013-09-26 | Novo Nordisk A/S | Insulin analogues with an acyl and aklylene glycol moiety |
| WO2009022006A1 (en) | 2007-08-15 | 2009-02-19 | Novo Nordisk A/S | Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids |
| ES2543393T3 (es) | 2007-11-08 | 2015-08-18 | Novo Nordisk A/S | Derivado de insulina |
| CN101970477B (zh) * | 2008-03-14 | 2014-12-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定的胰岛素类似物 |
| HUE032284T2 (en) * | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| EP2262539B1 (de) | 2008-04-01 | 2015-07-15 | Novo Nordisk A/S | Insulin-albumin-konzentrate |
| CN102202683A (zh) * | 2008-10-30 | 2011-09-28 | 诺沃-诺迪斯克有限公司 | 用少于每日一次的注射频率注射胰岛素来治疗糖尿病 |
| WO2010088294A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Conjugate based systems for controlled drug delivery |
| RU2011135730A (ru) | 2009-01-28 | 2013-03-10 | Смартселлз, Инк. | Кристаллические инсулин-коньюгаты |
| JP2012516339A (ja) | 2009-01-28 | 2012-07-19 | スマートセルズ・インコーポレイテツド | 外因的刺激型制御放出物質体およびその使用 |
| WO2010088286A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
| JP2012520879A (ja) | 2009-03-20 | 2012-09-10 | スマートセルズ・インコーポレイテツド | 末端官能基化コンジュゲートおよびその用途 |
| WO2010107520A1 (en) * | 2009-03-20 | 2010-09-23 | Smartcells, Inc. | Soluble non-depot insulin conjugates and uses thereof |
| CN102665676B (zh) | 2009-11-02 | 2015-04-01 | 诺沃-诺迪斯克有限公司 | 非共价结合的白蛋白和酰化胰岛素的药物溶液 |
| WO2012015691A2 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinant lectins, binding-site modified lectins and uses thereof |
| JP2013535467A (ja) | 2010-07-28 | 2013-09-12 | スマートセルズ・インコーポレイテツド | 組換えにより発現されたインスリンポリペプチドおよびその使用 |
| WO2012015681A2 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Drug-ligand conjugates, synthesis thereof, and intermediates thereto |
| DK2632478T3 (da) | 2010-10-27 | 2019-10-07 | Novo Nordisk As | Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller |
| EP2720711A1 (de) * | 2011-06-15 | 2014-04-23 | Novo Nordisk A/S | Mehrfach substituierte insuline |
| EP2836508B1 (de) | 2012-04-11 | 2016-06-29 | Novo Nordisk A/S | Insulinformulierungen |
| EP2991672A1 (de) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Neuartiges verabreichungsschema |
| US9884125B2 (en) | 2013-10-04 | 2018-02-06 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
| CA2926701A1 (en) | 2013-10-07 | 2015-04-16 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
| AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| EP3280450A4 (de) * | 2015-04-08 | 2018-12-12 | Merck Sharp & Dohme Corp. | Auf glucose reagierende insulinkonjugate |
| BR112018002416A2 (pt) | 2015-08-25 | 2018-09-18 | Novo Nordisk As | derivados de insulina e seus usos médicos |
| ES2886837T3 (es) | 2016-12-16 | 2021-12-21 | Novo Nordisk As | Composiciones farmacéuticas que contienen insulina |
| CN107602437A (zh) * | 2017-08-09 | 2018-01-19 | 上海昂德生物科技有限公司 | 活化酯的制备方法 |
| CA3071686A1 (en) | 2017-08-17 | 2019-02-21 | Novo Nordisk A/S | Novel acylated insulin analogues and uses thereof |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| TW202039437A (zh) | 2018-12-11 | 2020-11-01 | 法商賽諾菲公司 | 肽黏合劑 |
| US12427187B2 (en) | 2019-06-06 | 2025-09-30 | Merck Sharp & Dohme Llc | Glucose-responsive insulin conjugates |
| CN114096269B (zh) | 2019-07-12 | 2024-06-11 | 诺和诺德股份有限公司 | 高浓度胰岛素制剂 |
| MA58093B1 (fr) | 2019-12-11 | 2024-09-30 | Novo Nordisk A/S | Nouveaux analogues d'insuline et leurs utilisations |
| BR112022013009A2 (pt) * | 2019-12-30 | 2022-09-06 | Gan & Lee Pharmaceuticals Co Ltd | Derivados de insulina, composição farmacêutica, uso do derivado da insulina e métodos para tratar ou prevenir diabetes, para aumentar a capacidade de um derivado de insulina e para aumentar a potência de um derivado de insulina |
| CN113075342B (zh) * | 2020-01-04 | 2024-02-27 | 东莞市东阳光仿制药研发有限公司 | 一种分离检测德谷胰岛素侧链有关物质的方法 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US487000A (en) | 1892-11-29 | Shirt | ||
| US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| AU600885B2 (en) | 1984-05-25 | 1990-08-30 | Zymogenetics Inc. | Stable DNA constructs |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| NZ222907A (en) | 1986-12-16 | 1990-08-28 | Novo Industri As | Preparation for intranasal administration containing a phospholipid absorption enhancing system |
| DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
| HUT56857A (en) | 1988-12-23 | 1991-10-28 | Novo Nordisk As | Human insulin analogues |
| DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| IL93282A (en) | 1989-02-09 | 1995-08-31 | Lilly Co Eli | Insulin analogues |
| DK300090D0 (da) | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
| DK82893D0 (da) | 1993-07-08 | 1993-07-08 | Novo Nordisk As | Peptid |
| NZ273285A (en) | 1993-09-17 | 1997-10-24 | Novo Nordisk As | Insulin derivatives and compositions thereof |
| US6869930B1 (en) * | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
| US6011007A (en) * | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
| US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
| US5639642A (en) | 1994-06-16 | 1997-06-17 | Novo Nordisk A/S | Synthetic leader peptide sequences |
| US5646242A (en) * | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
| US6251856B1 (en) * | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
| CA2215694A1 (en) * | 1995-03-17 | 1996-09-26 | Novo Nordisk A/S | Insulin derivatives |
| US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
| US5905140A (en) * | 1996-07-11 | 1999-05-18 | Novo Nordisk A/S, Novo Alle | Selective acylation method |
| WO1998032867A1 (en) | 1997-01-24 | 1998-07-30 | Novo Nordisk A/S | Synthetic leader peptide sequences |
| US5898067A (en) * | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
| US6451762B1 (en) * | 1997-10-24 | 2002-09-17 | Novo Nordisk A/S | Aggregates of human insulin derivatives |
| PL195845B1 (pl) | 1997-10-24 | 2007-10-31 | Novo Nordisk As | Rozpuszczalny w wodzie agregat pochodnych insuliny |
| DE69924232D1 (de) * | 1998-01-09 | 2005-04-21 | Novo Nordisk As | Stabilisierte insulin-zubereitungen |
| CA2334859A1 (en) | 1998-06-12 | 1999-12-23 | Kings College London | Insulin analogue |
| EP1453860A2 (de) | 2001-12-02 | 2004-09-08 | Novo Nordisk A/S | Neue glukoseabhängige insuline |
| US8003605B2 (en) * | 2002-03-13 | 2011-08-23 | Novo Nordisk A/S | Minimising body weight gain in insulin treatment |
| US20040138099A1 (en) * | 2002-11-29 | 2004-07-15 | Draeger Eberhard Kurt | Insulin administration regimens for the treatment of subjects with diabetes |
| WO2004096854A2 (en) * | 2003-04-29 | 2004-11-11 | Eli Lilly And Company | Insulin analogs having protracted time action |
| EP1644411A2 (de) | 2003-07-11 | 2006-04-12 | Novo Nordisk A/S | Stabilisierte insulinzusammensetzungen |
| US20060183667A1 (en) * | 2003-07-11 | 2006-08-17 | Novo Nordisk A/S | Stabilised insulin compositions |
| AU2004261353B2 (en) * | 2003-08-05 | 2009-12-10 | Novo Nordisk A/S | Novel insulin derivatives |
| EP1687428A1 (de) | 2003-11-14 | 2006-08-09 | Novo Nordisk A/S | Verfahren zur herstellung von acyliertem insulin |
| WO2006008238A1 (en) | 2004-07-16 | 2006-01-26 | Novo Nordisk A/S | Method for selective acylation |
| WO2006082204A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
| EP1969004B1 (de) * | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen |
| JP5202338B2 (ja) | 2006-02-27 | 2013-06-05 | ノボ・ノルデイスク・エー／エス | 新規インシュリン誘導体 |
| AU2007247109B2 (en) | 2006-05-09 | 2012-03-15 | Novo Nordisk A/S | Insulin derivative |
| WO2007128815A1 (en) | 2006-05-09 | 2007-11-15 | Novo Nordisk A/S | Insulin derivative |
| JP5552046B2 (ja) * | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー／エス | インスリン誘導体を含有する薬学的製剤 |
| ES2543393T3 (es) | 2007-11-08 | 2015-08-18 | Novo Nordisk A/S | Derivado de insulina |
| CN101861333A (zh) | 2007-11-16 | 2010-10-13 | 诺沃-诺迪斯克有限公司 | 包含glp-1肽或毒蜥外泌肽-4和基础胰岛素肽的药物组合物 |
| CN102202683A (zh) * | 2008-10-30 | 2011-09-28 | 诺沃-诺迪斯克有限公司 | 用少于每日一次的注射频率注射胰岛素来治疗糖尿病 |
| AU2011252127B2 (en) | 2010-05-10 | 2014-02-20 | Novo Nordisk A/S | Process for the preparation of insulin-zinc complexes |
-
2007
- 2007-02-27 JP JP2008556768A patent/JP5202338B2/ja not_active Expired - Fee Related
- 2007-02-27 EP EP07712327A patent/EP1991576B1/de not_active Not-in-force
- 2007-02-27 US US12/280,851 patent/US8722620B2/en not_active Expired - Fee Related
- 2007-02-27 AT AT10168840T patent/ATE557037T1/de active
- 2007-02-27 AT AT07712327T patent/ATE482977T1/de not_active IP Right Cessation
- 2007-02-27 ES ES10168840T patent/ES2387955T3/es active Active
- 2007-02-27 EP EP10168840A patent/EP2256129B1/de not_active Not-in-force
- 2007-02-27 WO PCT/EP2007/051835 patent/WO2007096431A1/en not_active Ceased
- 2007-02-27 DE DE602007009496T patent/DE602007009496D1/de active Active
-
2012
- 2012-06-19 JP JP2012137431A patent/JP5475836B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009528325A (ja) | 2009-08-06 |
| JP5202338B2 (ja) | 2013-06-05 |
| JP2012214486A (ja) | 2012-11-08 |
| EP2256129A1 (de) | 2010-12-01 |
| EP1991576A1 (de) | 2008-11-19 |
| DE602007009496D1 (de) | 2010-11-11 |
| WO2007096431A1 (en) | 2007-08-30 |
| ATE557037T1 (de) | 2012-05-15 |
| JP5475836B2 (ja) | 2014-04-16 |
| ES2387955T3 (es) | 2012-10-04 |
| EP1991576B1 (de) | 2010-09-29 |
| US20090137454A1 (en) | 2009-05-28 |
| US8722620B2 (en) | 2014-05-13 |
| EP2256129B1 (de) | 2012-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |