ATE482977T1 - Insulinderivate - Google Patents
InsulinderivateInfo
- Publication number
- ATE482977T1 ATE482977T1 AT07712327T AT07712327T ATE482977T1 AT E482977 T1 ATE482977 T1 AT E482977T1 AT 07712327 T AT07712327 T AT 07712327T AT 07712327 T AT07712327 T AT 07712327T AT E482977 T1 ATE482977 T1 AT E482977T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin derivatives
- chain
- amino group
- present
- lys residue
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06110441 | 2006-02-27 | ||
| EP06118253 | 2006-08-01 | ||
| PCT/EP2007/051835 WO2007096431A1 (en) | 2006-02-27 | 2007-02-27 | Insulin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE482977T1 true ATE482977T1 (de) | 2010-10-15 |
Family
ID=38001155
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07712327T ATE482977T1 (de) | 2006-02-27 | 2007-02-27 | Insulinderivate |
| AT10168840T ATE557037T1 (de) | 2006-02-27 | 2007-02-27 | Insulin derivate |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT10168840T ATE557037T1 (de) | 2006-02-27 | 2007-02-27 | Insulin derivate |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8722620B2 (de) |
| EP (2) | EP1991576B1 (de) |
| JP (2) | JP5202338B2 (de) |
| AT (2) | ATE482977T1 (de) |
| DE (1) | DE602007009496D1 (de) |
| ES (1) | ES2387955T3 (de) |
| WO (1) | WO2007096431A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4463814B2 (ja) * | 2003-08-05 | 2010-05-19 | ノボ ノルディスク アクティーゼルスカブ | 新規のインスリン誘導体 |
| ES2435522T3 (es) | 2005-02-02 | 2013-12-20 | Novo Nordisk A/S | Derivados de insulina |
| US8067362B2 (en) | 2005-02-02 | 2011-11-29 | Novo Nordisk As | Insulin derivatives |
| EP1969004B1 (de) | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen |
| ATE482977T1 (de) | 2006-02-27 | 2010-10-15 | Novo Nordisk As | Insulinderivate |
| EP2386572B1 (de) * | 2006-05-09 | 2015-07-08 | Novo Nordisk A/S | Insulinderivat |
| WO2007128815A1 (en) * | 2006-05-09 | 2007-11-15 | Novo Nordisk A/S | Insulin derivative |
| WO2008034881A1 (en) | 2006-09-22 | 2008-03-27 | Novo Nordisk A/S | Protease resistant insulin analogues |
| CN101674812B (zh) | 2007-04-30 | 2013-12-11 | 诺沃-诺迪斯克有限公司 | 干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物 |
| US9034818B2 (en) | 2007-06-13 | 2015-05-19 | Novo Nordisk A/S | Pharmaceutical formulations comprising an insulin derivative |
| EP2708554A1 (de) | 2007-08-15 | 2014-03-19 | Novo Nordisk A/S | Insulinanaloge mit Acyl- und Alkylenglycolteilen |
| ES2526924T3 (es) | 2007-08-15 | 2015-01-16 | Novo Nordisk A/S | Insulinas con una fracción acilo que comprende unidades repetitivas de aminoácidos que contienen alquilenglicol |
| US8710000B2 (en) | 2007-11-08 | 2014-04-29 | Novo Nordisk A/S | Insulin derivative |
| WO2009112583A2 (en) * | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
| PT2910570T (pt) * | 2008-03-18 | 2017-01-24 | Novo Nordisk As | Análogos de insulina acilados, estabilizados contra proteases |
| EP2262539B1 (de) | 2008-04-01 | 2015-07-15 | Novo Nordisk A/S | Insulin-albumin-konzentrate |
| ES2607003T3 (es) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria |
| US8906850B2 (en) | 2009-01-28 | 2014-12-09 | Smartcells, Inc. | Crystalline insulin-conjugates |
| CA2750262C (en) | 2009-01-28 | 2016-08-09 | Smartcells, Inc. | Conjugate based systems for controlled drug delivery |
| JP2012516339A (ja) | 2009-01-28 | 2012-07-19 | スマートセルズ・インコーポレイテツド | 外因的刺激型制御放出物質体およびその使用 |
| AU2010208305A1 (en) | 2009-01-28 | 2011-09-08 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
| US8623345B2 (en) | 2009-03-20 | 2014-01-07 | Smartcells | Terminally-functionalized conjugates and uses thereof |
| WO2010107520A1 (en) * | 2009-03-20 | 2010-09-23 | Smartcells, Inc. | Soluble non-depot insulin conjugates and uses thereof |
| ES2552401T3 (es) | 2009-11-02 | 2015-11-27 | Novo Nordisk A/S | Solución farmacéutica de albúmina unida no covalentemente e insulina acilada |
| JP2013541500A (ja) | 2010-07-28 | 2013-11-14 | スマートセルズ・インコーポレイテツド | 組換えレクチン、結合部位修飾レクチンおよびそれらの用途 |
| CA2806399A1 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
| CA2805739A1 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Drug-ligand conjugates, synthesis thereof, and intermediates thereto |
| DK2632478T3 (da) | 2010-10-27 | 2019-10-07 | Novo Nordisk As | Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller |
| JP6058646B2 (ja) * | 2011-06-15 | 2017-01-11 | ノヴォ ノルディスク アー／エス | 多置換インスリン |
| CA2870313A1 (en) | 2012-04-11 | 2013-10-17 | Novo Nordisk A/S | Insulin formulations |
| JP2016519127A (ja) | 2013-04-30 | 2016-06-30 | ノヴォ ノルディスク アー／エス | 新規投与レジメン |
| CN105792852B (zh) | 2013-10-04 | 2019-12-10 | 默沙东公司 | 葡萄糖响应性的胰岛素缀合物 |
| CN105636979B (zh) | 2013-10-07 | 2020-01-10 | 诺和诺德股份有限公司 | 胰岛素类似物的新衍生物 |
| AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| WO2016164288A1 (en) * | 2015-04-08 | 2016-10-13 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
| ES2908373T3 (es) | 2015-08-25 | 2022-04-28 | Novo Nordisk As | Nuevos derivados de insulina y los usos médicos de los mismos |
| DK3554534T3 (da) | 2016-12-16 | 2021-08-23 | Novo Nordisk As | Farmaceutisk sammensætning omfattende insulin |
| CN107602437A (zh) * | 2017-08-09 | 2018-01-19 | 上海昂德生物科技有限公司 | 活化酯的制备方法 |
| SG11202001077UA (en) | 2017-08-17 | 2020-03-30 | Novo Nordisk As | Novel acylated insulin analogues and uses thereof |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| US11098102B2 (en) | 2018-12-11 | 2021-08-24 | Sanofi | Insulin conjugates |
| US12427187B2 (en) | 2019-06-06 | 2025-09-30 | Merck Sharp & Dohme Llc | Glucose-responsive insulin conjugates |
| JP7518149B2 (ja) | 2019-07-12 | 2024-07-17 | ノヴォ ノルディスク アー／エス | 高濃度インスリン製剤 |
| IL319162A (en) | 2019-12-11 | 2025-04-01 | Novo Nordisk As | New insulin analogs and their use |
| CN118598978A (zh) * | 2019-12-30 | 2024-09-06 | 甘李药业股份有限公司 | 胰岛素衍生物 |
| CN113075342B (zh) * | 2020-01-04 | 2024-02-27 | 东莞市东阳光仿制药研发有限公司 | 一种分离检测德谷胰岛素侧链有关物质的方法 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US487000A (en) | 1892-11-29 | Shirt | ||
| US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| AU600885B2 (en) | 1984-05-25 | 1990-08-30 | Zymogenetics Inc. | Stable DNA constructs |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| NZ222907A (en) | 1986-12-16 | 1990-08-28 | Novo Industri As | Preparation for intranasal administration containing a phospholipid absorption enhancing system |
| DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
| AU641631B2 (en) | 1988-12-23 | 1993-09-30 | Novo Nordisk A/S | Human insulin analogues |
| DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| IL93282A (en) | 1989-02-09 | 1995-08-31 | Lilly Co Eli | Insulin analogues |
| DK300090D0 (da) | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
| DK82893D0 (da) | 1993-07-08 | 1993-07-08 | Novo Nordisk As | Peptid |
| US6869930B1 (en) * | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
| DK0792290T3 (da) * | 1993-09-17 | 2001-10-01 | Novo Nordisk As | Acyleret insulin |
| US6011007A (en) * | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
| US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
| US5639642A (en) | 1994-06-16 | 1997-06-17 | Novo Nordisk A/S | Synthetic leader peptide sequences |
| US5646242A (en) * | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
| US6251856B1 (en) * | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
| WO1996029344A1 (en) | 1995-03-17 | 1996-09-26 | Novo Nordisk A/S | Insulin derivatives |
| US6451970B1 (en) * | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
| US5905140A (en) * | 1996-07-11 | 1999-05-18 | Novo Nordisk A/S, Novo Alle | Selective acylation method |
| EP0954589A1 (de) | 1997-01-24 | 1999-11-10 | Novo Nordisk A/S | Sythetische signalpeptid-sequenzen. |
| US5898067A (en) * | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
| EP1025125B1 (de) * | 1997-10-24 | 2003-06-25 | Novo Nordisk A/S | Aggregate von menschlichen insulinderivaten |
| US6451762B1 (en) * | 1997-10-24 | 2002-09-17 | Novo Nordisk A/S | Aggregates of human insulin derivatives |
| WO1999034821A1 (en) * | 1998-01-09 | 1999-07-15 | Novo Nordisk A/S | Stabilised insulin compositions |
| JP2002518408A (ja) * | 1998-06-12 | 2002-06-25 | キングス・カレツジ・ロンドン | インスリン類似体 |
| EP1453860A2 (de) | 2001-12-02 | 2004-09-08 | Novo Nordisk A/S | Neue glukoseabhängige insuline |
| US8003605B2 (en) * | 2002-03-13 | 2011-08-23 | Novo Nordisk A/S | Minimising body weight gain in insulin treatment |
| US20040138099A1 (en) * | 2002-11-29 | 2004-07-15 | Draeger Eberhard Kurt | Insulin administration regimens for the treatment of subjects with diabetes |
| KR20050121748A (ko) * | 2003-04-29 | 2005-12-27 | 일라이 릴리 앤드 캄파니 | 연장된 시간 작용을 갖는 인슐린 유사체 |
| WO2005005477A2 (en) | 2003-07-11 | 2005-01-20 | Novo Nordisk A/S | Stabilised insulin compositions |
| US20060183667A1 (en) * | 2003-07-11 | 2006-08-17 | Novo Nordisk A/S | Stabilised insulin compositions |
| JP4463814B2 (ja) * | 2003-08-05 | 2010-05-19 | ノボ ノルディスク アクティーゼルスカブ | 新規のインスリン誘導体 |
| WO2005047508A1 (en) | 2003-11-14 | 2005-05-26 | Novo Nordisk A/S | Processes for making acylated insulin |
| WO2006008238A1 (en) | 2004-07-16 | 2006-01-26 | Novo Nordisk A/S | Method for selective acylation |
| US8067362B2 (en) * | 2005-02-02 | 2011-11-29 | Novo Nordisk As | Insulin derivatives |
| EP1969004B1 (de) * | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen |
| ATE482977T1 (de) | 2006-02-27 | 2010-10-15 | Novo Nordisk As | Insulinderivate |
| EP2386572B1 (de) | 2006-05-09 | 2015-07-08 | Novo Nordisk A/S | Insulinderivat |
| WO2007128815A1 (en) | 2006-05-09 | 2007-11-15 | Novo Nordisk A/S | Insulin derivative |
| US9034818B2 (en) * | 2007-06-13 | 2015-05-19 | Novo Nordisk A/S | Pharmaceutical formulations comprising an insulin derivative |
| US8710000B2 (en) * | 2007-11-08 | 2014-04-29 | Novo Nordisk A/S | Insulin derivative |
| JP5241849B2 (ja) | 2007-11-16 | 2013-07-17 | ノボ・ノルデイスク・エー／エス | インスリン及びインスリン分泌性ペプチドを含む薬学的組成物 |
| ES2607003T3 (es) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria |
| RU2572214C2 (ru) | 2010-05-10 | 2015-12-27 | Ново Нордиск А/С | Способ получения цинковых комплексов инсулина |
-
2007
- 2007-02-27 AT AT07712327T patent/ATE482977T1/de not_active IP Right Cessation
- 2007-02-27 JP JP2008556768A patent/JP5202338B2/ja not_active Expired - Fee Related
- 2007-02-27 EP EP07712327A patent/EP1991576B1/de not_active Not-in-force
- 2007-02-27 WO PCT/EP2007/051835 patent/WO2007096431A1/en not_active Ceased
- 2007-02-27 DE DE602007009496T patent/DE602007009496D1/de active Active
- 2007-02-27 US US12/280,851 patent/US8722620B2/en not_active Expired - Fee Related
- 2007-02-27 AT AT10168840T patent/ATE557037T1/de active
- 2007-02-27 EP EP10168840A patent/EP2256129B1/de not_active Not-in-force
- 2007-02-27 ES ES10168840T patent/ES2387955T3/es active Active
-
2012
- 2012-06-19 JP JP2012137431A patent/JP5475836B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2256129A1 (de) | 2010-12-01 |
| EP1991576B1 (de) | 2010-09-29 |
| EP2256129B1 (de) | 2012-05-09 |
| ES2387955T3 (es) | 2012-10-04 |
| US8722620B2 (en) | 2014-05-13 |
| DE602007009496D1 (de) | 2010-11-11 |
| EP1991576A1 (de) | 2008-11-19 |
| JP2012214486A (ja) | 2012-11-08 |
| JP5202338B2 (ja) | 2013-06-05 |
| ATE557037T1 (de) | 2012-05-15 |
| US20090137454A1 (en) | 2009-05-28 |
| JP5475836B2 (ja) | 2014-04-16 |
| JP2009528325A (ja) | 2009-08-06 |
| WO2007096431A1 (en) | 2007-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |