ATE517096T1 - Verfahren zur herstellung von aminopyrimidinen - Google Patents

Verfahren zur herstellung von aminopyrimidinen

Info

Publication number: ATE517096T1
Authority: AT; Austria
Prior art keywords: alkyl; compound; formula; aminopyrimidines; producing
Prior art date: 2004-03-31

Application number

AT05729737T

Other languages

English (en)

Inventor

Ulf Larsson

Kajsa Radevik

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-31

Filing date

2005-03-29

Publication date

2011-08-15

2005-03-29 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2011-08-15 Application granted granted Critical

2011-08-15 Publication of ATE517096T1 publication Critical patent/ATE517096T1/de

Links

150000005005 aminopyrimidines Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
238000005580 one pot reaction Methods 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

AT05729737T 2004-03-31 2005-03-29 Verfahren zur herstellung von aminopyrimidinen ATE517096T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0401001A SE0401001D0 (sv)	2004-03-31	2004-03-31	Chemical process
PCT/GB2005/001188 WO2005095358A2 (en)	2004-03-31	2005-03-29	Process for the preparation of aminopyrimidines

Publications (1)

Publication Number	Publication Date
ATE517096T1 true ATE517096T1 (de)	2011-08-15

Family

ID=32294337

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05729737T ATE517096T1 (de)	2004-03-31	2005-03-29	Verfahren zur herstellung von aminopyrimidinen

Country Status (23)

Country	Link
US (2)	US7799914B2 (de)
EP (2)	EP1751117B1 (de)
JP (1)	JP5059599B2 (de)
KR (1)	KR101164265B1 (de)
CN (2)	CN101851212A (de)
AT (1)	ATE517096T1 (de)
AU (1)	AU2005227727B2 (de)
BR (1)	BRPI0509323A (de)
CA (1)	CA2560094C (de)
CY (1)	CY1111847T1 (de)
DK (1)	DK1751117T3 (de)
ES (1)	ES2368069T3 (de)
HR (1)	HRP20110658T1 (de)
IL (1)	IL177998A (de)
NO (1)	NO20064117L (de)
NZ (2)	NZ587999A (de)
PL (1)	PL1751117T3 (de)
PT (1)	PT1751117E (de)
SE (1)	SE0401001D0 (de)
SG (1)	SG151311A1 (de)
SI (1)	SI1751117T1 (de)
WO (1)	WO2005095358A2 (de)
ZA (1)	ZA200607708B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0401001D0 (sv) *	2004-03-31	2004-03-31	Astrazeneca Ab	Chemical process
TWI385156B (zh) *	2006-02-13	2013-02-11	Lonza Ag	５-（芳基-二氮烯基）-４，６-二鹵-嘧啶之還原作用
KR101669297B1 (ko)	2008-09-09	2016-10-25	아스트라제네카 아베	[1Ｓ-[1-알파,2-알파,3-베타(1Ｓ,2Ｒ),5-베타]]-3-[7-[2-(3,4-디플루오로페닐)-사이클로프로필아미노]-5-(프로필티오)-3Ｈ-1,2,3-트리아졸로[4,5-ｄ]피리미딘-3-일]-5-(2-하이드록시에톡시)사이클로펜탄-1,2-디올의 제조 방법 및 그 중간체
EP2305376A1 (de) *	2009-09-23	2011-04-06	Lonza Ltd.	Prozess und Katalysator zur katalytischen Hydrierung von aromatischen und heteroaromatischen Nitroverbindungen
US9233966B2 (en)	2012-04-05	2016-01-12	Dr. Reddy's Laboratories Limited	Preparation of ticagrelor
CN103130726A (zh) *	2013-02-07	2013-06-05	许学农	替卡格雷中间体4,6-二氯-2-(丙巯基)-5-氨基嘧啶的制备方法
WO2014206187A1 (zh)	2013-06-24	2014-12-31	苏州明锐医药科技有限公司	替卡格雷及其中间体的制备方法
CA2921956C (en)	2013-08-22	2021-10-19	Genentech, Inc.	Process for preparing (r)-5-bromo-4-(3-amino)piperidin-1-yl)-3-(cyclopropanecarboxamido)-1h-pyrrolo[2,3-b]pyridine
CN103588712B (zh) *	2013-11-08	2016-06-08	南京欧信医药技术有限公司	一种嘧啶类化合物及其制备方法、和应用
CN103923020A (zh) *	2014-04-02	2014-07-16	黄河三角洲京博化工研究院有限公司	一种2-丙硫基-4,6-二氯-5-氨基嘧啶的制备方法
CN105020602B (zh) *	2014-04-30	2017-12-08	欧普照明股份有限公司	一种led灯
CN103992277A (zh) *	2014-05-16	2014-08-20	苏州天马精细化学品股份有限公司	一种替卡格雷中间体4,6-二氯-5-氨基-2-丙硫基嘧啶的制备方法
CN105294573B (zh) *	2015-06-16	2018-07-10	厦门医学院	一种合成4,6-二氯-2-(丙硫基)-5-氨基嘧啶的方法
CN116283796A (zh) *	2023-02-14	2023-06-23	上海汇伦医药股份有限公司	一种循环催化氢化硝基化合物的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0579643A1 (de) *	1991-04-06	1994-01-26	FISONS plc	ATP-Analogen
CZ289721B6 (cs)	1995-05-19	2002-03-13	Syngenta Participations Ag	Způsob katalytické hydrogenace aromatických nitrosloučenin
AR017014A1 (es)	1997-07-22	2001-08-22	Astrazeneca Ab	Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos
TWI229674B (en)	1998-12-04	2005-03-21	Astra Pharma Prod	Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013488D0 (en) *	2000-06-02	2000-07-26	Astrazeneca Ab	Chemical compound
US6818720B2 (en) *	2001-11-08	2004-11-16	Degussa Ag	Supported hydrogenating catalyst in powder form
SE0401001D0 (sv) *	2004-03-31	2004-03-31	Astrazeneca Ab	Chemical process

2004
- 2004-03-31 SE SE0401001A patent/SE0401001D0/xx unknown
2005
- 2005-03-29 AU AU2005227727A patent/AU2005227727B2/en not_active Ceased
- 2005-03-29 PL PL05729737T patent/PL1751117T3/pl unknown
- 2005-03-29 AT AT05729737T patent/ATE517096T1/de active
- 2005-03-29 SG SG200902108-0A patent/SG151311A1/en unknown
- 2005-03-29 BR BRPI0509323-6A patent/BRPI0509323A/pt not_active Application Discontinuation
- 2005-03-29 EP EP05729737A patent/EP1751117B1/de not_active Expired - Lifetime
- 2005-03-29 HR HR20110658T patent/HRP20110658T1/hr unknown
- 2005-03-29 SI SI200531366T patent/SI1751117T1/sl unknown
- 2005-03-29 CN CN201010206146A patent/CN101851212A/zh active Pending
- 2005-03-29 WO PCT/GB2005/001188 patent/WO2005095358A2/en not_active Ceased
- 2005-03-29 KR KR1020067021443A patent/KR101164265B1/ko not_active Expired - Fee Related
- 2005-03-29 CN CN2005800102841A patent/CN1938284B/zh not_active Expired - Lifetime
- 2005-03-29 NZ NZ587999A patent/NZ587999A/en not_active IP Right Cessation
- 2005-03-29 US US10/599,377 patent/US7799914B2/en not_active Expired - Fee Related
- 2005-03-29 CA CA2560094A patent/CA2560094C/en not_active Expired - Fee Related
- 2005-03-29 PT PT05729737T patent/PT1751117E/pt unknown
- 2005-03-29 NZ NZ550128A patent/NZ550128A/en not_active IP Right Cessation
- 2005-03-29 JP JP2007505626A patent/JP5059599B2/ja not_active Expired - Fee Related
- 2005-03-29 DK DK05729737.6T patent/DK1751117T3/da active
- 2005-03-29 ES ES05729737T patent/ES2368069T3/es not_active Expired - Lifetime
- 2005-03-29 EP EP10179703A patent/EP2308853A1/de not_active Withdrawn
2006
- 2006-09-11 IL IL177998A patent/IL177998A/en not_active IP Right Cessation
- 2006-09-13 NO NO20064117A patent/NO20064117L/no not_active Application Discontinuation
- 2006-09-14 ZA ZA200607708A patent/ZA200607708B/en unknown
2010
- 2010-08-31 US US12/871,993 patent/US20100324289A1/en not_active Abandoned
2011
- 2011-09-15 CY CY20111100890T patent/CY1111847T1/el unknown

Also Published As

Publication number	Publication date
IL177998A (en)	2012-03-29
DK1751117T3 (da)	2011-10-10
KR101164265B1 (ko)	2012-07-09
JP2007530650A (ja)	2007-11-01
CA2560094A1 (en)	2005-10-13
CN1938284B (zh)	2010-08-11
KR20060133019A (ko)	2006-12-22
IL177998A0 (en)	2006-12-31
SI1751117T1 (sl)	2011-10-28
AU2005227727A1 (en)	2005-10-13
NO20064117L (no)	2006-10-30
US20100324289A1 (en)	2010-12-23
HRP20110658T1 (hr)	2011-10-31
PT1751117E (pt)	2011-09-19
EP2308853A1 (de)	2011-04-13
ES2368069T3 (es)	2011-11-14
NZ550128A (en)	2010-10-29
US20070219371A1 (en)	2007-09-20
PL1751117T3 (pl)	2011-11-30
CA2560094C (en)	2012-10-30
CN101851212A (zh)	2010-10-06
BRPI0509323A (pt)	2007-09-04
SE0401001D0 (sv)	2004-03-31
EP1751117A2 (de)	2007-02-14
CY1111847T1 (el)	2015-10-07
JP5059599B2 (ja)	2012-10-24
SG151311A1 (en)	2009-04-30
WO2005095358A2 (en)	2005-10-13
WO2005095358A3 (en)	2006-01-05
NZ587999A (en)	2012-04-27
CN1938284A (zh)	2007-03-28
ZA200607708B (en)	2008-06-25
EP1751117B1 (de)	2011-07-20
HK1103727A1 (en)	2007-12-28
US7799914B2 (en)	2010-09-21
AU2005227727B2 (en)	2009-03-26

Legal Events

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2012-02-15

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