SG155251A1 - Process for production of 1-(3-(2-(1-benzothiophen-5-yl)- ethoxy)propyl)azetidin-3-ol or salts thereof - Google Patents

Process for production of 1-(3-(2-(1-benzothiophen-5-yl)- ethoxy)propyl)azetidin-3-ol or salts thereof

Info

Publication number
SG155251A1
SG155251A1 SG200905724-1A SG2009057241A SG155251A1 SG 155251 A1 SG155251 A1 SG 155251A1 SG 2009057241 A SG2009057241 A SG 2009057241A SG 155251 A1 SG155251 A1 SG 155251A1
Authority
SG
Singapore
Prior art keywords
benzothiophen
azetidin
ethoxy
propyl
salts
Prior art date
Application number
SG200905724-1A
Other languages
English (en)
Inventor
Akihito Saitoh
Yoshiaki Suzuki
Kenji Yonezawa
Mitsuhide Kawamura
Takahiko Kusanagi
Takashi Nakai
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of SG155251A1 publication Critical patent/SG155251A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG200905724-1A 2005-03-28 2006-03-27 Process for production of 1-(3-(2-(1-benzothiophen-5-yl)- ethoxy)propyl)azetidin-3-ol or salts thereof SG155251A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005090831 2005-03-28
JP2005174738 2005-06-15
JP2005206808 2005-07-15
JP2005230666 2005-08-09

Publications (1)

Publication Number Publication Date
SG155251A1 true SG155251A1 (en) 2009-09-30

Family

ID=37053344

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200905724-1A SG155251A1 (en) 2005-03-28 2006-03-27 Process for production of 1-(3-(2-(1-benzothiophen-5-yl)- ethoxy)propyl)azetidin-3-ol or salts thereof

Country Status (22)

Country Link
US (2) US7951963B2 (de)
EP (4) EP2210884B1 (de)
JP (1) JP5031554B2 (de)
KR (2) KR101337382B1 (de)
CN (1) CN101151257B (de)
AT (2) ATE546443T1 (de)
AU (1) AU2006229271B2 (de)
BR (1) BRPI0609496C8 (de)
CA (2) CA2600381C (de)
CY (3) CY1112956T1 (de)
DK (2) DK2210884T3 (de)
ES (3) ES2398934T3 (de)
IL (2) IL186044A (de)
MX (1) MX2007011938A (de)
NO (3) NO340071B1 (de)
NZ (2) NZ583580A (de)
PL (3) PL2210884T3 (de)
PT (3) PT2210884E (de)
SG (1) SG155251A1 (de)
SI (3) SI2348022T1 (de)
WO (1) WO2006104088A1 (de)
ZA (1) ZA200708262B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1437353E (pt) 2001-10-19 2007-08-28 Toyama Chemical Co Ltd Derivados de éter de alquilo ou os seus sais.
PL2210884T3 (pl) * 2005-03-28 2012-07-31 Toyama Chemical Co Ltd Proces wytwarzania kwasu 3-(2-(1-benzotiofen-5-ylo)etoksy)propionowego lub jego soli
JP4902247B2 (ja) * 2005-04-08 2012-03-21 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの新規製造法およびその中間体
NZ596889A (en) 2006-04-07 2013-06-28 Vertex Pharma Use of amide indole derivatives as modulators of ATP-binding cassette transporters
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
KR20090038471A (ko) * 2006-08-04 2009-04-20 토야마 케미칼 컴퍼니 리미티드 알킬에테르 유도체 또는 그 염을 함유하는 프로테인키나제 ｃ 활성촉진제
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5592205B2 (ja) * 2009-09-03 2014-09-17 富山化学工業株式会社 （１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
JP5763313B2 (ja) * 2009-09-03 2015-08-12 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
RU2745977C2 (ru) * 2010-04-22 2021-04-05 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
JP6004307B2 (ja) * 2010-07-26 2016-10-05 富山化学工業株式会社 ３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
US9096568B2 (en) * 2011-03-02 2015-08-04 Bayer Intellectual Property Gmbh Process for preparing aryl- and heteroarylacetic acid derivatives
CN103842066B (zh) 2011-09-30 2016-08-24 日本化成株式会社 聚合性无机颗粒分散剂、含有该聚合性无机颗粒分散剂的无机有机复合颗粒以及无机有机树脂复合材料
JP6054940B2 (ja) 2012-02-22 2016-12-27 富山化学工業株式会社 １−（３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピル）アゼチジン−３−オールまたはその塩を含有する固形医薬組成物
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
ES2792950T3 (es) 2014-01-31 2020-11-12 Fujifilm Toyama Chemical Co Ltd Agente potenciador del efecto de rehabilitación después de una lesión nerviosa que comprende un derivado alquil éter o una sal del mismo
SG10201913575VA (en) 2014-04-15 2020-02-27 Vertex Pharma Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
JP6804520B2 (ja) * 2016-03-31 2020-12-23 富士フイルム富山化学株式会社 ５−ブロモメチル−１−ベンゾチオフェンの製造方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA844616B (en) 1983-06-20 1986-02-26 Merck & Co Inc 2-sulfamoylbenzo(b)thiophene derivatives for the treatment of elevated intraocular pressure
IL72070A (en) 1983-06-20 1988-11-30 Merck & Co Inc 2-sulfamoylbenzo(b)-thiophene derivatives,their preparation and pharmaceutical compositions containing them
US4668697A (en) * 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
CH673100A5 (de) 1987-08-10 1990-02-15 Josef Paul Huser
JPH04182463A (ja) 1990-11-17 1992-06-30 Sumitomo Seika Chem Co Ltd ハロゲノチオフェノール類およびその誘導体の製造方法
JPH05140086A (ja) 1991-09-26 1993-06-08 Sumitomo Seika Chem Co Ltd ハロゲノチオフエノールの製造方法および精製方法
JPH05178816A (ja) 1991-12-28 1993-07-20 Sumitomo Seika Chem Co Ltd ハロゲノチオフェノールの製造方法
JP2641363B2 (ja) 1992-04-22 1997-08-13 三共株式会社 新規なフェネチルアルコール及びその製法
GB9404775D0 (en) 1994-03-11 1994-04-27 Payne P P Ltd Improvements in or relating to article tagging
JPH08143533A (ja) 1994-11-24 1996-06-04 Sumitomo Seika Chem Co Ltd ハロチオフェノール類の製造方法
JPH1043967A (ja) 1996-08-06 1998-02-17 Calsonic Corp カシメ装置
WO1998043967A1 (en) 1997-03-31 1998-10-08 Toyama Chemical Co., Ltd. PROCESS FOR PRODUCING 2-(BENZO[b]THIOPHEN-5-YL)-2-HYDROXYACETIC ACID DERIVATIVES, OPTICALLY ACTIVE COMPOUNDS THEREOF, OR SALTS OF BOTH
GB9706574D0 (en) 1997-04-01 1997-05-21 Zeneca Ltd Cyano substituted cycloalkanes
JPH1112238A (ja) 1997-06-23 1999-01-19 Kao Corp １−（β−ヒドロキシエチル）−２，５−ジアミノベンゼン又はその塩の製造法
JPH1143455A (ja) 1997-07-25 1999-02-16 Mitsubishi Chem Corp ハロゲン化アルコールの製造方法
WO1999031056A1 (en) 1997-12-12 1999-06-24 Toyama Chemical Co., Ltd. Alkyl ether derivatives or salts thereof and calcium antagonists containing the same
DE69810625T2 (de) 1998-10-07 2003-11-27 St Microelectronics Srl Leistungsübertragungssteueurung in Sperrwandler durch lastabhängige Austastmodulation
JP4182463B2 (ja) 2000-07-19 2008-11-19 富士電機デバイステクノロジー株式会社 磁気ディスク評価装置およびその方法
WO2002100850A1 (en) 2001-06-08 2002-12-19 Kuraray Co., Ltd. Processes for preparation of heterocyclic compounds
PT1437353E (pt) * 2001-10-19 2007-08-28 Toyama Chemical Co Ltd Derivados de éter de alquilo ou os seus sais.
MXPA05011125A (es) 2003-04-17 2005-12-14 Toyama Chemical Co Ltd Remedio preventivo para enfermedades del nervio retiniano que contienen derivados de eter de alquilo o sales de los mismos.
JP2005012291A (ja) 2003-06-17 2005-01-13 National Institute Of Information & Communication Technology Ｔｖ会議用モバイル動画通信端末
US20050032873A1 (en) 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
WO2005019200A2 (en) * 2003-08-14 2005-03-03 Icos Corporation Aryl piperidine derivatives as vla-1 integrin antagonists and uses thereof
PL2210884T3 (pl) * 2005-03-28 2012-07-31 Toyama Chemical Co Ltd Proces wytwarzania kwasu 3-(2-(1-benzotiofen-5-ylo)etoksy)propionowego lub jego soli
PT2011796E (pt) * 2006-04-26 2014-11-26 Toyama Chemical Co Ltd Indutor de neurogénese ou agente terapêutico utilizado em neuropatias que compreende um derivado de um éter alquílico ou um seu sal

Also Published As

Publication number Publication date
PL2348022T3 (pl) 2013-06-28
NO340420B1 (no) 2017-04-18
WO2006104088A1 (ja) 2006-10-05
CY1112885T1 (el) 2016-04-13
EP2248809A1 (de) 2010-11-10
CA2600381C (en) 2013-11-12
IL214245A (en) 2014-12-31
PT2210884E (pt) 2012-04-10
BRPI0609496C8 (pt) 2021-05-25
CA2799659A1 (en) 2006-10-05
NO20161418A1 (no) 2007-10-25
EP1864978A4 (de) 2009-07-01
AU2006229271A1 (en) 2006-10-05
PT2348022E (pt) 2013-02-13
ATE546443T1 (de) 2012-03-15
CY1112956T1 (el) 2016-04-13
SI2210884T1 (sl) 2012-06-29
SI2348022T1 (sl) 2013-05-31
NZ561672A (en) 2010-04-30
BRPI0609496C1 (pt) 2021-05-11
US20090069576A1 (en) 2009-03-12
CY1113571T1 (el) 2016-06-22
CA2600381A1 (en) 2006-10-05
EP2210884A3 (de) 2010-09-22
US20110098484A1 (en) 2011-04-28
NO20074618L (no) 2007-10-25
PL2210884T3 (pl) 2012-07-31
BRPI0609496B1 (pt) 2020-11-24
IL186044A0 (en) 2008-02-09
EP2210884B1 (de) 2012-02-22
NZ583580A (en) 2010-10-29
EP2348022B1 (de) 2013-01-09
PL2248809T3 (pl) 2012-10-31
KR20130010090A (ko) 2013-01-25
CN101151257B (zh) 2012-07-18
AU2006229271B2 (en) 2012-02-09
ES2398934T3 (es) 2013-03-22
JPWO2006104088A1 (ja) 2008-09-04
KR101337382B1 (ko) 2013-12-06
EP1864978A1 (de) 2007-12-12
EP2210884A2 (de) 2010-07-28
EP2348022A1 (de) 2011-07-27
DK2210884T3 (da) 2012-03-26
PT2248809E (pt) 2012-07-02
CN101151257A (zh) 2008-03-26
MX2007011938A (es) 2008-03-14
ES2384312T3 (es) 2012-07-03
BRPI0609496A2 (pt) 2011-10-18
JP5031554B2 (ja) 2012-09-19
ATE557020T1 (de) 2012-05-15
NO340071B1 (no) 2017-03-06
SI2248809T1 (sl) 2012-09-28
ZA200708262B (en) 2009-01-28
IL186044A (en) 2013-12-31
NO20161419A1 (no) 2016-06-07
NO340366B1 (no) 2017-04-10
EP2248809B1 (de) 2012-05-09
DK2248809T3 (da) 2012-06-18
US8273902B2 (en) 2012-09-25
ES2380443T3 (es) 2012-05-11
CA2799659C (en) 2014-12-02
KR101283930B1 (ko) 2013-07-16
IL214245A0 (en) 2011-08-31
US7951963B2 (en) 2011-05-31
KR20080008334A (ko) 2008-01-23

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