ATE86867T1 - Thrombolytische zusammensetzung enthaltender gewebetyp, plasminogenaktivatoren oder derivate davon. - Google Patents

Thrombolytische zusammensetzung enthaltender gewebetyp, plasminogenaktivatoren oder derivate davon.

Info

Publication number: ATE86867T1
Authority: AT; Austria
Prior art keywords: salt; tissue type; derivatives; type containing; plasminogen activators
Prior art date: 1989-09-21

Application number

AT90310288T

Other languages

English (en)

Inventor

Yokio Shimazaki

Miyuki Kawashima

Masahiko Ishibashi

Ryo Tanaka

Kiyoshi Sakai

Hisahiro Ishiwari

Original Assignee

Mitsui Toatsu Chemicals

Mochida Pharm Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-21

Filing date

1990-09-20

Publication date

1993-04-15

1990-09-20 Application filed by Mitsui Toatsu Chemicals, Mochida Pharm Co Ltd filed Critical Mitsui Toatsu Chemicals

1993-04-15 Application granted granted Critical

1993-04-15 Publication of ATE86867T1 publication Critical patent/ATE86867T1/de

Links

239000000203 mixture Substances 0.000 title abstract 3
239000003146 anticoagulant agent Substances 0.000 title abstract 2
230000002537 thrombolytic effect Effects 0.000 title abstract 2
102000001938 Plasminogen Activators Human genes 0.000 title 1
108010001014 Plasminogen Activators Proteins 0.000 title 1
229940127126 plasminogen activator Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 6
-1 amine compound Chemical class 0.000 abstract 2
229920006318 anionic polymer Polymers 0.000 abstract 2
230000007935 neutral effect Effects 0.000 abstract 2
239000003186 pharmaceutical solution Substances 0.000 abstract 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
102000003978 Tissue Plasminogen Activator Human genes 0.000 abstract 1
108090000373 Tissue Plasminogen Activator Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
239000012895 dilution Substances 0.000 abstract 1
238000010790 dilution Methods 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
238000001802 infusion Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000002504 physiological saline solution Substances 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Immunology (AREA)
Inorganic Chemistry (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Dermatology (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preliminary Treatment Of Fibers (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Fats And Perfumes (AREA)

AT90310288T 1989-09-21 1990-09-20 Thrombolytische zusammensetzung enthaltender gewebetyp, plasminogenaktivatoren oder derivate davon. ATE86867T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP24331089		1989-09-21
EP90310288A EP0419252B1 (de)	1989-09-21	1990-09-20	Thrombolytische Zusammensetzung enthaltender Gewebetyp, Plasminogenaktivatoren oder Derivate davon

Publications (1)

Publication Number	Publication Date
ATE86867T1 true ATE86867T1 (de)	1993-04-15

Family

ID=17101932

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90310288T ATE86867T1 (de)	1989-09-21	1990-09-20	Thrombolytische zusammensetzung enthaltender gewebetyp, plasminogenaktivatoren oder derivate davon.

Country Status (15)

Country	Link
US (1)	US6051223A (de)
EP (1)	EP0419252B1 (de)
JP (1)	JP2520975B2 (de)
KR (1)	KR930008908B1 (de)
CN (1)	CN1041799C (de)
AT (1)	ATE86867T1 (de)
BR (1)	BR9004692A (de)
CA (1)	CA2025317C (de)
DE (1)	DE69001110T2 (de)
DK (1)	DK0419252T3 (de)
ES (1)	ES2054263T3 (de)
FI (1)	FI104953B (de)
GR (1)	GR3007396T3 (de)
NO (1)	NO904119L (de)
NZ (1)	NZ235298A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6207151B1 (en) *	1989-09-21	2001-03-27	Mitsui Chemicals Inc.	Aqueous solution of t-PA
US5272076A (en) *	1991-06-13	1993-12-21	Eli Lilly And Company	Compounds and methods for treatment of thromboembolic disorders using an adduct of t-PA
US6527979B2 (en) *	1999-08-27	2003-03-04	Corazon Technologies, Inc.	Catheter systems and methods for their use in the treatment of calcified vascular occlusions
US6533767B2 (en) *	2000-03-20	2003-03-18	Corazon Technologies, Inc.	Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same
EP2000540B1 (de) *	2006-03-27	2014-05-14	Tokyo University of Agriculture and Technology Tlo Co., Ltd.	Triprenylphenolverbindung, verfahren zur herstellung einer triprenylphenolverbindung und thrombolyseverstärker
CA2876177C (en) *	2012-06-11	2022-06-14	The Cleveland Clinic Foundation	Treatment and prevention of cardiovascular disease and thrombosis
CN103191054B (zh) *	2013-04-19	2015-05-27	范克	一种肝素钠封管注射液及其制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2310133A2 (fr) *	1975-05-05	1976-12-03	Fabre Sa Pierre	Nouveau medicament comportant un activateur du plasminogene perfectionne
JPS52145591A (en) *	1976-05-28	1977-12-03	Kanebo Ltd	Stabilization of urokinase
JPS5467089A (en) *	1977-11-07	1979-05-30	Dainippon Pharmaceut Co Ltd	Urokinase composition
JPS5568290A (en) *	1978-11-16	1980-05-22	Kanebo Ltd	Stabilization of urokinase
JPS59196824A (ja) *	1983-04-21	1984-11-08	Kowa Co	吸着防止剤
JPS60158117A (ja) *	1984-01-30	1985-08-19	Asahi Chem Ind Co Ltd	新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
JPS60158116A (ja) *	1984-01-30	1985-08-19	Asahi Chem Ind Co Ltd	新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
JPS60181028A (ja) *	1984-02-29	1985-09-14	Asahi Chem Ind Co Ltd	組織プラスミノ−ゲン・アクチベ−タ−の溶解補助法
JPS60184026A (ja) *	1984-03-01	1985-09-19	Asahi Chem Ind Co Ltd	組織プラスミノ−ゲン・アクチベ−タ−の溶解補助方法
ZA861695B (en) *	1985-03-06	1986-10-29	Survival Technology	T-pa composition and method of getting into blood stream
DE3512910A1 (de) *	1985-04-11	1986-10-16	Behringwerke Ag, 3550 Marburg	Verfahren zur reinigung von plasminogenaktivatoren
DE3512908A1 (de) *	1985-04-11	1986-10-23	Behringwerke Ag, 3550 Marburg	Gewebe-plasminogenaktivator (t-pa) enthaltendes mittel
DE3512909A1 (de) *	1985-04-11	1986-10-23	Behringwerke Ag, 3550 Marburg	Verfahren zur bestimmung von plasminogenaktivatoren (pa)
DE3687255T2 (de) *	1985-09-10	1993-05-06	Eisai Co Ltd	Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.
JPH0669960B2 (ja) *	1985-11-22	1994-09-07	エーザイ株式会社	水溶性を増加したｔＰＡ含有医薬組成物
JPH0672105B2 (ja) *	1985-10-02	1994-09-14	持田製薬株式会社	血栓溶解剤及びその製法
JPS62120321A (ja) *	1985-11-20	1987-06-01	Eisai Co Ltd	ｔＰＡ含有医薬組成物
US4777043A (en) *	1985-12-17	1988-10-11	Genentech, Inc.	Stabilized human tissue plasminogen activator compositions
JPH0678241B2 (ja) *	1986-04-02	1994-10-05	エーザイ株式会社	ｔＰＡ医薬組成物
JPS62292729A (ja) *	1986-06-12	1987-12-19	Toyobo Co Ltd	ヒト子宮組織由来プラスミノ−ゲン活性化因子製剤
US4857320A (en) *	1987-02-19	1989-08-15	Monsanto Company	Method of enhancing the solubility of tissue plasminogen activator
DE3718889A1 (de) *	1987-06-05	1988-12-22	Behringwerke Ag	Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin
JP2708749B2 (ja) *	1987-08-10	1998-02-04	エーザイ株式会社	修飾型ｔＰＡ含有注射用組成物
US4898826A (en) *	1987-12-10	1990-02-06	Invitron Corporation	Method to solubilize tissue plasminogen activator
US4980165A (en) *	1989-01-27	1990-12-25	Genetics Institute, Inc.	Pharmaceutical formulations of plasminogen activator proteins
JPH06226234A (ja) *	1993-02-01	1994-08-16	Shojiro Takeuchi	産業廃棄物の炭化処理方法
JPH06236332A (ja) *	1993-02-09	1994-08-23	Oki Electric Ind Co Ltd	プログラムローディング装置
JPH06259221A (ja) *	1993-03-05	1994-09-16	Tokyo Electric Co Ltd	画面表示器を備えた情報処理装置
JPH06281326A (ja) *	1993-03-30	1994-10-07	Shibaura Eng Works Co Ltd	洗浄物の乾燥方法

1990
- 1990-08-31 JP JP2227936A patent/JP2520975B2/ja not_active Expired - Lifetime
- 1990-09-13 NZ NZ235298A patent/NZ235298A/xx unknown
- 1990-09-13 CA CA002025317A patent/CA2025317C/en not_active Expired - Fee Related
- 1990-09-19 FI FI904617A patent/FI104953B/fi not_active IP Right Cessation
- 1990-09-20 NO NO90904119A patent/NO904119L/no unknown
- 1990-09-20 BR BR909004692A patent/BR9004692A/pt not_active Application Discontinuation
- 1990-09-20 DK DK90310288.7T patent/DK0419252T3/da active
- 1990-09-20 DE DE9090310288T patent/DE69001110T2/de not_active Expired - Fee Related
- 1990-09-20 ES ES90310288T patent/ES2054263T3/es not_active Expired - Lifetime
- 1990-09-20 AT AT90310288T patent/ATE86867T1/de not_active IP Right Cessation
- 1990-09-20 EP EP90310288A patent/EP0419252B1/de not_active Expired - Lifetime
- 1990-09-21 CN CN90107989A patent/CN1041799C/zh not_active Expired - Fee Related
- 1990-09-21 KR KR1019900015031A patent/KR930008908B1/ko not_active Expired - Fee Related
1993
- 1993-02-22 US US08/021,652 patent/US6051223A/en not_active Expired - Fee Related
- 1993-03-18 GR GR920403219T patent/GR3007396T3/el unknown

Also Published As

Publication number	Publication date
DE69001110D1 (de)	1993-04-22
AU619697B2 (en)	1992-01-30
KR910005883A (ko)	1991-04-27
NZ235298A (en)	1992-12-23
FI904617A0 (fi)	1990-09-19
EP0419252A1 (de)	1991-03-27
CN1041799C (zh)	1999-01-27
CA2025317C (en)	1996-05-07
BR9004692A (pt)	1991-09-10
EP0419252B1 (de)	1993-03-17
FI104953B (fi)	2000-05-15
NO904119D0 (no)	1990-09-20
JP2520975B2 (ja)	1996-07-31
US6051223A (en)	2000-04-18
DE69001110T2 (de)	1993-06-24
NO904119L (no)	1991-03-22
ES2054263T3 (es)	1994-08-01
GR3007396T3 (de)	1993-07-30
DK0419252T3 (da)	1993-04-19
JPH0418032A (ja)	1992-01-22
KR930008908B1 (ko)	1993-09-17
AU6246790A (en)	1991-03-28
CA2025317A1 (en)	1991-03-22
CN1050321A (zh)	1991-04-03

Legal Events

Date	Code	Title	Description
1993-09-15	UEP	Publication of translation of european patent specification
2003-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE60036017T2 (de)	2008-04-30	Verfahren zur thrombolyse durch lokale behandlung mit reversibel inaktiviertem, angesäuertem plasmin
KR950702419A (ko)	1995-07-29	오메프라졸 및 그의 동족체를 함유하는 주사제 및 주사제 키트(injection and injection kit containing omeprazole and its analogs)
NO871199D0 (no)	1987-03-23	Fremgangsmaate for fremstilling av farmasoeytiske preparater med langvarige frigjoeringsegenskaper.
DK642587D0 (da)	1987-12-08	Insulinpraeparat
GR3004869T3 (de)	1993-04-28
DE3680271D1 (de)	1991-08-22	Thrombolytische zusammensetzung und verfahren zu deren herstellung.
US4082612A (en)	1978-04-04	Plasminogen activator complex
ATE86867T1 (de)	1993-04-15	Thrombolytische zusammensetzung enthaltender gewebetyp, plasminogenaktivatoren oder derivate davon.
KR840005342A (ko)	1984-11-12	정맥투여용 수액제의 제조방법
IE890580L (en)	1989-08-24	Therapeutic agent for the prevention of intraventricular hemorrhage in premature infants
ATE82132T1 (de)	1992-11-15	Auf ligninsulfonat aufgebautes pharmazeutisches mittel mit einer atithrombose-aktivitaet.
KR970706844A (ko)	1997-12-01	트롬빈 억제제를 함유하는 저장 안정성 수용액상 주입액(A Storage Stable Water Solution for Infusion Containing A Thrombin Inhibitor)
DE3942141A1 (de)	1991-06-27	K2p pro-stabilisierung
FI91710B (fi)	1994-04-29	Menetelmä injektoitavan käyttövalmiin, säilytystä kestävän, steriilin antrasykliiniglykosidiliuoksen valmistamiseksi
FI98891B (fi)	1997-05-30	Menetelmä vesiliuoksen proteiinipitoisuuden lisäämiseksi
KR890003403A (ko)	1989-04-14	당뇨병의 합병증을 예방하거나 치료하기 위한 제제
DE68905577D1 (de)	1993-04-29	Doxorubicin-loesungen.