ATE87946T1 - Polymer, seine herstellung und verwendung. - Google Patents

Polymer, seine herstellung und verwendung.

Info

Publication number
ATE87946T1
ATE87946T1 AT86303417T AT86303417T ATE87946T1 AT E87946 T1 ATE87946 T1 AT E87946T1 AT 86303417 T AT86303417 T AT 86303417T AT 86303417 T AT86303417 T AT 86303417T AT E87946 T1 ATE87946 T1 AT E87946T1
Authority
AT
Austria
Prior art keywords
high molecular
molecular polymer
compounds
polymer
production
Prior art date
Application number
AT86303417T
Other languages
English (en)
Inventor
Masaki Yamamoto
Hiroaki Okada
Yasuaki Ogawa
Tsutomu Miyagawa
Original Assignee
Takeda Chemical Industries Ltd
Wako Pure Chem Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14197161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE87946(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd, Wako Pure Chem Ind Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE87946T1 publication Critical patent/ATE87946T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
  • Processing Of Solid Wastes (AREA)
AT86303417T 1985-05-07 1986-05-06 Polymer, seine herstellung und verwendung. ATE87946T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9761785 1985-05-07
EP86303417A EP0202065B1 (de) 1985-05-07 1986-05-06 Polymer, seine Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
ATE87946T1 true ATE87946T1 (de) 1993-04-15

Family

ID=14197161

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86303417T ATE87946T1 (de) 1985-05-07 1986-05-06 Polymer, seine herstellung und verwendung.

Country Status (8)

Country Link
US (2) US4728721A (de)
EP (1) EP0202065B1 (de)
JP (2) JP2551756B2 (de)
AT (1) ATE87946T1 (de)
CA (1) CA1262005A (de)
DE (1) DE3688213T2 (de)
HK (1) HK5796A (de)
HU (1) HU196703B (de)

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
AU634723B2 (en) * 1988-08-08 1993-03-04 Biopak Technology, Ltd. Degradable thermoplastic from lactides
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
US5424346A (en) * 1988-08-08 1995-06-13 Ecopol, Llc Biodegradable replacement of crystal polystyrene
US5180765A (en) * 1988-08-08 1993-01-19 Biopak Technology, Ltd. Biodegradable packaging thermoplastics from lactides
EP0428620B1 (de) * 1988-08-08 1999-03-03 Biopak Technology, Ltd. Verfahren zur Weichmachung von Lactidpolymerisaten
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
DE3936191C2 (de) * 1989-10-31 1996-10-17 Boehringer Ingelheim Kg Neue Copolymere aus Milchsäure und Weinsäure, ihre Herstellung sowie ihre Verwendung
MY107937A (en) * 1990-02-13 1996-06-29 Takeda Chemical Industries Ltd Prolonged release microcapsules.
JP2653255B2 (ja) * 1990-02-13 1997-09-17 武田薬品工業株式会社 長期徐放型マイクロカプセル
US5075115A (en) * 1990-04-02 1991-12-24 Fmc Corporation Process for polymerizing poly(lactic acid)
CA2040141C (en) * 1990-04-13 2002-05-14 Minoru Yamada Biodegradable high-molecular polymers, production and use therof
MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
AU8660191A (en) * 1990-09-06 1992-03-30 Biopak Technology, Ltd. Packaging thermoplastics from lactic acid
PH31064A (en) * 1990-09-07 1998-02-05 Nycomed As Of Nycoveten Polymers containing diester units.
NZ240214A (en) * 1990-10-16 1993-02-25 Takeda Chemical Industries Ltd Polymer compositions comprising a polylactic acid and a copolymer of glycolic acid and a hydroxycarboxylic acid; use as carrier for prolonged release pharmaceutical compositions of water soluble drugs
IT1249045B (it) * 1991-02-21 1995-02-11 Himont Inc Processo per la sintesi allo stato solido di polimeri dell'acido lattico e prodotti cosi ottenuti
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
US6005067A (en) 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
FR2692147B1 (fr) * 1992-06-15 1995-02-24 Centre Nat Rech Scient Microsphères en polymère biorésorbable exemptes de tensioactif, leur préparation et leur application comme médicament.
JP3258326B2 (ja) * 1992-10-02 2002-02-18 カーギル， インコーポレイテッド 溶融安定性ラクチドポリマーをコーティングした紙とその製造方法
US6005068A (en) * 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
CA2124842C (en) * 1992-10-02 2003-07-15 Patrick R. Gruber A melt-stable lactide polymer fabric and process for manufacture thereof
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6913767B1 (en) 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
US5643605A (en) * 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
US6080429A (en) * 1993-10-25 2000-06-27 Genentech, Inc. Method for drying microspheres
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
TW448055B (en) * 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
AU4239597A (en) 1996-08-29 1998-03-19 Advanced Research And Technology Institute, Inc. Novel pharmacotherapeutic process and composition for central nervous system disorders
US20070185032A1 (en) * 1996-12-11 2007-08-09 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US5989463A (en) * 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US6217844B1 (en) 1998-04-27 2001-04-17 Praecis Pharmaceuticals, Inc. Methods for detecting lesions in dense breast tissue using LHRH antagonists
US6565874B1 (en) * 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
ES2169980B1 (es) 1999-12-17 2003-11-01 Lipotec Sa Microcapsulas para la liberacion prolongada de farmacos.
TW200800298A (en) 2000-01-27 2008-01-01 Zentaris Ag Compressed microparticles for dry injection
AU2001257129A1 (en) * 2000-04-21 2001-11-07 Advanced Research And Technology Institute, Inc. Novel pharmacotherapeutic process and composition for central nervous system disorders
DK1310517T4 (da) † 2000-08-07 2011-01-17 Wako Pure Chem Ind Ltd Mælkesyrepolymer og fremgangsmåde til fremstilling af denne
US6362308B1 (en) * 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
DE60138641D1 (de) 2000-10-27 2009-06-18 Baxter Healthcare Sa Herstellung von mikrokügelchen
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
JP2004516262A (ja) 2000-12-21 2004-06-03 ネクター セラピューティクス 親水性活性剤を含有するマイクロ粒子の製造のための誘発相転移法
WO2003000156A1 (en) * 2001-06-22 2003-01-03 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
TWI225416B (en) 2001-06-29 2004-12-21 Takeda Chemical Industries Ltd Sustained-release composition and process for producing the same
TWI332407B (en) * 2001-06-29 2010-11-01 Takeda Chemical Industries Ltd Controlled release composition and method of producting the same
JP4612239B2 (ja) * 2001-07-18 2011-01-12 三井化学株式会社 生体吸収性ポリヒドロキシカルボン酸の製造方法
ES2307779T3 (es) * 2001-08-16 2008-12-01 Baxter International Inc. Formulaciones de microparticulas a base de propelentes.
US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
JP2003192773A (ja) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc 生体吸収性ポリヒドロキシカルボン酸及びその製造法
US6849600B2 (en) * 2002-03-25 2005-02-01 The Regents Of The University Of California, Berkeley Corticotropin-releasing hormone analogs
US20060193825A1 (en) * 2003-04-29 2006-08-31 Praecis Phamaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20050112087A1 (en) * 2003-04-29 2005-05-26 Musso Gary F. Pharmaceutical formulations for sustained drug delivery
BRPI0412735A (pt) * 2003-07-18 2006-09-26 Baxter Int métodos para a fabricação, uso e composição de partìculas esféricas pequenas preparadas mediante a separação de fase controlada
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
JP2007508240A (ja) * 2003-07-22 2007-04-05 バクスター・インターナショナル・インコーポレイテッド 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法
US20080318837A1 (en) * 2003-12-26 2008-12-25 Nastech Pharmaceutical Company Inc. Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide
US20060210614A1 (en) * 2003-12-26 2006-09-21 Nastech Pharmaceutical Company Inc. Method of treatment of a metabolic disease using intranasal administration of exendin peptide
US20050143303A1 (en) * 2003-12-26 2005-06-30 Nastech Pharmaceutical Company Inc. Intranasal administration of glucose-regulating peptides
US20060074025A1 (en) * 2003-12-26 2006-04-06 Nastech Pharmaceutical Company Inc. Therapeutic formulations for transmucosal administration that increase glucagon-like peptide-1 bioavailability
TW200529890A (en) * 2004-02-10 2005-09-16 Takeda Pharmaceutical Sustained-release preparations
JP4403846B2 (ja) * 2004-03-22 2010-01-27 東レ株式会社 ポリ乳酸のラクチド除去法
JP4403845B2 (ja) * 2004-03-22 2010-01-27 東レ株式会社 ラクチド含有量が少ないポリ乳酸の製造方法
WO2005112893A1 (en) * 2004-05-12 2005-12-01 Baxter International Inc. Microspheres comprising protein and showing injectability at high concentrations of said agent
JP2007537007A (ja) * 2004-05-12 2007-12-20 マサチューセッツ インスティテュート オブ テクノロジー 溶剤蒸気膜形成を含んだ立体印刷法等の製法
EP2335689A1 (de) * 2004-05-12 2011-06-22 Baxter International Inc. Herstellungsmethode von Nukleinsäure-Mikrokügelchen
JP2007537288A (ja) * 2004-05-12 2007-12-20 バクスター インターナショナル インコーポレイテッド オリゴヌクレオチド含有マイクロスフェア、１型糖尿病を処置する医薬の製造のための、その使用
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
TW200613012A (en) * 2004-07-02 2006-05-01 Takeda Pharmaceuticals Co Sustained-release composition, process for producing the same and use of the same
KR101231856B1 (ko) 2004-08-12 2013-02-08 큐피에스 엘엘씨 생물학적 활성 화합물의 제어 방출 전달용 약학 조성물
US20070254314A1 (en) * 2004-09-16 2007-11-01 Geier Mark R Methods of treating autism and autism spectrum disorders
US8541413B2 (en) * 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
US20080038316A1 (en) * 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
US9993558B2 (en) 2004-10-01 2018-06-12 Ramscor, Inc. Sustained release eye drop formulations
CN101890167B (zh) * 2004-10-01 2017-03-01 拉姆斯科股份有限公司 可方便植入的缓释药物组合物
US8394410B2 (en) * 2005-01-20 2013-03-12 Massachusetts Institute Of Technology Soft polylactides
EP1885335A1 (de) * 2005-04-27 2008-02-13 BAXTER INTERNATIONAL INC. (a Delaware corporation) Oberflächenmodifizierte mikroteilchen und verfahren zu ihrer bildung und verwendung
ATE382337T1 (de) * 2005-04-28 2008-01-15 Nipro Corp Bioabsorbierbare pharmazeutische zusammensetzung enthaltend einen plga-copolymer
US8840876B2 (en) * 2005-05-19 2014-09-23 Ethicon, Inc. Antimicrobial polymer compositions and the use thereof
US20070106271A1 (en) * 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Remote control of substance delivery system
JP2009520693A (ja) * 2005-12-08 2009-05-28 エムディーアールエヌエー，インコーポレイテッド 安定化されたエキセンディン製剤の粘膜送達
US20070154546A1 (en) * 2005-12-30 2007-07-05 Zhang Jack Y Sustained release pharmaceutical compositions
MX2008009125A (es) 2006-01-18 2008-10-23 Qps Llc Composiciones farmaceuticas con estabilidad mejorada.
WO2007088135A1 (en) * 2006-01-31 2007-08-09 Purac Biochem Bv Method for the purification of resorbable polymers from residual monomers
US20070179276A1 (en) * 2006-01-31 2007-08-02 Purac Biochem Bv Method for the purification of resorbable polymers from residual monomers
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
MX2009000434A (es) 2006-07-11 2009-01-29 Qps Llc Composiciones farmaceuticas para la distribucion de liberacion sostenida de peptidos.
JP5118139B2 (ja) 2006-08-04 2013-01-16 バクスター・インターナショナル・インコーポレイテッド 新規発症自己免疫性糖尿病を予防および／または逆転させるためのマイクロスフィアに基づく組成物
MX2009003661A (es) * 2006-10-06 2009-04-22 Baxter Int Microcapsulas que contienen microparticulas modificadas en la superficie y metodos para formar y utilizar las mismas.
US8076448B2 (en) 2006-10-11 2011-12-13 Tolmar Therapeutics, Inc. Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction
ES2905054T3 (es) 2006-11-01 2022-04-06 Ventana Med Syst Inc Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso
TWI481424B (zh) 2006-12-18 2015-04-21 Takeda Pharmaceutical 緩釋性組成物及其製法
US9187593B2 (en) 2007-02-15 2015-11-17 Tolmar Therapeutics, Inc. Low burst polymers and methods to produce polymer
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
EP2358684B8 (de) 2008-10-20 2014-10-22 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Schilddrüsen-stimulierende hormon (tsh) rezeptor agonisten mit eringem molekulargewicht
US8653086B2 (en) 2008-10-21 2014-02-18 Oregon Health & Science University Naphthamides as anticancer agents
US20100256746A1 (en) * 2009-03-23 2010-10-07 Micell Technologies, Inc. Biodegradable polymers
EP2246063A1 (de) 2009-04-29 2010-11-03 Ipsen Pharma S.A.S. GnRH Analoge enthaltende Retardformulierungen
WO2011005939A2 (en) 2009-07-09 2011-01-13 Mayo Foundation For Medical Education And Research Long acting atrial natriuretic peptide (la-anp) and methods for use thereof
US9365612B2 (en) 2010-01-29 2016-06-14 United States Of America As Represented By The Secretary, Department Of Health And Human Services Caspase inhibitors
CN102791705B (zh) 2010-04-08 2016-08-03 美国政府(由卫生和人类服务部的部长所代表) 用于tsh受体的反向激动剂和中性拮抗剂
WO2012125486A1 (en) 2011-03-11 2012-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination chemotherapy for treating cancer
US9446048B2 (en) 2011-03-17 2016-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for treating leukemia and disorders mediated by CBFβ and RUNX1 proteins
KR20140059249A (ko) 2011-08-30 2014-05-15 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 나트륨이뇨 폴리펩티드
WO2013039792A1 (en) 2011-09-12 2013-03-21 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Immunogens based on an hiv-1 gp120 v1v2 epitope
WO2013049535A2 (en) 2011-09-30 2013-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Influenza vaccine
WO2013103896A1 (en) 2012-01-06 2013-07-11 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases
EP2802565A4 (de) 2012-01-13 2015-07-08 Univ Oregon Health & Science Verbindungen, zusammensetzungen und zugehörige verfahren mit 3-aryl-chinolinen
CN107569483B (zh) 2012-06-08 2021-09-17 高等教育联邦系统-匹兹堡大学 选自苄星青霉素化合物等的化合物在制备用于治疗炎症疾病的药物中的用途
IN2015DN03733A (de) 2012-11-13 2015-09-18 Us Health
US9775895B2 (en) 2012-12-12 2017-10-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HIV therapeutics and methods of making and using same
CN105473604B (zh) 2013-03-13 2021-01-22 美国政府(由卫生和人类服务部的部长所代表) 融合前rsv f蛋白和其用途
EP2996691A1 (de) 2013-05-16 2016-03-23 The U.S.A. as represented by the Secretary, Department of Health and Human Services Verbindungen zur hemmung medikamentenresistenter stämme der hiv-1-integrase
CN103300120B (zh) * 2013-06-25 2015-04-22 南京工业大学 一种绿色家禽家畜脱毛剂及其制备方法
CA2924527C (en) 2013-09-20 2022-07-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compounds for treating prostate cancer
WO2015106003A1 (en) 2014-01-08 2015-07-16 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Ras pathways as markers of protection against hiv and methods to improve vaccine efficacy
EP3140288B1 (de) 2014-05-09 2023-01-25 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Pyrazol-derivate und deren verwendung als mediatoren des cannabinoid-rezeptors
JP6684780B2 (ja) 2014-08-25 2020-04-22 ソーク インスティテュート フォー バイオロジカル スタディーズ 新規ｕｌｋ１阻害剤およびそれを使用する方法
WO2016037154A1 (en) 2014-09-04 2016-03-10 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Recombinant hiv-1 envelope proteins and their use
WO2016064716A1 (en) 2014-10-20 2016-04-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination therapy of tshr antagonist and igfr inhibitor
EP3236998A1 (de) 2014-12-24 2017-11-01 The U.S.A. as represented by the Secretary, Department of Health and Human Services Rekombinante metapneumovirusproteine und deren verwendung
WO2016112036A1 (en) 2015-01-05 2016-07-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Myc g-quadruplex stabilizing small molecules and their use
RU2017132673A (ru) 2015-02-20 2019-03-20 Орегон Хэлт Энд Сайенс Юниверсити Производные собетирома
WO2016196646A1 (en) 2015-06-04 2016-12-08 The United States Of America, As Represented By The Secretary, Departmet Of Health & Human Services Cannabinoid receptor mediating compounds
CA2988405A1 (en) 2015-06-11 2016-12-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education P62-zz chemical inhibitor
US10799580B2 (en) 2015-09-09 2020-10-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Expression vector delivery system and use thereof for inducing an immune response
WO2017151802A1 (en) 2016-03-04 2017-09-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cannabinoid receptor mediating compounds
JP6900050B2 (ja) 2016-03-24 2021-07-07 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 去勢抵抗性前立腺がんの処置のためのアンドロゲン受容体の核移行の低分子阻害剤
CN113277958A (zh) 2016-05-18 2021-08-20 俄勒冈健康科学大学 苏比替罗衍生物
EP3471828A1 (de) 2016-06-16 2019-04-24 Acies Bio d.o.o. Zusammensetzungen und verfahren zur behandlung von krankheiten, die durch eine unzureichende pantothenatkinaseaktivität gekennzeichnet sind
TWI648291B (zh) * 2016-10-13 2019-01-21 傑安生技股份有限公司 氧化性修飾改善細胞穿透性胜肽之成藥性以作為藥物載體
ES3037586T3 (en) 2016-11-09 2025-10-03 Mayo Found Medical Education & Res Manp analogues
EP3554538A2 (de) 2016-12-16 2019-10-23 Institute for Research in Biomedicine Neuartige rekombinante rsv-f-präfusionsproteine und verwendungen davon
WO2018156459A1 (en) 2017-02-22 2018-08-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compounds and methods for inhibiting emt pathways to treat cancer, organ fibrosis and metabolic disorders
IL274130B2 (en) 2017-11-01 2025-08-01 Scripps Research Inst Novel scaffolded hiv-1 vaccine immunogens
WO2019118803A1 (en) 2017-12-14 2019-06-20 The United States Of America, As Represented By The Secretary,Department Of Health And Human Services Chemical entities for lytic activation of kshv and therapeutic targeting of viral enzymes/proteins
KR20200138756A (ko) 2018-03-29 2020-12-10 일렉스 바이오테크 아이엔씨. 심장부정맥 및 심부전 치료용 화합물
US20220033387A1 (en) 2018-09-25 2022-02-03 The Usa, As Represented By The Secretary, Department Of Health And Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
US20220118054A1 (en) 2018-11-09 2022-04-21 Mayo Foundation For Medical Education And Research Combination treatment for resistant hypertension
JP2022513449A (ja) 2018-12-12 2022-02-08 オートバーン セラピューティクス，インク． 新規な甲状腺模倣物
EP3931180A1 (de) 2019-03-01 2022-01-05 Autobahn Therapeutics, Inc. Neuartige thyromimetika
WO2020185695A1 (en) 2019-03-11 2020-09-17 Oregon State University Analogues and derivatives of cephalotaxine and methods for making and using the compounds
IL293389B1 (en) 2019-11-29 2025-12-01 Autobahn Therapeutics Inc Novel thyromimetics
US20210196648A1 (en) * 2019-12-31 2021-07-01 Industrial Technology Research Institute Drug-containing multilayer film and method for forming the same
US12528761B2 (en) 2020-06-17 2026-01-20 Autobahn Therapeutics, Inc. Thyromimetics
CN112409765A (zh) * 2020-11-16 2021-02-26 深圳市正旺环保新材料有限公司 一种可降解环保塑料袋及其制备方法
EP4352054A1 (de) 2021-06-09 2024-04-17 The United States of America, as represented by The Secretary, Department of Health and Human Services Verbindungen zur bindung nichtkanonischer g-quadruplex-strukturen und verfahren zur herstellung und verwendung davon
GB2613656A (en) * 2021-12-13 2023-06-14 Pharmathen Sa Sustained release injectable pharmaceutical formulation of levothyroxine and process for preparation thereof
WO2023059867A1 (en) 2021-10-08 2023-04-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds for treating or preventing alzheimer's disease
WO2023146771A1 (en) 2022-01-25 2023-08-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gingerenone a prodrugs as senotherapeutics and methods of use
IL314385A (en) 2022-03-14 2024-09-01 Us Health Cannabinoid receptor modulating compounds
WO2024151855A1 (en) 2023-01-13 2024-07-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bicyclic carbamoyl pyridone-based integrase strand transfer inhibitors
US12427185B2 (en) 2023-09-05 2025-09-30 E-Star Biotech, LLC Formulations of MANP and uses thereof
WO2025196270A1 (en) 2024-03-22 2025-09-25 Limmatech Biologics Ag Outer membrane vesicle vaccines for the prevention of n. gonorrhoeae and methods of making and using thereof
WO2025213007A1 (en) 2024-04-04 2025-10-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services S-hydroxychloroquine, optionally with tauroursodeoxycholic acid and/or 3,3'-diindolylmethane, for treating and/or preventing neurological disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297033A (en) * 1963-10-31 1967-01-10 American Cyanamid Co Surgical sutures
US3565869A (en) * 1968-12-23 1971-02-23 American Cyanamid Co Extrudable and stretchable polyglycolic acid and process for preparing same
US3755558A (en) * 1971-02-23 1973-08-28 Du Pont Polylactide drug mixtures for topical application atelet aggregation
US3839297A (en) * 1971-11-22 1974-10-01 Ethicon Inc Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures
US3912692A (en) * 1973-05-03 1975-10-14 American Cyanamid Co Process for polymerizing a substantially pure glycolide composition
US3890283A (en) * 1973-06-04 1975-06-17 American Cyanamid Co Process for post-polymerizing polyglycolic acid
US4249531A (en) * 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4479911A (en) * 1982-01-28 1984-10-30 Sandoz, Inc. Process for preparation of microspheres and modification of release rate of core material
US4605730A (en) * 1982-10-01 1986-08-12 Ethicon, Inc. Surgical articles of copolymers of glycolide and ε-caprolactone and methods of producing the same
US4523591A (en) * 1982-10-22 1985-06-18 Kaplan Donald S Polymers for injection molding of absorbable surgical devices
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法

Also Published As

Publication number Publication date
JP2551756B2 (ja) 1996-11-06
HUT43488A (en) 1987-11-30
DE3688213T2 (de) 1993-09-23
HK5796A (en) 1996-01-19
DE3688213D1 (de) 1993-05-13
HU196703B (en) 1989-01-30
JP2660401B2 (ja) 1997-10-08
JPS6254760A (ja) 1987-03-10
EP0202065A2 (de) 1986-11-20
EP0202065A3 (en) 1987-10-21
CA1262005A (en) 1989-09-26
JPH08169818A (ja) 1996-07-02
EP0202065B1 (de) 1993-04-07
US4728721A (en) 1988-03-01
US4849228A (en) 1989-07-18

Similar Documents

Publication Publication Date Title
ATE87946T1 (de) Polymer, seine herstellung und verwendung.
SE8501022L (sv) Format alster och forfarande for dess framstellning
SG108191G (en) Copolymer and method for producing the same
YU174490A (sh) Novi estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje i primena tih jedinjenja
SE8801240D0 (sv) Dosage form comprising parallel laminae
KR880700668A (ko) 특정 생체조직 부위로의 전달을 위한 아미노산 킬레이트의 조성물
DE3766200D1 (de) L-dopa enthaltendes arzneimittel.
DK581185D0 (da) Farmaceutisk praeparat indeholdende 13-cis-a-vitaminsyre
NO891523L (no) Alfa-substituerte 4-(kinolin-2-yl-metoksy)fenyl-eddiksyrerog -estere.
DE3688038D1 (de) Verwendung von buspiron zur herstellung von pharmazeutischen zusammensetzungen zur linderung von krankhaften angst.
AU532114B2 (en) Salts of n-substituted-2-pyrrolidone-4-carboxylic acids
ES8701717A1 (es) Un procedimiento para la preparacion de nuevos derivados del acido (5-amino-2-hidroxi)benzoico.
EP0354185A3 (de) Piperidin-Triazin-Verbindungen und ihre Verwendung als Stabilisatoren für organische Materialien
ATE47955T1 (de) Lagerstabile saure naehrmittelsosse, die faserige proteinkomplexe enthaelt.
DE59401990D1 (de) Imidazolyl-substituierte Phenylessigsäureprolinamide
EP0199257A3 (de) Ester von L-Aminodicarboxylsäure und eine geniessbare, sie als Süssstoff enthaltende Zusammensetzung
ES2087883T3 (es) Derivados de politetrahidrofurano con grupos aromaticos terminales.
RU93048332A (ru) Состав на основе гексадецилфосфохолина, способ его получения, лекарственное средство
ATE106407T1 (de) Derivate von thiazolidin-4-carbonsäure, deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DK8503352A (de)
DE68915025D1 (de) Herstellung von 3,3-Diarylacrylsäureamiden.
TR24121A (tr) Anti-koepuek maddeleri ve bunlarin kullanilmasi
EP0367302A3 (de) Verfahren zur Halbsynthese von menschlichem Insulin, dabei zu verwendende, vernetzte, wasserlösliche Achromobacter Protease I und Verfahren zu dessen Herstellung
EP0661293A3 (de) Protein mit Zellwachstumsstimulierender und Makrophage chemotaktischer Wirkung, Verfahren zur Herstellung und Verwendung
EP0256475A3 (de) Ester von L-Aminodicarboxylsäure

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time