HK5796A - Polymer, production and use thereof - Google Patents

Polymer, production and use thereof Download PDF

Info

Publication number
HK5796A
HK5796A HK5796A HK5796A HK5796A HK 5796 A HK5796 A HK 5796A HK 5796 A HK5796 A HK 5796A HK 5796 A HK5796 A HK 5796A HK 5796 A HK5796 A HK 5796A
Authority
HK
Hong Kong
Prior art keywords
water
polymer
lactic acid
high molecular
acid
Prior art date
Application number
HK5796A
Other languages
English (en)
French (fr)
Inventor
Yamamoto Masaki
Okada Hiroaki
Ogawa Yasuaki
Miyagawa Tsutomu
Original Assignee
Takeda Pharmaceutical Company Limited
Wako Pure Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14197161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK5796(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical Company Limited, Wako Pure Chemical Industries, Ltd. filed Critical Takeda Pharmaceutical Company Limited
Publication of HK5796A publication Critical patent/HK5796A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
  • Processing Of Solid Wastes (AREA)

Claims (8)

  1. Verfahren zur Herstellung eines biologisch abbaubaren hochmolekularen Polymers mit einem Gewichtsmittel des Molekulargewichts von 5 000 bis 35 000 und mit 50 bis 100 Mol-% Milchsäure-Resten und 50 bis 0 Mol-% Glycolsäure-Resten, bestehend aus dem Herstellen des Polymers aus Milchsäure oder Milchsäure und Glycolsäure unter wäßrigen Reaktionsbedingungen und danach dem Reduzieren des Gehalts der Milchsäure oder der Milchsäure und Glycolsäure in dem Polymer auf einen Wert von weniger als 0,01 mol auf 100 g des Polymers durch Extraktion mit Wasser oder einem Gemisch aus Wasser und einem wasserlöslichen organischen Lösungsmittel, dadurch gekennzeichnet, daß dieser Schritt der Extraktion das Auflösen des nicht weniger als 0,01 Mol-% Milchsäure oder Milchsäure und Glycolsäure enthaltenden Polymers in der 3-bis 20-fachen Menge (Gew./Vol.) eines organischen Lösungsmittels und das Eingießen der resultierenden Lösung in Wasser unter Rühren bei einer Temperatur von 20 °C bis 70 °C umfaßt.
  2. Verfahren nach Anspruch 1, worin der Gehalt der Milchsäure oder der Milchsäure und Glycolsäure auf einen Wert von 0,0055 mol oder weniger auf 100 g des Polymers reduziert wird.
  3. Verfahren nach Anspruch 1 oder Anspruch 2, worin das wasserlösliche organische Lösungsmittel Ethanol ist.
  4. Verfahren zur Herstellung einer Mikrokapsel zur verlängerten Abgabe eines injizierbaren Stoffes, enthaltend eine wirksame Menge eines aktiven Inhaltsstoffs und als Exzipienten ein biologisch abbaubares hochmolekulares Polymer, wie es in Anspruch 1 definiert ist, mit einem Gehalt an Milchsäure oder an Milchsäure und Glycolsäure von weniger als 0,01 mol auf 100 g des Polymers oder, wie es in Anspruch 2 definiert ist, mit einem Gehalt an Milchsäure oder an Milchsäure und Glycolsäure von weniger als 0,0055 mol auf 100 g des Polymers, umfassend das Herstellen einer Wasser/Öl(W/O)-Emulsion mit einer den aktiven Inhaltsstoff enthaltenden wäßrigen Lösung, die als innere Wasser-Phase dient, und einer das biologisch abbaubare Polymer enthaltenden Lösung, die als Öl-Phase dient, das Dispergieren der Emulsion in einer Wasser(W)-Phase zur Bildung einer (W/O)/W-Emulsion und das In-Berührung-Bringen der resultierenden Emulsion mit einer dritten wäßrigen Phase zur Bildung einer (W/O)/W-Ternär-Phasen-Emulsion, wobei das Lösungsmittel in der Öl-Phase desorbiert wird.
  5. Verfahren nach Anspruch 4, worin der aktive Inhaltsstoff ein wasserlösliches Peptid ist.
  6. Verwendung eines biologisch abbaubaren hochmolekularen Polymers als Matrix in einer Mikrokapsel für die verlängerte Abgabe eines aktiven Inhaltsstoffs aus dieser Mikrokapsel, wobei das Polymer eines ist, wie es in Anspruch 1 definiert ist.
HK5796A 1985-05-07 1996-01-11 Polymer, production and use thereof HK5796A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9761785 1985-05-07

Publications (1)

Publication Number Publication Date
HK5796A true HK5796A (en) 1996-01-19

Family

ID=14197161

Family Applications (1)

Application Number Title Priority Date Filing Date
HK5796A HK5796A (en) 1985-05-07 1996-01-11 Polymer, production and use thereof

Country Status (8)

Country Link
US (2) US4728721A (de)
EP (1) EP0202065B1 (de)
JP (2) JP2551756B2 (de)
AT (1) ATE87946T1 (de)
CA (1) CA1262005A (de)
DE (1) DE3688213T2 (de)
HK (1) HK5796A (de)
HU (1) HU196703B (de)

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US4849228A (en) 1989-07-18
ATE87946T1 (de) 1993-04-15
JP2551756B2 (ja) 1996-11-06
JP2660401B2 (ja) 1997-10-08
HUT43488A (en) 1987-11-30
CA1262005A (en) 1989-09-26
US4728721A (en) 1988-03-01
JPH08169818A (ja) 1996-07-02
HU196703B (en) 1989-01-30
JPS6254760A (ja) 1987-03-10
EP0202065A2 (de) 1986-11-20
EP0202065A3 (en) 1987-10-21
EP0202065B1 (de) 1993-04-07

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