ATE97957T1 - Verfahren zur herstellung des rekombinanten menschlichen faktors viii:c. - Google Patents

Verfahren zur herstellung des rekombinanten menschlichen faktors viii:c.

Info

Publication number: ATE97957T1
Authority: AT; Austria
Prior art keywords: factor viii; human factor; recombinant human; transformant; arg
Prior art date: 1987-09-10

Application number

AT88114769T

Other languages

English (en)

Inventor

Takashi Sugiyama

Kenichi Masuda

Yoshitaka Tajima

Hiroshi Yonemura

Original Assignee

Chemo Sero Therapeut Res Inst

Teijin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-10

Filing date

1988-09-09

Publication date

1993-12-15

1988-09-09 Application filed by Chemo Sero Therapeut Res Inst, Teijin Ltd filed Critical Chemo Sero Therapeut Res Inst

1993-12-15 Application granted granted Critical

1993-12-15 Publication of ATE97957T1 publication Critical patent/ATE97957T1/de

Links

101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 title abstract 4
102000057593 human F8 Human genes 0.000 title abstract 4
229960000900 human factor viii Drugs 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title abstract 2
108010054218 Factor VIII Proteins 0.000 abstract 2
102000001690 Factor VIII Human genes 0.000 abstract 2
210000004102 animal cell Anatomy 0.000 abstract 2
210000004978 chinese hamster ovary cell Anatomy 0.000 abstract 2
239000013604 expression vector Substances 0.000 abstract 2
229960000301 factor viii Drugs 0.000 abstract 2
YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 abstract 1
108010088751 Albumins Proteins 0.000 abstract 1
102000009027 Albumins Human genes 0.000 abstract 1
108010039627 Aprotinin Proteins 0.000 abstract 1
229920000858 Cyclodextrin Polymers 0.000 abstract 1
239000002202 Polyethylene glycol Substances 0.000 abstract 1
229960002684 aminocaproic acid Drugs 0.000 abstract 1
229960004405 aprotinin Drugs 0.000 abstract 1
229940097362 cyclodextrins Drugs 0.000 abstract 1
BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 abstract 1
239000003623 enhancer Substances 0.000 abstract 1
239000001963 growth medium Substances 0.000 abstract 1
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
239000002609 medium Substances 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
229960001471 sodium selenite Drugs 0.000 abstract 1
235000015921 sodium selenite Nutrition 0.000 abstract 1
239000011781 sodium selenite Substances 0.000 abstract 1
230000001131 transforming effect Effects 0.000 abstract 1
238000011144 upstream manufacturing Methods 0.000 abstract 1
108010047303 von Willebrand Factor Proteins 0.000 abstract 1
102100036537 von Willebrand factor Human genes 0.000 abstract 1
229960001134 von willebrand factor Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Plant Pathology (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)

AT88114769T 1987-09-10 1988-09-09 Verfahren zur herstellung des rekombinanten menschlichen faktors viii:c. ATE97957T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP22514787		1987-09-10
JP63085454A JPH0387173A (ja)	1987-09-10	1988-04-08	ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
EP88114769A EP0306968B1 (de)	1987-09-10	1988-09-09	Verfahren zur Herstellung des rekombinanten menschlichen Faktors VIII:C

Publications (1)

Publication Number	Publication Date
ATE97957T1 true ATE97957T1 (de)	1993-12-15

Family

ID=26426457

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88114769T ATE97957T1 (de)	1987-09-10	1988-09-09	Verfahren zur herstellung des rekombinanten menschlichen faktors viii:c.

Country Status (9)

Country	Link
EP (1)	EP0306968B1 (de)
JP (1)	JPH0387173A (de)
KR (1)	KR950012804B1 (de)
AT (1)	ATE97957T1 (de)
AU (1)	AU627432B2 (de)
CA (1)	CA1341236C (de)
DE (1)	DE3885983T2 (de)
ES (1)	ES2061582T3 (de)
NZ (1)	NZ226082A (de)

Families Citing this family (45)

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US5595886A (en)	1986-01-27	1997-01-21	Chiron Corporation	Protein complexes having Factor VIII:C activity and production thereof
WO1990002175A1 (en) *	1988-08-16	1990-03-08	Novo Nordisk A/S	A method of producing polypeptides by culturing eukaryotic cells in the presence of protease inhibitors
DE69029765T2 (de) *	1989-07-24	1997-05-15	Bayer Ag	Stabilisierung von hochgereinigten Proteinen
WO1991002065A1 (en) *	1989-08-11	1991-02-21	Zymogenetics, Inc.	Cell culture methods for producing activated protein c
FR2657884B1 (fr) *	1990-02-05	1994-09-02	Tm Innovation	Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.
US5378612A (en) *	1990-05-11	1995-01-03	Juridical Foundation The Chemo-Sero-Therapeutic Research Institute	Culture medium for production of recombinant protein
US6376463B1 (en)	1992-04-07	2002-04-23	Emory University	Modified factor VIII
US6180371B1 (en)	1996-06-26	2001-01-30	Emory University	Modified factor VIII
US5888974A (en) *	1992-04-07	1999-03-30	Emory University	Hybrid human/animal factor VIII
US5859204A (en) *	1992-04-07	1999-01-12	Emory University	Modified factor VIII
US5851800A (en) *	1996-05-14	1998-12-22	Pharmacia & Upjohn Ab	Process for producing a protein
US6458563B1 (en)	1996-06-26	2002-10-01	Emory University	Modified factor VIII
US7560107B2 (en)	1996-06-26	2009-07-14	Emory University	Modified factor VIII
US5804420A (en) *	1997-04-18	1998-09-08	Bayer Corporation	Preparation of recombinant Factor VIII in a protein free medium
JP2002524473A (ja) *	1998-09-09	2002-08-06	ジエンザイムコーポレイション	プラスミドベクターのメチル化
EP1820516B1 (de)	1999-02-22	2013-07-24	University of Connecticut	Neue albuminfreie Faktor VIII Formulierungen
PL1750733T3 (pl)	2004-05-03	2014-05-30	Univ Emory	Sposób podawania świńskiego czynnika krzepnięcia VIII pozbawionego domeny B
JP4769034B2 (ja) *	2005-07-08	2011-09-07	大東榮紙工株式会社	食品収納容器
US7985839B2 (en)	2006-03-31	2011-07-26	Baxter International Inc.	Factor VIII polymer conjugates
US7645860B2 (en)	2006-03-31	2010-01-12	Baxter Healthcare S.A.	Factor VIII polymer conjugates
WO2007126808A1 (en)	2006-03-31	2007-11-08	Baxter International Inc	Pegylated factor viii
US7982010B2 (en)	2006-03-31	2011-07-19	Baxter International Inc.	Factor VIII polymer conjugates
DK2101821T3 (da)	2006-12-15	2014-10-06	Baxter Healthcare Sa	Faktor VIIA-(poly)sialinsyre-konjugat med forlænget halveringstid in vivo
CA2679107C (en)	2007-02-23	2018-01-16	Sk Chemicals Co., Ltd.	Process for producing and purifying factor viii and its derivatives
AU2009303368B2 (en)	2008-10-15	2012-04-05	Takeda Pharmaceutical Company Limited	Pegylation of recombinant blood coagulation factors in the presence of bound antibodies
EP2385825B1 (de)	2008-11-07	2018-10-10	University of Connecticut	Faktor-viii-formulierungen
RU2744370C2 (ru)	2009-07-27	2021-03-05	Баксалта Инкорпорейтед	Конъюгаты белков свертывания крови
BR112012001814A8 (pt)	2009-07-27	2018-02-06	Baxalta GmbH	Conjugados de proteína de coagulação sanguínea
US8642737B2 (en)	2010-07-26	2014-02-04	Baxter International Inc.	Nucleophilic catalysts for oxime linkage
US8809501B2 (en)	2009-07-27	2014-08-19	Baxter International Inc.	Nucleophilic catalysts for oxime linkage
EP3081233B1 (de)	2009-07-27	2020-12-23	Baxalta GmbH	Glycopolysialylierung von proteinen ausser blutgerinnungsproteinen
WO2011075185A1 (en)	2009-12-18	2011-06-23	Oligasis	Targeted drug phosphorylcholine polymer conjugates
TWI534152B (zh)	2010-07-30	2016-05-21	巴克斯特國際公司	用於肟連接的親核性催化劑
BR112013011041B1 (pt)	2010-11-05	2021-05-25	Baxalta GmbH	variante de fator viii, método para produzir uma variante de fviii, uso da variante de fator viii, e, composição farmacêutica
ES2800983T3 (es)	2010-12-22	2021-01-07	Baxalta GmbH	Materiales y métodos para conjugar un derivado de ácido graso soluble en agua con una proteína
AU2013204754C1 (en)	2012-05-16	2018-10-11	Takeda Pharmaceutical Company Limited	Nucleophilic Catalysts for Oxime Linkage
ES2819217T3 (es)	2013-09-08	2021-04-15	Kodiak Sciences Inc	Conjugados de polímeros iónicos dipolares y factor VIII
KR102670157B1 (ko)	2015-10-28	2024-05-29	주식회사유한양행	이중 작용 단백질 및 이를 포함하는 약학적 조성물
KR102668200B1 (ko)	2015-10-28	2024-05-23	주식회사유한양행	지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
EP3167877A1 (de)	2015-11-12	2017-05-17	Bayer Pharma Aktiengesellschaft	Verfahren zur herstellung von gefriergetrockneten pellets mit faktor viii
TW201731869A (zh)	2015-12-03	2017-09-16	百克莎塔股份有限公司	具有延長之半衰期及降低之配位體結合性質的因子ｖｉｉｉ
HUE071618T2 (hu)	2016-11-10	2025-09-28	Yuhan Corp	Fúziós fehérjéket tartalmazó gyógyszerkészítmény hepatitisz, májfibrózis és májzsugor megelõzésére vagy kezelésére
CN110709520B (zh)	2017-04-21	2024-04-05	株式会社柳韩洋行	用于产生双功能蛋白质及其衍生物的方法
JP2022524103A (ja)	2019-03-08	2022-04-27	メビオン・メディカル・システムズ・インコーポレーテッド	カラム別の放射線の照射およびそのための治療計画の生成
CA3157509A1 (en)	2019-10-10	2021-04-15	Kodiak Sciences Inc.	Methods of treating an eye disorder

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL74909A (en) *	1984-04-20	1992-01-15	Genentech Inc	Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
MX9203440A (es) *	1985-04-12	1992-07-01	Genetics Inst	Proteinas procoagulantes novedosas.
KR910006424B1 (ko) *	1985-08-21	1991-08-24	인코텍스 비.브이	편성브리프(brief) 제조방법
ATE87663T1 (de) *	1986-01-03	1993-04-15	Genetics Inst	Verfahren zur herstellung von faktor-viii:c-typ- proteinen.
FI98829C (fi) *	1986-01-27	1997-08-25	Chiron Corp	Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
JP2872255B2 (ja) *	1987-01-30	1999-03-17	バイオジエン，インコーポレイティド	ファクター▲ｖｉｉｉ▼の高収量生産法
IE69026B1 (en) *	1987-06-12	1996-08-07	Immuno Ag	Novel proteins with factor VIII activity process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them

1988
- 1988-04-08 JP JP63085454A patent/JPH0387173A/ja active Pending
- 1988-09-08 AU AU22003/88A patent/AU627432B2/en not_active Expired
- 1988-09-08 CA CA000576808A patent/CA1341236C/en not_active Expired - Lifetime
- 1988-09-08 NZ NZ226082A patent/NZ226082A/xx unknown
- 1988-09-09 AT AT88114769T patent/ATE97957T1/de not_active IP Right Cessation
- 1988-09-09 KR KR1019880011686A patent/KR950012804B1/ko not_active Expired - Lifetime
- 1988-09-09 EP EP88114769A patent/EP0306968B1/de not_active Expired - Lifetime
- 1988-09-09 ES ES88114769T patent/ES2061582T3/es not_active Expired - Lifetime
- 1988-09-09 DE DE3885983T patent/DE3885983T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU627432B2 (en)	1992-08-27
NZ226082A (en)	1990-09-26
EP0306968A2 (de)	1989-03-15
DE3885983D1 (de)	1994-01-13
KR950012804B1 (ko)	1995-10-21
JPH0387173A (ja)	1991-04-11
KR890005268A (ko)	1989-05-13
AU2200388A (en)	1989-03-16
ES2061582T3 (es)	1994-12-16
EP0306968A3 (en)	1989-04-12
EP0306968B1 (de)	1993-12-01
DE3885983T2 (de)	1994-06-23
CA1341236C (en)	2001-05-22

Legal Events

Date	Code	Title
1994-10-15	UEP	Publication of translation of european patent specification
2002-10-15	EEIH	Change in the person of patent owner
2003-02-15	EEFA	Change of the company name
2008-12-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
DE3885983D1 (de)	1994-01-13	Verfahren zur Herstellung des rekombinanten menschlichen Faktors VIII:C.
FI104261B1 (fi)	1999-12-15	Menetelmä yhdistelmä ihmisen erytropoietiinin tuottamiseksi
ES8707564A1 (es)	1987-08-01	Un metodo para obtener expresion de una secuencia de codificacion deseada en celulas de mamifero
ATE177149T1 (de)	1999-03-15	Expression von menschlichen serum-albuminen in pichia pastoris
ATE107958T1 (de)	1994-07-15	Herstellung eines insulinähnlichen, wachstümsfaktor bindenden proteins.
ATE182174T1 (de)	1999-07-15	Gliazellen-aktivierender faktor und dessen herstellung
ATE159297T1 (de)	1997-11-15	Expression von menschlichen serumalbumin in methylotrophischen hefen
ATE123520T1 (de)	1995-06-15	Kex2-endoprotease und verfahren zu ihrer herstellung.
ATE26463T1 (de)	1987-04-15	Verfahren zur herstellung von menschlichem leukozyten-interferon.
ATE178354T1 (de)	1999-04-15	Plasmid das für die aminosäuresequenz von tcf-ii kodierende dns enthalt, transformierte zelle und produktion einer physiologisch aktiven substanz mit ihrer verwendung
DE69022297D1 (de)	1995-10-19	DNS und ihre Verwendung.
KR910004803A (ko)	1991-03-29	간의 실질 세포 성장 인자, 이를 코딩하는 유전자, 이 인자를 생산하는 방법, 및 이 인자를 생산하는 형질전환체
DE59611434D1 (de)	2007-07-26	Herstellung von Proteinen aus Pro-Proteinen durch Fusionsproteine abgeleitet von Furin oder Furinanalogen
SE8104482L (sv)	1982-02-28	Forfarande for framstellning av ett faktor viii (ahf)-hogkoncentrat
DE3650477D1 (de)	1996-03-14	Produktion von Cystinreste enthaltenden aktiven Proteinen
AU6707686A (en)	1987-07-09	Prostate-derived growth factor
IL82207A0 (en)	1987-10-30	Production of peptides,recombinant plasmid used therefor and animal cells transformed therewith
DE69027466D1 (de)	1996-07-25	Achromobacter-Protease-I-Gen sowie Genprodukt
DE69220259D1 (de)	1997-07-17	Verfahren zur Herstellung von menschlichem NGF-2
ATE117374T1 (de)	1995-02-15	Hühner-beta-actin-promoter und menschliches faktor viii-c-gen enthaltende plasmide, transformanten und verfahren zur herstellung des menschlichen faktors viii-c.
DE68920321D1 (de)	1995-02-09	Verfahren zur herstellung eines menschlichen "neutrophil chemotactic factor"-polypeptids.
ATE291629T1 (de)	2005-04-15	Expressionssystem für die sekretion von bioaktivem, menschlichem granulozyt-makrophagem koloniestimulierungsfaktor (gm-csf) und anderen heterologen proteinen aus streptomyces
ATE141093T1 (de)	1996-08-15	Polypeptid
DE58909205D1 (de)	1995-06-08	Expressionsvektor und Verfahren zur regulierbaren Herstellung von Proteinen in Eukaryonten.