BG50272A3 - Method for the preparation of (d)- alpha- ethyl- 2- oxo- 1- pyrolydinacetamide - Google Patents

Method for the preparation of (d)- alpha- ethyl- 2- oxo- 1- pyrolydinacetamide

Info

Publication number: BG50272A3
Authority: BG; Bulgaria
Prior art keywords: oxo; ethyl; alpha; denotes; pyrolydinacetamide
Prior art date: 1984-05-15

Application number

BG070237A

Other languages

Bulgarian (bg)

English (en)

Inventor

Jean Gobert

Corneliu Giurgea

Jean-Pierre Geerts

Guy Bodson

Original Assignee

Ucb S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-15

Filing date

1985-05-14

Publication date

1992-06-15

1985-05-14 Application filed by Ucb S.A. filed Critical Ucb S.A.

1992-06-15 Publication of BG50272A3 publication Critical patent/BG50272A3/xx

Links

238000000034 method Methods 0.000 title abstract 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
HPHUVLMMVZITSG-UHFFFAOYSA-N Etiracetam Chemical compound CCC(C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
230000001343 mnemonic effect Effects 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Detergent Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cephalosporin Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

BG070237A 1984-05-15 1985-05-14 Method for the preparation of (d)- alpha- ethyl- 2- oxo- 1- pyrolydinacetamide BG50272A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB848412358A GB8412358D0 (en)	1984-05-15	1984-05-15	Pharmaceutical composition

Publications (1)

Publication Number	Publication Date
BG50272A3 true BG50272A3 (en)	1992-06-15

Family

ID=10560975

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BG070237A BG50272A3 (en)	1984-05-15	1985-05-14	Method for the preparation of (d)- alpha- ethyl- 2- oxo- 1- pyrolydinacetamide
BG094053A BG60030B2 (bg)	1984-05-15	1985-05-14	Метод за получаване на (d)-алфа-етил-2-оксо-1- пиролидинацетамид

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
BG094053A BG60030B2 (bg)	1984-05-15	1985-05-14	Метод за получаване на (d)-алфа-етил-2-оксо-1- пиролидинацетамид

Country Status (23)

Country	Link
US (2)	US4696942A (de)
EP (1)	EP0165919B1 (de)
JP (1)	JPS60255764A (de)
AT (1)	ATE45348T1 (de)
AU (1)	AU574175B2 (de)
BG (2)	BG50272A3 (de)
CA (1)	CA1237138A (de)
CY (1)	CY1568A (de)
DE (1)	DE3572168D1 (de)
DK (1)	DK163500C (de)
ES (2)	ES8703419A1 (de)
FI (1)	FI80674C (de)
GB (1)	GB8412358D0 (de)
GR (1)	GR851156B (de)
HK (1)	HK62692A (de)
IE (1)	IE58393B1 (de)
IL (1)	IL75180A (de)
NO (1)	NO164535C (de)
PL (2)	PL144345B1 (de)
PT (1)	PT80461B (de)
SG (1)	SG80190G (de)
SU (3)	SU1417799A3 (de)
ZA (1)	ZA853636B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8412357D0 (en) *	1984-05-15	1984-06-20	Ucb Sa	Pharmaceutical composition
DE3420193A1 (de) *	1984-05-30	1985-12-05	Boehringer Ingelheim KG, 6507 Ingelheim	Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel
GB8827389D0 (en) *	1988-11-23	1988-12-29	Ucb Sa	Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide
US6124473A (en) *	1998-05-08	2000-09-26	Ucb, S.A.	Process for preparing (s)- and (R)-α-ethyl-2-oxo-1-pyrrolidineacetamide
GB0004297D0 (en)	2000-02-23	2000-04-12	Ucb Sa	2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
US7112612B2 (en) *	2000-11-21	2006-09-26	Ucb S.A.	N-alkylated GABA compounds, processes for their preparation and their use as medicaments
WO2002076451A1 (en) *	2001-03-22	2002-10-03	Ucb, S.A.	Use of certain substituted pyrrolidones such as piracetam in the treatment of viral and other diseases
JP4334344B2 (ja) *	2001-08-10	2009-09-30	ユセベファルマソシエテアノニム	オキソピロリジン化合物、当該化合物の調製、並びにレベチラセタム及び類似体の製造におけるその化合物の使用
CA2546970C (en)	2003-12-02	2011-04-26	Ucb, S.A.	Imidazole derivatives, processes for preparing them and their uses
CA2488325C (en) *	2004-11-22	2010-08-24	Apotex Pharmachem Inc.	Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
US8178533B2 (en)	2005-06-01	2012-05-15	Ucb Pharma, S.A.	2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
EP2346500B1 (de)	2008-10-16	2017-05-17	The Johns Hopkins University	Verfahren und zusammensetzungen zur verbesserung der kognitiven funktion
TW201118103A (en)	2009-10-23	2011-06-01	Ucb Pharma Sa	2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives
EP2533645B1 (de)	2010-02-09	2016-07-27	The Johns Hopkins University	Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
PL2699581T3 (pl)	2011-04-18	2016-05-31	Ucb Biopharma Sprl	Pochodne 2-okso-1-imidazolidynyloimidazotiadiazolu
CN102633675A (zh) *	2012-04-10	2012-08-15	南京大学	一种dl-2-氨基丁酰胺制备方法
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
CA2904767C (en)	2013-03-15	2022-06-21	Agenebio, Inc.	Methods and compositions for improving cognitive function
US10806717B2 (en)	2013-03-15	2020-10-20	The Johns Hopkins University	Methods and compositions for improving cognitive function
PL3096790T3 (pl)	2014-01-21	2020-01-31	Janssen Pharmaceutica, N.V.	Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie
ME03518B (de)	2014-01-21	2020-04-20	Janssen Pharmaceutica Nv	Kombinationen mit positiven allosterischen modulatoren von metabotropem glutamatergen rezeptor vom subtyp 2 und deren verwendung
EA034167B8 (ru)	2015-05-22	2021-04-27	Эйджинбайо, Инк.	Фармацевтические композиции леветирацетама пролонгированного высвобождения
JP2022510363A (ja)	2018-12-04	2022-01-26	メティスファーマシューティカルズアクチェンゲゼルシャフト	（ｒ）－２－（２－オキソピロリジン－１－イル）ブタンアミドと（ｓ）－２－（２－オキソピロリジン－１－イル）ブタンアミドを非ラセミ比で含む相乗的組成物
US11384050B1 (en)	2021-02-03	2022-07-12	Vitaworks Ip, Llc	Method for preparing levetiracetam and intermediates thereof
US12559456B2 (en)	2021-02-03	2026-02-24	Suzhou Brighthope Pharma Tech Co., Ltd	Method for preparing levetiracetam and intermediates thereof
US12590059B2 (en)	2023-03-28	2026-03-31	Suzhou Brighthope Pharmatech Co., Ltd	Process for the production of levetiracetam
US12528770B2 (en)	2023-06-12	2026-01-20	Suzhou Brighthope Pharmatech Co., Ltd.	Process for the production of levetiracetam and intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1309692A (en) *	1970-02-13	1973-03-14	Ucb Sa	N-substituted lactams
GB1583871A (en) *	1976-10-19	1981-02-04	Ucb Sa	Anti-aggregants
FR2418790A1 (fr) *	1978-03-02	1979-09-28	Philagro Sa	Nouveaux derives de pyrrolidinone-2 et compositions herbicides les contenant
AU579863B2 (en) *	1984-05-16	1988-12-15	Williams, David Andrew	A parking control apparatus

1984
- 1984-05-15 GB GB848412358A patent/GB8412358D0/en active Pending
1985
- 1985-05-13 IL IL75180A patent/IL75180A/xx unknown
- 1985-05-13 GR GR851156A patent/GR851156B/el unknown
- 1985-05-13 FI FI851876A patent/FI80674C/fi not_active IP Right Cessation
- 1985-05-14 PL PL1985253373A patent/PL144345B1/pl unknown
- 1985-05-14 SU SU3892951A patent/SU1417799A3/ru active
- 1985-05-14 DE DE8585870068T patent/DE3572168D1/de not_active Expired
- 1985-05-14 AU AU42529/85A patent/AU574175B2/en not_active Ceased
- 1985-05-14 ZA ZA853636A patent/ZA853636B/xx unknown
- 1985-05-14 PT PT80461A patent/PT80461B/pt not_active IP Right Cessation
- 1985-05-14 BG BG070237A patent/BG50272A3/xx unknown
- 1985-05-14 ES ES543125A patent/ES8703419A1/es not_active Expired
- 1985-05-14 CA CA000481511A patent/CA1237138A/en not_active Expired
- 1985-05-14 US US06/733,791 patent/US4696942A/en not_active Expired - Lifetime
- 1985-05-14 DK DK212885A patent/DK163500C/da not_active IP Right Cessation
- 1985-05-14 JP JP60102530A patent/JPS60255764A/ja active Pending
- 1985-05-14 AT AT85870068T patent/ATE45348T1/de not_active IP Right Cessation
- 1985-05-14 IE IE119285A patent/IE58393B1/en not_active IP Right Cessation
- 1985-05-14 BG BG094053A patent/BG60030B2/bg unknown
- 1985-05-14 PL PL1985257386A patent/PL147387B1/pl unknown
- 1985-05-14 NO NO851934A patent/NO164535C/no not_active IP Right Cessation
- 1985-05-14 EP EP85870068A patent/EP0165919B1/de not_active Expired
- 1985-10-25 SU SU853968801A patent/SU1320207A1/ru active
1986
- 1986-01-29 ES ES551366A patent/ES8706114A1/es not_active Expired
- 1986-08-13 SU SU4027936A patent/SU1428194A3/ru active
1987
- 1987-03-12 US US07/025,278 patent/US4837224A/en not_active Expired - Lifetime
1990
- 1990-10-02 SG SG801/90A patent/SG80190G/en unknown
1991
- 1991-12-20 CY CY1568A patent/CY1568A/xx unknown
1992
- 1992-08-20 HK HK626/92A patent/HK62692A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB8412358D0 (en)	1984-06-20
AU574175B2 (en)	1988-06-30
ATE45348T1 (de)	1989-08-15
ES543125A0 (es)	1987-02-16
ES8703419A1 (es)	1987-02-16
EP0165919A1 (de)	1985-12-27
ZA853636B (en)	1985-12-24
HK62692A (en)	1992-08-28
US4696942A (en)	1987-09-29
DK163500B (da)	1992-03-09
IE851192L (en)	1985-11-15
DE3572168D1 (de)	1989-09-14
EP0165919B1 (de)	1989-08-09
GR851156B (de)	1986-11-25
IL75180A0 (en)	1985-09-29
IE58393B1 (en)	1993-09-08
PL257386A1 (en)	1986-10-07
IL75180A (en)	1988-05-31
NO851934L (no)	1985-11-18
PT80461A (fr)	1985-06-01
PT80461B (pt)	1987-08-19
AU4252985A (en)	1985-11-21
DK212885D0 (da)	1985-05-14
SU1428194A3 (ru)	1988-09-30
PL144345B1 (en)	1988-05-31
ES8706114A1 (es)	1987-06-01
FI851876L (fi)	1985-11-16
SU1320207A1 (ru)	1987-06-30
DK163500C (da)	1992-07-27
CY1568A (en)	1991-12-20
SG80190G (en)	1990-11-23
FI851876A0 (fi)	1985-05-13
FI80674B (fi)	1990-03-30
PL147387B1 (en)	1989-05-31
NO164535C (no)	1990-10-17
PL253373A1 (en)	1986-05-06
BG60030B2 (bg)	1993-07-30
DK212885A (da)	1985-11-16
NO164535B (no)	1990-07-09
ES551366A0 (es)	1987-06-01
JPS60255764A (ja)	1985-12-17
CA1237138A (en)	1988-05-24
FI80674C (fi)	1990-07-10
US4837224A (en)	1989-06-06
SU1417799A3 (ru)	1988-08-15

Publication	Publication Date	Title
DK496089A (da)	1990-04-11	Biologisk aktive phenylalkansyreforbindelser og fremgangsmaade til fremstilling deraf
BG60262B1 (bg)	1994-03-31	Метод за получаване на заместени двупръстенни съединения
ES8703860A1 (es)	1987-03-01	Un procedimiento para preparar derivados de aminoalquilfenaxi.
ES2000185A6 (es)	1988-01-01	Procedimiento para preparar derivados de acidos piridoncaboxilicos
BG50939A3 (bg)	1992-12-15	Метод за получаване на пиридазинонови производни
PT80461A (fr)	1985-06-01	Procede de preparation du (r)-alfa-ethyl-2-oxo-1-pyrrolidine-acetamide
ES2000910A6 (es)	1988-03-16	Procedimiento para preparar piridina-2,3-dicarboxilatos sustituidos y disustituidos
DE3370585D1 (en)	1987-05-07	Use of aminophenylacetic acid derivatives for the manufacture of an immunomodulating medical preparation
ES2043830T3 (es)	1994-01-01	Un metodo para preparar un compuesto de bis-(metilenodioxi)bifenilo.
FR2355796A1 (fr)	1978-01-20	Procede de preparation de fluorures d'acides perfluoro-alcoxy-propioniques
ES8704445A1 (es)	1987-04-16	Procedimiento de preparar derivados aminicos
ES8306371A1 (es)	1983-06-01	"un procedimiento para la preparacion de sales de s-adenosilmetionina".
DE3477488D1 (en)	1989-05-03	Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives
ES468501A1 (es)	1978-11-16	Un procedimiento para la preparacion de derivados de imida- zodiacepina.
IL63648A (en)	1985-02-28	Azolylalkanoic acid(or nitrile)derivatives,their preparation and their use as fungicides
ES8801298A3 (es)	1987-12-16	Un procedimiento para la preparacion de un complejo de platino
DK422183A (da)	1984-03-18	Fremgangsmaade til fremstilling af 5-halogenvinyl-2'-deoxyuridinderivater
FR2443460A1 (fr)	1980-07-04	Derives mercaptoacyles d'acides 4,5-dihydro-1h-pyrrole-2-carboxyliques et d'acides 1,4,5,6-tetrahydropyridine-2-carboxyliques, utiles comme agents hypotenseurs
IL73042A (en)	1988-03-31	Oximes of beta-(1-azolylmethyl)-beta-hydroxyaryl-acetaldehydes and aralkylketones,their preparation and their use as fungicides
ES8304920A1 (es)	1983-03-16	Un procedimiento para preparar derivados de n-acil-n-hidroxi-a minoacidos.
DK161648C (da)	1992-01-27	I 3-, 7- og 9-stillingen substituerede 2,4,6,8-tetraoxo-3,7-diazabicyclooe3,3,1aanonan-forbindelser og laegemiddel indeholdende disse
FR2385723A1 (fr)	1978-10-27	Procede d'epimerisation d'une thiazolidine-azetidinone
GB1455169A (en)	1976-11-10	Amidic derivatives of nicotinic acid
EP0024866A3 (de)	1981-11-11	Mildiomycin-Analoge, Verfahren zu ihrer Herstellung und pestizide Mittel daraus
EP0301466A3 (en)	1990-09-12	Uricosuric composition