BG62337B1 - Биосензорен метод на базата на генна сонда - Google Patents

Биосензорен метод на базата на генна сонда Download PDF

Info

Publication number: BG62337B1
Authority: BG; Bulgaria
Prior art keywords: oligonucleotide; dna; immobilized; complementary; rna
Prior art date: 1991-09-16

Application number

BG98660A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG98660A (bg

Inventor

David J. Squirrell

Original Assignee

The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-16

Filing date

1994-03-15

Publication date

1999-08-31

1994-03-15 Application filed by The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland filed Critical The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland

1995-03-31 Publication of BG98660A publication Critical patent/BG98660A/bg

1999-08-31 Publication of BG62337B1 publication Critical patent/BG62337B1/bg

Links

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YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
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ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
YTAHJIFKAKIKAV-XNMGPUDCSA-N [(1R)-3-morpholin-4-yl-1-phenylpropyl] N-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]carbamate Chemical compound O=C1[C@H](N=C(C2=C(N1)C=CC=C2)C1=CC=CC=C1)NC(O[C@H](CCN1CCOCC1)C1=CC=CC=C1)=O YTAHJIFKAKIKAV-XNMGPUDCSA-N 0.000 description 2
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VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
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102000053602 DNA Human genes 0.000 description 1
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239000003298 DNA probe Substances 0.000 description 1
229920001917 Ficoll Polymers 0.000 description 1
108010001336 Horseradish Peroxidase Proteins 0.000 description 1
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108010090804 Streptavidin Proteins 0.000 description 1
OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
229960004373 acetylcholine Drugs 0.000 description 1
102000034337 acetylcholine receptors Human genes 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
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238000013459 approach Methods 0.000 description 1
OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
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BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
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235000009424 haa Nutrition 0.000 description 1
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230000007246 mechanism Effects 0.000 description 1
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
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UYRKBFNUAYFUTK-UHFFFAOYSA-N pentanedial;3-triethoxysilylpropan-1-amine Chemical compound O=CCCCC=O.CCO[Si](OCC)(OCC)CCCN UYRKBFNUAYFUTK-UHFFFAOYSA-N 0.000 description 1
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239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
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239000001509 sodium citrate Substances 0.000 description 1
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Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pathology (AREA)
Wood Science & Technology (AREA)
General Physics & Mathematics (AREA)
Plasma & Fusion (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

BG98660A 1991-09-16 1994-03-15 Биосензорен метод на базата на генна сонда BG62337B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB919119735A GB9119735D0 (en)	1991-09-16	1991-09-16	Gene probe biosensor method
PCT/GB1992/001698 WO1993006241A1 (en)	1991-09-16	1992-09-16	Gene probe biosensor method

Publications (2)

Publication Number	Publication Date
BG98660A BG98660A (bg)	1995-03-31
BG62337B1 true BG62337B1 (bg)	1999-08-31

Family

ID=10701461

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG98660A BG62337B1 (bg)	1991-09-16	1994-03-15	Биосензорен метод на базата на генна сонда

Country Status (20)

Country	Link
US (1)	US5750337A (de)
EP (1)	EP0604506B1 (de)
JP (1)	JP3324607B2 (de)
KR (1)	KR100249288B1 (de)
AT (1)	ATE174968T1 (de)
AU (1)	AU665369B2 (de)
BG (1)	BG62337B1 (de)
CA (1)	CA2116239C (de)
CZ (1)	CZ286927B6 (de)
DE (1)	DE69227997T2 (de)
DK (1)	DK0604506T3 (de)
ES (1)	ES2125272T3 (de)
FI (1)	FI108463B (de)
GB (2)	GB9119735D0 (de)
GR (1)	GR3029722T3 (de)
HU (1)	HU218596B (de)
NO (1)	NO315380B1 (de)
RU (1)	RU2116349C1 (de)
SK (1)	SK280713B6 (de)
WO (1)	WO1993006241A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993020240A1 (en) *	1992-04-06	1993-10-14	Abbott Laboratories	Method and device for detection of nucleic acid or analyte using total internal reflectance
WO1995026416A1 (en) *	1994-03-25	1995-10-05	Research Corporation Technologies, Inc.	Nucleic acid biosensor diagnostics
US5599668A (en) *	1994-09-22	1997-02-04	Abbott Laboratories	Light scattering optical waveguide method for detecting specific binding events
EP0795032A2 (de) *	1994-12-22	1997-09-17	Abbott Laboratories	Verfahren zur immobilisierung von oligonukleotiden auf festen trägermaterial und verfahren zur anwendung träger gebundener oligonukleotiden
US5690894A (en)	1995-05-23	1997-11-25	The Regents Of The University Of California	High density array fabrication and readout method for a fiber optic biosensor
SE9502608D0 (sv) *	1995-07-14	1995-07-14	Pharmacia Biosensor Ab	Method for nucleic acid senquencing
WO1997032212A1 (en) *	1996-03-01	1997-09-04	Beckman Instruments, Inc.	System for simultaneously conducting multiple ligand binding assays
US5832165A (en) *	1996-08-28	1998-11-03	University Of Utah Research Foundation	Composite waveguide for solid phase binding assays
AU755913B2 (en)	1997-06-18	2003-01-02	Masad Damha	Nucleic acid biosensor diagnostics
DE19730359A1 (de) *	1997-07-15	1999-01-21	Boehringer Mannheim Gmbh	Integriertes Verfahren und System zur Amplifizierung und zum Nachweis von Nukleinsäuren
DK1017848T3 (da) *	1997-07-28	2003-02-10	Medical Biosystems Ltd	Nucleinsyresekvensanalyse
GB2335035B (en) *	1998-03-03	2003-05-28	Brax Genomics Ltd	Screening for functional antisense agents
GB9805935D0 (en) *	1998-03-19	1998-05-13	Ciba Geigy Ag	Organic compounds
EP0957354A3 (de) *	1998-03-20	2000-03-22	IA Inc.	Verfahren und Vorrichtung zum Messen der Bindung zwischen Biomolekülen
US6429023B1 (en)	1998-07-20	2002-08-06	Shayda Technologies, Inc.	Biosensors with polymeric optical waveguides
DE60045059D1 (de) *	1999-04-20	2010-11-18	Nat Inst Of Advanced Ind Scien	Verfahren und Sonden zur Bestimmung der Konzentration von Nukleinsäure-Molekülen und Verfahren zur Analyse der gewonnenen Daten
RU2182708C2 (ru) *	2000-04-17	2002-05-20	Институт молекулярной биологии им. В.А. Энгельгардта РАН	Способ множественного параллельного скрининга специфичности связывания биологически активных соединений с нуклеиновыми кислотами с использованием биочипа (варианты)
US7205347B2 (en) *	2000-10-19	2007-04-17	Trans Photonics, Llc.	Substituted-polyaryl chromophoric compounds
AR031640A1 (es) *	2000-12-08	2003-09-24	Applied Research Systems	Amplificacion isotermica de acidos nucleicos en un soporte solido
US6597499B2 (en)	2001-01-25	2003-07-22	Olympus Optical Co., Ltd.	Total internal reflection fluorescence microscope having a conventional white-light source
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1991
- 1991-09-16 GB GB919119735A patent/GB9119735D0/en active Pending
1992
- 1992-09-16 HU HU9400770A patent/HU218596B/hu not_active IP Right Cessation
- 1992-09-16 CA CA002116239A patent/CA2116239C/en not_active Expired - Fee Related
- 1992-09-16 GB GB9402823A patent/GB2274710B/en not_active Revoked
- 1992-09-16 AU AU25641/92A patent/AU665369B2/en not_active Ceased
- 1992-09-16 WO PCT/GB1992/001698 patent/WO1993006241A1/en not_active Ceased
- 1992-09-16 ES ES92919549T patent/ES2125272T3/es not_active Expired - Lifetime
- 1992-09-16 SK SK306-94A patent/SK280713B6/sk not_active IP Right Cessation
- 1992-09-16 RU RU94019336A patent/RU2116349C1/ru not_active IP Right Cessation
- 1992-09-16 DK DK92919549T patent/DK0604506T3/da active
- 1992-09-16 US US08/196,185 patent/US5750337A/en not_active Expired - Lifetime
- 1992-09-16 JP JP50589793A patent/JP3324607B2/ja not_active Expired - Fee Related
- 1992-09-16 DE DE69227997T patent/DE69227997T2/de not_active Expired - Lifetime
- 1992-09-16 KR KR1019940700843A patent/KR100249288B1/ko not_active Expired - Fee Related
- 1992-09-16 AT AT92919549T patent/ATE174968T1/de not_active IP Right Cessation
- 1992-09-16 CZ CZ1994521A patent/CZ286927B6/cs not_active IP Right Cessation
- 1992-09-16 EP EP92919549A patent/EP0604506B1/de not_active Expired - Lifetime
1994
- 1994-03-14 NO NO19940901A patent/NO315380B1/no not_active IP Right Cessation
- 1994-03-15 BG BG98660A patent/BG62337B1/bg unknown
- 1994-03-15 FI FI941220A patent/FI108463B/fi active
1999
- 1999-03-18 GR GR990400807T patent/GR3029722T3/el unknown

Also Published As

Publication number	Publication date
CZ52194A3 (en)	1994-07-13
HU218596B (hu)	2000-10-28
AU665369B2 (en)	1996-01-04
NO315380B1 (no)	2003-08-25
ATE174968T1 (de)	1999-01-15
FI108463B (fi)	2002-01-31
JP3324607B2 (ja)	2002-09-17
EP0604506B1 (de)	1998-12-23
HU9400770D0 (en)	1994-06-28
AU2564192A (en)	1993-04-27
KR100249288B1 (ko)	2000-04-01
DE69227997D1 (de)	1999-02-04
GB2274710A (en)	1994-08-03
RU94019336A (ru)	1996-09-27
WO1993006241A1 (en)	1993-04-01
CA2116239A1 (en)	1993-04-01
GB9119735D0 (en)	1991-10-30
DE69227997T2 (de)	1999-05-12
GR3029722T3 (en)	1999-06-30
GB2274710B (en)	1995-09-06
CA2116239C (en)	2008-11-18
HUT68771A (en)	1995-07-28
CZ286927B6 (cs)	2000-08-16
JPH06510670A (ja)	1994-12-01
US5750337A (en)	1998-05-12
NO940901L (no)	1994-05-16
SK30694A3 (en)	1994-07-06
BG98660A (bg)	1995-03-31
ES2125272T3 (es)	1999-03-01
SK280713B6 (sk)	2000-06-12
EP0604506A1 (de)	1994-07-06
GB9402823D0 (en)	1994-04-27
FI941220A0 (fi)	1994-03-15
RU2116349C1 (ru)	1998-07-27
FI941220L (fi)	1994-03-15
DK0604506T3 (da)	1999-08-23
NO940901D0 (no)	1994-03-14

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