BR0116227A - Processo para a preparação de imidazotriazinonas substituìdas por sulfonamida - Google Patents

Processo para a preparação de imidazotriazinonas substituìdas por sulfonamida

Info

Publication number
BR0116227A
BR0116227A BR0116227-6A BR0116227A BR0116227A BR 0116227 A BR0116227 A BR 0116227A BR 0116227 A BR0116227 A BR 0116227A BR 0116227 A BR0116227 A BR 0116227A
Authority
BR
Brazil
Prior art keywords
preparation
sulfonamide
reacted
substituted imidazotriazinones
compounds
Prior art date
Application number
BR0116227-6A
Other languages
English (en)
Other versions
BRPI0116227B8 (pt
BR0116227B1 (pt
Inventor
Marc Nowakowski
Reinhold Gehring
Werner Heilmann
Karl-Heinz Wahl
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BR0116227A publication Critical patent/BR0116227A/pt
Publication of BR0116227B1 publication Critical patent/BR0116227B1/pt
Publication of BRPI0116227B8 publication Critical patent/BRPI0116227B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE IMIDAZOTRIAZINONAS SUBSTITUìDAS POR SULFONAMIDA". A presente invenção refere-se a um processo para a preparação de imidazotriazinonas substituídas por sulfonamida da fórmula geral (I) caracterizadas naqueles compostos da fórmula (II) são reagidos com ácido sulfúrico e os produtos obtidos são em seguida reagidos com cloreto de tionila e convertidos in situ em um solvente inerte empregando-se uma amina nos compostos de acordo com a invenção e, se apropriado, reagidos para fornecer os sais correspondentes, hidratos ou Nóxidos.
BRPI0116227A 2000-12-18 2001-12-05 processo para a preparação de imidazotriazinonas substituídas por sulfonamida BRPI0116227B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10063108A DE10063108A1 (de) 2000-12-18 2000-12-18 Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10063108.8 2000-12-18
PCT/EP2001/014239 WO2002050076A2 (de) 2000-12-18 2001-12-05 Verfahren zur herstellung von sulfonamid-substituierten imidazotriazinonen

Publications (3)

Publication Number Publication Date
BR0116227A true BR0116227A (pt) 2003-12-30
BR0116227B1 BR0116227B1 (pt) 2014-08-26
BRPI0116227B8 BRPI0116227B8 (pt) 2021-05-25

Family

ID=7667666

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0116227A BRPI0116227B8 (pt) 2000-12-18 2001-12-05 processo para a preparação de imidazotriazinonas substituídas por sulfonamida

Country Status (42)

Country Link
US (3) US6777551B2 (pt)
EP (1) EP1345939B1 (pt)
JP (1) JP4441175B2 (pt)
KR (1) KR100787288B1 (pt)
CN (1) CN1227253C (pt)
AR (1) AR032775A1 (pt)
AT (1) ATE328885T1 (pt)
AU (2) AU2002217089B2 (pt)
BG (1) BG66142B1 (pt)
BR (1) BRPI0116227B8 (pt)
CA (1) CA2431933C (pt)
CU (2) CU23341B7 (pt)
CY (1) CY1105197T1 (pt)
CZ (1) CZ297005B6 (pt)
DE (2) DE10063108A1 (pt)
DK (1) DK1345939T3 (pt)
DO (1) DOP2001000295A (pt)
EC (1) ECSP034657A (pt)
EE (1) EE05308B1 (pt)
ES (1) ES2266098T3 (pt)
GT (1) GT200100251A (pt)
HN (1) HN2001000278A (pt)
HR (1) HRP20030583B1 (pt)
HU (1) HU229296B1 (pt)
IL (2) IL156278A0 (pt)
MA (1) MA25927A1 (pt)
MX (1) MXPA03005429A (pt)
MY (1) MY126689A (pt)
NO (1) NO325398B1 (pt)
NZ (1) NZ526477A (pt)
PE (1) PE20020590A1 (pt)
PL (1) PL207294B1 (pt)
PT (1) PT1345939E (pt)
RU (1) RU2299211C2 (pt)
SI (1) SI1345939T1 (pt)
SK (1) SK286894B6 (pt)
SV (1) SV2003000766A (pt)
TW (1) TWI289562B (pt)
UA (1) UA75109C2 (pt)
UY (2) UY27070A1 (pt)
WO (1) WO2002050076A2 (pt)
ZA (1) ZA200304705B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10063108A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10107639A1 (de) * 2001-02-15 2002-08-22 Bayer Ag 2-Alkoxyphenyl-substituierte Imidazotriazinone
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
DE202004006552U1 (de) * 2004-04-26 2004-07-08 Knürr AG Kühlungssystem für Geräte- und Netzwerkschränke
DE102004023069A1 (de) 2004-05-11 2005-12-08 Bayer Healthcare Ag Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
US7977478B2 (en) * 2006-03-13 2011-07-12 Dr. Reddy's Laboratories Limited Polymorphic forms of vardenafil
WO2009030095A1 (fr) * 2007-09-06 2009-03-12 Topharman Shanghai Co., Ltd. Procédé de préparation de vardénafil et de ses intermédiaires
WO2009082845A1 (fr) 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd. N-{1-[3-(2-éthoxy-5-(4-éthylpipérazinyl)benzènesulfonyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]éthyl}butyramide, son procédé de préparation et son utilisation
AU2010280358A1 (en) 2009-08-07 2012-03-08 Ranbaxy Laboratories Limited Processes for the preparation of vardenafil
PL390079A1 (pl) * 2009-12-30 2011-07-04 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli
CN102134242B (zh) 2011-01-21 2013-08-28 浙江大德药业集团有限公司 一种用于治疗阳痿的快速长效的化合物
CZ2011767A3 (cs) * 2011-11-24 2013-06-05 Zentiva, K.S. Zpusob prípravy a izolace solí vardenafilu s kyselinami
WO2015089105A1 (en) 2013-12-09 2015-06-18 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
PL223869B1 (pl) 2013-12-16 2016-11-30 Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna Sposób otrzymywania wardenafilu i jego soli
CN107383020A (zh) * 2017-07-29 2017-11-24 合肥创新医药技术有限公司 一种伐地那非杂质的制备方法
CN111655229A (zh) 2017-12-20 2020-09-11 卡里亚制药控股有限公司 包含伐地那非的薄膜制剂、其制备方法及其用途
CN115043757B (zh) * 2022-07-27 2023-08-08 南京桦冠生物技术有限公司 一种连续化制备苄脒盐酸盐的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
HU227841B1 (en) 1997-11-12 2012-05-02 Bayer Pharma AG 2-phenyl substituted imidazotriazinones, process for their preparation and pharmaceutical compositions thereof
DE10063108A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10107639A1 (de) * 2001-02-15 2002-08-22 Bayer Ag 2-Alkoxyphenyl-substituierte Imidazotriazinone

Also Published As

Publication number Publication date
US20020137930A1 (en) 2002-09-26
BG107892A (bg) 2004-08-31
EE200300294A (et) 2003-10-15
AR032775A1 (es) 2003-11-26
ATE328885T1 (de) 2006-06-15
CN1227253C (zh) 2005-11-16
EP1345939A2 (de) 2003-09-24
NO20032731D0 (no) 2003-06-16
CU20080213A7 (es) 2012-06-21
EP1345939B1 (de) 2006-06-07
HN2001000278A (es) 2002-01-30
MY126689A (en) 2006-10-31
SK286894B6 (sk) 2009-07-06
NZ526477A (en) 2004-12-24
HUP0302467A3 (en) 2004-11-29
PL365310A1 (en) 2004-12-27
CA2431933C (en) 2009-12-01
MXPA03005429A (es) 2004-05-04
CN1481386A (zh) 2004-03-10
ECSP034657A (es) 2003-07-25
IL156278A0 (en) 2004-01-04
HRP20030583B1 (hr) 2011-09-30
PT1345939E (pt) 2006-08-31
CZ20031692A3 (cs) 2003-10-15
BG66142B1 (bg) 2011-07-29
DE50110080D1 (de) 2006-07-20
JP4441175B2 (ja) 2010-03-31
NO20032731L (no) 2003-06-16
US6777551B2 (en) 2004-08-17
US20050203298A1 (en) 2005-09-15
JP2004517849A (ja) 2004-06-17
IL156278A (en) 2009-06-15
KR100787288B1 (ko) 2007-12-20
SI1345939T1 (sl) 2006-10-31
PL207294B1 (pl) 2010-11-30
SK7502003A3 (en) 2003-10-07
CY1105197T1 (el) 2010-03-03
RU2299211C2 (ru) 2007-05-20
KR20030063430A (ko) 2003-07-28
UY37172A (es) 2017-06-30
CA2431933A1 (en) 2002-06-27
CU23341B7 (es) 2009-02-20
SV2003000766A (es) 2003-01-13
DK1345939T3 (da) 2006-09-25
TWI289562B (en) 2007-11-11
AU1708902A (en) 2002-07-01
BRPI0116227B8 (pt) 2021-05-25
EE05308B1 (et) 2010-06-15
WO2002050076A3 (de) 2002-08-29
UA75109C2 (en) 2006-03-15
DE10063108A1 (de) 2002-06-20
CZ297005B6 (cs) 2006-08-16
US6998483B2 (en) 2006-02-14
US20050014756A1 (en) 2005-01-20
PE20020590A1 (es) 2002-07-13
WO2002050076A2 (de) 2002-06-27
HK1063799A1 (en) 2005-01-14
CU23873B1 (es) 2013-04-19
HU229296B1 (en) 2013-10-28
GT200100251A (es) 2002-10-01
ZA200304705B (en) 2004-08-12
NO325398B1 (no) 2008-04-21
BR0116227B1 (pt) 2014-08-26
DOP2001000295A (es) 2002-12-15
AU2002217089B2 (en) 2006-01-12
HUP0302467A2 (hu) 2003-11-28
UY27070A1 (es) 2002-07-31
ES2266098T3 (es) 2007-03-01
MA25927A1 (fr) 2003-10-01
HRP20030583A2 (en) 2005-06-30

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: BAYER HEALTHCARE AG (DE)

Free format text: TRANSFERIDO DE: BAYER AKTIENGESELLSCHAFT

B25A Requested transfer of rights approved

Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE)

Free format text: TRANSFERIDO POR FUSAO DE: BAYER HEALTHCARE AG

B15K Others concerning applications: alteration of classification

Free format text: PARA:INT.CI. C07D 487/04, A61P 15/00

Ipc: C07D 487/04 (2006.01), A61P 15/00 (2006.01)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B25D Requested change of name of applicant approved

Owner name: BAYER PHARMA AKTIENGESELLSCHAFT (DE)

B25A Requested transfer of rights approved

Owner name: BAYER INTELLECTUAL PROPERTY GMBH. (DE)

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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