BRPI0413964A - ácido derivado do ácido carboxìlico quinolona, sua composição e agente antibacterial - Google Patents

ácido derivado do ácido carboxìlico quinolona, sua composição e agente antibacterial

Info

Publication number
BRPI0413964A
BRPI0413964A BRPI0413964-0A BRPI0413964A BRPI0413964A BR PI0413964 A BRPI0413964 A BR PI0413964A BR PI0413964 A BRPI0413964 A BR PI0413964A BR PI0413964 A BRPI0413964 A BR PI0413964A
Authority
BR
Brazil
Prior art keywords
composition
antibacterial agent
carboxylic acid
acid
acid derivative
Prior art date
Application number
BRPI0413964-0A
Other languages
English (en)
Inventor
Yoshikazu Asahina
Masaya Takei
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of BRPI0413964A publication Critical patent/BRPI0413964A/pt
Publication of BRPI0413964B1 publication Critical patent/BRPI0413964B1/pt
Publication of BRPI0413964B8 publication Critical patent/BRPI0413964B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"áCIDO DERIVADO DO áCIDO CARBOXìLICO QUINOLONA, SUA COMPOSIçãO E AGENTE ANTIBACTERIAL". Para prover novidade em composição do ácido quinolonecarboxilico, atuando com segurança, como possante agente antibacteriano que são efetivos contra bactérias resistentes a medicamento que são menos suscetíveis do que agentes antibacterianos convencionais. São providos 7-(4-substituído-3-ciclopropilaminometilpirolidinil) ácido quinolonecarboxilico derivados (como 1 -ciclopropil-7-(3S,4S)-3ciclopropilaminometil-4-fluoro-1 -pirolidinil-6-fluoro-1,4-dihidro-8-metoxi-3-ácido quinolonecarboxilico) que exibem resistente atividade antibacteriana contra bactéria gram-positiva, como MRSA, PRSP e VRE, sendo devidamente seguras. A composição é mostrada pela seguinte fórmula geral (I):
BRPI0413964A 2003-09-10 2004-09-08 ácido derivado do ácido carboxílico quinolona, sua composição e agente antibacterial BRPI0413964B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003318897 2003-09-10
PCT/JP2004/013049 WO2005026147A1 (ja) 2003-09-10 2004-09-08 ７−（４−置換−３−シクロプロピルアミノメチル−１−ピロリジニル）キノロンカルボン酸誘導体

Publications (3)

Publication Number Publication Date
BRPI0413964A true BRPI0413964A (pt) 2006-10-31
BRPI0413964B1 BRPI0413964B1 (pt) 2017-03-28
BRPI0413964B8 BRPI0413964B8 (pt) 2021-05-25

Family

ID=34308537

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413964A BRPI0413964B8 (pt) 2003-09-10 2004-09-08 ácido derivado do ácido carboxílico quinolona, sua composição e agente antibacterial

Country Status (18)

Country Link
US (2) US7514451B2 (pt)
EP (1) EP1666477B1 (pt)
JP (1) JP4639149B2 (pt)
KR (1) KR101077755B1 (pt)
CN (1) CN100410249C (pt)
AU (1) AU2004272414B2 (pt)
BR (1) BRPI0413964B8 (pt)
CA (1) CA2536429C (pt)
CY (1) CY1114476T1 (pt)
DK (1) DK1666477T3 (pt)
ES (1) ES2424676T3 (pt)
NO (1) NO333481B1 (pt)
NZ (1) NZ545472A (pt)
PL (1) PL1666477T3 (pt)
PT (1) PT1666477E (pt)
SG (1) SG144936A1 (pt)
SI (1) SI1666477T1 (pt)
WO (1) WO2005026147A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1666477T1 (sl) * 2003-09-10 2013-10-30 Kyorin Pharmaceutical Co., Ltd. Derivati 7-(4-substituiran 3-ciklopropilaminometil-1-pirolidinil) kinolonkarboksilne kisline
CA2645191C (en) * 2006-03-09 2014-05-06 Kyorin Pharmaceutical Co., Ltd. Process for producing 3,4-disubstituted pyrrolidine derivative and production intermediate thereof
SG185619A1 (en) * 2010-05-31 2012-12-28 Kyorin Seiyaku Kk Method for producing 3-substituted-4-fluoropyrrolidine derivative
CA2815952A1 (en) 2010-10-25 2012-05-03 Kyorin Pharmaceutical Co., Ltd. Method for producing 3,4-disubstituted pyrrolidine derivative
SA112330992B1 (ar) * 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي
WO2013145749A1 (ja) * 2012-03-29 2013-10-03 杏林製薬株式会社 カプセル製剤
JP6062422B2 (ja) * 2012-03-29 2017-01-18 杏林製薬株式会社 カプセル製剤
WO2014174847A1 (ja) * 2013-04-25 2014-10-30 杏林製薬株式会社 固形医薬組成物
US9603804B2 (en) 2013-04-25 2017-03-28 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
WO2014174848A1 (ja) * 2013-04-25 2014-10-30 杏林製薬株式会社 錠剤
JP6018334B2 (ja) * 2014-10-23 2016-11-02 杏林製薬株式会社 固形医薬組成物
SG10201908007UA (en) * 2015-03-13 2019-10-30 Kyorin Pharmaceutical Co Ltd Respiratory infection treating agent
JP6031216B1 (ja) * 2015-06-02 2016-11-24 杏林製薬株式会社 水性液剤
US10617684B2 (en) 2015-06-02 2020-04-14 Kyorin Pharmaceutical Co., Ltd. Aqueous drug
US10406149B2 (en) 2015-06-02 2019-09-10 Kyorin Pharmaceutical Co., Ltd. Aqueous liquid formulation
JP6031217B1 (ja) * 2015-06-02 2016-11-24 杏林製薬株式会社 水性液剤
WO2016195020A1 (ja) * 2015-06-02 2016-12-08 杏林製薬株式会社 水性液剤
CN106831795B (zh) * 2017-01-16 2018-12-21 石家庄学院 喹诺酮异土木香内酯衍生物及其制备和应用
WO2018230686A1 (ja) 2017-06-16 2018-12-20 杏林製薬株式会社 誤嚥性肺炎、肺化膿症又は肺膿瘍の治療剤
BR112019025960A2 (pt) 2017-06-16 2020-11-03 Kyorin Pharmaceutical Co., Ltd. agente terapêutico para pneumonia aspirativa, supuração pulmonar ou abcesso pulmonar

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292317A (en) 1977-09-20 1981-09-29 Laboratorie Roger Bellon 1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them
SE440354B (sv) 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
JPH0640814B2 (ja) 1982-07-24 1994-06-01 株式会社東芝 自動化学分析装置
US5281612A (en) 1982-09-09 1994-01-25 Warner-Lambert Company Naphthyridine antibacterial agents
US4638067A (en) 1982-09-09 1987-01-20 Warner-Lambert Co. Antibacterial agents
US4665079A (en) 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE55898B1 (en) 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US4777175A (en) 1982-09-09 1988-10-11 Warner-Lambert Company Antibacterial agents
US4822801A (en) 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4604401A (en) 1984-07-20 1986-08-05 Warner-Lambert Company Antibacterial agents III
IE58742B1 (en) 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
US5097032A (en) 1984-07-20 1992-03-17 Warner-Lambert Company Antibacterial agents - II
US4771054A (en) 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
AU578793B2 (en) * 1985-02-15 1988-11-03 Dainippon Pharmaceutical Co. Ltd. Novel 1,8-naphthyridine derivatives and processes for preparation thereof
JPS61282362A (ja) 1985-06-07 1986-12-12 バイエル・アクチエンゲゼルシヤフト キノロンカルボン酸エステル
IL79189A (en) 1985-06-26 1990-07-12 Daiichi Seiyaku Co Quinoline and/or naphthyridine-4-oxo-3-carboxylic acid derivatives,process for their preparation and pharmaceutical compositions comprising them
JPH0635457B2 (ja) 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法
JPH0696572B2 (ja) 1985-07-17 1994-11-30 大日本製薬株式会社 ピリドンカルボン酸誘導体、そのエステルおよびその塩
DE3617803A1 (de) 1985-11-07 1987-11-19 Bayer Ag Verwendung von gyrasehemmern zur dekontamination von mycoplasma-infizierten zellkulturen
JPH0633256B2 (ja) 1985-12-20 1994-05-02 大塚製薬株式会社 キノリンカルボン酸誘導体
JPS62228063A (ja) 1985-12-27 1987-10-06 Sankyo Co Ltd キノリンカルボン酸誘導体
JPS62215572A (ja) 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPS63198664A (ja) 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
US4771055A (en) 1986-07-28 1988-09-13 Warner-Lambert Company 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
DE3632222A1 (de) 1986-09-23 1988-04-07 Bayer Ag Topisch anwendbare zubereitungen von gyrase-inhibitoren
US4954507A (en) 1986-10-08 1990-09-04 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents
US4965273A (en) 1986-10-08 1990-10-23 Bristol-Myers Company Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents
ZA877471B (en) 1986-10-08 1988-04-05 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents
DE3641312A1 (de) 1986-12-03 1988-06-09 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
JPH0723369B2 (ja) 1986-12-27 1995-03-15 第一製薬株式会社 ピリドンカルボン酸誘導体
DE3704907A1 (de) 1987-02-17 1988-08-25 Bayer Ag Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
DE3711193A1 (de) 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
US5290934A (en) 1987-04-16 1994-03-01 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US5591744A (en) 1987-04-16 1997-01-07 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
DE3719764A1 (de) 1987-06-13 1988-12-22 Bayer Ag Ionenaustauscherharze beladen mit chinoloncarbonsaeurederivaten, ihre herstellung und verwendung
JP2598929B2 (ja) 1987-11-19 1997-04-09 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
US5585491A (en) 1988-01-25 1996-12-17 Otsuka Pharmaceutical Co., Ltd. Antibacterial agents
US5173484A (en) 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
DE3814517A1 (de) 1988-02-05 1989-08-17 Bayer Ag Chinolon- und naphthyridoncarbonsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende antibakterielle mittel und futterzusatzstoffe
US5336768A (en) 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
DE3902079A1 (de) 1988-04-15 1989-10-26 Bayer Ag I.m. injektionsformen von gyrase-inhibitoren
JP2844079B2 (ja) 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
US5262417A (en) 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
EP0447484A1 (en) 1988-12-06 1991-09-25 The Upjohn Company Antibacterial quinolone compounds
CA2012681A1 (en) 1989-03-31 1990-09-30 Masayasu Okuhira Quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same
JPH03188074A (ja) * 1989-03-31 1991-08-16 Wakunaga Pharmaceut Co Ltd 新規キノロン誘導体及びこれを含有する抗菌剤
US5407932A (en) 1989-03-31 1995-04-18 Wakunaga Seiyaku Kabushiki Kaisha Quinolone derivatives and antibacterial agents containing the same
US5140033A (en) 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
DE3910663A1 (de) 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
US5252734A (en) 1989-04-03 1993-10-12 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
PL166381B1 (pl) 1989-08-16 1995-05-31 Pfizer Sposób wytwarzania nowych podstawionych kwasów 7-azabicyklochinolonokarboksylowych PL PL PL PL
US5164402A (en) 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
US5266569A (en) 1989-08-16 1993-11-30 Pfizer Inc. Azatricyclo carboxylic acids useful as anti-bacterial agents
JP2939280B2 (ja) 1990-01-10 1999-08-25 三共株式会社 フッ素置換メトキシキノロンカルボン酸誘導体
US5391763A (en) 1990-07-11 1995-02-21 Pfizer Inc. 3-aza-bicyclo[3.1.0]hexanes which are intermediates for anti-bacterial azabicyclo quinolone carboxylic acids
US5137892A (en) 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
US5468742A (en) 1991-07-19 1995-11-21 Bayer Aktiengesellschaft 8-vinyl- and 9-ethinyl-quinolone-carboxylic acids
DE4123918A1 (de) 1991-07-19 1993-01-21 Bayer Ag 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren
KR950014567B1 (ko) 1991-08-01 1995-12-08 주식회사대웅제약 신규한 퀴놀론 카르복실산 유도체
WO1993025545A1 (en) 1992-06-09 1993-12-23 Korea Research Institute Of Chemical Technology Novel quinoline derivatives and processes for preparing the same
JP3209367B2 (ja) 1992-08-25 2001-09-17 セイコー化成株式会社 透湿性防水布帛の製造方法
US5646163A (en) 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
EG20543A (en) 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
CA2152828A1 (en) 1993-03-16 1994-07-07 Shin-Ichi Uesato 8-methoxy-quinolonecarboxylic acid derivatives
ES2065846B1 (es) 1993-04-20 1995-10-01 Cusi Lab Formulacion farmaceutica a base de un agente antiinflamatorio esteroidico o no esteroidico y un antibiotico pertenciente al grupo de los inhibidores de la adn girasa para su utilizacion topica oftalmica.
DE69428206T2 (de) 1993-10-28 2002-06-13 Kaken Pharmaceutical Co., Ltd. Chinolincarbonsäurederivate und ihre salze
DE4408212A1 (de) 1994-03-11 1995-09-14 Bayer Ag 5-Vinyl- und 5-Ethinyl-chinolon- und -naphthyridon-carbonsäuren
JPH07300471A (ja) 1994-04-28 1995-11-14 Kaken Pharmaceut Co Ltd キノリンカルボン酸誘導体およびその塩
SI0787726T1 (en) 1994-06-14 2002-04-30 Dainippon Pharmaceutical Co., Ltd. Novel compound, process for producing the same, and antitumor agent
WO1996033992A1 (en) 1995-04-27 1996-10-31 Kaken Pharmaceutical Co., Ltd. Optically active quinolinecarboxylic acid derivatives and salts thereof
JP3833738B2 (ja) 1995-11-15 2006-10-18 第一製薬株式会社 置換アミノメチルピロリジン誘導体
TW425394B (en) 1996-04-24 2001-03-11 Daiichi Seiyaku Co Antimicrobial quinolone derivatives having 3-(N-cycloalkyl) aminomethylpyrrolidine group
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
ATE423776T1 (de) 1997-09-15 2009-03-15 Procter & Gamble Antimikrobielle chinolone, ihre zusammensetzungen und ihre verwendungen
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
AR020661A1 (es) 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
US6440964B1 (en) 1998-09-30 2002-08-27 Alcon Manufacturing, Ltd. Compositions and methods for treating ophthalmic and otic infections
US6740664B2 (en) 1998-09-30 2004-05-25 Alcon, Inc. Methods for treating otic and ophthalmic infections
JP2000319261A (ja) 1999-05-13 2000-11-21 Dai Ichi Seiyaku Co Ltd キノロンカルボン酸類の製造方法
SE9904108D0 (sv) 1999-11-15 1999-11-15 New Pharma Research Ab Nya föreningar
DE19962470A1 (de) 1999-12-22 2001-07-12 Schulz Hans Herrmann Verwendung von Chemotherapeutika
PT1262477E (pt) 2000-02-09 2008-11-14 Daiichi Sankyo Co Ltd Agentes anti-bacterianos resistentes a ácidos contendo, como princípio activo, ácidos piridinocarboxílicos
US6699989B1 (en) 2000-08-28 2004-03-02 B. Vithal Shetty Antiviral and antimicrobial guanidine or biguanidine derivatives
JP2003096075A (ja) 2001-09-26 2003-04-03 Dai Ichi Seiyaku Co Ltd キノロンカルボン酸誘導体の製法
ATE443064T1 (de) 2002-03-18 2009-10-15 Kyorin Seiyaku Kk 10-(3-cyclo propyl amino methyl-1-pyrrolidinyl) pyridobenzoxazin carbonsäure derivat mit wirkung gegen resistente bakterien
SI1666477T1 (sl) * 2003-09-10 2013-10-30 Kyorin Pharmaceutical Co., Ltd. Derivati 7-(4-substituiran 3-ciklopropilaminometil-1-pirolidinil) kinolonkarboksilne kisline
WO2005049602A1 (en) 2003-11-18 2005-06-02 Warner-Lambert Company Llc Quinolone antibacterial agents
EP1723150A1 (en) 2004-01-13 2006-11-22 Cumbre Pharmaceuticals Inc. Rifamycin imino derivatives effective against drug-resistant microbes
CN1273452C (zh) 2004-06-01 2006-09-06 中国医学科学院医药生物技术研究所 7－（4，4－二甲基－3－氨甲基吡咯烷－1－基）取代的新喹啉羧酸衍生物及其制法
CN1861599A (zh) 2005-05-11 2006-11-15 孙飘扬 喹诺酮羧酸类衍生物及其制备方法和药物用途
CA2695072A1 (en) 2006-08-16 2008-02-21 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones

Also Published As

Publication number Publication date
CN100410249C (zh) 2008-08-13
EP1666477B1 (en) 2013-07-03
SI1666477T1 (sl) 2013-10-30
ES2424676T3 (es) 2013-10-07
KR101077755B1 (ko) 2011-10-27
DK1666477T3 (da) 2013-07-29
EP1666477A4 (en) 2008-10-22
AU2004272414A1 (en) 2005-03-24
PT1666477E (pt) 2013-08-28
NZ545472A (en) 2009-09-25
CN1849316A (zh) 2006-10-18
BRPI0413964B1 (pt) 2017-03-28
JPWO2005026147A1 (ja) 2007-11-08
SG144936A1 (en) 2008-08-28
CY1114476T1 (el) 2016-10-05
CA2536429A1 (en) 2005-03-24
AU2004272414B2 (en) 2009-05-28
EP1666477A1 (en) 2006-06-07
US7514451B2 (en) 2009-04-07
NO333481B1 (no) 2013-06-24
PL1666477T3 (pl) 2013-11-29
WO2005026147A1 (ja) 2005-03-24
US20090176824A1 (en) 2009-07-09
NO20061050L (no) 2006-04-04
KR20060123096A (ko) 2006-12-01
BRPI0413964B8 (pt) 2021-05-25
US20060281779A1 (en) 2006-12-14
JP4639149B2 (ja) 2011-02-23
US8106072B2 (en) 2012-01-31
CA2536429C (en) 2012-02-14

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