PL1792927T3 - Nowy kopolimer blokowy, preparat micelarny i lek przeciwnowotworowy zawierający ten preparat micelarny jako składnik czynny - Google Patents

Nowy kopolimer blokowy, preparat micelarny i lek przeciwnowotworowy zawierający ten preparat micelarny jako składnik czynny

Info

Publication number
PL1792927T3
PL1792927T3 PL05783310T PL05783310T PL1792927T3 PL 1792927 T3 PL1792927 T3 PL 1792927T3 PL 05783310 T PL05783310 T PL 05783310T PL 05783310 T PL05783310 T PL 05783310T PL 1792927 T3 PL1792927 T3 PL 1792927T3
Authority
PL
Poland
Prior art keywords
active ingredient
block copolymer
same
agent containing
anticancer agent
Prior art date
Application number
PL05783310T
Other languages
English (en)
Inventor
Kazuhisa Shimizu
Keizou Ishikawa
Takeshi Nakanishi
Original Assignee
Nippon Kayaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Kk filed Critical Nippon Kayaku Kk
Publication of PL1792927T3 publication Critical patent/PL1792927T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Epoxy Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
PL05783310T 2004-09-22 2005-09-16 Nowy kopolimer blokowy, preparat micelarny i lek przeciwnowotworowy zawierający ten preparat micelarny jako składnik czynny PL1792927T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004275625 2004-09-22
EP05783310A EP1792927B1 (en) 2004-09-22 2005-09-16 Novel block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
PCT/JP2005/017127 WO2006033296A1 (ja) 2004-09-22 2005-09-16 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤

Publications (1)

Publication Number Publication Date
PL1792927T3 true PL1792927T3 (pl) 2013-09-30

Family

ID=36090056

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05783310T PL1792927T3 (pl) 2004-09-22 2005-09-16 Nowy kopolimer blokowy, preparat micelarny i lek przeciwnowotworowy zawierający ten preparat micelarny jako składnik czynny

Country Status (15)

Country Link
US (3) US20080113028A1 (pl)
EP (1) EP1792927B1 (pl)
JP (2) JP4820758B2 (pl)
KR (1) KR101203475B1 (pl)
CN (1) CN101023119B (pl)
AU (1) AU2005285953B2 (pl)
BR (1) BRPI0515573A (pl)
CA (1) CA2581125C (pl)
DK (1) DK1792927T3 (pl)
ES (1) ES2410591T3 (pl)
PL (1) PL1792927T3 (pl)
PT (1) PT1792927E (pl)
RU (1) RU2375384C2 (pl)
TW (2) TWI394774B (pl)
WO (1) WO2006033296A1 (pl)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1761485B (zh) * 2003-03-20 2010-04-28 日本化药株式会社 含略微水溶性抗癌剂和新型嵌段共聚物的胶束制剂
JP4820758B2 (ja) 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
KR20080064827A (ko) * 2005-10-05 2008-07-09 도쿄 씨알오 가부시키가이샤 생체 적합성 블록 공중합체, 그 용도 및 제조법
US8323669B2 (en) * 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
RU2447095C2 (ru) * 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся Высокомолекулярный конъюгат подофиллотоксинов
JP5548364B2 (ja) * 2006-10-03 2014-07-16 日本化薬株式会社 レゾルシノール誘導体の高分子結合体
US8334364B2 (en) * 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
JP5548365B2 (ja) * 2006-11-08 2014-07-16 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
JP5349318B2 (ja) 2007-09-28 2013-11-20 日本化薬株式会社 ステロイド類の高分子結合体
CN101977631A (zh) 2008-03-18 2011-02-16 日本化药株式会社 生理活性物质的高分子量偶联物
JP5366940B2 (ja) 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
JP5544357B2 (ja) 2009-05-15 2014-07-09 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
US20120231053A1 (en) 2009-10-21 2012-09-13 Nippon Kayaku Kabushiki Kaisha Block Copolymer For Intraperitoneal Administration Containing Anti-Cancer Agent, Micelle Preparation Thereof, And Cancer Therapeutic Agent Comprising The Micelle Preparation As Active Ingredient
JP5886749B2 (ja) * 2010-09-02 2016-03-16 日本化薬株式会社 薬物−ブロックコポリマー複合体とそれを含有する医薬の製造方法
KR20140024833A (ko) 2010-11-17 2014-03-03 니폰 가야꾸 가부시끼가이샤 신규한 시티딘계 대사길항제의 고분자 유도체
CN103874722B (zh) 2011-09-11 2016-06-29 日本化药株式会社 嵌段共聚物的制造方法
CN102440961B (zh) * 2011-12-08 2013-10-09 中山大学 一种具有酸敏亚表层的靶向聚合物胶束及其制备方法
CN102875789B (zh) * 2012-09-26 2015-10-07 中国科学院长春应用化学研究所 一种聚醚嵌段共聚物及其制备方法
CN102875790B (zh) * 2012-09-26 2016-03-23 中国科学院长春应用化学研究所 一种聚醚无规共聚物及其制备方法
WO2015002078A1 (ja) 2013-07-03 2015-01-08 日本化薬株式会社 ボロン酸化合物の新規製剤
EP2942348B1 (en) 2014-05-07 2017-10-25 Johannes Gutenberg-Universität Mainz Thiol-protected amino acid derivatives and uses thereof
CN104086769A (zh) * 2014-07-13 2014-10-08 成都市绿科华通科技有限公司 新型医用功能性聚乙二醇材料
CN104109255A (zh) * 2014-07-13 2014-10-22 成都市绿科华通科技有限公司 新型医药用聚乙二醇功能材料
CN104072758A (zh) * 2014-07-13 2014-10-01 成都市绿科华通科技有限公司 一种医药用功能性聚乙二醇
US10226193B2 (en) 2015-03-31 2019-03-12 Medtronic Ps Medical, Inc. Wireless pressure measurement and monitoring for shunts
EP3378495B1 (en) * 2015-11-18 2020-08-05 Nippon Kayaku Kabushiki Kaisha Composition comprising novel glutamic acid derivative and block copolymer, and use thereof
JP6831796B2 (ja) 2015-12-22 2021-02-17 日本化薬株式会社 スルホキシド誘導体配位白金（ｉｉ）錯体の高分子結合体
JP6924191B2 (ja) 2016-07-30 2021-08-25 日本化薬株式会社 新規な高分子誘導体、及びそれらを用いた新規な高分子誘導体イメージングプローブ
EP3495406A4 (en) 2016-08-02 2020-04-01 Nippon Kayaku Kabushiki Kaisha ACTIVE TARGETING TYPE POLYMER DERIVATIVE, COMPOSITION CONTAINING SAID POLYMER DERIVATIVE, AND USES OF SAID POLYMER DERIVATIVE AND COMPOSITION THEREOF
JP6848743B2 (ja) * 2017-07-24 2021-03-24 信越化学工業株式会社 ポリアルキレングリコール誘導体の製造方法及び精製方法
CN111253345B (zh) * 2020-03-02 2021-11-23 东北林业大学 一种红豆杉枝叶中紫杉醇的提取方法
WO2022008527A1 (en) 2020-07-06 2022-01-13 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Polymeric micelles comprising glucuronide-prodrugs
CN112691081B (zh) * 2021-01-18 2022-04-22 首都医科大学 一种基于(s)-2-癸酰氨基-3-(1-萘基)丙酰基-亮氨酰-缬氨酸的紫杉醇胶束

Family Cites Families (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467587A (en) * 1974-07-11 1977-03-16 Nestle Sa Preparation of an asparagine or a glutamine
GB8500209D0 (en) 1985-01-04 1985-02-13 Ceskoslovenska Akademie Ved Synthetic polymeric drugs
JPS6296088A (ja) 1985-10-22 1987-05-02 Kanebo Ltd 抗腫瘍性物質の製法
US4734512A (en) 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
JPS6310789A (ja) 1986-07-01 1988-01-18 Nippon Kayaku Co Ltd 新規ポドフイロトキシン誘導体
JPS6323884A (ja) 1986-07-17 1988-02-01 Nippon Kayaku Co Ltd 新規ポドフイロトキシン誘導体
JPS6461422A (en) 1987-09-02 1989-03-08 Nippon Kayaku Kk Water-soluble polymeric carcinostatic agent
JPS6461423A (en) 1987-09-02 1989-03-08 Nippon Kayaku Kk Water-soluble polymeric carcinostatic agent
US5182203A (en) * 1989-03-29 1993-01-26 E. I. Du Pont De Nemours And Company Bifunctional compounds useful in catalyzed reporter deposition
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5543390A (en) * 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
JP3310000B2 (ja) 1990-11-07 2002-07-29 靖久 桜井 水溶性高分子抗癌剤及び薬物担持用担体
JPH05117385A (ja) 1991-10-31 1993-05-14 Res Dev Corp Of Japan ブロツク共重合体の製造法、ブロツク共重合体及び水溶性高分子抗癌剤
AU4406793A (en) 1992-06-04 1993-12-30 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
KR940003548U (ko) 1992-08-14 1994-02-21 김형술 세탁물 건조기
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
JP3270592B2 (ja) * 1992-10-26 2002-04-02 日本化薬株式会社 ブロック共重合体−抗癌剤複合体医薬製剤
JPH06206830A (ja) 1992-10-27 1994-07-26 Nippon Kayaku Co Ltd ブロック共重合体−薬剤複合体及び高分子ブロック共重合体
JP3268913B2 (ja) * 1992-10-27 2002-03-25 日本化薬株式会社 高分子担体
FR2698543B1 (fr) * 1992-12-02 1994-12-30 Rhone Poulenc Rorer Sa Nouvelles compositions à base de taxoides.
US5985548A (en) * 1993-02-04 1999-11-16 E. I. Du Pont De Nemours And Company Amplification of assay reporters by nucleic acid replication
DE4307114A1 (de) * 1993-03-06 1994-09-08 Basf Ag Verfahren zur Herstellung von Umsetzungsprodukten aus Polyasparaginsäureamid und Aminosäuren und ihre Verwendung
JP2894923B2 (ja) 1993-05-27 1999-05-24 日立造船株式会社 ウォータージェット式双胴船のジェット水吸込口部構造
US5880131A (en) 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5840900A (en) 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
US5571889A (en) * 1994-05-30 1996-11-05 Mitsui Toatsu Chemicals, Inc. Polymer containing monomer units of chemically modified polyaspartic acids or their salts and process for preparing the same
JPH0848766A (ja) 1994-05-30 1996-02-20 Mitsui Toatsu Chem Inc 重合体及びその製造方法
US5552517A (en) * 1995-03-03 1996-09-03 Monsanto Company Production of polysuccinimide in an organic medium
SG50747A1 (en) 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
JP2694923B2 (ja) 1995-08-21 1997-12-24 科学技術振興事業団 水溶性高分子化医薬製剤
CN1304058C (zh) * 1996-03-12 2007-03-14 Pg－Txl有限公司 水溶性紫杉醇产品
WO1997038727A1 (en) 1996-04-15 1997-10-23 Asahi Kasei Kogyo Kabushiki Kaisha Medicament composite
US5877205A (en) * 1996-06-28 1999-03-02 Board Of Regents, The University Of Texas System Parenteral paclitaxel in a stable non-toxic formulation
AU710156B2 (en) 1996-07-15 1999-09-16 Kabushiki Kaisha Yakult Honsha Taxane derivatives and drugs containing the same
DK0941066T3 (da) 1996-08-26 2004-02-23 Transgene Sa Kationisk lipid-nukleinsyre-komplekser
GB9625895D0 (en) * 1996-12-13 1997-01-29 Riley Patrick A Novel compound useful as therapeutic agents and assay reagents
ATE236657T1 (de) * 1997-05-09 2003-04-15 Deutsches Krebsforsch Konjugat, umfassend einen folsäureantagonisten und einen träger
WO1999030727A1 (en) 1997-12-17 1999-06-24 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6824766B2 (en) * 1998-04-17 2004-11-30 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
US6153655A (en) * 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
JPH11335267A (ja) 1998-05-27 1999-12-07 Nano Career Kk 水難溶性薬物を含有するポリマーミセル系
IN191203B (pl) * 1999-02-17 2003-10-04 Amarnath Prof Maitra
US6207832B1 (en) * 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US20010041189A1 (en) 1999-04-13 2001-11-15 Jingya Xu Poly(dipeptide) as a drug carrier
US6380405B1 (en) 1999-09-13 2002-04-30 Nobex Corporation Taxane prodrugs
US6713454B1 (en) 1999-09-13 2004-03-30 Nobex Corporation Prodrugs of etoposide and etoposide analogs
WO2001019361A2 (en) 1999-09-14 2001-03-22 Tepha, Inc. Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate
US6376470B1 (en) 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
BRPI0014652B1 (pt) 1999-10-12 2016-08-09 Cell Therapeutics Inc fabricação de conjugados de agente terapêutico-poliglutamato
US20030054977A1 (en) * 1999-10-12 2003-03-20 Cell Therapeutics, Inc. Manufacture of polyglutamate-therapeutic agent conjugates
JP3523821B2 (ja) * 2000-02-09 2004-04-26 ナノキャリア株式会社 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物
EP1267871A2 (en) 2000-02-29 2003-01-02 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives
HUP0204562A2 (hu) 2000-03-17 2003-04-28 Cell Therapeutics, Inc. Poliglutaminsav-kamptotecin konjugátumok, eljárás előállításukra és ilyen konjugátumokat tartalmazó gyógyászati készítmények
US20020161062A1 (en) * 2001-11-06 2002-10-31 Biermann Paul J. Structure including a plurality of cells of cured resinous material, method of forming the structure and apparatus for forming the structure
MXPA02011891A (es) 2000-06-02 2004-04-02 Eidgenoess Tech Hochschule Reacciones de adicion conjugadas para la entrega controlada de compuestos farmaceuticamente activos.
JP2002069184A (ja) 2000-06-12 2002-03-08 Mitsui Chemicals Inc 重合体及びその製造方法
AU2001296215A1 (en) 2000-07-17 2002-01-30 Oxi-Gene, Inc. Efficient method of synthesizing combretastatin a-4 prodrugs
US20020099013A1 (en) * 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
DE60233137D1 (de) * 2001-02-16 2009-09-10 Univ R Transporter mit beabstandeten arginin-teilchen
ATE378342T1 (de) 2001-02-20 2007-11-15 Enzon Inc Terminal verzweigte, polymere linker und diese enthaltende polymere konjugate
MXPA03007391A (es) 2001-02-20 2003-12-04 Enzon Inc Enlazantes polimericos ramificados terminalmente y conjugados polimericos que contienen los mismos.
EP1408066B1 (en) * 2001-06-20 2010-03-31 Nippon Kayaku Kabushiki Kaisha Block copolymer reduced in impurity content; polymeric carrier; pharmaceutical preparations in polymeric form and process for the preparation of the same
EP1438281A4 (en) * 2001-10-26 2006-04-26 Oxigene Inc FUNCTIONALIZED STILBENE DERIVATIVES USEFUL AS IMPROVED VASCULAR TARGETING AGENTS
ATE374753T1 (de) 2001-12-21 2007-10-15 Vernalis Cambridge Ltd 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung
US7771727B2 (en) * 2002-03-01 2010-08-10 The Administrators Of The Tulane Educational Fund Conjugates of therapeutic or cytotoxic agents and biologically active peptides
CN100475269C (zh) 2002-03-05 2009-04-08 北京键凯科技有限公司 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途
PL370866A1 (pl) * 2002-03-26 2005-05-30 Banyu Pharmaceutical Co, Ltd. Łączne stosowanie przeciwnowotworowej pochodnej indolopirolokarbazolowej i innego środka przeciwnowotworowego
US6596757B1 (en) * 2002-05-14 2003-07-22 Immunogen Inc. Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use
JP2003342168A (ja) 2002-05-24 2003-12-03 Nano Career Kk 注射用薬物含有ポリマーミセル製剤の製造方法
JP2003342167A (ja) 2002-05-24 2003-12-03 Nano Career Kk カンプトテシン誘導体の製剤およびその調製方法
JP4270485B2 (ja) 2002-05-28 2009-06-03 第一三共株式会社 タキサン類の還元方法
JP2004010479A (ja) * 2002-06-03 2004-01-15 Japan Science & Technology Corp ブロック共重合体とアンスラサイクリン系抗癌剤を含む新規固型製剤及びその製造法
AU2003280592B2 (en) 2002-10-31 2008-12-18 Nippon Kayaku Kabushiki Kaisha High-molecular weight derivatives of camptothecins
GB0228417D0 (en) 2002-12-05 2003-01-08 Cancer Rec Tech Ltd Pyrazole compounds
GB0229618D0 (en) 2002-12-19 2003-01-22 Cancer Rec Tech Ltd Pyrazole compounds
US7169892B2 (en) * 2003-01-10 2007-01-30 Astellas Pharma Inc. Lipid-peptide-polymer conjugates for long blood circulation and tumor specific drug delivery systems
SI1611112T1 (sl) 2003-02-11 2012-12-31 Vernalis (R&D) Limited Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov
CN1761485B (zh) * 2003-03-20 2010-04-28 日本化药株式会社 含略微水溶性抗癌剂和新型嵌段共聚物的胶束制剂
WO2004084871A1 (en) * 2003-03-26 2004-10-07 Ltt Bio-Pharma Co., Ltd. Intravenous nanoparticles for targenting drug delivery and sustained drug release
GB0309637D0 (en) 2003-04-28 2003-06-04 Cancer Rec Tech Ltd Pyrazole compounds
US20070004674A1 (en) * 2003-08-22 2007-01-04 Kyowa Hakko Kogyo Co. Ltd. Remedy for diseases associated with immunoglobulin gene translocation
CA2542834C (en) * 2003-10-21 2012-04-24 Igf Oncology, Llc Conjugates or co-administration of igf-1 receptor ligands with anti-cancer chemotherapeutic agents
FR2862536B1 (fr) 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
US7176185B2 (en) * 2003-11-25 2007-02-13 Tsrl, Inc. Short peptide carrier system for cellular delivery of agent
EP1710257A4 (en) * 2004-01-07 2011-03-23 Seikagaku Kogyo Co Ltd HYALURONIC ACID DERIVATIVE AND MEDICAMENT CONTAINING THEREOF
JP4820758B2 (ja) 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
CA2600085A1 (en) * 2005-03-09 2006-09-14 Toray Industries, Inc. Microparticle and pharmaceutical preparation
CN101160291B (zh) 2005-03-09 2012-09-05 日本化药株式会社 作为hsp90抑制剂的三唑衍生物
JP2008137894A (ja) 2005-03-22 2008-06-19 Nippon Kayaku Co Ltd 新規なアセチレン誘導体
JPWO2006115293A1 (ja) 2005-04-22 2008-12-18 国立大学法人 東京大学 ｐＨ応答性高分子ミセルの調製に用いる新規ブロック共重合体及びその製造法
DE602006016103D1 (de) * 2005-05-11 2010-09-23 Nippon Kayaku Kk Polymer-derivat von cytidin metabolit antagonist
WO2006120915A1 (ja) * 2005-05-12 2006-11-16 Nipro Corporation 循環障害改善剤
EP2382995A3 (en) * 2005-08-19 2013-09-25 Endocyte, Inc. Ligand conjugates of Vinca alkaloids, analogs and derivatives
CN1800238A (zh) 2005-12-05 2006-07-12 中国科学院长春应用化学研究所 有生物功能的脂肪族聚酯—聚氨基酸共聚物及合成方法
JP2007182407A (ja) 2006-01-10 2007-07-19 Medgel Corp 徐放性ハイドロゲル製剤
JP2007191643A (ja) 2006-01-20 2007-08-02 Mitsui Chemicals Inc 生体への定着性が付与されたポリアミノ酸誘導体
US8323669B2 (en) * 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
RU2447095C2 (ru) 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся Высокомолекулярный конъюгат подофиллотоксинов
CA2658100A1 (en) 2006-07-19 2008-01-24 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of combretastatins
JP5548364B2 (ja) 2006-10-03 2014-07-16 日本化薬株式会社 レゾルシノール誘導体の高分子結合体
US8334364B2 (en) * 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
JP5548365B2 (ja) * 2006-11-08 2014-07-16 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
JP5349318B2 (ja) 2007-09-28 2013-11-20 日本化薬株式会社 ステロイド類の高分子結合体
CN101977631A (zh) 2008-03-18 2011-02-16 日本化药株式会社 生理活性物质的高分子量偶联物
JP5366940B2 (ja) * 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
JP5037684B2 (ja) 2008-05-23 2012-10-03 ナノキャリア株式会社 ドセタキセル高分子誘導体、並びにその製造方法及びその用途
JP5544357B2 (ja) * 2009-05-15 2014-07-09 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
KR20140024833A (ko) * 2010-11-17 2014-03-03 니폰 가야꾸 가부시끼가이샤 신규한 시티딘계 대사길항제의 고분자 유도체
CN103874722B (zh) * 2011-09-11 2016-06-29 日本化药株式会社 嵌段共聚物的制造方法

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EP1792927A1 (en) 2007-06-06
TW200616663A (en) 2006-06-01
AU2005285953B2 (en) 2011-01-20
BRPI0515573A (pt) 2008-07-29
CN101023119A (zh) 2007-08-22
CA2581125C (en) 2013-04-23
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US9434822B2 (en) 2016-09-06
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EP1792927B1 (en) 2013-03-06
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CN101023119B (zh) 2010-05-05
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WO2006033296A1 (ja) 2006-03-30
AU2005285953A1 (en) 2006-03-30
KR101203475B1 (ko) 2012-11-21
EP1792927A4 (en) 2011-11-30
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