BRPI0517945A - derivados de quinuclidina e seu uso como antagonistas de receptor muscarìnico m3 - Google Patents

derivados de quinuclidina e seu uso como antagonistas de receptor muscarìnico m3

Info

Publication number
BRPI0517945A
BRPI0517945A BRPI0517945-9A BRPI0517945A BRPI0517945A BR PI0517945 A BRPI0517945 A BR PI0517945A BR PI0517945 A BRPI0517945 A BR PI0517945A BR PI0517945 A BRPI0517945 A BR PI0517945A
Authority
BR
Brazil
Prior art keywords
receptor antagonists
muscarinic receptor
quinuclidine derivatives
compounds
quinuclidine
Prior art date
Application number
BRPI0517945-9A
Other languages
English (en)
Inventor
Stephen Paul Collingwood
Urs Baettig
Brian Cox
Sudhakar Devidasrao Garad
Hyungchul Kim
Dmitris Papoutsakis
Simon James Watson
Neil John Press
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33515948&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0517945(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0517945A publication Critical patent/BRPI0517945A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE QUINUCLIDINA E SEU USO COMO ANTAGONISTAS DE RECEPTOR MUSCARìNICO M3. Compostos da fórmula (I), em forma de sal ou zwitterionic em que R˜, R, R e R¬4¬ têm os significados como indicado na especificação, são úteis para tratar condições que são mediadas por receptor muscarínico M3, especialmente doenças obstrutivas ou inflamatórias das vias aéreas. Composições farmacêuticas que contêm os compostos e um processo para preparar os compostos são também descritos.
BRPI0517945-9A 2004-11-02 2005-10-31 derivados de quinuclidina e seu uso como antagonistas de receptor muscarìnico m3 BRPI0517945A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0424284.8A GB0424284D0 (en) 2004-11-02 2004-11-02 Organic compounds
PCT/EP2005/011662 WO2006048225A1 (en) 2004-11-02 2005-10-31 Quinuclidine derivatives and their use as muscarinic m3 receptor antagonists

Publications (1)

Publication Number Publication Date
BRPI0517945A true BRPI0517945A (pt) 2008-10-21

Family

ID=33515948

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517945-9A BRPI0517945A (pt) 2004-11-02 2005-10-31 derivados de quinuclidina e seu uso como antagonistas de receptor muscarìnico m3

Country Status (33)

Country Link
US (2) US7723356B2 (pt)
EP (2) EP1811999B1 (pt)
JP (1) JP4950896B2 (pt)
KR (1) KR101252307B1 (pt)
CN (1) CN101056634B (pt)
AR (1) AR054090A1 (pt)
AT (1) ATE481099T1 (pt)
AU (1) AU2005300710B2 (pt)
BR (1) BRPI0517945A (pt)
CA (1) CA2583237C (pt)
CY (1) CY1110952T1 (pt)
DE (1) DE602005023639D1 (pt)
DK (1) DK1811999T3 (pt)
EC (1) ECSP077424A (pt)
ES (1) ES2353142T3 (pt)
GB (1) GB0424284D0 (pt)
HR (1) HRP20100693T1 (pt)
IL (1) IL182695A0 (pt)
JO (1) JO2613B1 (pt)
MA (1) MA29080B1 (pt)
MX (1) MX2007005189A (pt)
MY (1) MY145207A (pt)
NO (1) NO20072371L (pt)
NZ (1) NZ554302A (pt)
PE (1) PE20060609A1 (pt)
PL (1) PL1811999T3 (pt)
PT (1) PT1811999E (pt)
RU (1) RU2399620C2 (pt)
SI (1) SI1811999T1 (pt)
TN (1) TNSN07164A1 (pt)
TW (1) TW200628154A (pt)
WO (1) WO2006048225A1 (pt)
ZA (1) ZA200702772B (pt)

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WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
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