NO20071794L - Disubstituerte pyrazolobenzodiazepiner nyttige som inhibitorer for CDK2 og angiogenese, og for behandling av bryst, tarm, lunge og prostata cancer - Google Patents

Disubstituerte pyrazolobenzodiazepiner nyttige som inhibitorer for CDK2 og angiogenese, og for behandling av bryst, tarm, lunge og prostata cancer

Info

Publication number: NO20071794L
Authority: NO; Norway
Prior art keywords: treatment; cdk2; breast; angiogenesis; lung
Prior art date: 2004-10-13

Application number

NO20071794A

Other languages

English (en)

Norwegian (no)

Inventor

Peter Michael Wovkulich

Jin-Jun Liu

Kin-Chun Luk

Giacomo Pizzolato

Yi Ren

Kshitij Chhabilbhai Thakkar

Zhuming Zhang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-13

Filing date

2007-04-03

Publication date

2007-07-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35311946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20071794(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-04-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-07-10 Publication of NO20071794L publication Critical patent/NO20071794L/no

Links

206010006187 Breast cancer Diseases 0.000 title abstract 2
208000026310 Breast neoplasm Diseases 0.000 title abstract 2
102000015792 Cyclin-Dependent Kinase 2 Human genes 0.000 title abstract 2
108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 title abstract 2
208000000236 Prostatic Neoplasms Diseases 0.000 title abstract 2
230000033115 angiogenesis Effects 0.000 title abstract 2
210000000481 breast Anatomy 0.000 title abstract 2
208000020816 lung neoplasm Diseases 0.000 title abstract 2
201000003741 Gastrointestinal carcinoma Diseases 0.000 title 1
206010058467 Lung neoplasm malignant Diseases 0.000 title 1
206010060862 Prostate cancer Diseases 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
201000002313 intestinal cancer Diseases 0.000 title 1
210000004072 lung Anatomy 0.000 title 1
201000005202 lung cancer Diseases 0.000 title 1
QBCJSMSLBBCZGU-UHFFFAOYSA-N pyrazolo[3,4-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=NN=C3C=CC2=C1 QBCJSMSLBBCZGU-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
102000001253 Protein Kinase Human genes 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
210000001072 colon Anatomy 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
210000002307 prostate Anatomy 0.000 abstract 1
108060006633 protein kinase Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20071794A 2004-10-13 2007-04-03 Disubstituerte pyrazolobenzodiazepiner nyttige som inhibitorer for CDK2 og angiogenese, og for behandling av bryst, tarm, lunge og prostata cancer NO20071794L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US61817404P	2004-10-13	2004-10-13
PCT/EP2005/010653 WO2006040036A1 (en)	2004-10-13	2005-10-04	Disubstituted pyrazolobenzodiazepines useful as inhibitors for cdk2 and angiogesis, and for the treatment of breast, colon, lung and prostate cancer

Publications (1)

Publication Number	Publication Date
NO20071794L true NO20071794L (no)	2007-07-10

Family

ID=35311946

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20071794A NO20071794L (no)	2004-10-13	2007-04-03	Disubstituerte pyrazolobenzodiazepiner nyttige som inhibitorer for CDK2 og angiogenese, og for behandling av bryst, tarm, lunge og prostata cancer

Country Status (25)

Country	Link
US (1)	US7524840B2 (pt)
EP (1)	EP1802625B1 (pt)
JP (1)	JP2008515939A (pt)
KR (1)	KR100858262B1 (pt)
CN (2)	CN101039946B (pt)
AR (1)	AR051326A1 (pt)
AT (1)	ATE398619T1 (pt)
AU (1)	AU2005293818A1 (pt)
BR (1)	BRPI0518152A (pt)
CA (1)	CA2582985A1 (pt)
DE (1)	DE602005007623D1 (pt)
DK (1)	DK1802625T3 (pt)
ES (1)	ES2308551T3 (pt)
HR (1)	HRP20080429T3 (pt)
IL (1)	IL182423A0 (pt)
MX (1)	MX2007004464A (pt)
NO (1)	NO20071794L (pt)
NZ (1)	NZ554353A (pt)
PL (1)	PL1802625T3 (pt)
PT (1)	PT1802625E (pt)
RU (1)	RU2394826C2 (pt)
SI (1)	SI1802625T1 (pt)
TW (1)	TWI309652B (pt)
WO (1)	WO2006040036A1 (pt)
ZA (1)	ZA200702973B (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5119154B2 (ja) *	2005-09-22	2013-01-16	インサイト・コーポレイション	Ｊａｎｕｓキナーゼの四環系阻害剤
EP1940410A1 (en) *	2005-10-14	2008-07-09	F.Hoffmann-La Roche Ag	Regimen of administration for 5-(2-chlorophenyl)-1 ,2-dihydro-7-fluoro-8-methoxy-3-methyl-pyrazolo [3, 4.-b] [1, 4] benzodiazepine
TWI630207B (zh)	2005-12-13	2018-07-21	英塞特控股公司	作為傑納斯激酶（ＪＡＮＵＳＫＩＮＡＳＥ）抑制劑之經雜芳基取代之吡咯并〔２，３-ｂ〕吡啶及吡咯并〔２，３-ｂ〕嘧啶
EP3070090B1 (en)	2007-06-13	2018-12-12	Incyte Holdings Corporation	Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
CL2009001884A1 (es) *	2008-10-02	2010-05-14	Incyte Holdings Corp	Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
KR20100073454A (ko) *	2008-12-23	2010-07-01	국립암센터	트란스글루타미나제 억제제로 사용되는 신규한 피라졸로디아제핀계 화합물, 이의 제조방법 및 이를 포함하는 조성물
EP3643312A1 (en)	2009-05-22	2020-04-29	Incyte Holdings Corporation	3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
AR076794A1 (es)	2009-05-22	2011-07-06	Incyte Corp	Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
AR078012A1 (es) *	2009-09-01	2011-10-05	Incyte Corp	Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
EP3050882B1 (en)	2010-03-10	2018-01-31	Incyte Holdings Corporation	Piperidin-4-yl azetidine derivatives as jak1 inhibitors
JP2011201794A (ja) *	2010-03-24	2011-10-13	Fujifilm Corp	５−アミノピラゾール誘導体及びその塩の製造方法
SG10201503983QA (en)	2010-05-21	2015-06-29	Incyte Corp	Topical Formulation for a JAK Inhibitor
US9034884B2 (en)	2010-11-19	2015-05-19	Incyte Corporation	Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
CN103415515B (zh)	2010-11-19	2015-08-26	因塞特公司	作为jak抑制剂的环丁基取代的吡咯并吡啶和吡咯并嘧啶衍生物
PE20140832A1 (es)	2011-06-20	2014-07-14	Incyte Corp	Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
TW201313721A (zh)	2011-08-18	2013-04-01	Incyte Corp	作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk)	2011-09-07	2016-06-24	Інсайт Холдінгс Корпорейшн	Способи і проміжні сполуки для отримання інгібіторів jak
CN102603743B (zh) *	2012-02-24	2014-05-28	南京天易生物科技有限公司	抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途
TW201406761A (zh)	2012-05-18	2014-02-16	Incyte Corp	做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
CN103626761B (zh) *	2012-08-24	2015-07-29	上海医药工业研究院	苯并吡啶氮杂卓类化合物及其作为抗肿瘤药物的应用
PL2919766T3 (pl)	2012-11-15	2021-10-04	Incyte Holdings Corporation	Postacie dawkowania ruksolitynibu o przedłużonym uwalnianiu
CN105189509B (zh)	2013-03-06	2017-12-19	因赛特公司	用于制备jak抑制剂的方法及中间体
SG10201912203XA (en)	2013-08-07	2020-02-27	Incyte Corp	Sustained release dosage forms for a jak1 inhibitor
WO2015184305A1 (en)	2014-05-30	2015-12-03	Incyte Corporation	TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
EP3353164B1 (en)	2015-09-23	2021-11-03	Janssen Pharmaceutica, N.V.	Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
CA2996857C (en) *	2015-09-23	2024-05-21	Janssen Pharmaceutica Nv	Quinoxaline, quinoline and quinazolinone derivative compounds for the treatment of cancer
CN106928040A (zh) *	2015-12-31	2017-07-07	上海医药工业研究院	Sglt2抑制剂中间体的制备方法
FI3551631T3 (fi) *	2016-12-12	2025-01-16	Kinoxis Therapeutics Pty Ltd	Ei-peptidit-oksytosiinireseptoriagonistit
JP6594571B2 (ja) *	2016-12-13	2019-10-23	南京薬捷安康生物科技有限公司	マルチキナーゼ阻害剤化合物、並びにその結晶形及びその使用
CN109020980B (zh) *	2017-06-09	2020-11-20	华东师范大学	一类抗肿瘤作用的吡唑并嘧啶二氮*衍生物
WO2019113487A1 (en)	2017-12-08	2019-06-13	Incyte Corporation	Low dose combination therapy for treatment of myeloproliferative neoplasms
EP3746429B1 (en)	2018-01-30	2022-03-09	Incyte Corporation	Processes for preparing (1-(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
PT3773593T (pt)	2018-03-30	2024-06-25	Incyte Corp	Tratamento da hidradenite supurativa com inibidores de jak
US11833155B2 (en)	2020-06-03	2023-12-05	Incyte Corporation	Combination therapy for treatment of myeloproliferative neoplasms
AR124154A1 (es)	2020-11-27	2023-02-22	Rhizen Pharmaceuticals Ag	Inhibidores de cdk
WO2022149057A1 (en)	2021-01-05	2022-07-14	Rhizen Pharmaceuticals Ag	Cdk inhibitors
KR20240020735A (ko)	2021-05-07	2024-02-15	카이메라 쎄라퓨틱스 인코포레이티드	Cdk2 분해제 및 그 용도
CN120051473A (zh)	2022-08-17	2025-05-27	韩国化学研究院	抑制或降解cdk2和/或cdk9的化合物及其医学用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3681341A (en)	1970-12-23	1972-08-01	Hoffmann La Roche	Process for preparing 1-lower alkyl-1,4-benzodiazepin-2-ones
ZA889116B (en) *	1987-12-18	1989-08-30	Hoffmann La Roche	Tricyclic compounds
MC1999A1 (fr) *	1987-12-18	1990-01-26	Hoffmann La Roche	Composes tricycliques
US5625031A (en)	1994-02-08	1997-04-29	Bristol-Myers Squibb Company	Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein
US5631156A (en)	1994-06-21	1997-05-20	The University Of Michigan	DNA encoding and 18 KD CDK6 inhibiting protein
US5733920A (en)	1995-10-31	1998-03-31	Mitotix, Inc.	Inhibitors of cyclin dependent kinases
FR2741881B1 (fr)	1995-12-01	1999-07-30	Centre Nat Rech Scient	Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US5866702A (en)	1996-08-02	1999-02-02	Cv Therapeutics, Incorporation	Purine inhibitors of cyclin dependent kinase 2
US6440959B1 (en)	1999-04-21	2002-08-27	Hoffman-La Roche Inc.	Pyrazolobenzodiazepines
JP3826400B2 (ja) *	2000-12-01	2006-09-27	味の素株式会社	ラクタム化合物及びその医薬用途

2005
- 2005-10-04 RU RU2007117770/04A patent/RU2394826C2/ru not_active IP Right Cessation
- 2005-10-04 CN CN2005800351219A patent/CN101039946B/zh not_active Expired - Fee Related
- 2005-10-04 BR BRPI0518152-6A patent/BRPI0518152A/pt not_active IP Right Cessation
- 2005-10-04 PT PT05792946T patent/PT1802625E/pt unknown
- 2005-10-04 JP JP2007536037A patent/JP2008515939A/ja active Pending
- 2005-10-04 WO PCT/EP2005/010653 patent/WO2006040036A1/en not_active Ceased
- 2005-10-04 ES ES05792946T patent/ES2308551T3/es not_active Expired - Lifetime
- 2005-10-04 KR KR1020077008406A patent/KR100858262B1/ko not_active Expired - Fee Related
- 2005-10-04 MX MX2007004464A patent/MX2007004464A/es active IP Right Grant
- 2005-10-04 CN CN2010101585349A patent/CN101899049A/zh active Pending
- 2005-10-04 EP EP05792946A patent/EP1802625B1/en not_active Expired - Lifetime
- 2005-10-04 AT AT05792946T patent/ATE398619T1/de active
- 2005-10-04 DK DK05792946T patent/DK1802625T3/da active
- 2005-10-04 CA CA002582985A patent/CA2582985A1/en not_active Abandoned
- 2005-10-04 PL PL05792946T patent/PL1802625T3/pl unknown
- 2005-10-04 DE DE602005007623T patent/DE602005007623D1/de not_active Expired - Lifetime
- 2005-10-04 AU AU2005293818A patent/AU2005293818A1/en not_active Abandoned
- 2005-10-04 NZ NZ554353A patent/NZ554353A/en not_active IP Right Cessation
- 2005-10-04 HR HR20080429T patent/HRP20080429T3/xx unknown
- 2005-10-04 SI SI200530331T patent/SI1802625T1/sl unknown
- 2005-10-05 US US11/244,251 patent/US7524840B2/en not_active Expired - Fee Related
- 2005-10-11 AR ARP050104254A patent/AR051326A1/es not_active Application Discontinuation
- 2005-10-12 TW TW094135532A patent/TWI309652B/zh not_active IP Right Cessation
2007
- 2007-04-03 NO NO20071794A patent/NO20071794L/no not_active Application Discontinuation
- 2007-04-10 IL IL182423A patent/IL182423A0/en unknown
- 2007-04-11 ZA ZA200702973A patent/ZA200702973B/xx unknown

Also Published As

Publication number	Publication date
MX2007004464A (es)	2007-05-07
DE602005007623D1 (de)	2008-07-31
RU2394826C2 (ru)	2010-07-20
WO2006040036A1 (en)	2006-04-20
EP1802625A1 (en)	2007-07-04
CN101039946B (zh)	2010-12-08
AU2005293818A1 (en)	2006-04-20
NZ554353A (en)	2010-01-29
PL1802625T3 (pl)	2008-12-31
EP1802625B1 (en)	2008-06-18
JP2008515939A (ja)	2008-05-15
RU2007117770A (ru)	2008-11-20
IL182423A0 (en)	2007-07-24
KR20070054243A (ko)	2007-05-28
SI1802625T1 (sl)	2008-10-31
ZA200702973B (en)	2009-09-30
BRPI0518152A (pt)	2008-11-04
US7524840B2 (en)	2009-04-28
CN101039946A (zh)	2007-09-19
US20060079511A1 (en)	2006-04-13
CA2582985A1 (en)	2006-04-20
PT1802625E (pt)	2008-08-06
CN101899049A (zh)	2010-12-01
AR051326A1 (es)	2007-01-03
KR100858262B1 (ko)	2008-09-11
TW200628469A (en)	2006-08-16
ATE398619T1 (de)	2008-07-15
TWI309652B (en)	2009-05-11
ES2308551T3 (es)	2008-12-01
DK1802625T3 (da)	2008-09-01
HK1108284A1 (en)	2008-05-02
HRP20080429T3 (en)	2008-09-30

Legal Events

Date	Code	Title	Description
2012-06-04	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20071794L (no)	2007-07-10	Disubstituerte pyrazolobenzodiazepiner nyttige som inhibitorer for CDK2 og angiogenese, og for behandling av bryst, tarm, lunge og prostata cancer
BRPI0511975A (pt)	2008-01-22	pirazolopirimidinas
IL260127B (en)	2022-04-01	mek inhibitors and methods of using them
MY149512A (en)	2013-09-13	Pyrazolylaminopyridine derivatives useful as kinase inhibitors
WO2006123113A3 (en)	2007-01-04	Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
NO20081952L (no)	2008-06-20	Substituerte pyrazolforbindelser
GEP20125368B (en)	2012-01-10	Kinase inhibitors
MX2008005398A (es)	2008-09-24	Derivados de 4-(3-amino-pirazol)-pirimidina para uso como inhibidores de tirosina cinasa en el tratamiento de cancer.
MX2009005011A (es)	2009-05-20	Imidazopirazinas como inhibidores de proteina quinasa.
PL1853602T3 (pl)	2010-11-30	Związki chemiczne
PT1853588E (pt)	2008-08-25	Compostos químicos
TNSN08020A1 (en)	2009-07-14	1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them
NO20044526L (no)	2004-12-21	Hemisterlinderivater og anvendelser derav
MXPA05009151A (es)	2005-10-20	Inhibidores de cinasa heterociclica.
ATE419242T1 (de)	2009-01-15	Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren
MXPA05006507A (es)	2006-02-17	Inhibidores de ccxckr2 expresado en tumor humano.
TW200716545A (en)	2007-05-01	Indole derivatives having anti-tumor activity
WO2005103034A8 (en)	2006-11-02	Novel piperidine substituted diaminothiazoles
TH82893A (th)	2007-02-08	ไดซับสทิทิวเต็ดไพราโซโลเบนโซไดอะเซพีน
UA96742C2 (en)	2011-12-12	Mek inhibitors and use thereof
ATE540951T1 (de)	2012-01-15	Substituierte 7,8-dihydro-1h-pyrimidoä4,5- büdiazepin-4-amine als kinase inhibitoren