BRPI0519784A2 - processo para a produção de compostos de aldose com carbono reduzido - Google Patents
processo para a produção de compostos de aldose com carbono reduzidoInfo
- Publication number
- BRPI0519784A2 BRPI0519784A2 BRPI0519784-8A BRPI0519784A BRPI0519784A2 BR PI0519784 A2 BRPI0519784 A2 BR PI0519784A2 BR PI0519784 A BRPI0519784 A BR PI0519784A BR PI0519784 A2 BRPI0519784 A2 BR PI0519784A2
- Authority
- BR
- Brazil
- Prior art keywords
- production
- compounds
- arabinose
- deoxy
- present
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 5
- 230000008569 process Effects 0.000 title abstract 5
- 229910052799 carbon Inorganic materials 0.000 title abstract 4
- -1 carbon aldose compounds Chemical class 0.000 title abstract 3
- WDRISBUVHBMJEF-YUPRTTJUSA-N (2r,3s,4s)-2,3,4-trihydroxypentanal Chemical compound C[C@H](O)[C@H](O)[C@@H](O)C=O WDRISBUVHBMJEF-YUPRTTJUSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- HSJKGGMUJITCBW-UHFFFAOYSA-N 3-hydroxybutanal Chemical class CC(O)CC=O HSJKGGMUJITCBW-UHFFFAOYSA-N 0.000 abstract 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 abstract 2
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 abstract 2
- PNNNRSAQSRJVSB-BXKVDMCESA-N aldehydo-L-rhamnose Chemical compound C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C=O PNNNRSAQSRJVSB-BXKVDMCESA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000008570 general process Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 abstract 1
- 229960004617 sapropterin Drugs 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/08—Deoxysugars; Unsaturated sugars; Osones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCESSO PARA A PRODUçãO DE COMPOSTOS DE ALDOSE COM CARBONO REDUZIDO. A presente invenção proporciona um processo capaz de produzir industrialmente a 5-deóxi-L-arabinose, importante como uma matéria-prima para a produção de sapropterina útil como um agente terapêutico para a hiperfenilalaninemia atípica, satisfatoriamente e eficientemente mesmo com um aparelho de produção simples. E provido um processo para a produção de 5-deóxi-L-arabinose caracterizado por incluir: reagindo a L-ramnose com um composto de mercaptano de C~ 11-16~ alquila de cadeia linear na presença de um catalisador ácido para a preparação do dialquilmercaptal de L-ramnose; submetendo o composto obtido a uma reação de oxidação para a preparação de um derivado de dissulfonila; e submetendo em seguida o derivado de dissulfonila a uma reação de redução de carbono para preparar a 5-deóxi-L-arabinose. O presente processo de produção também pode ser aplicado a um processo para produzir compostos obtidos pela remoção de um átomo de carbono a partir de compostos de aldol, e desse modo a presente invenção proporciona um processo geral para a produção de compostos obtidos pela redução do número de átomos de carbono a partir de compostos de aldose.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004379231 | 2004-12-28 | ||
| PCT/JP2005/024049 WO2006070862A1 (ja) | 2004-12-28 | 2005-12-28 | アルドース類の減炭素化合物の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0519784A2 true BRPI0519784A2 (pt) | 2009-03-17 |
Family
ID=36614973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0519784-8A BRPI0519784A2 (pt) | 2004-12-28 | 2005-12-28 | processo para a produção de compostos de aldose com carbono reduzido |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090030191A1 (pt) |
| EP (1) | EP1849793A1 (pt) |
| JP (1) | JPWO2006070862A1 (pt) |
| KR (1) | KR20070092309A (pt) |
| CN (1) | CN101090907A (pt) |
| AU (1) | AU2005320585A1 (pt) |
| BR (1) | BRPI0519784A2 (pt) |
| CA (1) | CA2592598A1 (pt) |
| MX (1) | MX2007007927A (pt) |
| WO (1) | WO2006070862A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101792445B (zh) * | 2010-04-16 | 2012-05-30 | 北京理工大学 | L-赤型生物喋呤的制备方法 |
| IT1400964B1 (it) * | 2010-06-15 | 2013-07-05 | Dipharma Francis Srl | Procedimento per la preparazione di derivati pteridinici |
| CN104558065B (zh) * | 2014-12-08 | 2017-05-24 | 重庆威鹏药业有限公司 | L‑鼠李糖二(十二烷基)缩硫醛的制备方法 |
| CN107353314A (zh) * | 2016-05-10 | 2017-11-17 | 江苏福锌雨医药科技有限公司 | 一种5-脱氧-l-阿拉伯糖的合成方法 |
| CN106117097B (zh) * | 2016-06-20 | 2017-12-05 | 四川大学 | L‑鼠李糖二烷基缩硫醛类化合物的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2369612A (en) * | 1937-05-07 | 1945-02-13 | Schirm Erik | Method for the production of higher molecular mercaptals and mercaptols |
| US3505329A (en) * | 1968-02-06 | 1970-04-07 | Smithkline Corp | Process for the synthesis of biopterin |
| JPS60169493A (ja) * | 1984-02-14 | 1985-09-02 | Suntory Ltd | ５−デオキシ−ｌ−アラビノ−スの製造法 |
| EP0162016B1 (de) * | 1984-05-15 | 1992-06-03 | Ciba-Geigy Ag | Zusätze für Materialien |
| JPS617287A (ja) * | 1984-06-21 | 1986-01-13 | Kanegafuchi Chem Ind Co Ltd | ５‐デオキシ‐ｌ‐アラビノースの製造法 |
| JPH0723367B2 (ja) * | 1986-02-27 | 1995-03-15 | サントリー株式会社 | オキサビシクロヘプタン誘導体 |
-
2005
- 2005-12-28 WO PCT/JP2005/024049 patent/WO2006070862A1/ja not_active Ceased
- 2005-12-28 MX MX2007007927A patent/MX2007007927A/es unknown
- 2005-12-28 JP JP2006550839A patent/JPWO2006070862A1/ja active Pending
- 2005-12-28 EP EP05844822A patent/EP1849793A1/en not_active Withdrawn
- 2005-12-28 CA CA002592598A patent/CA2592598A1/en not_active Abandoned
- 2005-12-28 AU AU2005320585A patent/AU2005320585A1/en not_active Abandoned
- 2005-12-28 KR KR1020077017165A patent/KR20070092309A/ko not_active Withdrawn
- 2005-12-28 US US11/793,447 patent/US20090030191A1/en not_active Abandoned
- 2005-12-28 CN CNA2005800452116A patent/CN101090907A/zh not_active Withdrawn
- 2005-12-28 BR BRPI0519784-8A patent/BRPI0519784A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20090030191A1 (en) | 2009-01-29 |
| CA2592598A1 (en) | 2006-07-06 |
| JPWO2006070862A1 (ja) | 2008-06-12 |
| AU2005320585A1 (en) | 2006-07-06 |
| MX2007007927A (es) | 2007-10-08 |
| WO2006070862A1 (ja) | 2006-07-06 |
| EP1849793A1 (en) | 2007-10-31 |
| CN101090907A (zh) | 2007-12-19 |
| KR20070092309A (ko) | 2007-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |