BRPI0610580A8 - compostos ou sais farmaceuticamente aceitáveis dos mesmos, antagonista ou agonista inverso do receptor de histamina-h3, e, preventivo ou medicamento - Google Patents

compostos ou sais farmaceuticamente aceitáveis dos mesmos, antagonista ou agonista inverso do receptor de histamina-h3, e, preventivo ou medicamento

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Publication number
BRPI0610580A8
BRPI0610580A8 BRPI0610580A BRPI0610580A BRPI0610580A8 BR PI0610580 A8 BRPI0610580 A8 BR PI0610580A8 BR PI0610580 A BRPI0610580 A BR PI0610580A BR PI0610580 A BRPI0610580 A BR PI0610580A BR PI0610580 A8 BRPI0610580 A8 BR PI0610580A8
Authority
BR
Brazil
Prior art keywords
pharmaceutically acceptable
histamine
medicament
inverse agonist
substituted
Prior art date
Application number
BRPI0610580A
Other languages
English (en)
Inventor
Takahashi Hidekazu
Sato Nagaaki
Tokita Shigeru
Ishikawa Shiho
Wada Toshihiro
Nagase Tsuyoshi
Original Assignee
Banyu Pharma Co Ltd
Msd Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd, Msd Kk filed Critical Banyu Pharma Co Ltd
Publication of BRPI0610580A2 publication Critical patent/BRPI0610580A2/pt
Publication of BRPI0610580A8 publication Critical patent/BRPI0610580A8/pt
Publication of BRPI0610580B1 publication Critical patent/BRPI0610580B1/pt
Publication of BRPI0610580B8 publication Critical patent/BRPI0610580B8/pt

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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

compostos ou sais farmaceuticamente aceitáveis dosmesmos, antagomsta ou agonista inverso do receptor de histamina-113, e, preventivo ou medicamento divulgada é um substância tendo um efeito antagonístico na ligação de histamina a um receptor de histamina 113 ou um efeito inibitório na atividade que um receptor de histamina h3 constantemente exibe. um composto representado pela fórmula (1) ou um sal farmaceuticamente aceitável deste; em que rt representa um grupo fenila que pode ser substituído ou semelhantes e r2 representa um grupo ciano que pode ser substituído ou semelhantes, ou r' e r2 juntos formam um anel heterocíclico alifático que pode ser substituido; r3 representa um grupo representado pela fórmula (11-1) abaixo e todos de xi a x4 representam um átomo de carbono ousemelhantes: (11-1) onde r4 e r5 representam um grupo alquila inferior ou semelhantes; e ml representa um número inteiro de 2 a 4.
BRPI0610580A 2005-05-30 2006-05-29 composto derivado de piperidina BRPI0610580B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2005-157739 2005-05-30
JP2005157739 2005-05-30
JP2006-115778 2006-04-19
JP2006115778 2006-04-19
PCT/JP2006/311155 WO2006129826A1 (ja) 2005-05-30 2006-05-29 新規ピペリジン誘導体

Publications (4)

Publication Number Publication Date
BRPI0610580A2 BRPI0610580A2 (pt) 2010-11-09
BRPI0610580A8 true BRPI0610580A8 (pt) 2018-03-13
BRPI0610580B1 BRPI0610580B1 (pt) 2020-09-15
BRPI0610580B8 BRPI0610580B8 (pt) 2021-05-25

Family

ID=37481747

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Application Number Title Priority Date Filing Date
BRPI0610580A BRPI0610580B8 (pt) 2005-05-30 2006-05-29 composto derivado de piperidina

Country Status (13)

Country Link
US (1) US8138206B2 (pt)
EP (1) EP1892241B1 (pt)
JP (1) JP5154927B2 (pt)
KR (1) KR101397913B1 (pt)
AU (1) AU2006253312B2 (pt)
BR (1) BRPI0610580B8 (pt)
CA (1) CA2609388C (pt)
ES (1) ES2574014T3 (pt)
IL (1) IL187533A0 (pt)
NO (1) NO20076614L (pt)
NZ (1) NZ562766A (pt)
RU (1) RU2417985C2 (pt)
WO (1) WO2006129826A1 (pt)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
WO2009037542A2 (en) * 2007-09-20 2009-03-26 Glenmark Pharmaceuticals, S.A. Spirocyclic compounds as stearoyl coa desaturase inhibitors
KR102218333B1 (ko) 2016-06-07 2021-02-22 자코바이오 파마슈티칼스 컴퍼니 리미티드 Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
HRP20241239T1 (hr) 2017-03-23 2024-12-06 Jacobio Pharmaceuticals Co., Ltd. Novi heterociklički derivati korisni kao shp2 inhibitori
US20210393623A1 (en) 2018-09-26 2021-12-23 Jacobio Pharmaceuticals Co., Ltd. Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors

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WO2006129826A1 (ja) 2006-12-07

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