BRPI0923500A2 - uso e composição farmacêutica compreendendo agonista ou modulador do receptor s1p, e kit. - Google Patents

uso e composição farmacêutica compreendendo agonista ou modulador do receptor s1p, e kit.

Info

Publication number
BRPI0923500A2
BRPI0923500A2 BRPI0923500-0A BRPI0923500A BRPI0923500A2 BR PI0923500 A2 BRPI0923500 A2 BR PI0923500A2 BR PI0923500 A BRPI0923500 A BR PI0923500A BR PI0923500 A2 BRPI0923500 A2 BR PI0923500A2
Authority
BR
Brazil
Prior art keywords
modulator
kit
composition
receptor agonist
pharmaceutical use
Prior art date
Application number
BRPI0923500-0A
Other languages
English (en)
Inventor
Schmouder Robert
Dumortier Thomas
David Olivier
Looby Michael
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41667217&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0923500(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0923500A2 publication Critical patent/BRPI0923500A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0923500-0A 2008-12-22 2009-12-21 uso e composição farmacêutica compreendendo agonista ou modulador do receptor s1p, e kit. BRPI0923500A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US13967208P 2008-12-22 2008-12-22
US61/139,672 2008-12-22
US21853009P 2009-06-19 2009-06-19
US61/218,530 2009-06-19
US24671509P 2009-09-29 2009-09-29
US61/246,715 2009-09-29
PCT/US2009/068888 WO2010075239A1 (en) 2008-12-22 2009-12-21 Dosage regimen for a s1p receptor agonist

Publications (1)

Publication Number Publication Date
BRPI0923500A2 true BRPI0923500A2 (pt) 2018-05-29

Family

ID=41667217

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923500-0A BRPI0923500A2 (pt) 2008-12-22 2009-12-21 uso e composição farmacêutica compreendendo agonista ou modulador do receptor s1p, e kit.

Country Status (43)

Country Link
US (12) US20100160259A1 (pt)
EP (7) EP3453387B1 (pt)
JP (7) JP2012513401A (pt)
KR (1) KR101347919B1 (pt)
CN (1) CN102264359A (pt)
AR (1) AR074826A1 (pt)
AU (1) AU2009330176C9 (pt)
BR (1) BRPI0923500A2 (pt)
CA (1) CA2747802C (pt)
CL (2) CL2011001529A1 (pt)
CO (1) CO6390117A2 (pt)
CR (1) CR20110274A (pt)
CU (1) CU20110136A7 (pt)
CY (5) CY1116990T1 (pt)
DK (4) DK3409274T3 (pt)
EA (1) EA201100978A1 (pt)
EC (1) ECSP11011222A (pt)
ES (4) ES3017254T3 (pt)
FI (2) FI4098256T3 (pt)
FR (2) FR20C1060I1 (pt)
HN (1) HN2011001759A (pt)
HR (4) HRP20151190T1 (pt)
HU (6) HUE048717T4 (pt)
IL (3) IL213170A0 (pt)
LT (5) LT3453387T (pt)
LU (1) LUC00183I2 (pt)
MA (1) MA32981B1 (pt)
ME (2) ME03802B (pt)
MX (3) MX385959B (pt)
NO (1) NO2020038I1 (pt)
NZ (1) NZ593065A (pt)
PE (1) PE20120337A1 (pt)
PL (4) PL2379067T3 (pt)
PT (4) PT4098256T (pt)
RS (3) RS60666B1 (pt)
SG (1) SG171404A1 (pt)
SI (4) SI3409274T1 (pt)
SM (2) SMT202000441T1 (pt)
TN (1) TN2011000272A1 (pt)
TW (1) TW201028143A (pt)
UY (1) UY32352A (pt)
WO (1) WO2010075239A1 (pt)
ZA (2) ZA201103863B (pt)

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WO2009115954A1 (en) * 2008-03-17 2009-09-24 Actelion Pharmaceuticals Ltd Dosing regimen for a selective s1p1 receptor agonist
PL2379067T3 (pl) 2008-12-22 2016-02-29 Novartis Ag Schemat dawkowania fingolimodu w leczeniu stwardnienia rozsianego
EP3061449A1 (en) 2009-09-29 2016-08-31 Novartis AG Dosage regimen of an s1p receptor modulator
US20110124605A1 (en) * 2009-11-20 2011-05-26 Shreeram Aradhye Use of an S1P Receptor Agonist
CA2786994C (en) 2010-01-27 2018-01-16 Arena Pharmaceuticals, Inc. Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
AU2011249789B2 (en) * 2010-05-06 2015-03-19 Novartis Ag Dosage regimen of diaryl sulfide derivatives
EP2455080A1 (en) * 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of multiple sclerosis
FR2968556B1 (fr) 2010-12-13 2013-12-27 Centre Nat Rech Scient Inhibiteurs des infections a vih et leurs utilisations
JP6111202B2 (ja) 2011-01-07 2017-04-05 ノバルティス アーゲー 免疫抑制製剤
US9592288B2 (en) 2011-02-18 2017-03-14 The Scripps Research Institute Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
JO3177B1 (ar) 2011-04-01 2018-03-08 Novartis Ag تركيبات تتالف من 2-أمينو-2- [ 2- ( 4- أكتيل فينيل ) إثيل ] بروبان - 3, 1- ديول
WO2012162392A1 (en) * 2011-05-23 2012-11-29 Timothy Hla Endothelium protective materials and methods of use
TW201320994A (zh) * 2011-10-11 2013-06-01 Novartis Ag 投藥療程
SMT202000298T1 (it) 2012-08-17 2020-07-08 Actelion Pharmaceuticals Ltd Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo
US20160129084A1 (en) * 2013-03-06 2016-05-12 Acorda Therapeutics, Inc. Therapeutic Dosing of a Neuregulin or a Fragment Thereof for Treatment or Prophylaxis of Heart Failure
US10022340B2 (en) 2013-10-11 2018-07-17 Teikoku Pharma Usa, Inc. Topical sphingosine-1-phosphate receptor agonist formulations and methods of using the same
US10675254B2 (en) 2013-10-11 2020-06-09 Teikoku Seiyaku Co., Ltd. Sphingosine-1-phosphate receptor agonist iontophoretic devices and methods of using the same
EP3831378A1 (en) * 2014-04-10 2021-06-09 Novartis AG Siponimod immediate release dosage regimen for treating autoimmune diseases
DK3256125T3 (da) 2014-12-11 2022-03-21 Actelion Pharmaceuticals Ltd Doseringsregimen for ponesimod, en selektiv s1p1-receptoragonist
MA41139B1 (fr) 2014-12-11 2026-02-27 Laboratoires Juvise Pharmaceuticals Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
US20180042895A1 (en) 2015-02-26 2018-02-15 Novartis Ag Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
PL3310760T3 (pl) 2015-06-22 2023-03-06 Arena Pharmaceuticals, Inc. Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
KR20190116416A (ko) 2017-02-16 2019-10-14 아레나 파마슈티칼스, 인크. 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
JP2020507610A (ja) 2017-02-16 2020-03-12 アリーナ ファーマシューティカルズ， インコーポレイテッド 腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法
AU2019280822A1 (en) 2018-06-06 2021-01-07 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
TW202131921A (zh) 2019-10-31 2021-09-01 瑞士商愛杜西亞製藥有限公司 Cxcr7拮抗劑與s1p1受體調節劑之組合
WO2021158838A1 (en) 2020-02-07 2021-08-12 Argentum Pharmaceuticals Llc Dosage regimen of an s1p receptor modulator
WO2021158848A1 (en) * 2020-02-07 2021-08-12 Argentum Pharmaceuticals Llc Dosage regimen of an s1p receptor agonist
EP4110332A4 (en) * 2020-02-28 2024-03-06 Akaal Pharma Pty Ltd S1p receptor modulators
CN113332435B (zh) * 2021-06-18 2022-10-18 广州中医药大学(广州中医药研究院) 鞘氨醇-1-磷酸4受体激动剂及其与真武汤联合在制备治疗慢性肾小球肾炎药物中的应用

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EP0627406B1 (en) 1992-10-21 1998-10-28 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1,3-propanediol compound and immunosuppressant
AU8533101A (en) 2000-08-31 2002-03-13 Merck & Co Inc Phosphate derivatives as immunoregulatory agents
CA2483594C (en) 2002-05-16 2011-02-15 Novartis Ag Use of edg receptor binding agents in cancer
US20050090520A1 (en) * 2003-09-12 2005-04-28 Per Lindquist Treatment of disease or injury of the nervous system with FTY720
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
SG187468A1 (en) * 2004-11-29 2013-02-28 Novartis Ag Dosage regimen of an s1p receptor agonist
EP1688141A1 (en) * 2005-01-31 2006-08-09 elbion AG The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome
CN101541227B (zh) * 2005-02-10 2013-06-05 G.I.视频有限公司 用于带导向元件的胃肠工具的前进技术
PT2465492E (pt) * 2007-10-12 2015-10-15 Novartis Ag Composições que compreendem moduladores de receptores de esfingosina-1-fosfato (s1p)
WO2009115954A1 (en) * 2008-03-17 2009-09-24 Actelion Pharmaceuticals Ltd Dosing regimen for a selective s1p1 receptor agonist
KR20180017232A (ko) * 2008-06-20 2018-02-20 노파르티스 아게 다발성 경화증을 치료하기 위한 소아용 조성물
PL2379067T3 (pl) 2008-12-22 2016-02-29 Novartis Ag Schemat dawkowania fingolimodu w leczeniu stwardnienia rozsianego
WO2010072703A1 (en) 2008-12-22 2010-07-01 Novartis Ag Dosage regimen of an s1p receptor agonist

Also Published As

Publication number Publication date
JP2024129030A (ja) 2024-09-26
PT3409274T (pt) 2019-12-17
US20250262171A1 (en) 2025-08-21
KR20110096175A (ko) 2011-08-29
ZA201205942B (en) 2013-03-27
SMT202000441T1 (it) 2020-09-10
EP4098256A1 (en) 2022-12-07
CY1123255T1 (el) 2021-10-29
ECSP11011222A (es) 2011-08-31
CY2020036I2 (el) 2021-06-25
SI2379067T1 (sl) 2016-01-29
PE20120337A1 (es) 2012-04-24
HRP20151190T1 (hr) 2016-01-01
TN2011000272A1 (en) 2012-12-17
CU20110136A7 (es) 2012-01-31
SI3453387T1 (sl) 2020-10-30
ES2810823T3 (es) 2021-03-09
CL2011001529A1 (es) 2012-02-24
WO2010075239A1 (en) 2010-07-01
NZ593065A (en) 2012-11-30
CR20110274A (es) 2011-07-19
EP4098256B1 (en) 2025-02-26
CN102264359A (zh) 2011-11-30
FR20C1060I1 (fr) 2020-12-25
EP3409274A1 (en) 2018-12-05
DK3409274T3 (da) 2019-12-16
FIC20253002I1 (fi) 2025-05-23
CA2747802A1 (en) 2010-07-01
SG171404A1 (en) 2011-07-28
US20100160259A1 (en) 2010-06-24
EP3453387A1 (en) 2019-03-13
EP2907511A1 (en) 2015-08-19
FR25C1012I1 (fr) 2025-06-13
EA201100978A1 (ru) 2012-01-30
JP2017141238A (ja) 2017-08-17
HRP20192175T1 (hr) 2020-03-20
HUE026869T2 (en) 2016-08-29
PL3453387T3 (pl) 2020-11-02
ZA201103863B (en) 2012-10-31
CO6390117A2 (es) 2012-02-29
LT3409274T (lt) 2020-02-10
US20220142949A1 (en) 2022-05-12
US20140148415A1 (en) 2014-05-29
ES3017254T3 (en) 2025-05-12
JP2019167360A (ja) 2019-10-03
CY1122812T1 (el) 2021-05-05
RS60666B1 (sr) 2020-09-30
JP2016135752A (ja) 2016-07-28
CL2013001558A1 (es) 2013-10-25
SMT202000054T1 (it) 2020-03-13
US20200330407A1 (en) 2020-10-22
LT4098256T (lt) 2025-06-10
EP2379067B1 (en) 2015-09-02
US20160081949A1 (en) 2016-03-24
MA32981B1 (fr) 2012-01-02
PL3409274T3 (pl) 2020-06-01
AU2009330176C9 (en) 2017-01-05
PT4098256T (pt) 2025-04-10
DK2379067T3 (en) 2015-12-07
CY1116990T1 (el) 2017-04-05
CY2020036I1 (el) 2021-03-12
AU2009330176B2 (en) 2014-03-06
HUE048717T2 (hu) 2020-08-28
ES2552823T3 (es) 2015-12-02
AR074826A1 (es) 2011-02-16
MX385959B (es) 2025-03-18
ME03594B (me) 2020-07-20
JP2022103194A (ja) 2022-07-07
MX2021010759A (es) 2022-07-19
IL274756A (en) 2020-07-30
SI4098256T1 (sl) 2025-06-30
EP3677260A1 (en) 2020-07-08
ES2760607T3 (es) 2020-05-14
IL278914A (en) 2021-01-31
JP7329965B2 (ja) 2023-08-21
LTPA2025520I1 (pt) 2025-06-25
HUE048717T4 (hu) 2022-02-28
DK4098256T5 (da) 2025-07-21
DK3453387T3 (da) 2020-08-10
DK4098256T3 (da) 2025-04-22
HRP20250568T1 (hr) 2025-07-04
PL2379067T3 (pl) 2016-02-29
AU2009330176A1 (en) 2011-07-07
RS59857B1 (sr) 2020-02-28
HRP20201167T1 (hr) 2020-12-11
CY2025012I1 (el) 2026-02-25
HN2011001759A (es) 2013-11-26
HUE052048T2 (hu) 2021-04-28
EP4098256B9 (en) 2025-06-18
PT2379067E (pt) 2015-12-23
PL4098256T3 (pl) 2025-06-09
US20180289638A1 (en) 2018-10-11
TW201028143A (en) 2010-08-01
MX2011006623A (es) 2011-07-12
RS66784B9 (sr) 2025-08-29
EP3120844A1 (en) 2017-01-25
IL213170A0 (en) 2011-07-31
KR101347919B1 (ko) 2014-01-07
EP3453387B1 (en) 2020-06-03
JP2012513401A (ja) 2012-06-14
LT3453387T (lt) 2020-08-25
JP2014144970A (ja) 2014-08-14
HUE071189T2 (hu) 2025-08-28
US20140066657A1 (en) 2014-03-06
ME03802B (me) 2021-04-20
PT3453387T (pt) 2020-08-11
RS66784B1 (sr) 2025-06-30
HUS2000046I1 (hu) 2020-12-28
US20170189353A1 (en) 2017-07-06
EP2379067A1 (en) 2011-10-26
UY32352A (es) 2010-07-30
LTPA2020005I1 (lt) 2020-12-10
LUC00183I2 (pt) 2024-07-01
SI3409274T1 (sl) 2020-03-31
US20110257133A1 (en) 2011-10-20
NO2020038I1 (no) 2020-11-18
CY2025012I2 (el) 2026-02-25
AU2009330176C1 (en) 2016-12-08
US20190091180A1 (en) 2019-03-28
FI4098256T3 (fi) 2025-03-31
EP3409274B1 (en) 2019-11-20
CA2747802C (en) 2021-02-09
US20160263061A1 (en) 2016-09-15
HUS2500026I1 (hu) 2025-07-28

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]