ME03802B - Rezim doziranja agonista s1p receptora - Google Patents
Rezim doziranja agonista s1p receptoraInfo
- Publication number
- ME03802B ME03802B MEP-2020-156A MEP2020156A ME03802B ME 03802 B ME03802 B ME 03802B ME P2020156 A MEP2020156 A ME P2020156A ME 03802 B ME03802 B ME 03802B
- Authority
- ME
- Montenegro
- Prior art keywords
- dose
- receptor
- agonist
- product
- use according
- Prior art date
Links
- 229940044601 receptor agonist Drugs 0.000 title claims 9
- 239000000018 receptor agonist Substances 0.000 title 1
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 claims 14
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 claims 14
- 239000000556 agonist Substances 0.000 claims 9
- 229940075993 receptor modulator Drugs 0.000 claims 8
- 238000011287 therapeutic dose Methods 0.000 claims 7
- 238000011282 treatment Methods 0.000 claims 6
- 238000011283 initial treatment period Methods 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000005987 polymyositis Diseases 0.000 claims 2
- 238000000159 protein binding assay Methods 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (11)
1. Upotreba modulatora ili agonista S1P receptora u proizvodnji leka za lečenje autoimunske bolesti, pri čemu je autoimunska bolest izabrana sa liste koja se sastoji od multiple skleroze, polimiozitisa, lupus nefritisa, reumatoidnog artritisa, zapaljenske bolesti creva i psorijaze, pri čemu se, pre otpočinjanja primene modulatora ili agonista SIP receptora u standardnoj dnevnoj terapijskoj dozi, navedeni modulator ili agonist S1P receptora primenjuje u dnevnoj dozi koja je niža od standardne dnevne terapijske doze tokom početnog perioda lečenja i pri čemu je najviša početna doza izmedu 0,01 mg i 0,30 mg.
2. Modulator ili agonist S1P receptora za upotrebu u lečenju autoimunske bolesti, pri čemu je autoimunska bolest izabrana sa liste koja se sastoji od multiple skleroze, polimiozitisa, lupus nefritisa, reumatoidnog artritisa, zapaljenske bolesti creva i psorijaze, pri čemu se, pre otpočinjanja primene modulatora ili agonista S1P receptora u standardnoj dnevnoj terapijskoj dozi, navedeni modulator ili agonist S1P receptora primenjuje u dnevnoj dozi koja je niža od standardne dnevne terapijske doze tokom početnog perioda lečenja i pri čemu je najviša početna doza izmedu 0,01 mg i 0,30 mg.
3. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačeni time što početni period lečenja je izabran iz grupe koja se sastoji od:do 10 dana i 5 do 14 dana.
4. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačeni time što se ista doza daje u toku prvih 2 do 4 dana lečenja pre povećanja doze.
5. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačeni time što se ista doza daje u toku prvih 4 dana lečenja pre povećanja doze.
6. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačeni time što u poetnom periodu lečenja dnevna doza je povećavana postepeno do 6 puta do standardne dnevne terapijske doze i zatim se lečenje nastavlja sa standardnom terapijskomdnevnom dozom.
7. Upotreba ili proizvod za upotrebu prema bilo kom od patentnih zahteva 1-8, naznačeni time što se tokom početnog perioda lečenja javlja samo jedno povećanje doze pre davanja standardne dnevne terapijske doze.
8. Upotreba ili proizvod za upotrebu prema bilo kom od patentnih zahteva 1-8, naznačeni time to je u toku početnog perioda lečenja doza povećana samo jednom da bi se dostigla standardna dnevna terapijska doza.
9. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačeni time što je modulator ili agonist S1P receptora selektivan za S1P1receptor.
10. Upotreba ili proizvod za upotrebu prema patentnom zahtevu 9, naznačeni time što modulator ili agonist S1P receptora poseduje selektivnost za S1P1 receptor u odnosu na S1P3 receptor od najmanje 20, 100, 500, 1000 ili 2000 puta više, kao to je mereno preko odnosa EC50 za S1P1receptor prema EC50 za S1P3 receptor kao to je mereno preko analize vezivanja 35S-GTPγS i pri čemu navedeni modulator ili agonist S1P receptora ima EC50 za vezivanje za S1P1 receptor od 100 nM ili manje kao to je procenjivano preko analize vezivanja 35S-GTPγS.
11. Upotreba ili proizvod za upotrebu prema bilo kom od prethodnih patentnih zahteva, naznačen time, bolest je multipla skleroza.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13967208P | 2008-12-22 | 2008-12-22 | |
| US21853009P | 2009-06-19 | 2009-06-19 | |
| US24671509P | 2009-09-29 | 2009-09-29 | |
| EP18201062.9A EP3453387B1 (en) | 2008-12-22 | 2009-12-21 | Dosage regimen for a s1p receptor agonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME03802B true ME03802B (me) | 2021-04-20 |
Family
ID=41667217
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2019-339A ME03594B (me) | 2008-12-22 | 2009-12-21 | Režim doziranja agonista s1p receptora |
| MEP-2020-156A ME03802B (me) | 2008-12-22 | 2009-12-21 | Rezim doziranja agonista s1p receptora |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2019-339A ME03594B (me) | 2008-12-22 | 2009-12-21 | Režim doziranja agonista s1p receptora |
Country Status (43)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2278960T5 (pl) | 2008-03-17 | 2020-06-29 | Actelion Pharmaceuticals Ltd. | Schemat dawkowania dla selektywnego agonisty receptora sip1 |
| TW201028143A (en) | 2008-12-22 | 2010-08-01 | Novartis Ag | Dosage regimen for a S1P receptor agonist |
| NZ598534A (en) | 2009-09-29 | 2014-03-28 | Novartis Ag | Dosage regimen of an s1p receptor modulator |
| US20110124605A1 (en) * | 2009-11-20 | 2011-05-26 | Shreeram Aradhye | Use of an S1P Receptor Agonist |
| JP5856980B2 (ja) | 2010-01-27 | 2016-02-10 | アリーナ ファーマシューティカルズ， インコーポレイテッド | （Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸およびその塩の調製のためのプロセス |
| BR112012028248A2 (pt) * | 2010-05-06 | 2016-08-02 | Novartis Ag | derivados de sulfeto de diarila, seu uso, e kit |
| EP2455080A1 (en) * | 2010-11-23 | 2012-05-23 | Almirall, S.A. | S1P1 receptor agonists for use in the treatment of multiple sclerosis |
| FR2968556B1 (fr) | 2010-12-13 | 2013-12-27 | Centre Nat Rech Scient | Inhibiteurs des infections a vih et leurs utilisations |
| JP6111202B2 (ja) | 2011-01-07 | 2017-04-05 | ノバルティス アーゲー | 免疫抑制製剤 |
| EP3502236B1 (en) | 2011-02-18 | 2023-08-23 | The Scripps Research Institute | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate |
| AR085749A1 (es) | 2011-04-01 | 2013-10-23 | Novartis Ag | Formulaciones |
| US9592268B2 (en) | 2011-05-23 | 2017-03-14 | Cornell University | Endothelium protective materials and methods of use |
| TW201320994A (zh) * | 2011-10-11 | 2013-06-01 | Novartis Ag | 投藥療程 |
| SMT202000298T1 (it) | 2012-08-17 | 2020-07-08 | Actelion Pharmaceuticals Ltd | Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo |
| JP6542678B2 (ja) * | 2013-03-06 | 2019-07-10 | アコーダ セラピューティクス インコーポレイテッド | 心不全の治療または予防のためのニューレグリンまたはその断片の治療的投与の方法 |
| US10675254B2 (en) | 2013-10-11 | 2020-06-09 | Teikoku Seiyaku Co., Ltd. | Sphingosine-1-phosphate receptor agonist iontophoretic devices and methods of using the same |
| CN105611917A (zh) | 2013-10-11 | 2016-05-25 | 帝国制药美国公司 | 局部鞘氨醇-1-磷酸酯受体激动剂制剂及其使用方法 |
| EP3129020A1 (en) * | 2014-04-10 | 2017-02-15 | Novartis AG | S1p modulator immediate release dosage regimen |
| KR20200013086A (ko) | 2014-12-11 | 2020-02-05 | 액테리온 파마슈티칼 리미티드 | 선택적 s1p1 수용체 효능제에 대한 투약 섭생 |
| MA41139B1 (fr) | 2014-12-11 | 2026-02-27 | Laboratoires Juvise Pharmaceuticals | Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque |
| PL3242666T3 (pl) | 2015-01-06 | 2025-02-17 | Arena Pharmaceuticals, Inc. | Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1 |
| WO2016135644A1 (en) | 2015-02-26 | 2016-09-01 | Novartis Ag | Treatment of autoimmune disease in a patient receiving additionally a beta-blocker |
| BR112017027656B1 (pt) | 2015-06-22 | 2023-12-05 | Arena Pharmaceuticals, Inc. | Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo |
| MX2019009841A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
| MX2019009843A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la enfermedad inflamatoria intestinal con manifestaciones extraintestinales. |
| CA3102136A1 (en) | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| JP7749552B2 (ja) | 2019-10-31 | 2025-10-06 | イドルシア・ファーマシューティカルズ・リミテッド | Ｃｘｃｒ７アンタゴニストのｓ１ｐ１受容体調節剤との合剤 |
| WO2021158848A1 (en) * | 2020-02-07 | 2021-08-12 | Argentum Pharmaceuticals Llc | Dosage regimen of an s1p receptor agonist |
| US11135197B2 (en) | 2020-02-07 | 2021-10-05 | Argentum Pharmaceuticals Llc | Dosage regimen of an S1P receptor modulator |
| AU2021228371A1 (en) * | 2020-02-28 | 2022-10-13 | Akaal Pharma Pty Ltd | S1P receptor modulators |
| CN113332435B (zh) * | 2021-06-18 | 2022-10-18 | 广州中医药大学(广州中医药研究院) | 鞘氨醇-1-磷酸4受体激动剂及其与真武汤联合在制备治疗慢性肾小球肾炎药物中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69321823T2 (de) | 1992-10-21 | 1999-06-02 | Taito Co., Ltd., Tokio/Tokyo | 2-amino-1, 3- propandiolverbindung und immunosuppressium |
| EP1315735A4 (en) | 2000-08-31 | 2005-04-06 | Merck & Co Inc | Phosphate derivatives as immunoregulatory compounds |
| PT1505959E (pt) | 2002-05-16 | 2009-02-05 | Novartis Ag | Utilização de agentes de ligação do receptor edg em cancro |
| AU2004271804B2 (en) * | 2003-09-12 | 2011-01-06 | Newron Sweden Ab | Treatment of disorders of the nervous system |
| US20060002999A1 (en) * | 2004-06-17 | 2006-01-05 | Forest Laboratories, Inc. | Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane |
| KR20070085465A (ko) * | 2004-11-29 | 2007-08-27 | 노파르티스 아게 | Ｓ１ｐ 수용체 효능제의 투여 용법 |
| EP1688141A1 (en) * | 2005-01-31 | 2006-08-09 | elbion AG | The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome |
| CN101541227B (zh) * | 2005-02-10 | 2013-06-05 | G.I.视频有限公司 | 用于带导向元件的胃肠工具的前进技术 |
| EP3733161A1 (en) * | 2007-10-12 | 2020-11-04 | Novartis AG | Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators |
| PL2278960T5 (pl) * | 2008-03-17 | 2020-06-29 | Actelion Pharmaceuticals Ltd. | Schemat dawkowania dla selektywnego agonisty receptora sip1 |
| JP2011525189A (ja) * | 2008-06-20 | 2011-09-15 | ノバルティス アーゲー | 多発性硬化症を治療するための小児科の組成物 |
| TW201028143A (en) | 2008-12-22 | 2010-08-01 | Novartis Ag | Dosage regimen for a S1P receptor agonist |
| JP5657565B2 (ja) * | 2008-12-22 | 2015-01-21 | ノバルティス アーゲー | Ｓ１ｐ受容体アゴニストの投与レジメン |
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2009
- 2009-12-21 TW TW098143960A patent/TW201028143A/zh unknown
- 2009-12-21 LT LTEP18201062.9T patent/LT3453387T/lt unknown
- 2009-12-21 SM SM20200441T patent/SMT202000441T1/it unknown
- 2009-12-21 PT PT221870074T patent/PT4098256T/pt unknown
- 2009-12-21 SI SI200931311T patent/SI2379067T1/sl unknown
- 2009-12-21 RS RS20200900A patent/RS60666B1/sr unknown
- 2009-12-21 ES ES22187007T patent/ES3017254T3/es active Active
- 2009-12-21 HU HUE18179301A patent/HUE048717T4/hu unknown
- 2009-12-21 UY UY0001032352A patent/UY32352A/es not_active Application Discontinuation
- 2009-12-21 JP JP2011542521A patent/JP2012513401A/ja not_active Withdrawn
- 2009-12-21 SI SI200932080T patent/SI3453387T1/sl unknown
- 2009-12-21 ES ES18201062T patent/ES2810823T3/es active Active
- 2009-12-21 SI SI200932015T patent/SI3409274T1/sl unknown
- 2009-12-21 EP EP20160225.7A patent/EP3677260A1/en active Pending
- 2009-12-21 EP EP18179301.9A patent/EP3409274B1/en not_active Revoked
- 2009-12-21 PL PL18179301T patent/PL3409274T3/pl unknown
- 2009-12-21 SG SG2011037629A patent/SG171404A1/en unknown
- 2009-12-21 EP EP16182876.9A patent/EP3120844A1/en not_active Withdrawn
- 2009-12-21 LT LTEP22187007.4T patent/LT4098256T/lt unknown
- 2009-12-21 DK DK22187007.4T patent/DK4098256T5/da active
- 2009-12-21 RS RS20191546A patent/RS59857B1/sr unknown
- 2009-12-21 PL PL09797234T patent/PL2379067T3/pl unknown
- 2009-12-21 LT LTEP18179301.9T patent/LT3409274T/lt unknown
- 2009-12-21 AU AU2009330176A patent/AU2009330176C9/en not_active Withdrawn - After Issue
- 2009-12-21 PT PT182010629T patent/PT3453387T/pt unknown
- 2009-12-21 BR BRPI0923500-0A patent/BRPI0923500A2/pt not_active Application Discontinuation
- 2009-12-21 US US13/141,552 patent/US20110257133A1/en not_active Abandoned
- 2009-12-21 FI FIEP22187007.4T patent/FI4098256T3/fi active
- 2009-12-21 EP EP15158251.7A patent/EP2907511A1/en not_active Withdrawn
- 2009-12-21 WO PCT/US2009/068888 patent/WO2010075239A1/en not_active Ceased
- 2009-12-21 DK DK18179301.9T patent/DK3409274T3/da active
- 2009-12-21 ME MEP-2019-339A patent/ME03594B/me unknown
- 2009-12-21 PL PL18201062T patent/PL3453387T3/pl unknown
- 2009-12-21 SI SI200932211T patent/SI4098256T1/sl unknown
- 2009-12-21 MX MX2011006623A patent/MX2011006623A/es unknown
- 2009-12-21 HR HRP20250568TT patent/HRP20250568T1/hr unknown
- 2009-12-21 KR KR1020117017073A patent/KR101347919B1/ko active Active
- 2009-12-21 SM SM20200054T patent/SMT202000054T1/it unknown
- 2009-12-21 PT PT97972343T patent/PT2379067E/pt unknown
- 2009-12-21 PE PE2011001265A patent/PE20120337A1/es not_active Application Discontinuation
- 2009-12-21 MA MA34034A patent/MA32981B1/fr unknown
- 2009-12-21 CN CN2009801518640A patent/CN102264359A/zh active Pending
- 2009-12-21 HU HUE18201062A patent/HUE052048T2/hu unknown
- 2009-12-21 ES ES09797234.3T patent/ES2552823T3/es active Active
- 2009-12-21 HU HUE22187007A patent/HUE071189T2/hu unknown
- 2009-12-21 MX MX2018006099A patent/MX385959B/es unknown
- 2009-12-21 CA CA2747802A patent/CA2747802C/en active Active
- 2009-12-21 DK DK18201062.9T patent/DK3453387T3/da active
- 2009-12-21 DK DK09797234.3T patent/DK2379067T3/en active
- 2009-12-21 EA EA201100978A patent/EA201100978A1/ru unknown
- 2009-12-21 PL PL22187007.4T patent/PL4098256T3/pl unknown
- 2009-12-21 ES ES18179301T patent/ES2760607T3/es active Active
- 2009-12-21 HR HRP20151190TT patent/HRP20151190T1/hr unknown
- 2009-12-21 ME MEP-2020-156A patent/ME03802B/me unknown
- 2009-12-21 EP EP22187007.4A patent/EP4098256B9/en active Active
- 2009-12-21 US US12/642,892 patent/US20100160259A1/en not_active Abandoned
- 2009-12-21 HU HUE09797234A patent/HUE026869T2/en unknown
- 2009-12-21 PT PT181793019T patent/PT3409274T/pt unknown
- 2009-12-21 RS RS20250452A patent/RS66784B9/sr unknown
- 2009-12-21 EP EP18201062.9A patent/EP3453387B1/en not_active Revoked
- 2009-12-21 AR ARP090105010A patent/AR074826A1/es not_active Application Discontinuation
- 2009-12-21 NZ NZ593065A patent/NZ593065A/xx not_active IP Right Cessation
- 2009-12-21 EP EP09797234.3A patent/EP2379067B1/en not_active Revoked
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2011
- 2011-05-25 CR CR20110274A patent/CR20110274A/es not_active Application Discontinuation
- 2011-05-25 ZA ZA2011/03863A patent/ZA201103863B/en unknown
- 2011-05-26 TN TN2011000272A patent/TN2011000272A1/fr unknown
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