BRPI9801092A - processo para a produção de fator recombinante viii e meio de cultura de célula. - Google Patents
processo para a produção de fator recombinante viii e meio de cultura de célula.Info
- Publication number
- BRPI9801092A BRPI9801092A BRPI9801092A BRPI9801092A BRPI9801092A BR PI9801092 A BRPI9801092 A BR PI9801092A BR PI9801092 A BRPI9801092 A BR PI9801092A BR PI9801092 A BRPI9801092 A BR PI9801092A BR PI9801092 A BRPI9801092 A BR PI9801092A
- Authority
- BR
- Brazil
- Prior art keywords
- factor viii
- recombinant factor
- production
- culture medium
- cell culture
- Prior art date
Links
- 229960000301 factor viii Drugs 0.000 title abstract 3
- 239000006143 cell culture medium Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 abstract 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 229910052804 chromium Inorganic materials 0.000 abstract 1
- 239000011651 chromium Substances 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 229910000365 copper sulfate Inorganic materials 0.000 abstract 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 235000003891 ferrous sulphate Nutrition 0.000 abstract 1
- 239000011790 ferrous sulphate Substances 0.000 abstract 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 abstract 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 229910052750 molybdenum Inorganic materials 0.000 abstract 1
- 239000011733 molybdenum Substances 0.000 abstract 1
- 229920001993 poloxamer 188 Polymers 0.000 abstract 1
- 239000010695 polyglycol Substances 0.000 abstract 1
- 229920000151 polyglycol Polymers 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052710 silicon Inorganic materials 0.000 abstract 1
- 239000010703 silicon Substances 0.000 abstract 1
- 229910021654 trace metal Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/35—Polyols, e.g. glycerin, inositol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/95—Protein-free medium and culture conditions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
patente de invenção: <b>"preparação de fator recombinante viii em um meio isento de proteína"<d>. fator viii recombinante pode ser produzido em quantidades relativamente grandes em uma base contínua a partir de células de mamíferos na ausência de quaisquer proteínas derivadas de animal tal como albumina pelo cultivo das células em um meio isento de proteína suplementado com copolímeros de poliol, de preferência na presença de traços de metais tal como cobre. em modelidades muito preferidas, o meio inclui um poliglicol conhecido como pluronic f-68, sulfato de cobre, complexo sulfato ferroso/edta e sais de metais em traços tais como manganês, molibdênio, silício, lítio e cromo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/844,714 US5804420A (en) | 1997-04-18 | 1997-04-18 | Preparation of recombinant Factor VIII in a protein free medium |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI9801092A true BRPI9801092A (pt) | 2000-01-11 |
| BRPI9801092B1 BRPI9801092B1 (pt) | 2013-04-02 |
| BRPI9801092B8 BRPI9801092B8 (pt) | 2021-07-06 |
Family
ID=25293446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9801092 BRPI9801092B8 (pt) | 1997-04-18 | 1998-04-17 | processo para a produÇço de fator recombinante viii e meio de cultura de cÉlula. |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US5804420A (pt) |
| EP (1) | EP0872487B1 (pt) |
| JP (1) | JP4257685B2 (pt) |
| KR (1) | KR100496111B1 (pt) |
| CN (1) | CN1127518C (pt) |
| AR (1) | AR012451A1 (pt) |
| AT (1) | ATE342921T1 (pt) |
| AU (1) | AU748731B2 (pt) |
| BR (1) | BRPI9801092B8 (pt) |
| CA (1) | CA2234215C (pt) |
| CO (1) | CO4790112A1 (pt) |
| CZ (1) | CZ295049B6 (pt) |
| DE (1) | DE69836164T2 (pt) |
| DK (1) | DK0872487T3 (pt) |
| ES (1) | ES2273380T3 (pt) |
| HU (1) | HU224306B1 (pt) |
| ID (1) | ID20193A (pt) |
| IL (1) | IL124123A (pt) |
| MY (1) | MY115583A (pt) |
| NZ (1) | NZ330183A (pt) |
| PL (1) | PL192072B1 (pt) |
| PT (1) | PT872487E (pt) |
| RU (1) | RU2222547C2 (pt) |
| SK (1) | SK285684B6 (pt) |
| TR (1) | TR199800493A1 (pt) |
| TW (1) | TW490469B (pt) |
| UA (1) | UA66340C2 (pt) |
| ZA (1) | ZA983234B (pt) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501040D0 (en) * | 1995-01-19 | 1995-03-08 | Quadrant Holdings Cambridge | Dried composition |
| US8183344B2 (en) * | 1996-04-24 | 2012-05-22 | University Of Michigan | Inactivation resistant factor VIII |
| US6475725B1 (en) * | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| US6528286B1 (en) * | 1998-05-29 | 2003-03-04 | Genentech, Inc. | Mammalian cell culture process for producing glycoproteins |
| AUPP521298A0 (en) * | 1998-08-12 | 1998-09-03 | Life Therapeutics Limited | Purification of fibrinogen |
| US6358703B1 (en) * | 1998-12-10 | 2002-03-19 | Bayer Corporation | Expression system for factor VIII |
| US20050224355A1 (en) * | 1999-12-23 | 2005-10-13 | Brendon Conlan | Removal of biological contaminants |
| AUPP790898A0 (en) | 1998-12-23 | 1999-01-28 | Life Therapeutics Limited | Renal dialysis |
| AUPP790698A0 (en) * | 1998-12-23 | 1999-01-28 | Life Therapeutics Limited | Separation of microorganisms |
| AUPP971399A0 (en) | 1999-04-12 | 1999-05-06 | Life Therapeutics Limited | Separation of plasma components |
| AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| EP1194161B1 (en) * | 1999-07-13 | 2005-11-23 | Biovitrum Ab | Stable factor viii compositions |
| US6767741B1 (en) | 1999-08-27 | 2004-07-27 | Invitrogen Corporation | Metal binding compounds and their use in cell culture medium compositions |
| EP1144060B1 (en) | 1999-08-31 | 2009-02-18 | Sony Computer Entertainment Inc. | Entertainment system, recording medium, and program |
| US7077942B1 (en) | 1999-12-23 | 2006-07-18 | Gradipore Limited | Removal of biological contaminants |
| AUPQ691400A0 (en) | 2000-04-14 | 2000-05-11 | Life Therapeutics Limited | Separation of micromolecules |
| AUPQ697300A0 (en) | 2000-04-18 | 2000-05-11 | Life Therapeutics Limited | Separation apparatus |
| EP1294472B1 (en) | 2000-04-18 | 2009-11-18 | Gradipore Limited | Electrophoresis separation and treatment of samples |
| US6923896B2 (en) * | 2000-09-22 | 2005-08-02 | The Texas A&M University System | Electrophoresis apparatus and method |
| DE60142520D1 (de) * | 2000-10-06 | 2010-08-19 | Arturus Capital Ltd | Multi-port-elektrophorese-trennvorrichtung und entsprechendes verfahren |
| AUPR222300A0 (en) * | 2000-12-21 | 2001-01-25 | Life Therapeutics Limited | Electrophoresis device and method |
| EP1418810A4 (en) | 2001-08-03 | 2006-08-02 | Us Gov Health & Human Serv | ORAL TREATMENT OF HEMOPHILIA |
| EP2292273A3 (en) | 2001-10-10 | 2011-11-23 | BioGeneriX AG | Remodeling and glycoconjugation of peptides |
| JP2005530683A (ja) | 2001-12-21 | 2005-10-13 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第ｖｉｉ因子ポリペプチドの液体組成物 |
| KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| CN101912601B (zh) | 2002-06-21 | 2012-08-29 | 诺和诺德医疗保健公司 | 因子vii多肽的稳定化固体组合物 |
| DK1520008T3 (da) | 2002-07-09 | 2012-10-15 | Baxter Int | Medium frit for dyreprotein til dyrkning af celler |
| EP1596887B1 (en) | 2003-02-26 | 2022-03-23 | Nektar Therapeutics | Polymer-factor viii moiety conjugates |
| CA2518327A1 (en) * | 2003-03-18 | 2004-09-30 | Novo Nordisk Health Care Ag | Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides |
| US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| KR20060015574A (ko) * | 2003-05-23 | 2006-02-17 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 용액 중 단백질 안정화 |
| ES2382157T3 (es) * | 2003-06-25 | 2012-06-05 | Novo Nordisk Health Care Ag | Composición líquida de polipépttidos del factor VII |
| JP5306597B2 (ja) * | 2003-07-01 | 2013-10-02 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第ｖｉｉ因子ポリペプチドの液体水性薬学的組成物 |
| EP1656158B1 (en) | 2003-08-14 | 2016-03-09 | Novo Nordisk Health Care AG | Liquid, aqueous pharmaceutical composition of factor vii polypeptides |
| EP2311437A1 (en) * | 2003-12-19 | 2011-04-20 | Novo Nordisk Health Care AG | Stabilised compositions of factor VII polypeptides |
| GB0414825D0 (en) | 2004-07-02 | 2004-08-04 | Biostatus Ltd | Gel formulations and uses thereof |
| US7422875B2 (en) | 2004-07-20 | 2008-09-09 | Board Of Regents Of The University Of Nebraska | Compositions and methods for increasing protein production |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| EP1812557A4 (en) * | 2004-10-29 | 2009-11-04 | Centocor Ortho Biotech Inc | COMPOSITIONS OF CHEMICALLY DEFINED MEDIA |
| EP1841474A2 (en) * | 2005-01-25 | 2007-10-10 | Wyeth Research Ireland Limited | Method for diafiltration |
| EP1707634A1 (en) * | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
| ES2474573T3 (es) * | 2006-01-04 | 2014-07-09 | Baxter International Inc | Medio de cultivo celular sin oligop�ptidos |
| US20080070251A1 (en) * | 2006-06-30 | 2008-03-20 | Kaufman Randal J | Method of Producing Factor VIII Proteins by Recombinant Methods |
| US20090203077A1 (en) * | 2006-06-30 | 2009-08-13 | The Regents Of The University Of Michigan | Method of producing factor viii proteins by recombinant methods |
| CA2679107C (en) * | 2007-02-23 | 2018-01-16 | Sk Chemicals Co., Ltd. | Process for producing and purifying factor viii and its derivatives |
| EP2150264A4 (en) | 2007-04-26 | 2014-09-24 | Bayer Healthcare Llc | STABILIZATION OF LIQUID SOLUTIONS OF A RECOMBINANT PROTEIN FOR FROZEN STORAGE |
| CA2703948A1 (en) * | 2007-11-01 | 2009-05-07 | University Of Rochester | Recombinant factor viii having increased stability |
| SI2574677T1 (sl) * | 2007-12-27 | 2017-11-30 | Baxalta GmbH | Procesi celične kulture |
| DE102008051574A1 (de) | 2008-10-14 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung von Interferon-beta und deren Varianten |
| PT2356247E (pt) * | 2008-11-12 | 2015-10-26 | Baxalta Inc | Método de produção de fator vii isento de soro e de insulina |
| NZ597727A (en) | 2009-07-31 | 2013-08-30 | Baxter Int | Cell culture medium for adamts protein expression |
| EP4218797B9 (en) | 2009-09-21 | 2025-04-30 | Takeda Pharmaceutical Company Limited | Stabilized liquid and lyophilized adamts13 formulations |
| RU2579977C2 (ru) | 2009-11-13 | 2016-04-10 | Грифольс Терапьютикс Инк. | СОДЕРЖАЩИЕ ФАКТОР ФОН ВИЛЛЕБРАНДА (vWF) ПРЕПАРАТЫ И СПОСОБЫ, НАБОРЫ И ПРИМЕНЕНИЯ, СВЯЗАННЫЕ С НИМИ |
| AU2011246503B2 (en) | 2010-04-26 | 2013-09-26 | Novartis Ag | Improved cell culture medium |
| EA202090067A3 (ru) | 2010-07-08 | 2020-07-31 | Баксалта Инкорпорейтид | Способ получения рекомбинантного adamts13 в культуре клеток |
| GB201014121D0 (en) * | 2010-08-24 | 2010-10-06 | Univ Gent | Particulate biologic drug delivery system |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| RU2592680C2 (ru) * | 2011-04-29 | 2016-07-27 | Биокон Рисерч Лимитед | Способ снижения накопления лактата при культивировании и способ получения антитела |
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| WO2013098676A1 (en) | 2011-12-30 | 2013-07-04 | Grifols, S.A. | Method for purifying factor viii |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
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| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
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| US20140271622A1 (en) * | 2013-03-14 | 2014-09-18 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
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| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| CA2942770A1 (en) * | 2014-03-23 | 2015-10-01 | Advantech Bioscience Farmaceutica Ltda. | Enhancement of recombinant protein expression with copper |
| SG11201607929PA (en) | 2014-03-25 | 2016-10-28 | Genentech Inc | Methods of preparing a poloxamer for use in cell culture medium |
| US9907835B2 (en) | 2014-04-01 | 2018-03-06 | Advanced Bioscience Farmacêutica LTDA | Stable Factor VIII formulations with low sugar-glycine |
| CN106456720A (zh) | 2014-04-01 | 2017-02-22 | 爱德技术生物科学有限公司 | 在无钙作为赋形剂下因子viii的稳定性 |
| US20190177686A1 (en) * | 2016-05-09 | 2019-06-13 | Kyowa Hakko Bio Co., Ltd. | Medium, additive for albumin-free medium, and method for culturing pluripotent stem cells |
| EP3625329A1 (en) * | 2017-05-17 | 2020-03-25 | Octapharma AG | Method for the production of a recombinant target protein |
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| CN113015805B (zh) | 2018-11-13 | 2024-12-03 | 詹森生物科技公司 | 抗cd38抗体产生期间的痕量金属的控制 |
| KR20210141990A (ko) | 2019-03-14 | 2021-11-23 | 얀센 바이오테크 인코포레이티드 | 항-il12/il23 항체 조성물을 생성하기 위한 제조 방법 |
| MA55283A (fr) | 2019-03-14 | 2022-01-19 | Janssen Biotech Inc | Procédés de production de compositions d'anticorps anti-tnf |
| CN113840837A (zh) | 2019-03-14 | 2021-12-24 | 詹森生物科技公司 | 用于产生抗tnf抗体组合物的方法 |
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| IL309560B2 (en) | 2019-12-06 | 2025-05-01 | Regeneron Pharma | Anti-VEGF protein preparations and methods for their production |
| EP4127158A2 (en) | 2020-04-02 | 2023-02-08 | Takeda Pharmaceutical Company Limited | Adamts13 variant, compositions, and uses thereof |
| MX2022013812A (es) | 2020-05-08 | 2022-12-15 | Regeneron Pharma | Trampas y mini-trampas de vegf y metodos para el tratamiento de trastornos oculares y cancer. |
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| US4440679A (en) * | 1980-03-05 | 1984-04-03 | Cutter Laboratories, Inc. | Pasteurized therapeutically active protein compositions |
| US4767704A (en) * | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US5576194A (en) * | 1986-07-11 | 1996-11-19 | Bayer Corporation | Recombinant protein production |
| NO162160C (no) * | 1987-01-09 | 1989-11-15 | Medi Cult As | Serumfritt vekstmedium, samt anvendelse derav. |
| US5024947A (en) * | 1987-07-24 | 1991-06-18 | Cetus Corporation | Serum free media for the growth on insect cells and expression of products thereby |
| JPH0387173A (ja) * | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体 |
| US5378612A (en) * | 1990-05-11 | 1995-01-03 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Culture medium for production of recombinant protein |
| CA2078721A1 (en) * | 1991-09-24 | 1993-03-25 | Hiroshi Yonemura | Process for preparing human coagulation factor viii protein complex |
| US6103529A (en) * | 1996-10-10 | 2000-08-15 | Life Technologies, Inc. | Animal cell culture media comprising peptides derived from rice |
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