CA1269496C - Mercaptocycloalcoylcarbonyl- et mercaptoarylcarbonyldipeptides - Google Patents

Mercaptocycloalcoylcarbonyl- et mercaptoarylcarbonyldipeptides

Info

Publication number
CA1269496C
CA1269496C CA482355A CA482355A CA1269496C CA 1269496 C CA1269496 C CA 1269496C CA 482355 A CA482355 A CA 482355A CA 482355 A CA482355 A CA 482355A CA 1269496 C CA1269496 C CA 1269496C
Authority
CA
Canada
Prior art keywords
mercaptoarylcarbonyl
dipeptides
mercaptocycloalkylcarbonyl
inhibition activity
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA482355A
Other languages
English (en)
Other versions
CA1269496A (fr
Inventor
Harold N Weller
Eric M Gordon
Norma G Delaney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to CA000482355A priority Critical patent/CA1269496A/fr
Application granted granted Critical
Publication of CA1269496C publication Critical patent/CA1269496C/fr
Publication of CA1269496A publication Critical patent/CA1269496A/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000482355A 1984-05-25 1985-05-24 Mercaptocycloalcoylcarbonyl- et mercaptoarylcarbonyldipeptides Expired - Lifetime CA1269496A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000482355A CA1269496A (fr) 1984-05-25 1985-05-24 Mercaptocycloalcoylcarbonyl- et mercaptoarylcarbonyldipeptides

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US614-090 1984-05-25
US06/614,090 US4560506A (en) 1984-05-25 1984-05-25 Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
CA000482355A CA1269496A (fr) 1984-05-25 1985-05-24 Mercaptocycloalcoylcarbonyl- et mercaptoarylcarbonyldipeptides

Publications (2)

Publication Number Publication Date
CA1269496C true CA1269496C (fr) 1990-05-22
CA1269496A CA1269496A (fr) 1990-05-22

Family

ID=24459829

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000482355A Expired - Lifetime CA1269496A (fr) 1984-05-25 1985-05-24 Mercaptocycloalcoylcarbonyl- et mercaptoarylcarbonyldipeptides

Country Status (7)

Country Link
US (1) US4560506A (fr)
JP (1) JPH0762029B2 (fr)
CA (1) CA1269496A (fr)
DE (1) DE3518817A1 (fr)
FR (1) FR2564845B1 (fr)
GB (1) GB2159160B (fr)
IT (1) IT1183677B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
US5686422A (en) * 1987-03-17 1997-11-11 Research Corporation Technologies, Inc. Synthetic inhibitors of mammalian collagenase
ATE106087T1 (de) * 1987-03-17 1994-06-15 Res Corp Technologies Inc Synthetische inhibitoren von säugetier- collagenase.
CA1337400C (fr) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibiteurs de l'endopeptidase neutre
US4849525A (en) * 1987-09-21 1989-07-18 E. R. Squibb & Sons, Inc. Phosphinylcycloalkylcarbonyl and phosphinylcycloalkenylcarbonyl dipeptides
US5117335A (en) * 1989-12-28 1992-05-26 Koito Manufacturing Co., Ltd. Headlight for vehicle
EP0723451B1 (fr) * 1993-10-13 1999-08-25 Karla Lehmann Utilisation de composes de lithium en combinaison avec des inhibiteurs de l'ace et/ou des antagonistes du recepteur a angiotensin-ii pour traiter l'hypertension
FR2729668A1 (fr) * 1995-01-23 1996-07-26 Adir Nouveaux derives de mercaptoalcanoyldipeptides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7022677B1 (en) * 1999-02-18 2006-04-04 Kaken Pharmaceutical Co., Ltd. Amide derivatives as growth hormone secretagogues
US7528274B2 (en) * 2001-08-03 2009-05-05 The United States Of America As Represented By The Department Of Health And Human Services Acylthiols and component thiol compositions as anti-HIV and anti-retroviral agents
UA96283C2 (uk) 2005-12-23 2011-10-25 Зіланд Фарма А/С Модифіковані міметики лізину
PL2468724T3 (pl) 2006-12-21 2016-05-31 Zealand Pharma As Synteza związków pirolidynowych
JP6989864B2 (ja) 2017-05-05 2022-02-03 ジーランド ファーマ，アー／エス ギャップ結合細胞間コミュニケーションモジュレータ及び糖尿病性眼疾患の治療のためのそれらの使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
GR75019B (fr) * 1980-09-17 1984-07-12 Univ Miami
US4440941A (en) * 1980-12-22 1984-04-03 Usv Pharmaceutical Corporation Aroyl-aminoacids, amides and esters thereof
IT1195287B (it) * 1981-11-05 1988-10-12 Ausonia Farma Srl Derivato tiazolico,procedimento per la sua preparazione e relative composizioni farmaceutiche
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides
JPS6034993A (ja) * 1983-05-23 1985-02-22 ユーエスヴイー　フアーマシユーテイカル　コーポレーシヨン 高血圧治療用化合物

Also Published As

Publication number Publication date
IT8520872A0 (it) 1985-05-24
IT1183677B (it) 1987-10-22
JPS617295A (ja) 1986-01-13
FR2564845A1 (fr) 1985-11-29
JPH0762029B2 (ja) 1995-07-05
DE3518817A1 (de) 1985-11-28
US4560506A (en) 1985-12-24
CA1269496A (fr) 1990-05-22
GB2159160B (en) 1987-10-28
GB2159160A (en) 1985-11-27
GB8513178D0 (en) 1985-06-26
FR2564845B1 (fr) 1990-04-27

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Legal Events

Date Code Title Description
MKLA Lapsed
MKLA Lapsed

Effective date: 19951122