CA2005986A1 - Derive de benzimidazole ayant un effet inhibiteur sur l'acide gastrique et procede de preparation correspondant - Google Patents

Derive de benzimidazole ayant un effet inhibiteur sur l'acide gastrique et procede de preparation correspondant

Info

Publication number
CA2005986A1
CA2005986A1 CA2005986A CA2005986A CA2005986A1 CA 2005986 A1 CA2005986 A1 CA 2005986A1 CA 2005986 A CA2005986 A CA 2005986A CA 2005986 A CA2005986 A CA 2005986A CA 2005986 A1 CA2005986 A1 CA 2005986A1
Authority
CA
Canada
Prior art keywords
gastric acid
preparation
inhibitory effect
benzimidazole derivative
acid inhibitory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2005986A
Other languages
English (en)
Other versions
CA2005986C (fr
Inventor
Arne E. Brandstrom
Per L. Lindberg
Gunnel E. Sunden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hassle AB filed Critical Hassle AB
Publication of CA2005986A1 publication Critical patent/CA2005986A1/fr
Application granted granted Critical
Publication of CA2005986C publication Critical patent/CA2005986C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002005986A 1988-12-22 1989-12-19 Derive de benzimidazole ayant un effet inhibiteur sur l'acide gastrique et procede de preparation correspondant Expired - Lifetime CA2005986C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE19888804629A SE8804629D0 (sv) 1988-12-22 1988-12-22 New therapeutically active compounds
SE8804629-7 1988-12-22

Publications (2)

Publication Number Publication Date
CA2005986A1 true CA2005986A1 (fr) 1990-06-22
CA2005986C CA2005986C (fr) 1999-08-03

Family

ID=20374310

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002005986A Expired - Lifetime CA2005986C (fr) 1988-12-22 1989-12-19 Derive de benzimidazole ayant un effet inhibiteur sur l'acide gastrique et procede de preparation correspondant

Country Status (32)

Country Link
US (2) US5008278A (fr)
EP (1) EP0449940B1 (fr)
JP (1) JP2793906B2 (fr)
KR (1) KR910700249A (fr)
CN (1) CN1028231C (fr)
AR (1) AR248136A1 (fr)
AT (1) ATE127799T1 (fr)
AU (1) AU634741B2 (fr)
BG (1) BG60102B2 (fr)
CA (1) CA2005986C (fr)
DD (2) DD296079A5 (fr)
DE (1) DE68924273T2 (fr)
DK (1) DK170800B1 (fr)
EG (1) EG19303A (fr)
FI (2) FI954768A7 (fr)
GR (1) GR1002252B (fr)
HR (1) HRP920831A2 (fr)
HU (2) HU205926B (fr)
IE (1) IE894048L (fr)
IL (1) IL92798A0 (fr)
LT (2) LT3914B (fr)
LV (1) LV10187B (fr)
NZ (1) NZ231872A (fr)
PH (1) PH27400A (fr)
PL (1) PL161150B1 (fr)
PT (1) PT92648B (fr)
RO (1) RO110494B1 (fr)
RU (2) RU2073676C1 (fr)
SE (1) SE8804629D0 (fr)
WO (1) WO1990006925A1 (fr)
YU (1) YU46806B (fr)
ZA (2) ZA899795B (fr)

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TNSN95063A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux benzimidazoles substitues
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
CZ289804B6 (cs) * 1994-07-08 2002-04-17 Astrazeneca Ab Multijednotková tabletovaná dávková forma I
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
DE19758573C2 (de) * 1997-11-26 2001-03-01 Implex Hear Tech Ag Fixationselement für ein implantierbares Mikrofon
KR100627614B1 (ko) * 1998-04-20 2006-09-25 에자이 가부시키가이샤 안정화된 벤즈이미다졸계 화합물 함유 조성물로 이루어지는 의약제제
SE9900274D0 (sv) * 1999-01-28 1999-01-28 Astra Ab New compound
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
RU2232159C2 (ru) * 1999-07-29 2004-07-10 Регентский Совет Университета Калифорнии Производные бензимидазола и фармацевтические композиции, содержащие пролекарство ингибитора протонного насоса
CN1197574C (zh) 1999-10-20 2005-04-20 卫材株式会社 稳定苯并咪唑化合物的方法
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
US20040006111A1 (en) * 2002-01-25 2004-01-08 Kenneth Widder Transmucosal delivery of proton pump inhibitors
WO2003082858A1 (fr) * 2002-03-26 2003-10-09 Dr. Reddy's Laboratories Limited Formes cristallines de rabeprazole sodique
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
EP1603537A4 (fr) * 2003-02-20 2009-11-04 Santarus Inc Liberation immediate d'un complexe antacide d'omeprazole presentant une nouvelle formulation pour une elimination rapide et prolongee d'acide gastrique
JP2006528182A (ja) * 2003-07-18 2006-12-14 サンタラス インコーポレイティッド 薬学的製剤および酸に起因する消化器疾患の治療法
JP2006528181A (ja) * 2003-07-18 2006-12-14 サンタラス インコーポレイティッド 酸分泌を阻害するために有用な薬学的製剤ならびにそれらを作製および使用する方法
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8246986B2 (en) 2003-09-26 2012-08-21 Alza Corporation Drug coating providing high drug loading
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
RU2325960C2 (ru) * 2005-09-22 2008-06-10 Белорусский Национальный Технический Университет Способ получения товарной продукции на литейно-прокатном комплексе металлургического мини-завода
US9233092B2 (en) 2006-07-25 2016-01-12 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
EA201100313A1 (ru) 2008-09-09 2011-10-31 Астразенека Аб Способ доставки фармацевтической композиции пациенту, нуждающемуся в этом
CA2764963C (fr) 2009-06-25 2016-11-01 Astrazeneca Ab Procede pour le traitement d'un patient a risque de developer un ulcere associe a nsaid
WO2011080502A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080500A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080501A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
EP2601947A1 (fr) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Combinaison à dose fixe pour le traitement de maladies associées à Hélicobacter pylori
BR112014016085A8 (pt) 2011-12-28 2017-07-04 Pozen Inc composições aprimoradas e métodos para distribuição de omeprazol mais ácido acetilsalicílico

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US428098A (en) 1890-05-20 Electric railway
US727150A (en) 1902-06-18 1903-05-05 Peter Paul Keller Adjustable hanger for incandescent lamps.
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (fr) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
DE3215503A1 (de) 1982-04-26 1983-11-03 Zängl GmbH, 8000 München Elektrisch beheiztes schneidgeraet
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
JPS6261978A (ja) * 1985-09-12 1987-03-18 Otsuka Pharmaceut Co Ltd ５−フルオロ−１ｈ−ベンズイミダゾ−ル誘導体
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
JPS62201884A (ja) * 1986-02-28 1987-09-05 Tokyo Tanabe Co Ltd ベンズイミダゾール誘導体及びその製造法
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
JPH0676323B2 (ja) * 1987-08-28 1994-09-28 東京田辺製薬株式会社 抗潰瘍剤

Also Published As

Publication number Publication date
FI954768A0 (fi) 1995-10-06
EP0449940B1 (fr) 1995-09-13
RU2073676C1 (ru) 1997-02-20
WO1990006925A1 (fr) 1990-06-28
FI954768L (fi) 1995-10-06
PL161150B1 (en) 1993-05-31
BG60102B2 (bg) 1993-10-29
HU205927B (en) 1992-07-28
ZA899795B (en) 1990-08-29
DK122291D0 (da) 1991-06-21
JP2793906B2 (ja) 1998-09-03
US5008278A (en) 1991-04-16
LTIP1721A (en) 1995-07-25
DD296078A5 (de) 1991-11-21
DE68924273D1 (de) 1995-10-19
CN1043713A (zh) 1990-07-11
PT92648A (pt) 1990-06-29
AR248136A1 (es) 1995-06-30
DK122291A (da) 1991-06-24
KR910700249A (ko) 1991-03-14
IL92798A0 (en) 1990-09-17
HRP920831A2 (en) 1995-12-31
US5039808A (en) 1991-08-13
FI913035A0 (fi) 1991-06-20
AU634741B2 (en) 1993-03-04
DE68924273T2 (de) 1996-02-15
YU242689A (en) 1991-04-30
LT3980B (en) 1996-06-25
GR1002252B (en) 1996-04-23
LV10187B (en) 1995-04-20
FI913035A7 (fi) 1991-06-20
HUT57202A (en) 1991-11-28
GR890100838A (el) 1991-03-15
HU205926B (en) 1992-07-28
JPH04502461A (ja) 1992-05-07
NZ231872A (en) 1992-03-26
CN1028231C (zh) 1995-04-19
FI954768A7 (fi) 1995-10-06
ZA899794B (en) 1990-08-29
IE894048L (en) 1990-06-22
PT92648B (pt) 1995-09-12
DK170800B1 (da) 1996-01-22
PH27400A (en) 1993-06-21
YU46806B (sh) 1994-06-10
SE8804629D0 (sv) 1988-12-22
ATE127799T1 (de) 1995-09-15
CA2005986C (fr) 1999-08-03
EG19303A (en) 1994-11-30
AU4817590A (en) 1990-07-10
LV10187A (lv) 1994-10-20
HU901084D0 (en) 1991-09-30
EP0449940A1 (fr) 1991-10-09
LT3914B (en) 1996-04-25
DD296079A5 (de) 1991-11-21
RU2042673C1 (ru) 1995-08-27
LTIP1726A (en) 1995-07-25
RO110494B1 (ro) 1996-01-30

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121202