CA3076993A1 - Intranasal delivery devices - Google Patents

Intranasal delivery devices Download PDF

Info

Publication number
CA3076993A1
CA3076993A1 CA3076993A CA3076993A CA3076993A1 CA 3076993 A1 CA3076993 A1 CA 3076993A1 CA 3076993 A CA3076993 A CA 3076993A CA 3076993 A CA3076993 A CA 3076993A CA 3076993 A1 CA3076993 A1 CA 3076993A1
Authority
CA
Canada
Prior art keywords
instances
nozzle
poppet valve
micro
pump
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3076993A
Other languages
English (en)
French (fr)
Inventor
Shunji Haruta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shin Nippon Biomedical Laboratories Ltd
Original Assignee
Shin Nippon Biomedical Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shin Nippon Biomedical Laboratories Ltd filed Critical Shin Nippon Biomedical Laboratories Ltd
Publication of CA3076993A1 publication Critical patent/CA3076993A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/061—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump characterised by the means producing the gas or vapour pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/075—Bulb type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0618—Nose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1052—Actuation means

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3076993A 2017-09-26 2018-09-26 Intranasal delivery devices Pending CA3076993A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762563244P 2017-09-26 2017-09-26
US62/563,244 2017-09-26
PCT/JP2018/035560 WO2019065673A1 (en) 2017-09-26 2018-09-26 INTRANASAL DELIVERY DEVICES

Publications (1)

Publication Number Publication Date
CA3076993A1 true CA3076993A1 (en) 2019-04-04

Family

ID=65806470

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3076993A Pending CA3076993A1 (en) 2017-09-26 2018-09-26 Intranasal delivery devices

Country Status (10)

Country Link
US (3) US11744967B2 (ko)
EP (1) EP3687607B1 (ko)
JP (1) JP7187563B2 (ko)
KR (1) KR102637129B1 (ko)
CN (1) CN111386137B (ko)
AU (1) AU2018343545B2 (ko)
CA (1) CA3076993A1 (ko)
ES (1) ES3012532T3 (ko)
MX (1) MX2020003693A (ko)
WO (1) WO2019065673A1 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3049059T3 (da) 2013-09-24 2022-01-31 Satsuma Pharmaceuticals Inc Intranasal dhe formulering til behandlingen af hovedpine
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US20240157180A1 (en) 2021-02-04 2024-05-16 Mighty Fire Breaker Llc Method of and kit for installing and operating a wildfire defense spraying system on a property parcel for proactively spraying environmentally-clean liquid fire inhibitor thereover to inhibit fire ignition and flame spread caused by wind-driven wildfire embers
US11865390B2 (en) 2017-12-03 2024-01-09 Mighty Fire Breaker Llc Environmentally-clean water-based fire inhibiting biochemical compositions, and methods of and apparatus for applying the same to protect property against wildfire
US11865394B2 (en) 2017-12-03 2024-01-09 Mighty Fire Breaker Llc Environmentally-clean biodegradable water-based concentrates for producing fire inhibiting and fire extinguishing liquids for fighting class A and class B fires
US12594448B2 (en) 2019-06-22 2026-04-07 Mighty Fire Breaker Llc Environmentally-clean aqueous-based fire extinguishing biochemical liquid concentrates for mixing with proportioned quantities of water to produce fire extinguishing water streams
US10653904B2 (en) 2017-12-02 2020-05-19 M-Fire Holdings, Llc Methods of suppressing wild fires raging across regions of land in the direction of prevailing winds by forming anti-fire (AF) chemical fire-breaking systems using environmentally clean anti-fire (AF) liquid spray applied using GPS-tracking techniques
US11826592B2 (en) 2018-01-09 2023-11-28 Mighty Fire Breaker Llc Process of forming strategic chemical-type wildfire breaks on ground surfaces to proactively prevent fire ignition and flame spread, and reduce the production of smoke in the presence of a wild fire
CN112312951A (zh) 2018-04-12 2021-02-02 火箭科学健康公司 鼻内药物输送装置、系统和过程
KR101947403B1 (ko) * 2018-05-11 2019-02-13 김대황 비강 및 부비동 약물투여장치 및 방법
CN120284965A (zh) 2018-12-11 2025-07-11 小蜜橘制药公司 用于治疗或预防头痛的组合物、装置和方法
CN113784703A (zh) * 2019-05-16 2021-12-10 株式会社新日本科学 经鼻施予用粉末制剂及其制造方法
EP4041354A4 (en) * 2019-10-11 2024-01-24 Rocket Science Health Corp. DEVICE, SYSTEM AND METHOD FOR INTRANASAL DRUG DELIVERY
US11911643B2 (en) * 2021-02-04 2024-02-27 Mighty Fire Breaker Llc Environmentally-clean fire inhibiting and extinguishing compositions and products for sorbing flammable liquids while inhibiting ignition and extinguishing fire
US20240252866A1 (en) 2020-03-01 2024-08-01 Mighty Fire Breaker Llc Liquid hydrocarbon sorbing article of manufacture for inhibiting fire ignition involving flammable liquid hydrocarbons, while absorbing the flammable liquid hydrocarbons when spilled on a body of water and/or land
US12414916B2 (en) 2021-06-10 2025-09-16 Belhaven BioPharma Inc. Dry powder formulations of epinephrine and associated methods
US12005185B2 (en) 2021-12-17 2024-06-11 Belhaven BioPharma Inc. Medical counter measures including dry powder formulations and associated methods
US20240173308A1 (en) * 2022-11-30 2024-05-30 Griffin Katz System, method, and treatment for the overdose of xylazine containing substances
US20260108686A1 (en) 2024-10-21 2026-04-23 Belhaven BioPharma Inc. Compositions, devices, and methods for intranasal delivery of dry powder epinephrine

Family Cites Families (205)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2218983A (en) * 1937-10-14 1940-10-22 Eaton Mfg Co Valve structure
US3809084A (en) * 1970-02-16 1974-05-07 American Cyanamid Co Pressurized portable dispenser
FR2224175B1 (ko) 1973-04-04 1978-04-14 Isf Spa
US3921857A (en) * 1973-11-29 1975-11-25 Ciba Geigy Corp Non-spitting liquid dispensing device
US3856185A (en) 1973-12-26 1974-12-24 Ciba Geigy Corp Single dose, replaceable supply air pressure operated dispenser
US4017007A (en) 1973-12-26 1977-04-12 Ciba-Geigy Corporation Single dose air pressure operated dispenser
IT1017153B (it) 1974-07-15 1977-07-20 Isf Spa Apparecchio per inalazioni
DE2716323C2 (de) 1977-04-07 1986-03-13 Schering AG, 1000 Berlin und 4709 Bergkamen Vorrichtung zur Inhalation von Arzneimitteln
JPS5420126A (en) 1977-07-12 1979-02-15 Asahi Chem Ind Co Ltd Pharmaceutical composition
AU508480B2 (en) 1977-04-13 1980-03-20 Asahi Kasei Kogyo Kabushiki Kaisha Microcrystalline cellulose excipient and pharmaceutical composition containing thesame
JPS53127553A (en) 1977-04-13 1978-11-07 Asahi Chem Ind Co Ltd Vehicle
JPS5462328A (en) 1977-10-24 1979-05-19 Asahi Chem Ind Co Ltd Additive for cosmetics
US4226233A (en) 1978-10-10 1980-10-07 Longevity Products, Inc. Respirators
US4300545A (en) 1980-06-23 1981-11-17 Schering Corporation Method and nozzle for nasal vaccination of immature mammals
JPS5934267A (ja) 1982-08-23 1984-02-24 帝人株式会社 粉状薬剤施薬装置
JPS59163313A (ja) 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
US4535808A (en) * 1983-07-08 1985-08-20 Dicken Manufacturing Company Check valve
DE3345722A1 (de) 1983-12-17 1985-06-27 Boehringer Ingelheim KG, 6507 Ingelheim Inhalator
JPS60224616A (ja) 1984-04-24 1985-11-09 Teijin Ltd 経鼻投与用組成物
US5731303A (en) 1985-12-04 1998-03-24 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery compositions
JPS63267731A (ja) 1987-04-23 1988-11-04 Asahi Chem Ind Co Ltd 錠剤組成物
DE3886880T2 (de) 1987-10-15 1994-07-14 Syntex Inc Pulverförmige Zubereitungen zur intranasalen Verabreichung von Polypeptiden.
US5046493A (en) 1988-02-16 1991-09-10 James Kropkowski Nasal dispenser
DK479189D0 (da) 1989-01-06 1989-09-28 Hans Gernot Schenk Inhalator
JPH02196719A (ja) 1989-01-24 1990-08-03 Green Cross Corp:The 粉末状医薬組成物
JP2539333Y2 (ja) 1989-04-03 1997-06-25 オムロン株式会社 吸入器
US5178138A (en) * 1990-09-11 1993-01-12 Walstrom Dennis R Drug delivery device
JP2726177B2 (ja) 1991-08-01 1998-03-11 帝人株式会社 安定化されたカルシトニン類医薬組成物
DK198591D0 (da) 1991-12-10 1991-12-10 Novo Nordisk As Apparat
US5320094A (en) 1992-01-10 1994-06-14 The Johns Hopkins University Method of administering insulin
GB2269992A (en) 1992-08-14 1994-03-02 Rh Ne Poulenc Rorer Limited Powder inhalation formulations
US5417984A (en) 1992-12-14 1995-05-23 Biocontrol, Inc. Low crystallinity cellulose excipients
EP0681491B1 (en) 1993-01-29 2000-12-13 Aradigm Corporation Intrapulmonary delivery of hormones
US5672581A (en) 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
ATE290864T1 (de) 1993-03-26 2005-04-15 Franciscus Wilhelmus He Merkus Pharmazeutische zusammensetzungen zur intranasalen verabreichung von dihydroergotamin
SE9302550D0 (sv) * 1993-07-30 1993-07-30 Ernst Hoerlin Powder inhaler
JPH07165613A (ja) 1993-10-19 1995-06-27 Dot:Kk 経鼻吸収薬物用キャリヤおよび生理活性ペプチド組成物
SE9303574D0 (sv) 1993-11-01 1993-11-01 Kabi Pharmacia Ab Composition for drug delivery and method the manufacturing thereof
US5958458A (en) 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
EP0714411B1 (en) 1994-06-16 1999-07-21 PHARMACIA & UPJOHN S.p.A. Process for obtaining mucoadhesive starch
JPH0871152A (ja) 1994-09-02 1996-03-19 Unisia Jecs Corp 吸入式投薬器
NZ293163A (en) 1994-09-21 1998-09-24 Inhale Therapeutic Syst Inhalation medicament disperser, aerosol from high pressure gas entrainment of fluidised powder drawn from receptacle feed tube
JPH0898888A (ja) 1994-09-30 1996-04-16 Teijin Ltd 粉末状薬剤噴霧施薬装置
JPH08103499A (ja) 1994-10-04 1996-04-23 Unisia Jecs Corp 吸入式投薬器
JP3516739B2 (ja) 1994-10-17 2004-04-05 大成化工株式会社 粉体薬剤カプセルの開封及び体腔内噴射用の多重筒機構並びに圧送用気体の容器を装着したキット
JP3308419B2 (ja) 1995-02-06 2002-07-29 株式会社ユニシアジェックス 鼻腔用投薬器
US5901703A (en) 1995-02-06 1999-05-11 Unisia Jecs Corporation Medicine administering device for nasal cavities
JP3308425B2 (ja) 1995-03-10 2002-07-29 株式会社ユニシアジェックス 鼻腔用投薬器
JPH08243164A (ja) 1995-03-13 1996-09-24 Unisia Jecs Corp 鼻腔用投薬器
JP3308426B2 (ja) 1995-04-12 2002-07-29 株式会社ユニシアジェックス 鼻腔用投薬器
DE19518810A1 (de) 1995-05-26 1996-11-28 Bayer Ag Nasal-Applikator
JPH08322934A (ja) 1995-05-29 1996-12-10 Unisia Jecs Corp 鼻腔用投薬器
JP3320261B2 (ja) 1995-06-01 2002-09-03 株式会社ユニシアジェックス 吸入式投薬器
JP3098401B2 (ja) 1995-07-12 2000-10-16 株式会社エルティーティー研究所 経鼻投与用製剤
JPH0928805A (ja) 1995-07-24 1997-02-04 Unisia Jecs Corp 鼻腔用投薬器
CN1155440A (zh) 1995-10-09 1997-07-30 株式会社优尼希雅杰克斯 用于装满粉末状药品的胶囊的喷药器
JP3317827B2 (ja) 1995-10-09 2002-08-26 株式会社ユニシアジェックス 投薬器
JP3317828B2 (ja) 1995-10-09 2002-08-26 株式会社ユニシアジェックス 投薬器
JP3197221B2 (ja) 1996-02-27 2001-08-13 帝人株式会社 吸収性が改善された粉末状経鼻投与組成物
JP3634380B2 (ja) 1996-02-27 2005-03-30 帝人株式会社 粉末状経鼻投与組成物
JP3197223B2 (ja) 1996-02-28 2001-08-13 帝人株式会社 即効性と持続性を兼ね備えた粉末状経鼻投与用組成物
JP3328131B2 (ja) 1996-03-15 2002-09-24 株式会社ユニシアジェックス 吸入式投薬器
JPH09253208A (ja) 1996-03-21 1997-09-30 Unisia Jecs Corp 鼻腔用投薬器
FR2746676B1 (fr) 1996-04-02 1998-05-22 Valois Dispositif de distribution d'une dose unique de produit fluide
JPH09276405A (ja) 1996-04-15 1997-10-28 Unisia Jecs Corp 鼻腔用投薬器
AUPN976496A0 (en) 1996-05-10 1996-05-30 Glaxo Wellcome Australia Ltd Unit dose dispensing device
JPH1028735A (ja) 1996-05-11 1998-02-03 Unisia Jecs Corp 鼻腔用投薬器
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5839623A (en) * 1996-07-29 1998-11-24 Pure Vision International, L.L.P. Reusable pressure spray container
JP3020141B2 (ja) 1996-10-07 2000-03-15 株式会社富士薬品 経鼻投与用製剤
GB9700624D0 (en) 1997-01-14 1997-03-05 Danbiosyst Uk Drug delivery composition
EP1350532B1 (en) 1997-01-30 2008-04-09 Hitachi, Ltd. Capsule type powder Inhaler
FR2764807B1 (fr) 1997-06-18 1999-08-20 Valois Sa Dispositif de distribution nasale d'un produit fluide ou pulverulent
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
AU756693B2 (en) 1997-09-29 2003-01-23 Novartis Ag Stabilized bioactive preparations and methods of use
RU2184570C2 (ru) 1997-09-30 2002-07-10 Дайити Фармасьютикал Ко., Лтд. Препараты для орального введения
FR2771012B1 (fr) 1997-11-17 2000-03-10 Sofab Pulverisateur nasal
JP3547605B2 (ja) 1998-01-07 2004-07-28 株式会社日立ユニシアオートモティブ 鼻腔用投薬器
JPH11216357A (ja) 1998-02-03 1999-08-10 Tsutsumi Techno Planning Kk 生理活性物質用の吸着担体
JP3530004B2 (ja) 1998-02-06 2004-05-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
JP3488624B2 (ja) 1998-02-18 2004-01-19 株式会社日立ユニシアオートモティブ 鼻腔用投薬器
GB9807232D0 (en) 1998-04-03 1998-06-03 Univ Cardiff Aerosol composition
JPH11322582A (ja) 1998-05-06 1999-11-24 Dot:Kk 経鼻吸収用鼻粘膜付着・滞留型キャリヤ
GT199900061A (es) 1998-05-15 2000-10-14 Pfizer Formulaciones farmaceuticas.
WO1999062560A1 (en) 1998-06-05 1999-12-09 Warner-Lambert Company Stabilization of compositions containing ace inhibitors using magnesium oxide
TWI223598B (en) 1998-06-22 2004-11-11 Pfizer Ireland Pharmaceuticals An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
FR2782024B1 (fr) 1998-08-04 2000-10-13 Valois Sa Tete de distribution et dispositif de distribution de produit fluide comportant une telle tete
EP1108423B1 (en) 1998-08-26 2005-03-30 Teijin Limited Powdery pernasal compositions
US6428805B1 (en) 1998-08-26 2002-08-06 Teijin Limited Powdery nasal compositions
EP1143896B1 (en) 1998-10-20 2006-12-13 The University of North Carolina at Chapel Hill Methods of hydrating the nasal mucosal surface
SE9803770D0 (sv) 1998-11-05 1998-11-05 Astra Ab Dry powder pharmaceutical formulation
GB9828721D0 (en) 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
ID28302A (id) 1999-01-14 2001-05-10 Teijin Ltd Alat untuk mengumpankan suatu bubuk dalam jumlah tertentu
JP2000229859A (ja) 1999-02-12 2000-08-22 Teijin Ltd 安定なブプレノルフィン経鼻製剤
JP2000239187A (ja) 1999-02-22 2000-09-05 Dotto:Kk 経鼻吸収用組成物
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
GB0114272D0 (en) 2001-06-12 2001-08-01 Optinose As Nasal delivery device
CN1736502A (zh) 1999-03-03 2006-02-22 奥普蒂诺斯公司 鼻传送装置
JP3912469B2 (ja) 1999-05-13 2007-05-09 セイコーエプソン株式会社 偽造印刷物判定用インク
US6290667B1 (en) 1999-06-11 2001-09-18 Health & Technology, Inc. Nasal aspirator
JP2001055323A (ja) 1999-08-12 2001-02-27 Teijin Ltd 粉末状経鼻投与用組成物
US6197328B1 (en) 1999-08-20 2001-03-06 Dott Research Laboratory Nasally administrable compositions
JP3678955B2 (ja) 1999-09-28 2005-08-03 株式会社日立製作所 鼻腔用投薬器
JP4691298B2 (ja) 1999-10-12 2011-06-01 科研製薬株式会社 粉末吸入用製剤及びその製造方法
DE10049392A1 (de) 1999-10-14 2001-04-19 Becton Dickinson Co Flüssigkeits-Ausgabevorrichtung
GB9925934D0 (en) 1999-11-03 1999-12-29 Glaxo Group Ltd Novel apparatus and process
ATE267582T1 (de) 2000-01-20 2004-06-15 Basilea Pharmaceutica Ag Nasal verabreichbare cyclische antimykotische peptidzusammensetzungen
US6644305B2 (en) 2000-04-14 2003-11-11 Trudell Medical International Nasal inhaler
BR0106729B1 (pt) 2000-06-12 2009-08-11 dispositivo de administração de multiplas doses de medicamento em pó.
US6494204B1 (en) 2000-06-23 2002-12-17 Pedro D. Ponce Nasal medication administering device
DE10031043A1 (de) 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
IT1317998B1 (it) 2000-06-26 2003-07-21 Medical Internat Licensing N V Valvola erogatrice per spray nasale.
US6981660B2 (en) * 2000-09-25 2006-01-03 Evit Labs Shock wave aerosolization apparatus and method
GB2367756B (en) 2000-10-12 2003-01-08 Bespak Plc Dispensing apparatus
AU2440802A (en) 2000-10-18 2002-04-29 Massachusetts Inst Technology Methods and products related to pulmonary delivery of polysaccharides
DE20018518U1 (de) * 2000-10-28 2001-02-01 Boehringer Ingelheim Pharma KG, 55218 Ingelheim Zerstäuber für Nasenspray
US6595210B2 (en) 2000-11-27 2003-07-22 Unisia Jecs Corporation Inhalator for administering powder composition
FR2817847B1 (fr) 2000-12-08 2003-03-28 Tebro Dispositif de distribution de produit fluide ou pulverulent
US6782887B2 (en) * 2001-01-12 2004-08-31 Becton, Dickinson And Company Medicament respiratory delivery device and cartridge
JP2002255795A (ja) 2001-02-26 2002-09-11 Teijin Ltd 経鼻投与用組成物
ZA200306564B (en) 2001-02-26 2004-10-15 Optinose As Nasal devices.
US20020174865A1 (en) 2001-03-01 2002-11-28 Gatton Brian M. Nasal spray apparatus and system
DE10121232C2 (de) * 2001-04-30 2003-10-02 Braun Gmbh E Vorrichtung zum Verabreichen von Medikamenten
DE60227660D1 (de) 2001-05-24 2008-08-28 Alexza Pharmaceuticals Inc Freisetzung von antiemetika auf dem inhalationsweg
GB0112888D0 (en) 2001-05-26 2001-07-18 Innovata Biomed Ltd Device
KR20030027108A (ko) 2001-07-05 2003-04-03 트렌스레셔널 리서치 가부시키가이샤 인슐린의 경비 투여용 조성물
JP3513660B2 (ja) 2001-07-30 2004-03-31 日立化成工業株式会社 感光性樹脂組成物積層体
US8337816B2 (en) 2001-09-17 2012-12-25 Glaxo Group Limited Dry powder medicament formulations
ES2292848T3 (es) 2001-10-12 2008-03-16 Elan Pharma International Limited Composiciones que tienen una combinacion de caracteristicas de liberacion inmediata y liberacion controlada.
JP3975327B2 (ja) 2001-11-19 2007-09-12 株式会社 バイオアクティス 鼻腔用粉状薬剤施薬装置
WO2003045357A1 (en) 2001-11-27 2003-06-05 Transform Pharmaceuticals, Inc. Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
JP2003175103A (ja) 2001-12-12 2003-06-24 Teijin Ltd 粉末薬剤多回投与器
FR2834212B1 (fr) 2001-12-27 2004-07-09 Besins Int Belgique Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques
JP4212019B2 (ja) 2002-01-09 2009-01-21 Ｔｒａｎｓｌａｔｉｏｎａｌ Ｒｅｓｅａｒｃｈ 株式会社 薬物の経鼻投与用組成物
EP1467790A1 (en) * 2002-01-25 2004-10-20 Glaxo Group Limited Medicament dispenser
AU2003225777B2 (en) 2002-03-12 2008-04-10 Microdose Therapeutx, Inc. Site specific delivery of co-administered drugs via inhalation
AU2003209851A1 (en) 2002-03-20 2003-09-29 The University Of Queensland Method of treatment and/or prophylaxis
JP3950738B2 (ja) 2002-05-14 2007-08-01 株式会社 バイオアクティス 鼻腔用粉状薬剤施薬装置
SI1531794T1 (sl) 2002-06-28 2017-12-29 Civitas Therapeteutics, Inc. Epinefrin za vdihavanje
GB0215270D0 (en) 2002-07-02 2002-08-14 Optinose As Nasal devices
US7115281B2 (en) 2002-07-08 2006-10-03 Ranbaxy Laboratories Limited Processes for the preparation of oral dosage formulations of modafinil
GB0215904D0 (en) 2002-07-09 2002-08-21 Team Holdings Uk Ltd Drug delivery system and method
US6855913B2 (en) 2002-08-06 2005-02-15 Hobart Brothers Company Flux-cored wire formulation for welding
US20060024185A1 (en) 2002-09-03 2006-02-02 Aakerman Aake Nasal sprays
DE10244795A1 (de) 2002-09-26 2004-04-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
GB2395900A (en) 2002-12-04 2004-06-09 Elan Drug Delivery Ltd Therapeutic composition for respiratory delivery
GB0228826D0 (en) 2002-12-11 2003-01-15 Okpala Joseph Hair technology in creating particles with improved delivery capabilities
US20040173211A1 (en) 2003-01-14 2004-09-09 Boehringer Ingelheim International Gmbh Powder inhaler
NZ541167A (en) 2003-01-31 2008-07-31 Orexo Ab A rapid-acting pharmaceutical composition comprising e.g. fentanyl and particles insoluble in water
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
JP4136724B2 (ja) 2003-03-05 2008-08-20 株式会社日立製作所 鼻腔用投薬器
WO2004082506A1 (de) 2003-03-21 2004-09-30 Alfred Schmid Ag Gossau Mischkapsel
AU2003220808B2 (en) 2003-03-27 2008-08-21 Bioactis Limited Powder medicine applicator for nasal cavity
GB2400565B (en) 2003-04-17 2005-03-02 Bespak Plc Nasal drug delivery
KR20060015641A (ko) 2003-06-06 2006-02-17 글락소 그룹 리미티드 트립탄 및 ｎｓａｉｄ를 포함하는 조성물
US7954491B2 (en) 2003-06-13 2011-06-07 Civitas Therapeutics, Inc. Low dose pharmaceutical powders for inhalations
GB2403153A (en) 2003-06-26 2004-12-29 Bespak Plc Hand held nasal dispensing device
US20050042177A1 (en) 2003-07-23 2005-02-24 Elan Pharma International Ltd. Novel compositions of sildenafil free base
EP1673123A2 (en) 2003-09-05 2006-06-28 Kurve Technology, Inc. Integrated nebulizer and particle dispersing chamber for delivery of medicament
CN100515511C (zh) 2003-10-09 2009-07-22 株式会社;生命科学活效 鼻腔用粉状药剂施药装置
GB0328186D0 (en) 2003-12-05 2004-01-07 West Pharm Serv Drug Res Ltd Intranasal compositions
DE102004012093A1 (de) * 2004-03-05 2005-09-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator mit Merkanaldüse
US8545881B2 (en) 2004-04-19 2013-10-01 Eurand Pharmaceuticals, Ltd. Orally disintegrating tablets and methods of manufacture
CN101098678A (zh) 2004-04-23 2008-01-02 锡德克斯公司 含有磺基烷基醚环糊精的dpi制剂
WO2006016530A1 (ja) 2004-08-10 2006-02-16 Translational Research, Ltd. 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
GB0420513D0 (en) 2004-09-15 2004-10-20 Optinose As Powder delivery devices
US9283335B2 (en) 2004-10-06 2016-03-15 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing powder
MX2007004495A (es) 2004-10-15 2007-05-10 Pfizer Prod Inc Composiciones y procedimientos para la administracion intranasal, bucal, sublingual y pulmonar de vareniclina.
JP2006122189A (ja) 2004-10-27 2006-05-18 Fumio Saito パウダー点鼻薬用噴霧容器
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
GB0503738D0 (en) 2005-02-23 2005-03-30 Optinose As Powder delivery devices
US7708025B2 (en) * 2005-03-07 2010-05-04 Colder Products Company Poppet valve member
CN100431634C (zh) 2005-04-04 2008-11-12 陈庆堂 干粉气溶胶化吸入器
JP2006314627A (ja) * 2005-05-13 2006-11-24 Hitachi Ltd 粉末薬剤投与器
CA2617909C (en) 2005-08-05 2014-02-04 3M Innovative Properties Company Compositions exhibiting improved flowability
US8591457B2 (en) 2005-08-10 2013-11-26 Alza Corporation Method for making a needle-free jet injection drug delivery device
EP1843770B1 (en) 2005-08-29 2008-06-18 Teva Pharmaceutical Industries Ltd Solid particulate tadalafil having a bimodal particle size distribution
US8106100B2 (en) 2005-12-06 2012-01-31 Asahi Kasei Chemicals Corporation Process for producing tablet by high-speed direct compression
CA2630240A1 (en) 2006-01-31 2007-08-09 Teva Pharmaceutical Industries Ltd. Oxcarbazepine pharmaceutical formulation and its method of preparation, wherein oxcarbazepine has a broad and multi-modal particle size distribution
GB2433207B (en) 2006-02-21 2009-01-07 Jianhe Li Active suction actuated inhalers with timing devices
GB0604444D0 (en) 2006-03-06 2006-04-12 Optinose As Nasal devices
TW200811104A (en) 2006-04-25 2008-03-01 Theravance Inc Crystalline forms of a dimethylphenyl compound
US7806117B2 (en) 2006-06-07 2010-10-05 Shin Nippon Biomedical Laboratories, Ltd. Peroral powder delivery device
US20080031959A1 (en) 2006-07-28 2008-02-07 Blondino Frank E Anti-migraine oral spray formulations and methods
US20080029084A1 (en) 2006-08-04 2008-02-07 Nastech Pharmaceutical Company Inc. Device for improved peptide delivery
US8360056B2 (en) 2006-08-31 2013-01-29 Hitachi, Ltd. Medicine sprayer
AU2007294547A1 (en) 2006-09-07 2008-03-13 Parion Sciences, Inc. Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
US8327848B2 (en) 2006-09-28 2012-12-11 Ric Investments, Llc Pressure reducing valve
WO2008061250A2 (en) 2006-11-16 2008-05-22 Ventus Medical, Inc. Adjustable nasal devices
GB0625322D0 (en) 2006-12-19 2007-01-24 Pharmakodex Ltd Pharmaceutical compositions
US8337817B2 (en) 2006-12-26 2012-12-25 Shin Nippon Biomedical Laboratories, Ltd. Preparation for transnasal application
GB2448183A (en) 2007-04-05 2008-10-08 Optinose As Nasal powder delivery device
JP2009076785A (ja) 2007-09-21 2009-04-09 Panasonic Corp 半導体装置の製造方法
GB0719299D0 (en) * 2007-10-03 2007-11-14 Optinose As Nasal delivery devices
US8486043B2 (en) 2007-10-12 2013-07-16 Map Pharmaceuticals, Inc. Inhalation drug delivery
WO2009095684A1 (en) 2008-02-01 2009-08-06 Vectura Limited Pulmonary formulations of triptans
WO2010131486A1 (en) 2009-05-15 2010-11-18 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
JP4986192B2 (ja) 2009-06-12 2012-07-25 伸晃化学株式会社 投薬容器
WO2011013003A2 (en) 2009-07-31 2011-02-03 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
CA2825541C (en) 2011-01-31 2020-06-02 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
ES3034743T3 (en) 2014-06-25 2025-08-22 Optinose Inc Nasal administration
JP6416004B2 (ja) 2015-01-30 2018-10-31 株式会社吉野工業所 粉体投与容器
JP6384834B2 (ja) 2015-01-30 2018-09-05 株式会社吉野工業所 粉体投与容器
WO2019054121A1 (ja) 2017-09-15 2019-03-21 株式会社新日本科学 薬剤保管用のノズル付きカートリッジとその噴射器、および鼻腔用粉状薬剤施薬装置
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices

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