CH235945A - Verfahren zur Darstellung eines Calciumsalzes eines Sulfonamids. - Google Patents

Verfahren zur Darstellung eines Calciumsalzes eines Sulfonamids.

Info

Publication number
CH235945A
CH235945A CH235945DA CH235945A CH 235945 A CH235945 A CH 235945A CH 235945D A CH235945D A CH 235945DA CH 235945 A CH235945 A CH 235945A
Authority
CH
Switzerland
Prior art keywords
sep
preparation
sulfonamide
calcium salt
amino
Prior art date
Application number
Other languages
English (en)
Inventor
Dr. A. Wander Ag.
Original Assignee
Wander Ag Dr A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wander Ag Dr A filed Critical Wander Ag Dr A
Publication of CH235945A publication Critical patent/CH235945A/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • C07D231/48—Oxygen atom in position 3 or 5 and nitrogen atom in position 4 with hydrocarbon radicals attached to said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description


      Yerfaliren        zur    Darstellung eines     Caleiumsalzes    eines     Sulfonamids.     
EMI0001.0005     
  
    -Im <SEP> Hauptpatent <SEP> wt <SEP> ein <SEP> Verfahren <SEP> zur
<tb>  Herstellung <SEP> von <SEP> organischen <SEP> Salzen <SEP> der
<tb>  p-Amino-benzolsulfonyl-a-amino-.pyriidin-Bz  N-methylensulfosä,uTe <SEP> beschrieben.     
EMI0001.0006     
  
    Es <SEP> wurde <SEP> nun: <SEP> gefunden, <SEP> .dass <SEP> das <SEP> Caleivnm  salz@ <SEP> der <SEP> erwähnten <SEP> Säure <SEP> der <SEP> folgenden
<tb>  Formel <SEP> .

       
EMI0001.0007     
    hohen     therapeutischen        Wert    und     gute        Ver-          traglichkeit    besitzt und sich ausserdem durch       ausserordentlich    leichte     Wasserlöslichkeit        aus-          zeichnet.    Die 10%ige     wässerige        Lösung        hat     ein     p$    von 6,7.  



       Gegenstand:    des vorliegenden     Patentes        ist     ein Verfahren zur     Darstellung        des    oben ge  nannten     Calciumsalzes,    welches dadurch     ge-          kennzeichnet    ist, dass man eine basische     Cal-          ciumverbindung,    z.

   B.     Calciumcarbonat    oder       Calciumhydrogyd,        gegebenenfalls    in der  Wärme, oder auch     Calciumogyd    in     Gegen-          wart    ' von Wasser auf die p-Amino,-benzol-         sulfonyl    -a-     am@iuo-pyridini-B.z-N-        methylen-          suulfosäun    einwirken     lässt    und das     Reaktions-          produkt        in,        Gegenwart    von Alkohol,

       beispiels-          weise    von     Äthyl-    oder     Isopropylalkohol,        zur     Kristallisation bringt.  



  <I>Beispiel 1:</I>  68,6 g     p--Amiuo-benzolsulfonyl-a-amina-          pyridin-Bz-N-methylensulfosäure        lässt    man  mit 11 g     Calciumcarbonat        in    250     cm3    Wasser  bei     mässiger    Wärme     reagieren,    bis die     Ent-          wicklung    von<B>CO,</B> aufgehört hat,     filtriert         und versetzt die     klare    Lösung mit 2000     cms          Isopro@pylalkohol.     



  Das neue     Salz    kristallisiert in schöne Na  deln     mit    2     Mol.        gristallwasIser.     



  <I>" Beispiel 2:</I>  15 g     Calciumogyd        versetzt    man zuerst  mit wenig, dann mit 250     cm3    Wasser, fügt  85,84 g     p-Amino-benzal@sulfonyl-a-amino-          pyTidin-Bz-N-methylensulfosäure    hinzu, wo  bei     unter        Umrühren    bei mässigem     Erwärmen     Auflösung     erfolbgt.    Man filtriert und     versetzt     ,

  das Filtrat mit 1250     ein'        Isopropylalkohol.     Die neue     Calciumv'orbindung        wird        dadurch          ausgefällt.    Das weisse, leicht     wasserlösliche     Pulver enthält     kein;        Kristallwasser.

Claims (1)

  1. PATENTANSPRUCH: Verfahren zur Darstellung eines Calcium- salzes eines Sulfonamides, dadurch gekenn zeichnet, dass man eine basische Caleium- verbindung auf dio p-Amino-benzolsu-lfanyl- a - amino - pyridin -Bz -N - methylensulfosäure einwirken lässt und das Reaktionsprodukt in Gegenwart eines Alkohols zur Kristallisation bringt.
    Das neue Produkt ist in Wasser sehr leicht löslich. Die 10%ige wässerige Lösung hat einen pH-Wert von 6,7.
CH235945D 1942-09-19 1942-09-19 Verfahren zur Darstellung eines Calciumsalzes eines Sulfonamids. CH235945A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH235945T 1942-09-19
CH228551T 1943-04-06

Publications (1)

Publication Number Publication Date
CH235945A true CH235945A (de) 1944-12-31

Family

ID=25727224

Family Applications (1)

Application Number Title Priority Date Filing Date
CH235945D CH235945A (de) 1942-09-19 1942-09-19 Verfahren zur Darstellung eines Calciumsalzes eines Sulfonamids.

Country Status (1)

Country Link
CH (1) CH235945A (de)

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