CH235946A - Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem 4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolon. - Google Patents

Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem 4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolon.

Info

Publication number
CH235946A
CH235946A CH235946DA CH235946A CH 235946 A CH235946 A CH 235946A CH 235946D A CH235946D A CH 235946DA CH 235946 A CH235946 A CH 235946A
Authority
CH
Switzerland
Prior art keywords
amino
phenyl
pyridine
dimethylamino
acid
Prior art date
Application number
Other languages
English (en)
Inventor
Dr. A. Wander Aktiengesellschaft
Original Assignee
Wander Ag Dr A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wander Ag Dr A filed Critical Wander Ag Dr A
Publication of CH235946A publication Critical patent/CH235946A/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • C07D231/48—Oxygen atom in position 3 or 5 and nitrogen atom in position 4 with hydrocarbon radicals attached to said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Description


  Verfahren zur Herstellung von     p-amino-benzolsulfonyl-a-amino-pvridin-Bz-N-          methylensulfosaurem        4-Dimethylamino-l-phenyl-2,3-dimethylpyrazolon.       Im     Üauptpatent    ist     ein.    Verfahren zur       Herstellung    von     p-amino--benzolsulfonyl-a-          amino    ,     pyxidin    -     Bz    - N-     methylensulfosaurem          Hegametihylentetramin    durch Einwirkung  .der     freien    Säure auf     Hegamethylentetramin     beschrieben.  



  Es     wurde    nun     gefunden,    dass man     thera          peutisch    ebenso     wertvolle    Salze der genann  ten Säure     erhält,        wenn    man diese auf ein       Pyrazolon    einwirken lässt.  



       Gegenstand    ,des vorliegenden Patentes ist  ein Verfahren zur Herstellung von     p-amino-          benzolsulfonyl    - a -     amino    -     pyridin    - Bz - N     -          methylemulfosaurem        4-Dimethylamino-l-          phenyl-2,3-dimethyl-pyrazolon,    welches     da-          ,durch        gekennzeichnet        ist,

      dass man     p-Amino-          benzolsulfonyl    - a -     amino    -     pyridin    - Bz - N     -          methylensulfosäure    in Gegenwart eines mit  Wasser mischbaren Alkohols auf     4-Dimethyl-          amino-l-phenyl-2,3-@dimethyl-pyrazolon    ein  wirken lässt.

      <I>Beispiel:</I>  59,7     ,g        p-Amino-benzalsulfonyl-a-amino-          pyridin-Bz-N-methylensu:lfosäure    und 40,3 g       4-Dimethylenamino-l-phenyl-2,3-dimethyl-,          pyrazolon    lösen sich in 100 cm' Wasser     unter     Umrühren     auf.    Nach     Zusatz    von 650     cm3     eines mit     Wasser        mischbaren    Alkohols,     bei-          spiehweise        Äthanol,        kristallisiert    allmählich,  gegebenenfalls im Eisschrank,

       das        p-amino-          benzolsulfonyl    - a -     amino    -     pyridin    - Bz - N     -          methylensul'fo@saure    4 -     Dimethylenamnno        -1-          phenyf-2,3-cUmethyl-pyrazolon    in Form von  weissen     Nädelchen    in dichten seidigen Bü  scheln     auso;        sie    schmelzen     unter        Zersetzung     bei     130     C.

   Das neue Salz ist überraschender  weise     in    jedem     Verhältnis    in Wasser     läslich          und        soll,    besonders in     Lösung    zu Injektionen,  therapeutisch angewandt werden.

Claims (1)

  1. PATENTANSPRUCH: Verfahren zur Herstellung von p-amino- benzolsulfonyl - a - amino - pyridin - Bz - N- methylensulf osaurem 4 - Dimethylamino -1- phenyl-2,3-dimethyl-pyrazolon, dadurch ge- kennzeichnet,
    dass man p - Amino - benzol - sulfonyl -a- amino-pyridin- Bz - N - methylen- su,Ifosäure in Gegenwart eines mit Wasser mischbaren Alkohols auf 4-Dimethylamino- 1-phenyl - 2,3 - dimethyl-pyrazolon einwirken lässt. Das neue Produkt bildet weisse Nädelchen, die bei 130 C unter Zersetzung schmelzen.
    Es ist in Wasser in jedem Verhältnis löslich.
CH235946D 1942-05-02 1942-05-02 Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem 4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolon. CH235946A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH235946T 1942-05-02
CH228551T 1943-04-06

Publications (1)

Publication Number Publication Date
CH235946A true CH235946A (de) 1944-12-31

Family

ID=25727225

Family Applications (1)

Application Number Title Priority Date Filing Date
CH235946D CH235946A (de) 1942-05-02 1942-05-02 Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem 4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolon.

Country Status (1)

Country Link
CH (1) CH235946A (de)

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