CH236538A - Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem Natrium. - Google Patents

Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem Natrium.

Info

Publication number
CH236538A
CH236538A CH236538DA CH236538A CH 236538 A CH236538 A CH 236538A CH 236538D A CH236538D A CH 236538DA CH 236538 A CH236538 A CH 236538A
Authority
CH
Switzerland
Prior art keywords
amino
sulfonic acid
benzenesulfonyl
pyridine
methylene
Prior art date
Application number
Other languages
English (en)
Inventor
Dr. A. Wander Aktiengesellschaft
Original Assignee
Wander Ag Dr A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wander Ag Dr A filed Critical Wander Ag Dr A
Publication of CH236538A publication Critical patent/CH236538A/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • C07D231/48—Oxygen atom in position 3 or 5 and nitrogen atom in position 4 with hydrocarbon radicals attached to said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Description


  verfahren zur Herstellung von     p-amino-benzolsulfonyl-a-amino-pyridin-Bz-N-          methylensulfosaurem    Natrium.    Im Hauptpatent ist ein Verfahren zur  Herstellung von     p-amino-benzolsulfonyl-a-          amino    -     pyridin    - Bz - N     -methylensulfosaurem          Hexamethylentetramin    durch Umsetzung der  freien Säure mit     Hexamethylentetramin    be  schrieben.  



  Das     Natriumsalz    der genannten Säure ist  nun     zwar    bereits bekannt     (schweiz.    Patent  Nr. 214045), doch wurde es bisher durch     Ein-          wirkung    von     Formaldehydnatriumbisulfit    auf       p-Amino-benzolsulfon-a-amino-pyridin    herge  stellt.  



  Es wurde nun     gefunden,    dass man dieses       Natriumsalz    auch direkt durch     Einwirkung     von     Itznatron    auf     p-Amino-benzolsulfonyl-          a        -amino-        pyridin    -Bz -N -     methylensulf        osäure     herstellen kann, wobei es sich überraschender  weise herausstellte, dass das so erhaltene  Produkt viel reiner ist als das nach dem be  kannten Verfahren hergestellte.

           p-Amino-benzolsulf        onyl    -a -     amino-pyridin-Bz-          N-methylensulfosäure    eingetragen. Nach er  folgter Auflösung wird     filtriert,    mit einem  mit Wasser mischbaren Alkohol, beispiels  weise mit 900 cm'     Athanol,    versetzt und,  gegebenenfalls im Eisschrank, der Kristalli  sation überlassen.

   Das     p-amino-benzolsul-          fonyl    -<B>,</B>a-     amino        -pyridin-Bz-N-methylensulf        o-          saure    Natrium kristallisiert in Form kleiner       weisser        Nädelchen;    es     ist    in Wasser mit neu  traler Reaktion sehr gut löslich.  



  Man erhält mittels dieser     Darstellungsart     ein sehr reines Endprodukt.

Claims (1)

  1. PATENTANSPRUCH: Verfahren zur Herstellung von p-amino- benzolsulf onyl-a-amino - pyri din-Bz-N-methy- lensulfosaurem Natrium, dadurch gekenn zeichnet, dass man Amino-benzolsulfonyl-a- amino-pyridin-Bz-N-methylensulfosäure und Atznatron aufeinander einwirken läBt. <I>Beispiel:</I> 28 g Natriumhydroxyd werden in 400 cm' Wasser aufgelöst und in diese Lösung 171,5 g
CH236538D 1943-04-06 1943-04-06 Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem Natrium. CH236538A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH228551T 1943-04-06
CH236538T 1943-04-06

Publications (1)

Publication Number Publication Date
CH236538A true CH236538A (de) 1945-02-15

Family

ID=25727230

Family Applications (1)

Application Number Title Priority Date Filing Date
CH236538D CH236538A (de) 1943-04-06 1943-04-06 Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem Natrium.

Country Status (1)

Country Link
CH (1) CH236538A (de)

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