CL2004000498A1 - Polimorfo alpha, beta, gamma de rifaximina; procesos para la preparacion de dichos polimorfos; composicion farmaceutica que comprende dichos polimorfos, utiles como antibacterianos. - Google Patents
Polimorfo alpha, beta, gamma de rifaximina; procesos para la preparacion de dichos polimorfos; composicion farmaceutica que comprende dichos polimorfos, utiles como antibacterianos.Info
- Publication number
- CL2004000498A1 CL2004000498A1 CL200400498A CL2004000498A CL2004000498A1 CL 2004000498 A1 CL2004000498 A1 CL 2004000498A1 CL 200400498 A CL200400498 A CL 200400498A CL 2004000498 A CL2004000498 A CL 2004000498A CL 2004000498 A1 CL2004000498 A1 CL 2004000498A1
- Authority
- CL
- Chile
- Prior art keywords
- polymorphes
- useful
- rifaximina
- rifaxymin
- antibacterial
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- NZCRJKRKKOLAOJ-XRCRFVBUSA-N rifaximin Chemical compound OC1=C(C(O)=C2C)C3=C4N=C5C=C(C)C=CN5C4=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O NZCRJKRKKOLAOJ-XRCRFVBUSA-N 0.000 abstract 5
- 238000002425 crystallisation Methods 0.000 abstract 2
- 230000008025 crystallization Effects 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241000123326 Fomes Species 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 229960003040 rifaximin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/02—Induction heating
- H05B6/10—Induction heating apparatus, other than furnaces, for specific applications
- H05B6/12—Cooking devices
- H05B6/1209—Cooking devices induction cooking plates or the like and devices to be used in combination with them
- H05B6/1236—Cooking devices induction cooking plates or the like and devices to be used in combination with them adapted to induce current in a coil to supply power to a device and electrical heating devices powered in this way
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/02—Induction heating
- H05B6/10—Induction heating apparatus, other than furnaces, for specific applications
- H05B6/12—Cooking devices
- H05B6/1209—Cooking devices induction cooking plates or the like and devices to be used in combination with them
- H05B6/1245—Cooking devices induction cooking plates or the like and devices to be used in combination with them with special coil arrangements
- H05B6/1263—Cooking devices induction cooking plates or the like and devices to be used in combination with them with special coil arrangements using coil cooling arrangements
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Abstract
FOMAS CRISTALINAS DEL ANTOBIOTICO RIFAXIMINA (INN) DENOMINADAS RIFAXIMINA a Y RIFAXIMINA b Y UNA FORMA POBREMENTE CRIATALINA DENOMINADA RIFAXIMINA y. ESTAS FORMAS SON DE UTILIDAD EN LA PRODUCCION DE PREPARACIONES MEDICINALES PARA USO POR VIA ORAL Y TOPICA Y SE PUEDE OBTENER POR MEDIO DE UN PROCESO DE CRISTALIZACION LLEVADO A CABO POR DISOLUCION EN CALIENTE DE LA RIFAXIMINA CRUDA EN ALCOHOL ETILICO Y POR CRISTALIZACION DEL PRODUCTO MEDIANTE LA ADICION DE AGUA A UNA TEMPERATURA DETERMINADA Y POR UN PERIODO DE TIEMPO DETERMINADO. LA CRISTALIZACION ES SEGUIDA DE UN SECADO LLVADO ACABO BAJO CONDICIONES CONTROLADAS HASTA ALCANZAR UN CONTENIDO DE AGUA ESPECIFICO EN EL PRODUCTO FINAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002144A ITMI20032144A1 (it) | 2003-11-07 | 2003-11-07 | Forme polimorfe di rifaximina, processi per ottenerle e |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2004000498A1 true CL2004000498A1 (es) | 2005-03-11 |
Family
ID=33187382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200400498A CL2004000498A1 (es) | 2003-11-07 | 2004-03-11 | Polimorfo alpha, beta, gamma de rifaximina; procesos para la preparacion de dichos polimorfos; composicion farmaceutica que comprende dichos polimorfos, utiles como antibacterianos. |
Country Status (37)
| Country | Link |
|---|---|
| US (5) | US7045620B2 (es) |
| EP (6) | EP1676847B1 (es) |
| JP (5) | JP2005139161A (es) |
| KR (4) | KR20050043589A (es) |
| CN (4) | CN1613858A (es) |
| AR (3) | AR043547A1 (es) |
| AT (3) | ATE361927T1 (es) |
| AU (2) | AU2004200964A1 (es) |
| BR (2) | BRPI0402382A (es) |
| CA (2) | CA2460384A1 (es) |
| CL (1) | CL2004000498A1 (es) |
| CO (1) | CO5560083A1 (es) |
| CY (3) | CY1108017T1 (es) |
| DE (4) | DE602004019296D1 (es) |
| DK (3) | DK1557421T3 (es) |
| ES (3) | ES2244364T3 (es) |
| HR (2) | HRP20040265A2 (es) |
| IL (2) | IL160798A0 (es) |
| IT (1) | ITMI20032144A1 (es) |
| JO (1) | JO2470B1 (es) |
| MA (1) | MA27069A1 (es) |
| MD (1) | MD3653G8 (es) |
| ME (1) | ME00424B (es) |
| MX (2) | MXPA04002353A (es) |
| NO (1) | NO334950B1 (es) |
| NZ (1) | NZ531622A (es) |
| PL (3) | PL1557421T3 (es) |
| PT (3) | PT1557421E (es) |
| RS (4) | RS54571B1 (es) |
| RU (1) | RU2270200C2 (es) |
| SI (3) | SI1676848T1 (es) |
| TN (2) | TNSN04044A1 (es) |
| TW (1) | TWI285107B (es) |
| UA (1) | UA86384C2 (es) |
| WO (1) | WO2005044823A2 (es) |
| YU (1) | YU24804A (es) |
| ZA (1) | ZA200401948B (es) |
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| US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US7902206B2 (en) * | 2003-11-07 | 2011-03-08 | Alfa Wassermann, S.P.A. | Polymorphic forms α, β and γ of rifaximin |
| ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
| US7923553B2 (en) * | 2003-11-07 | 2011-04-12 | Alfa Wassermann, S.P.A. | Processes for the production of polymorphic forms of rifaximin |
| US7906542B2 (en) * | 2004-11-04 | 2011-03-15 | Alfa Wassermann, S.P.A. | Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin |
| US20080262024A1 (en) * | 2003-11-07 | 2008-10-23 | Giuseppe Claudio Viscomi | Rifaximin compositions and method of use |
| SI1698630T1 (sl) | 2005-03-03 | 2015-01-30 | Alfa Wassermann S.P.A. | Nove polimorfne oblike rifaksimina, postopki za njihovo pripravo in njihova uporaba v medicinskih pripravkih |
| ITBO20050123A1 (it) * | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
| JP5844961B2 (ja) | 2006-08-02 | 2016-01-20 | サリックス ファーマシューティカルズ, インコーポレイテッド | 放射線直腸s状結腸炎を処置するための組成物および方法 |
| ITMI20061692A1 (it) | 2006-09-05 | 2008-03-06 | Alfa Wassermann Spa | Uso di polioli per ottenere forme polimorfe stabili di rifaximina |
| EP2069363B1 (en) * | 2006-09-22 | 2013-03-20 | Cipla Ltd. | Rifaximin in an amorphous form |
| US20080159987A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Restless Legs Syndrome |
| US20080161337A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Chronic Prostatitis |
| ITMI20071241A1 (it) * | 2007-06-20 | 2008-12-21 | Solmag S P A | Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta |
| AU2008273699A1 (en) * | 2007-07-06 | 2009-01-15 | Lupin Limited | Pharmaceutical compositions of rifaximin |
| AU2016203925B2 (en) * | 2007-07-06 | 2016-10-20 | Lupin Limited | Pharmaceutical compositions of rifaximin |
| EP2420226B1 (en) * | 2007-07-06 | 2020-03-04 | Lupin Limited | Pharmaceutical compositions of rifaximin |
| US7709634B2 (en) * | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
| WO2009108730A2 (en) * | 2008-02-25 | 2009-09-03 | Salix Pharmaceuticals, Ltd. | Forms of rifaximin and uses thereof |
| US8486956B2 (en) * | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
| ES2727728T3 (es) | 2008-02-26 | 2019-10-18 | Salix Pharmaceuticals Ltd | Métodos para el tratamiento del síndrome del intestino irritable |
| US11779571B2 (en) * | 2008-02-26 | 2023-10-10 | Salix Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome (IBS) |
| PL2294012T3 (pl) | 2008-05-07 | 2014-12-31 | Salix Pharmaceuticals Inc | Podawanie środka czyszczącego jelito i antybiotyku w leczeniu choroby jelit |
| DK2327407T3 (da) | 2008-09-26 | 2014-08-25 | Aska Pharm Co Ltd | Profylaktisk og/eller terapeutisk middel til funktionelle gastrointestinale sygdomme |
| US12285414B2 (en) | 2008-10-02 | 2025-04-29 | Salix Pharmaceuticals, Inc. | Methods of treating hepatic encephalopathy |
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| EP2773205B1 (en) | 2011-11-02 | 2024-05-22 | Salix Pharmaceuticals, Inc. | Rifaximin for retreating diarrhea-predominant irritable bowel syndrome |
| JP2013184902A (ja) * | 2012-03-06 | 2013-09-19 | Aska Pharmaceutical Co Ltd | リファキシミン含有結晶 |
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