CL2007002615A1 - Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto. - Google Patents

Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto.

Info

Publication number
CL2007002615A1
CL2007002615A1 CL200702615A CL2007002615A CL2007002615A1 CL 2007002615 A1 CL2007002615 A1 CL 2007002615A1 CL 200702615 A CL200702615 A CL 200702615A CL 2007002615 A CL2007002615 A CL 2007002615A CL 2007002615 A1 CL2007002615 A1 CL 2007002615A1
Authority
CL
Chile
Prior art keywords
product
elect
insulate
purify
methods
Prior art date
Application number
CL200702615A
Other languages
English (en)
Inventor
Shujun Gallo Christopher Sun
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39158086&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2007002615(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CL2007002615A1 publication Critical patent/CL2007002615A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CL200702615A 2006-09-08 2007-09-07 Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto. CL2007002615A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84308406P 2006-09-08 2006-09-08

Publications (1)

Publication Number Publication Date
CL2007002615A1 true CL2007002615A1 (es) 2008-04-18

Family

ID=39158086

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200702615A CL2007002615A1 (es) 2006-09-08 2007-09-07 Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto.

Country Status (17)

Country Link
US (2) US8350013B2 (es)
EP (1) EP2059258B1 (es)
JP (1) JP5386354B2 (es)
KR (1) KR20090064377A (es)
CN (1) CN101511387A (es)
AR (1) AR062711A1 (es)
AU (1) AU2007292253A1 (es)
BR (1) BRPI0716597A2 (es)
CA (1) CA2661645C (es)
CL (1) CL2007002615A1 (es)
ES (1) ES2764222T3 (es)
IL (1) IL197053A0 (es)
MX (1) MX2009002576A (es)
PE (1) PE20080913A1 (es)
RU (1) RU2009106083A (es)
TW (1) TW200821026A (es)
WO (1) WO2008031020A2 (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2655873C (en) 2006-07-14 2017-10-17 Wisconsin Alumni Research Foundation Adsorptive membranes for trapping viruses
TWI456062B (zh) 2006-09-13 2014-10-11 Abbvie Inc 細胞培養改良
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
EP2089429B1 (en) * 2006-10-19 2014-11-26 Janssen Biotech, Inc. Process for preparing unaggregated antibody fc domains
JP5505853B2 (ja) 2007-02-13 2014-05-28 味の素株式会社 微酸性アルギニンを添加剤とするウイルス不活化法
MX2011004201A (es) 2008-10-20 2011-05-24 Abbott Lab Desactivacion viral durante purificacion de anticuerpos.
AU2009347206C1 (en) 2008-10-20 2016-12-08 Abbvie Inc. Isolation and purification of antibodies using Protein A affinity chromatography
CA2742817A1 (en) 2008-11-20 2010-05-27 Biogen Idec Ma Inc. Arginine inactivation of viruses
CN102395597A (zh) 2009-03-11 2012-03-28 惠氏有限责任公司 纯化小模块免疫药物蛋白的方法
CN104193798A (zh) 2009-12-18 2014-12-10 Csl有限公司 纯化多肽的方法
EP2513134B1 (en) * 2009-12-18 2017-09-06 Novartis AG Wash solution and method for affinity chromatography
SG182553A1 (en) * 2010-01-22 2012-08-30 Boehringer Ingelheim Int Chromatographic method for purifying fc-containing proteins
EP3266793A1 (en) * 2010-06-21 2018-01-10 Kyowa Hakko Kirin Co., Ltd. Method for purifying protein using amino acid
BR112013030628B1 (pt) * 2011-06-01 2022-01-25 Novartis Ag Método para produção de uma proteína purificada de interesse utilizando uma matriz de cromatografia de afinidade, e método para produção de um anticorpo purificado, fragmento de anticorpo ou proteína de fusão de fc utilizando uma coluna de proteína a
CN107266577B (zh) 2011-10-11 2022-09-13 弗·哈夫曼-拉罗切有限公司 双特异性抗体的改进的组装
US20130109807A1 (en) * 2011-10-26 2013-05-02 Bio-Rad Laboratories, Inc. Removal of virucidal agents in mixed mode chromatography
JP6599773B2 (ja) 2013-03-15 2019-10-30 グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッド 抗体を精製するための方法
AR096713A1 (es) 2013-06-25 2016-01-27 Cadila Healthcare Ltd Proceso de purificación para anticuerpos monoclonales
KR101414897B1 (ko) * 2013-11-29 2014-07-04 씨제이헬스케어 주식회사 다베포에틴 알파의 정제 방법
MX2017003927A (es) 2014-09-24 2017-06-30 Basf Se Proceso para producir diesteres de acido tereftalico.
CN107074720B (zh) 2014-09-24 2021-01-08 巴斯夫欧洲公司 以反应混合物的循环制备对苯二甲酸二酯的方法
EP3197860A1 (de) 2014-09-24 2017-08-02 Basf Se Verfahren zur herstellung von terephthalsäurediestern mit rückalkohol-anreicherung
MX2017003920A (es) 2014-09-24 2017-06-28 Basf Se Metodo para producir diesteres de acido tereftalico con deshidratacion de alcohol recirculado.
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
KR102490956B1 (ko) 2015-03-13 2023-01-19 브리스톨-마이어스 스큅 컴퍼니 불순물을 제거하기 위한 크로마토그래피 동안의 알칼리성 세척의 용도
HRP20160086A2 (hr) 2016-01-27 2017-08-11 Sveučilište u Zagrebu Eluens za imunoafinitetnu kromatografiju virusa i proteina
DE102016106271B4 (de) 2016-04-06 2018-03-29 Axagarius Gmbh & Co. Kg Aufreinigung von Nukleinsäure aus einer Nukleinsäure und Endotoxin enthaltenden Probe
JP6987424B2 (ja) 2016-05-11 2022-01-05 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックスを洗浄および/または消毒する方法
US11708390B2 (en) 2016-05-11 2023-07-25 Cytiva Bioprocess R&D Ab Method of storing a separation matrix
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
CN109071613A (zh) 2016-05-11 2018-12-21 通用电气医疗集团生物工艺研发股份公司 分离基质
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10688412B2 (en) * 2016-07-25 2020-06-23 Cehpalon, Inc. Affinity chromatography wash buffer
EP3510042B1 (en) * 2016-09-07 2024-05-22 GlaxoSmithKline Intellectual Property Development Limited Methods for purifying antibodies
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
EP4403193A3 (en) * 2017-01-30 2025-01-22 Regeneron Pharmaceuticals, Inc. Method for reducing bioburden in chromatography
TW202000891A (zh) * 2018-03-07 2020-01-01 英商葛蘭素史克智慧財產發展有限公司 純化抗體之方法
CN111902720B (zh) 2018-03-21 2025-02-07 沃特世科技公司 基于非抗体高亲和力的样品制备、吸附剂、装置和方法
CN108586606A (zh) * 2018-04-24 2018-09-28 上海药明生物技术有限公司 一种用于去除抗体蛋白中内毒素的方法
JP2023523324A (ja) * 2020-04-27 2023-06-02 アレクシオン ファーマシューティカルズ, インコーポレイテッド 抗体のプロテインaクロマトグラフィー精製
WO2021220253A1 (en) * 2020-05-01 2021-11-04 Kashiv Biosciences, Llc An improved process of affinity chromatography
EP4142792A4 (en) 2020-05-01 2024-11-27 Kashiv Biosciences, LLC An improved process of purification of protein
CN113980092B (zh) * 2021-12-09 2024-05-14 上海药明生物技术有限公司 一种蛋白质亲和纯化方法
CN114891061A (zh) * 2022-04-25 2022-08-12 杭州艾策生物技术有限公司 一种糖基化重组蛋白的纯化方法
EP4634201A1 (en) * 2022-12-12 2025-10-22 H. Lundbeck A/S Arginine wash in protein purification

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4010148A (en) 1975-05-12 1977-03-01 Board Of Regents Of The University Of Texas System Purified thymosin and process
IL47645A (en) * 1975-07-04 1980-10-26 Yeda Res & Dev Substantially pure and uniform thymic hormone thf,its preparation and pharmaceutical compositions containing it
JPS6030291B2 (ja) * 1978-03-20 1985-07-16 森永乳業株式会社 人顆粒球の分化増殖を促進するhgi糖蛋白質、hgi糖蛋白質の製造法及びhgi糖蛋白質を含有する白血球減少症治療剤
US4230697A (en) 1978-07-03 1980-10-28 Morinaga Milk Industry Co. Ltd. Virus-inactivated HGI-glycoprotein capable of stimulating proliferation and differentiation of human granulocyte, process for preparing same and leukopenia curative containing same
US4624932A (en) * 1978-09-13 1986-11-25 Samuel Bogoch Recognins and their chemoreciprocals
DE2962521D1 (en) * 1978-09-29 1982-05-27 Mitsubishi Chem Ind Process for the purification of long-chain acyl-coenzyme-a synthetase and the enzyme, acyl-coa synthetase, purified thereby
JPS5569595A (en) * 1978-11-20 1980-05-26 Suguru Abe Novel substance having fibrinolytic activity, remedy for thrombotic embolic disease comprising it, and its preparation
CA1172980A (en) * 1979-04-02 1984-08-21 Kenji Takemoto Pentadecapeptide and process for the preparation thereof
DE3034529C2 (de) * 1980-09-12 1982-09-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Leukorekrutin: Ein Entzündungsmediatorprotein aus Säugerserum zur Induzierung einer Leukozytosereaktion, Herstellungsverfahren, Gewinnung in molekular einheitlicher, kristallisierbarer und biologisch spezifisch wirkender Form und Leukorekrutin enthaltendes Arzneimittel
DE3110560A1 (de) * 1981-03-18 1982-10-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen "angiotropine der leukozyten und des entzuendungsgewebes: eine neue klasse natuerlicher chemotropischer mitogene fuer das richtungswachstum von blutgefaessen und zur neovaskularisierung von geweben"
DE3110561A1 (de) * 1981-03-18 1982-11-04 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Chemorekrutine der leukozyten und des entszuendungsgewebes: eine neue klasse natuerlicher leukopoetine zurselektiven chemorekrutierung von leukozyten aus dem knochenmark in den blutstrom (leukozytose- und linskverschiebungsreaktion)
US4532207A (en) * 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase
US4390468A (en) 1982-08-04 1983-06-28 Maruzen Oil Co., Ltd. Preparation of antitumor agent from shellfish
US4882421A (en) 1982-09-23 1989-11-21 Alfacell Corporation Pharmaceutical for treating tumors and method for making it
US4568545A (en) 1982-10-02 1986-02-04 Amano Seiyaku Kabushiki Kaisha Thrombolytic agent
JPS5980613A (ja) * 1982-10-29 1984-05-10 Mitsui Toatsu Chem Inc 新規なプラスミノ−ゲン・アクチベ−タ及びその製造方法
US4880914A (en) * 1982-11-09 1989-11-14 Cornell Research Foundation, Inc. Assay for qualitatively and/or quantitatively measuring hLH or hCG in body fluids and reagents therefor
US4966888A (en) 1985-07-08 1990-10-30 Cornell Research Foundation, Inc. hCG-hLH receptor and hCG-hLH receptor-hCG complex as antigens, antibodies thereto and contraceptive vaccine
US4639513A (en) 1984-02-02 1987-01-27 Cuno Inc. Intravenously injectable immunoglobulin G (IGG) and method for producing same
GB8314362D0 (en) 1983-05-24 1983-06-29 Celltech Ltd Polypeptide and protein products
US4456676A (en) * 1983-06-10 1984-06-26 E. I. Du Pont De Nemours And Company Amine stabilizers for wash-off systems
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
JPS6028999A (ja) * 1983-06-30 1985-02-14 Maruho Kk 細胞増殖促進作用を有するたんぱく質、その組成物と製造方法
JPH0794473B2 (ja) * 1984-03-02 1995-10-11 サントリー株式会社 新規なペプチド及びこれを有効成分とする利尿剤
JPS60184098A (ja) * 1984-03-02 1985-09-19 Suntory Ltd 新規なペプチド及びこれを有効成分とする利尿剤
US4670539A (en) * 1984-07-27 1987-06-02 Board Of Regents, The University Of Texas Peptide growth factors derived from estrogen responsive kidney tissue
US5132214A (en) * 1986-04-09 1992-07-21 Monsanto Company Large scale production of plasminogen activator from normal human colon cells
US5030559A (en) * 1986-04-01 1991-07-09 Board Of Regents, The University Of Texas System Methods and compositions for the identification of metastatic human tumors
US5213970A (en) 1987-01-23 1993-05-25 Board Of Regents, The University Of Texas System Method for obtaining soluble antitumor factor
US5162507A (en) * 1987-05-11 1992-11-10 Cetus Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
DE3877529T2 (de) 1987-10-23 1996-11-07 Centre Regional De Transfusion Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat und dessen therapeutische Verwendung.
JPH01238534A (ja) 1988-03-17 1989-09-22 Mitsui Toatsu Chem Inc エンドトキシンの除去方法
US5760183A (en) 1989-02-17 1998-06-02 Association D'aquitaine Pour De Developpment De La Transfusion Sanguine Et Des Recherches Hematologiques Process for the manufacture of very high-purity antithaemophilic factor (FVIIIC), and von Willebrand factor, and pharmaceutical compositions containing same
DE3914354C1 (es) * 1989-04-29 1990-10-31 Schaper & Bruemmer Gmbh & Co Kg, 3320 Salzgitter, De
DK165090D0 (da) 1990-07-09 1990-07-09 Kem En Tec As Konglomererede partikler
FR2676231A1 (fr) * 1991-05-07 1992-11-13 Aetsrn Concentre de facteur xi de la coagulation sanguine a haute activite specifique, approprie a usage therapeutique et son procede de preparation.
JPH0518950A (ja) 1991-07-09 1993-01-26 Showa Denko Kk アフイニテイクロマトグラフイー用吸着担体
DK0547544T3 (da) 1991-12-18 1997-09-08 Hoechst Ag Fremgangsmåde til fremstilling af insulinholdige opløsninger.
US5372942A (en) 1992-02-10 1994-12-13 Coriell Institute For Medical Research Protease K resistant arginine deiminase, its method of preparation and its use as an anti-neoplastic agent
CH685498A5 (fr) * 1992-02-14 1995-07-31 Om Lab Sa Extrait de macromolécules bactériennes, procédé pour sa préparation et composition pharmaceutique contenant cet extrait.
JP2767521B2 (ja) 1992-09-04 1998-06-18 農林水産省食品総合研究所長 新規抗腫瘍性蛋白質とその製造法および該蛋白質を有効成分として含有する抗腫瘍剤
DE69424687T2 (de) * 1993-03-09 2000-09-07 Genzyme Corp., Cambridge Verfahren zur isolierung von proteinen aus milch
US5710126A (en) * 1993-03-12 1998-01-20 Immulogic Pharmaceutical Corporation T cell epitopes of ryegrass pollen allergen
US6607884B1 (en) * 1993-03-19 2003-08-19 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-8
US5332503A (en) * 1993-04-16 1994-07-26 Baxter International Inc. Process for purifying collagenase
US5330972A (en) * 1993-05-28 1994-07-19 Abbott Laboratories Method of impeding apoptosis of CD4 cells in persons infected with human immunodeficiency virus
JP2971293B2 (ja) * 1993-06-11 1999-11-02 株式会社細菌化学研究所 溶血性連鎖球菌の産生する生理活性物質及びその製造法
US5500413A (en) * 1993-06-29 1996-03-19 Ferring Ab Process for manufacture of 1-deamino-8-D-arginine vasopressin
US5478924A (en) * 1994-02-16 1995-12-26 Cramer; Steven M. Displacement chromatography of proteins using low molecular weight displacers
US5570389A (en) * 1994-06-30 1996-10-29 Compaq Computer Corporation Method for reliable exchange of modem handshaking information over a cellular radio carrier
US5659017A (en) 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
DE19600939C1 (de) * 1996-01-12 1997-08-28 Immuno Ag Verfahren zur Trennung von IgG und IgA
SE9603068D0 (sv) * 1996-08-23 1996-08-23 Pharmacia & Upjohn Ab Process for purifying a protein
EP0950067B1 (en) * 1996-11-27 2007-08-29 Genentech, Inc. Affinity purification of polypeptide on protein a matrix
ZA9711580B (en) * 1996-12-25 1999-09-23 Hoechst Marion Roussel Ltd Process for the production of purified dimeric bone morphogenetic factors.
GB9717953D0 (en) * 1997-08-22 1997-10-29 Smithkline Beecham Biolog Vaccine
US6451260B1 (en) 1997-08-26 2002-09-17 Dyax Corp. Method for producing microporous elements, the microporous elements thus produced and uses thereof
US20030036629A1 (en) * 1997-12-12 2003-02-20 Barry Foster Novel tgf-beta protein purification methods
US6673629B2 (en) * 1998-01-15 2004-01-06 Abbott Laboratories Neutralization of polycations in a chromatographic device for whole blood use
DE19937219A1 (de) 1999-08-06 2001-02-08 Aventis Behring Gmbh Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Ionenaustauscherchromatographie
WO1999061464A1 (en) * 1998-05-28 1999-12-02 Korea Green Cross Corporation Process of purifying angiogenesis inhibitors
DK2270044T3 (en) * 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
GB9815666D0 (en) * 1998-07-17 1998-09-16 Smithkline Beecham Plc Novel compounds
RU2143492C1 (ru) 1998-07-23 1999-12-27 Навашин Петр Сергеевич Рекомбинантная плазмида, кодирующая гибридный белок - предшественник инсулина человека (варианты), штамм бактерий e.coli - продуцент гибридного белка - предшественника инсулина человека (варианты), способ получения инсулина человека
RU2144082C1 (ru) 1998-07-23 2000-01-10 Навашин Петр Сергеевич Рекомбинантная плазмида, кодирующая гибридный белок-предшественник инсулина человека (варианты), штамм бактерий e.coli - продуцент гибридного белка-предшественника инсулина человека (варианты) и способ получения инсулина человека
US7300753B2 (en) * 1998-09-04 2007-11-27 John Rush Immunoaffinity isolation of modified peptides from complex mixtures
US7198896B2 (en) * 1998-09-04 2007-04-03 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US6939545B2 (en) 1999-04-28 2005-09-06 Genetics Institute, Llc Composition and method for treating inflammatory disorders
US7307161B1 (en) * 1999-04-28 2007-12-11 Genetics Institute, Llc Human Gil-19/AE289 polynucleotides
DE19937218A1 (de) * 1999-08-06 2001-02-08 Aventis Behring Gmbh Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Affinitätschromatographie
US6774102B1 (en) 1999-09-29 2004-08-10 Gambro Dialysatoren Gmbh & Co. Kg Extracorporeal endotoxin removal method
WO2001032915A2 (en) * 1999-11-04 2001-05-10 Genentech, Inc. Reversed-phase hplc assay for plasminogen activators
US6825164B1 (en) * 2000-08-14 2004-11-30 The Trustees Of Columbia University In The City Of New York Method to increase cerebral blood flow in amyloid angiopathy
DE10046960A1 (de) * 2000-09-22 2002-04-11 Roche Diagnostics Gmbh Verfahren zur Herstellung einer aktiven, heterodimeren AMW-RT in prokaryotischen Zellen
US20030133939A1 (en) * 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) * 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US7638604B2 (en) 2001-02-23 2009-12-29 Genetics Institute, Llc Monoclonal antibodies against interleukin-22
US20040058445A1 (en) * 2001-04-26 2004-03-25 Ledbetter Jeffrey Alan Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
DE60213248T2 (de) * 2001-06-05 2006-11-30 Genetics Institute, LLC, Cambridge Verfahren zur reinigung hochanionischer proteine
WO2003031471A1 (en) * 2001-10-09 2003-04-17 The Government Of The United States Of America, As Represented By The Department Of Health And Human Services Methods and compositions for production and purification of recombinant staphylococcal enterotoxin b (rseb)
US20040161776A1 (en) * 2001-10-23 2004-08-19 Maddon Paul J. PSMA formulations and uses thereof
WO2003066669A2 (en) * 2002-02-04 2003-08-14 Millipore Corporation Process for removing protein aggregates and virus from a protein solution
AU2003210802B2 (en) * 2002-02-05 2009-09-10 Genentech Inc. Protein purification
WO2004000220A2 (en) * 2002-06-21 2003-12-31 Genetix Pharmaceuticals, Inc. Methods for purifying viral particles for gene therapy
AR047392A1 (es) 2002-10-22 2006-01-18 Wyeth Corp Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
EP2336172B1 (en) * 2003-10-27 2014-12-10 Wyeth LLC Removal of high molecular weight aggregates using hydroxyapatite chromatography
US7065110B2 (en) * 2004-01-20 2006-06-20 Northrop Grumman Corporation Scalable wavelength shifted laser source and method
US8084032B2 (en) * 2004-01-21 2011-12-27 Ajinomoto Co., Inc. Purification method which prevents denaturation of an antibody
US7501121B2 (en) * 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
AR049390A1 (es) * 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
AU2006223180B2 (en) * 2005-03-11 2011-11-24 Wyeth Llc A method of weak partitioning chromatography

Also Published As

Publication number Publication date
EP2059258A2 (en) 2009-05-20
KR20090064377A (ko) 2009-06-18
PE20080913A1 (es) 2008-08-21
BRPI0716597A2 (pt) 2013-10-08
ES2764222T3 (es) 2020-06-02
MX2009002576A (es) 2009-03-20
AU2007292253A1 (en) 2008-03-13
WO2008031020A3 (en) 2008-10-23
US20080064860A1 (en) 2008-03-13
EP2059258A4 (en) 2012-05-02
US8350013B2 (en) 2013-01-08
CN101511387A (zh) 2009-08-19
IL197053A0 (en) 2009-11-18
US7714111B2 (en) 2010-05-11
JP5386354B2 (ja) 2014-01-15
RU2009106083A (ru) 2010-10-20
US20080064861A1 (en) 2008-03-13
WO2008031020A2 (en) 2008-03-13
JP2010502737A (ja) 2010-01-28
AR062711A1 (es) 2008-11-26
CA2661645A1 (en) 2008-03-13
TW200821026A (en) 2008-05-16
CA2661645C (en) 2016-11-08
EP2059258B1 (en) 2019-11-13

Similar Documents

Publication Publication Date Title
CL2007002615A1 (es) Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto.
CR10719A (es) Producto alimenticio sustituto de carne y proceso para preparar el mismo
DE602006017985D1 (de) Reinigungsmittel mit alkoxylierten polyalkyleniminen
DE602006015022D1 (de) Laufmaschine mit Rädern
GB2456466A (en) Sanitizing surfaces
AP2012006265A0 (en) Methods and istallations for manufacturing biaxially oriented tubing and the tubing itself.
ATE446607T1 (de) Endstufe mit niedriger leistungsaufnahme
IL187909A0 (en) Fibre composite that can be dissolved or decomposed in water, and products thereof
BRPI0921012A2 (pt) inserto e cortador que pode ser montado com o inserto.
SE0602204L (sv) Sätt att övervaka artiklar i kylskåp
DE602006003466D1 (de) Kältemaschine mit Kondensatbecken
EP1981039A4 (en) COMPOSED SUPRALEITER
NL1035245A1 (nl) In situ, ex situ en in-line procesbewaking, optimalisatie en fabricage.
CA119996S (en) Bottle
DE602006014236D1 (de) Tastschalter mit Rückbeleuchtung
DE602006016400D1 (de) Damit
FI20095020L (fi) Menetelmä aukirullaimen yhteydessä
NL1030673A1 (nl) Verpakkingsmachine met meerdere UV-lampen dwars ten opzichte van het verpakkingspad.
EP1900126A4 (en) SERIAL CLUSTER
NO20056159L (no) Lofting i prosessreoler
FI20085884L (fi) Järjestely nesteenkäsittelytilassa
ITMI20080035A1 (it) Gruppo di illuminazione, in particolare per gruppi espositivi, e gruppo espositivo dotato di tale gruppo di illuminazione
PL120663U1 (pl) Komora kriogeniczna
FI20060299L (fi) Sähkökemiallinen menetelmä rikastusprosessissa
PL380012A1 (pl) Sposób lokalizacji zwarć w liniach energetycznych z wieloma odgałęzieniami