CL2012000520A1 - Anticuerpo o fragmento de union a antigeno del mismo capaz de unirse a dll4 humana; conjugado que comprende a dicho anticuerpo; vector aislado y celula huesped; metodo para producir dicho anticuerpo; composicion farmaceutica que lo comprende; y uso medico de dicho anticuerpo. - Google Patents

Anticuerpo o fragmento de union a antigeno del mismo capaz de unirse a dll4 humana; conjugado que comprende a dicho anticuerpo; vector aislado y celula huesped; metodo para producir dicho anticuerpo; composicion farmaceutica que lo comprende; y uso medico de dicho anticuerpo.

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Publication number
CL2012000520A1
CL2012000520A1 CL2012000520A CL2012000520A CL2012000520A1 CL 2012000520 A1 CL2012000520 A1 CL 2012000520A1 CL 2012000520 A CL2012000520 A CL 2012000520A CL 2012000520 A CL2012000520 A CL 2012000520A CL 2012000520 A1 CL2012000520 A1 CL 2012000520A1
Authority
CL
Chile
Prior art keywords
antibody
host cell
human dll4
conjugate
antigen
Prior art date
Application number
CL2012000520A
Other languages
English (en)
Inventor
Lorenzo Benatuil
Erwin R Boghaert
Maria Harris
Jonathan A Hickson
Chung-Ming Hsieh
Yuliya Kutskova
Yingchun Li
Zhihong Liu
Susan Morgan-Lappe
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43035018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012000520(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of CL2012000520A1 publication Critical patent/CL2012000520A1/es

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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2857—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, orphan receptor
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Oncology (AREA)
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Abstract

Proteína de unión a DLL4 humana; construcción de anticuerpo que comprende la proteína de unión antes mencionada; anticuerpo conjugado que comprende dicha proteína; ácido nucleico, vector y célula huésped que comprenden anticuerpo; composición para la liberación de una proteína; método para el tratamiento de un mamífero; método para disminuir la actividad del DLL4 humano.
CL2012000520A 2009-08-29 2012-02-28 Anticuerpo o fragmento de union a antigeno del mismo capaz de unirse a dll4 humana; conjugado que comprende a dicho anticuerpo; vector aislado y celula huesped; metodo para producir dicho anticuerpo; composicion farmaceutica que lo comprende; y uso medico de dicho anticuerpo. CL2012000520A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23815209P 2009-08-29 2009-08-29
US26172809P 2009-11-16 2009-11-16

Publications (1)

Publication Number Publication Date
CL2012000520A1 true CL2012000520A1 (es) 2013-07-12

Family

ID=43035018

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012000520A CL2012000520A1 (es) 2009-08-29 2012-02-28 Anticuerpo o fragmento de union a antigeno del mismo capaz de unirse a dll4 humana; conjugado que comprende a dicho anticuerpo; vector aislado y celula huesped; metodo para producir dicho anticuerpo; composicion farmaceutica que lo comprende; y uso medico de dicho anticuerpo.

Country Status (25)

Country Link
US (5) US8623358B2 (es)
EP (2) EP2470568A2 (es)
JP (2) JP5903382B2 (es)
KR (1) KR20120089659A (es)
CN (2) CN102741288B (es)
AR (1) AR077998A1 (es)
AU (2) AU2010286518C1 (es)
BR (1) BR112012004546A8 (es)
CA (2) CA2771575A1 (es)
CL (1) CL2012000520A1 (es)
CO (1) CO6612215A2 (es)
CR (1) CR20120105A (es)
DO (1) DOP2012000052A (es)
HK (1) HK1225743A1 (es)
IL (1) IL218401A (es)
MX (2) MX336152B (es)
MY (1) MY159837A (es)
NZ (1) NZ598524A (es)
PE (1) PE20121647A1 (es)
RU (1) RU2570639C2 (es)
SG (1) SG178930A1 (es)
TW (1) TWI465250B (es)
UY (1) UY32869A (es)
WO (1) WO2011025964A2 (es)
ZA (1) ZA201201298B (es)

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EP4793360A2 (en) 2006-03-31 2026-08-19 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
EP3127921A1 (en) 2007-09-26 2017-02-08 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substition in cdr
EP2282769A4 (en) 2008-04-29 2012-04-25 Abbott Lab DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES
EP2297209A4 (en) 2008-06-03 2012-08-01 Abbott Lab IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF
CA2771575A1 (en) 2009-08-29 2011-03-03 Abbott Laboratories Therapeutic dll4 binding proteins
EP3485908B1 (en) 2009-10-16 2021-08-18 Mereo BioPharma 5, Inc. Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents
JO3183B1 (ar) 2010-01-29 2018-03-08 Regeneron Pharma طرق لمعالجة أمراض المناعة الذاتية مضادات dll4
WO2011109298A2 (en) 2010-03-02 2011-09-09 Abbott Laboratories Therapeutic dll4 binding proteins
KR20130100118A (ko) 2010-08-03 2013-09-09 아비에 인코포레이티드 이원 가변 도메인 면역글로불린 및 이의 용도
US9046513B2 (en) 2010-08-26 2015-06-02 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
TWI736437B (zh) 2010-11-30 2021-08-11 日商中外製藥股份有限公司 細胞傷害誘導治療劑
TWI583699B (zh) 2011-09-23 2017-05-21 安可美德藥物股份有限公司 Ｖｅｇｆ／ｄｌｌ４結合劑類及彼等之用途
CN104203981A (zh) * 2011-12-19 2014-12-10 合成免疫股份有限公司 双特异性抗体分子
AR089529A1 (es) 2011-12-30 2014-08-27 Abbvie Inc Proteinas de union especificas duales dirigidas contra il-13 y/o il-17
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