CL2016003335A1 - Diacuerpos enlazados covalentemente que tienen inmunoreactividad con pd-1 y lag-3, y metodos de uso de los mismos - Google Patents
Diacuerpos enlazados covalentemente que tienen inmunoreactividad con pd-1 y lag-3, y metodos de uso de los mismosInfo
- Publication number
- CL2016003335A1 CL2016003335A1 CL2016003335A CL2016003335A CL2016003335A1 CL 2016003335 A1 CL2016003335 A1 CL 2016003335A1 CL 2016003335 A CL2016003335 A CL 2016003335A CL 2016003335 A CL2016003335 A CL 2016003335A CL 2016003335 A1 CL2016003335 A1 CL 2016003335A1
- Authority
- CL
- Chile
- Prior art keywords
- specific
- lag
- immune
- epithope
- addressed
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
<p>LA PRESENTE INVENCIÓN SE DIRIGE A UN DIACUERPO BI-ESPECIFICO QUE COMPRENDE DOS O MÁS CADENAS DE POLIPÉPTIDOS Y QUE POSEEN AL MENOS UN SITIO DE UNION DE EPITOPO QUE ES INMUNOESPECÍFICO PARA UN EPITOPO DE PD-1 Y AL MENOS UN SITIO DE UNIÓN DE EPITOPO QUE ES INMUNOESPECÍFICO PARA UN EPITOPO DE LAG-3 (ES DECIR, UN "DIACUERPO BI-ESPECIFICO DE PD-1 X LAG-3"). DE MAYOR PREFERENCIA, LA PRESENTE INVENCIÓN SE DIRIGE A DIACUERPOS BI-ESPECIFICOS QUE COMPRENDEN CUATRO CADENAS DE POLIPÉPTIDOS Y QUE POSEEN DOS SITIOS DE UNIÓN DE EPITOPO QUE SON INMUNOESPECÍFICOS PARA UN (O DOS) EPITOPOS DE PD- 1 Y DOS SITIO DE UNIÓN DE EPITOPO QUE SON INMUNOESPECÍFICOS PARA UNO (O DOS) EPITOPOS DE LAG-3 (ES DECIR, UN "DIACUERPO TETRAVALENTE BI-ESPECIFICO DE PD-1 X LAG-3"). LA PRESENTE INVENCIÓN TAMBIÉN SE DIRIGE A TALES DIACUERPOS QUE COMPRENDEN ADICIONALMENTE UN DOMINIO DE Fc DE INMUNOGLOBULINA (“DIACUERPOS DE Fc BI-ESPECIFICOS Y DIACUERPOS DE Fc TETRAVALENTES BI-ESPECIFLCOS"). LOS DIACUERPOS DE LA PRESENTE INVENCIÓN SON CAPACES DE UNIRSE SIMULTÁNEAMENTE A PD-1 Y A LAG-3, PARTICULARMENTE CUANDO TALES MOLÉCULAS SE DISPONEN SOBRE LAS SUPERFICIES DE LAS CÉLULAS HUMANAS. LA INVENCIÓN SE DIRIGE A COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN TALES DIACUERPOS, Y A MÉTODOS QUE IMPLICAN EL USO DE TALES DIACUERPOS EN EL TRATAMIENTO DE CÁNCER Y OTRAS ENFERMEDADES Y PADECIMIENTOS.</p>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462017467P | 2014-06-26 | 2014-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2016003335A1 true CL2016003335A1 (es) | 2017-07-14 |
Family
ID=54938685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2016003335A CL2016003335A1 (es) | 2014-06-26 | 2016-12-26 | Diacuerpos enlazados covalentemente que tienen inmunoreactividad con pd-1 y lag-3, y metodos de uso de los mismos |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US10160806B2 (es) |
| EP (1) | EP3161004B1 (es) |
| JP (2) | JP6890421B2 (es) |
| KR (1) | KR102514330B1 (es) |
| CN (1) | CN106715470B (es) |
| AR (1) | AR101009A1 (es) |
| AU (1) | AU2015280392B2 (es) |
| CA (1) | CA2953818C (es) |
| CL (1) | CL2016003335A1 (es) |
| CR (1) | CR20160599A (es) |
| CY (1) | CY1123917T1 (es) |
| DK (1) | DK3161004T3 (es) |
| EA (1) | EA036737B1 (es) |
| EC (1) | ECSP16096342A (es) |
| ES (1) | ES2843269T3 (es) |
| GE (2) | GEAP201914392A (es) |
| HR (1) | HRP20210041T1 (es) |
| HU (1) | HUE052615T2 (es) |
| IL (1) | IL249764B (es) |
| LT (1) | LT3161004T (es) |
| MX (1) | MX369486B (es) |
| MY (1) | MY177324A (es) |
| PE (1) | PE20170767A1 (es) |
| PH (1) | PH12016502590A1 (es) |
| PL (1) | PL3161004T3 (es) |
| PT (1) | PT3161004T (es) |
| RS (1) | RS61284B1 (es) |
| SA (1) | SA516380600B1 (es) |
| SG (1) | SG11201610715SA (es) |
| SI (1) | SI3161004T1 (es) |
| SM (1) | SMT202100021T1 (es) |
| TW (1) | TWI693232B (es) |
| UA (1) | UA119673C2 (es) |
| WO (1) | WO2015200119A1 (es) |
| ZA (1) | ZA201608768B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12102681B2 (en) | 2014-08-19 | 2024-10-01 | Merck Sharp & Dohme Llc | Anti-LAG3 antibodies and antigen-binding fragments |
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| SG11201506052PA (en) | 2013-02-22 | 2015-09-29 | Curevac Gmbh | Combination of vaccination and inhibition of the pd-1 pathway |
| CN105682683A (zh) * | 2013-08-02 | 2016-06-15 | 阿杜罗生物科技控股有限公司 | 结合cd27激动剂以及免疫检查点抑制以用于免疫刺激 |
| CR20160319A (es) | 2013-12-12 | 2016-11-08 | Jiangsu Hengrui Medicine Co | Anticuerpo pd-1, fragmento de union al antigeno de este y uso médico de este |
| GB201322626D0 (en) | 2013-12-19 | 2014-02-05 | Immutep S A | Combined preparations for the treatment of cancer |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| EA201691765A1 (ru) | 2014-03-14 | 2016-12-30 | Новартис Аг | Молекулы антител против lag-3 и их применения |
| TWI693232B (zh) * | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| EP3180087B1 (en) | 2014-08-12 | 2019-03-13 | Alligator Bioscience AB | Combination therapies with anti cd40 antibodies |
| EA201790719A1 (ru) * | 2014-09-26 | 2017-07-31 | Макродженикс, Инк. | Биспецифические моновалентные диатела, которые способны связывать cd19 и cd3, а также их применения |
| GB201500374D0 (en) | 2015-01-09 | 2015-02-25 | Immutep S A | Combined preparations for the treatment of cancer |
| HUE045585T2 (hu) | 2015-05-18 | 2020-01-28 | Tolero Pharmaceuticals Inc | Megnövelt biológiai hozzáférhetõséggel rendelkezõ Alvocidib gyógyszer-elõanyagok |
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| BR112018006237A2 (pt) | 2015-09-29 | 2018-10-09 | Celgene Corp | proteínas de ligação a pd-1 e métodos de uso das mesmas |
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| JP7085709B2 (ja) | 2016-06-20 | 2022-06-17 | エフ－スター セラピューティクス リミテッド | Ｐｄ－ｌ１及びｌａｇ－３に結合する結合分子 |
| GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
| EP3515943A4 (en) | 2016-09-19 | 2020-05-06 | Celgene Corporation | METHODS OF TREATING VITILIGO WITH PD-1 BINDING PROTEINS |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12102681B2 (en) | 2014-08-19 | 2024-10-01 | Merck Sharp & Dohme Llc | Anti-LAG3 antibodies and antigen-binding fragments |
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