CL2018000378A1 - Receptores de antígenos quiméricos basados en anticuerpos de dominio simple y métodos de uso de estos - Google Patents

Receptores de antígenos quiméricos basados en anticuerpos de dominio simple y métodos de uso de estos

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Publication number
CL2018000378A1
CL2018000378A1 CL2018000378A CL2018000378A CL2018000378A1 CL 2018000378 A1 CL2018000378 A1 CL 2018000378A1 CL 2018000378 A CL2018000378 A CL 2018000378A CL 2018000378 A CL2018000378 A CL 2018000378A CL 2018000378 A1 CL2018000378 A1 CL 2018000378A1
Authority
CL
Chile
Prior art keywords
single domain
methods
receptors
domain antibodies
chimeric antigens
Prior art date
Application number
CL2018000378A
Other languages
English (en)
Inventor
Xiaohu Fan
Chuan-Chu Chou
Qiuchuan Zhuang
Pingyan Wang
Lin Wang
Jiaying Hao
Lei Yang
Original Assignee
Legend Biotech Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Legend Biotech Ireland Ltd filed Critical Legend Biotech Ireland Ltd
Publication of CL2018000378A1 publication Critical patent/CL2018000378A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001116—Receptors for cytokines
    • A61K39/001117—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR] or CD30
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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Abstract

La presente solicitud proporciona anticuerpos de dominio simple, y receptores de antígenos quiméricos que comprenden uno o más dominios de unión al antígeno, cada uno de los cuales comprende un anticuerpo de dominio simple. También se proporcionan células efectoras inmunitarias modificadas genéticamente (tales como linfocitos T) que comprenden los receptores de antígenos quiméricos. También se proporcionan composiciones farmacéuticas, kits y métodos para tratar el cáncer.
CL2018000378A 2015-08-11 2018-02-09 Receptores de antígenos quiméricos basados en anticuerpos de dominio simple y métodos de uso de estos CL2018000378A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510490002 2015-08-11
CN201510733585.2A CN105384825B (zh) 2015-08-11 2015-11-02 一种基于单域抗体的双特异性嵌合抗原受体及其应用

Publications (1)

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CL2018000378A1 true CL2018000378A1 (es) 2018-08-17

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