CL2018001110A1 - Mutaciones de punto en cáncer resistente a inhibidor de trk y métodos relacionados con el mismo - Google Patents

Mutaciones de punto en cáncer resistente a inhibidor de trk y métodos relacionados con el mismo

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Publication number
CL2018001110A1
CL2018001110A1 CL2018001110A CL2018001110A CL2018001110A1 CL 2018001110 A1 CL2018001110 A1 CL 2018001110A1 CL 2018001110 A CL2018001110 A CL 2018001110A CL 2018001110 A CL2018001110 A CL 2018001110A CL 2018001110 A1 CL2018001110 A1 CL 2018001110A1
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CL
Chile
Prior art keywords
methods
subject
cancer
trk
trk inhibitor
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Application number
CL2018001110A
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English (en)
Inventor
Qian Zhao
Barbara J Brandhuber
Gabrielle R Kolakowski
James F Blake
Steven W Andrews
Robert C Doebele
Nisha Nanda
Joshua H Bilenker
Original Assignee
Array Biopharma Inc
Loxo Oncology Inc
Univ Colorado Regents
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Publication date
Application filed by Array Biopharma Inc, Loxo Oncology Inc, Univ Colorado Regents filed Critical Array Biopharma Inc
Publication of CL2018001110A1 publication Critical patent/CL2018001110A1/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

En el presente se suministran métodos para tratar a un sujeto que tiene cáncer, métodos para seleccionar un tratamientos para un sujeto con cáncer, métodos para seleccionar a un sujeto con un tipo de cáncer para un tratamiento que no incluye un inhibidor de Trk, métodos para determinar la probabilidad de que un sujeto con cáncer tenga una respuesta positiva a un tratamiento con un inhibidor Trk, métodos para predecir la eficacia de un inhibidor de Trk en un sujeto con cáncer, métodos para determinar el riesgo que un sujeto tiene de desarrollar un inhibidor de Trk -resistente al cáncer, y métodos para determinar la presencia de un inhibidor Trk -resistente al cáncer en un sujeto, en base a la detección de una célula a partir de una muestra del sujeto que presenta por lo menos una de las mutaciones puntuales en NTRK1 y/o NTRK2 y/o NTRK3. 
CL2018001110A 2015-10-26 2018-04-26 Mutaciones de punto en cáncer resistente a inhibidor de trk y métodos relacionados con el mismo CL2018001110A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562246580P 2015-10-26 2015-10-26
US201662287778P 2016-01-27 2016-01-27
US201662323586P 2016-04-15 2016-04-15

Publications (1)

Publication Number Publication Date
CL2018001110A1 true CL2018001110A1 (es) 2018-12-07

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CL2018001110A CL2018001110A1 (es) 2015-10-26 2018-04-26 Mutaciones de punto en cáncer resistente a inhibidor de trk y métodos relacionados con el mismo

Country Status (17)

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US (6) US10724102B2 (es)
EP (1) EP3368039A1 (es)
JP (1) JP2018534296A (es)
KR (1) KR20180102544A (es)
CN (1) CN108697708A (es)
AU (1) AU2016344058A1 (es)
BR (1) BR112018008357A2 (es)
CA (1) CA3003153A1 (es)
CL (1) CL2018001110A1 (es)
IL (1) IL258877A (es)
MX (1) MX2018005087A (es)
PH (1) PH12018500902A1 (es)
RU (1) RU2744852C2 (es)
SG (1) SG11201803438XA (es)
SV (1) SV2018005677A (es)
TN (2) TN2018000138A1 (es)
WO (1) WO2017075107A1 (es)

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