CN1187312C - 无定形化合物和它们的药物组合物 - Google Patents

无定形化合物和它们的药物组合物 Download PDF

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Publication number
CN1187312C
CN1187312C CNB008091919A CN00809191A CN1187312C CN 1187312 C CN1187312 C CN 1187312C CN B008091919 A CNB008091919 A CN B008091919A CN 00809191 A CN00809191 A CN 00809191A CN 1187312 C CN1187312 C CN 1187312C
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China
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compound
formula
branched
straight
active ingredient
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Expired - Fee Related
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CNB008091919A
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English (en)
Chinese (zh)
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CN1356975A (zh
Inventor
F·贝尼蒂尼
P·安托纳扎
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Nicox SA
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Nicox SA
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Publication of CN1356975A publication Critical patent/CN1356975A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNB008091919A 1999-06-24 2000-06-21 无定形化合物和它们的药物组合物 Expired - Fee Related CN1187312C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001402A IT1312115B1 (it) 1999-06-24 1999-06-24 Composti amorfi e relative composizioni farmaceutiche
ITMI99A001402 1999-06-24

Publications (2)

Publication Number Publication Date
CN1356975A CN1356975A (zh) 2002-07-03
CN1187312C true CN1187312C (zh) 2005-02-02

Family

ID=11383219

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008091919A Expired - Fee Related CN1187312C (zh) 1999-06-24 2000-06-21 无定形化合物和它们的药物组合物

Country Status (23)

Country Link
US (1) US6753442B1 (it)
EP (1) EP1187803B1 (it)
JP (1) JP2003503380A (it)
KR (1) KR100672001B1 (it)
CN (1) CN1187312C (it)
AT (1) ATE302746T1 (it)
AU (1) AU781479B2 (it)
BR (1) BR0011831A (it)
CA (1) CA2377132A1 (it)
DE (1) DE60022188T2 (it)
DK (1) DK1187803T3 (it)
ES (1) ES2246878T3 (it)
HU (1) HUP0201721A3 (it)
IL (1) IL146789A0 (it)
IT (1) IT1312115B1 (it)
MX (1) MXPA01013273A (it)
NO (1) NO321523B1 (it)
NZ (1) NZ515757A (it)
PL (1) PL195557B1 (it)
RU (1) RU2248963C2 (it)
TR (1) TR200103624T2 (it)
WO (1) WO2001000563A1 (it)
ZA (1) ZA200109862B (it)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2393724A1 (en) 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
JP4092203B2 (ja) 2000-12-21 2008-05-28 ニトロメッド，インク． 新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
WO2003103602A2 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
CA2491127A1 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
PT1558582E (pt) 2003-07-22 2006-05-31 Arena Pharm Inc Derivados de diaril- e aril-heteroaril-ureia como moduladores do receptor de serotonina 5-ht2a uteis para a profilaxia e tratamento de desordens relacionadas com o mesmo
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
WO2009023253A2 (en) 2007-08-15 2009-02-19 Arena Pharmaceuticals Inc. IMIDAZO[L,2-α]PYRIDINE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
CN101977888B (zh) 2007-10-17 2014-05-28 托德·F·奥沃凯泰斯 室温下稳定的非结晶阿司匹林
WO2009052246A1 (en) 2007-10-17 2009-04-23 Ovokaitys, Todd, F. Process for the modification of the solid state of a compound and co-amorphous compositions produced with same
ES2324007A1 (es) * 2007-10-25 2009-07-28 Ferrer Internacional, S.A. Una forma amorfa de un compuesto antiinflamatorio.
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
CN104739829B (zh) 2008-10-28 2018-11-06 艾尼纳制药公司 用于治疗5-ht2a5-羟色胺受体相关障碍的5-ht2a5-羟色胺受体调节剂组合物
CN102186933B (zh) 2008-11-04 2014-06-25 帝斯曼知识产权资产管理有限公司 光纤用的d 1413 ht可辐射固化涂层
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
US10040728B2 (en) 2014-06-06 2018-08-07 Todd Frank Ovokaitys Methods and compositions for increasing the bioactivity of nutrients
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
WO2016201373A1 (en) 2015-06-12 2016-12-15 Axovant Sciences Ltd. Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder
WO2017011767A2 (en) 2015-07-15 2017-01-19 Axovant Sciences Ltd. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease
WO2022126109A1 (en) 2020-12-08 2022-06-16 Ovokaitys Todd Frank Methods and systems for increased production of stem cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1256345B (it) * 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
SI0759899T1 (en) * 1994-05-10 1999-12-31 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
KR19990001564A (ko) * 1997-06-16 1999-01-15 유충식 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
IT1307928B1 (it) 1999-01-26 2001-11-29 Nicox Sa Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.

Also Published As

Publication number Publication date
EP1187803B1 (en) 2005-08-24
TR200103624T2 (tr) 2002-04-22
PL195557B1 (pl) 2007-10-31
DE60022188T2 (de) 2006-06-08
AU6264400A (en) 2001-01-31
NO20016232D0 (no) 2001-12-19
CN1356975A (zh) 2002-07-03
WO2001000563A1 (en) 2001-01-04
NO20016232L (no) 2001-12-19
JP2003503380A (ja) 2003-01-28
IL146789A0 (en) 2002-07-25
HUP0201721A3 (en) 2003-08-28
KR20020008220A (ko) 2002-01-29
AU781479B2 (en) 2005-05-26
ITMI991402A0 (it) 1999-06-24
RU2248963C2 (ru) 2005-03-27
US6753442B1 (en) 2004-06-22
ATE302746T1 (de) 2005-09-15
EP1187803A1 (en) 2002-03-20
DK1187803T3 (da) 2005-11-28
CA2377132A1 (en) 2001-01-04
BR0011831A (pt) 2002-03-19
ITMI991402A1 (it) 2000-12-24
ZA200109862B (en) 2003-05-28
NZ515757A (en) 2004-02-27
PL352529A1 (en) 2003-08-25
KR100672001B1 (ko) 2007-01-19
MXPA01013273A (es) 2003-07-14
ES2246878T3 (es) 2006-03-01
NO321523B1 (no) 2006-05-15
IT1312115B1 (it) 2002-04-04
HUP0201721A2 (en) 2002-10-28
DE60022188D1 (de) 2005-09-29

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Granted publication date: 20050202