CU24275B1 - Derivados de cicloalquilo pirrolo [2,3-d] pirimidina-4-il amino útiles como inhibidores de quinasas janus relacionadas y composiciones farmacéuticas que contienen tales compuestos - Google Patents

Derivados de cicloalquilo pirrolo [2,3-d] pirimidina-4-il amino útiles como inhibidores de quinasas janus relacionadas y composiciones farmacéuticas que contienen tales compuestos

Info

Publication number: CU24275B1
Authority: CU; Cuba
Prior art keywords: derivatives; inhibitors; cyclalquylcal; pirimidina; pirrolo
Prior art date: 2013-02-22

Application number

CUP2015000078A

Other languages

English (en)

Spanish (es)

Other versions

CU20150078A7 (es

Inventor

Matthew Frank Brown

Ashley Edward Fenwick

Mark Edward Flanagan

Andrea Gonzales

Timothy Allan Johnson

Neelu Kaila

Mark J Mitton-Fry

Mihir D Parikh

Joseph Walter Strohbach

Ruth E Tenbrink

John David Trzupek

Rayomand Jal Unwalla

Michael L Vazquez

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-02-22

Filing date

2014-02-11

Publication date

2017-10-05

2014-02-11 Application filed by Pfizer filed Critical Pfizer

2016-01-29 Publication of CU20150078A7 publication Critical patent/CU20150078A7/es

2017-10-05 Publication of CU24275B1 publication Critical patent/CU24275B1/xx

Links

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
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Immunology (AREA)
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Pulmonology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
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Diabetes (AREA)
Psychiatry (AREA)
Oncology (AREA)
Hematology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)

CUP2015000078A 2013-02-22 2014-02-11 Derivados de cicloalquilo pirrolo [2,3-d] pirimidina-4-il amino útiles como inhibidores de quinasas janus relacionadas y composiciones farmacéuticas que contienen tales compuestos CU24275B1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361767947P	2013-02-22	2013-02-22
PCT/IB2014/058889 WO2014128591A1 (fr)	2013-02-22	2014-02-11	Dérivés de pyrrolo[2,3-d]pyrimidine en tant qu'inhibiteurs de janus kinases (jak)

Publications (2)

Publication Number	Publication Date
CU20150078A7 CU20150078A7 (es)	2016-01-29
CU24275B1 true CU24275B1 (es)	2017-10-05

Family

ID=50151346

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CUP2015000078A CU24275B1 (es)	2013-02-22	2014-02-11	Derivados de cicloalquilo pirrolo [2,3-d] pirimidina-4-il amino útiles como inhibidores de quinasas janus relacionadas y composiciones farmacéuticas que contienen tales compuestos

Country Status (48)

Country	Link
US (3)	US9035074B2 (fr)
EP (2)	EP3290421B1 (fr)
JP (2)	JP6145179B2 (fr)
KR (1)	KR101787858B1 (fr)
CN (2)	CN107089985B (fr)
AP (1)	AP2015008664A0 (fr)
AR (1)	AR094857A1 (fr)
AU (1)	AU2014220357B2 (fr)
BR (1)	BR112015019634B1 (fr)
CA (1)	CA2900703C (fr)
CL (1)	CL2015002303A1 (fr)
CR (1)	CR20150395A (fr)
CU (1)	CU24275B1 (fr)
CY (3)	CY1119502T1 (fr)
DK (2)	DK3290421T3 (fr)
DO (1)	DOP2015000206A (fr)
EA (1)	EA027879B1 (fr)
ES (2)	ES2713052T3 (fr)
FR (1)	FR22C1006I2 (fr)
GE (1)	GEP201606600B (fr)
HR (2)	HRP20171599T2 (fr)
HU (3)	HUE037192T2 (fr)
IL (1)	IL240132B (fr)
LT (3)	LT2958921T (fr)
LU (1)	LUC00261I2 (fr)
MA (1)	MA38347A1 (fr)
MD (1)	MD4735C1 (fr)
ME (2)	ME03301B (fr)
MX (1)	MX374338B (fr)
MY (1)	MY177476A (fr)
NL (1)	NL301155I2 (fr)
NO (2)	NO3052752T3 (fr)
NZ (1)	NZ710411A (fr)
PE (1)	PE20151764A1 (fr)
PH (1)	PH12015501779B1 (fr)
PL (2)	PL3290421T3 (fr)
PT (2)	PT2958921T (fr)
PY (1)	PY1407086A (fr)
RS (2)	RS58245B1 (fr)
SG (1)	SG11201505816UA (fr)
SI (2)	SI2958921T1 (fr)
TN (1)	TN2015000355A1 (fr)
TR (1)	TR201902525T4 (fr)
TW (1)	TWI507408B (fr)
UA (1)	UA111804C2 (fr)
UY (1)	UY35337A (fr)
WO (1)	WO2014128591A1 (fr)
ZA (1)	ZA201505454B (fr)

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EP3456325A3 (fr)	2013-02-22	2019-05-22	Samumed, LLC	Gamma-dicétones en tant qu'activateurs de la voie de signalisation wnt/ -caténine
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SI3206686T1 (sl)	2014-08-20	2020-03-31	Samumed, Llc	Gama-diketoni za zdravljenje in preprečevanje staranja kože in gub
PL3305788T3 (pl) *	2015-05-29	2021-03-08	Wuxi Fortune Pharmaceutical Co., Ltd	Inhibitor kinazy janusowej
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MD3762368T2 (ro)	2018-03-08	2022-07-31	Incyte Corp	Compuși diol aminopirazină ca inhibitori ai PI3K-Y
WO2020010003A1 (fr)	2018-07-02	2020-01-09	Incyte Corporation	DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ
EP3817743A4 (fr)	2018-07-02	2022-07-06	Palvella Therapeutics, Inc.	Compositions anhydres d'inhibiteurs de mtor et méthodes d'utilisation
ES3045115T3 (en)	2018-07-06	2025-11-27	Pfizer	Manufacturing process and intermediates for a pyrrolo[2,3- d]pyrimidine compound and use thereof
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LTPA2022502I1 (fr)	2022-03-10
US9549929B2 (en)	2017-01-24
US20150225408A1 (en)	2015-08-13
IL240132B (en)	2020-09-30
BR112015019634B1 (pt)	2022-09-20
CN105008362A (zh)	2015-10-28
MX374338B (es)	2025-03-06
ME02904B (fr)	2018-04-20
LT3290421T (lt)	2019-02-25
ME03301B (fr)	2019-07-20
JP2016509049A (ja)	2016-03-24
GEP201606600B (en)	2017-01-10
MX2015010928A (es)	2015-10-29
NZ710411A (en)	2017-11-24
CN107089985B (zh)	2019-06-07
MY177476A (en)	2020-09-16
HRP20171599T1 (hr)	2017-12-01
FR22C1006I1 (fr)	2022-03-25
HUE037192T2 (hu)	2018-08-28
PE20151764A1 (es)	2015-12-03
AU2014220357B2 (en)	2017-04-27
CY1121468T1 (el)	2020-05-29
US20140243312A1 (en)	2014-08-28
SI2958921T1 (sl)	2017-12-29
US20150246048A1 (en)	2015-09-03
LTC2958921I2 (fr)	2024-03-25
PY1407086A (es)	2017-10-02
US9545405B2 (en)	2017-01-17
CU20150078A7 (es)	2016-01-29
US9035074B2 (en)	2015-05-19
EP3290421B1 (fr)	2019-01-02
CY1119502T1 (el)	2018-03-07
HUE041778T2 (hu)	2019-05-28
MD20150073A2 (ro)	2016-01-31
WO2014128591A1 (fr)	2014-08-28
DK3290421T3 (en)	2019-03-18
DOP2015000206A (es)	2016-02-15
DK2958921T3 (da)	2017-11-06
IL240132A0 (en)	2015-09-24
KR101787858B1 (ko)	2017-10-18
HUS2200003I1 (hu)	2022-02-28
NO2022004I1 (no)	2022-02-01
EA201591255A1 (ru)	2016-03-31
HK1213881A1 (zh)	2016-07-15
CA2900703A1 (fr)	2014-08-28
NL301155I2 (nl)	2022-02-23
PT2958921T (pt)	2017-11-20
CA2900703C (fr)	2017-11-28
TWI507408B (zh)	2015-11-11
EP3290421A1 (fr)	2018-03-07
ES2713052T3 (es)	2019-05-17
SG11201505816UA (en)	2015-09-29
MA38347A1 (fr)	2017-10-31
UA111804C2 (uk)	2016-06-10
RS56503B1 (sr)	2018-02-28
EP2958921B1 (fr)	2017-09-20
PH12015501779A1 (en)	2015-12-02
SI3290421T1 (sl)	2019-03-29
MD4735B1 (ro)	2020-12-31
CL2015002303A1 (es)	2015-12-18
AP2015008664A0 (en)	2015-08-31
CY2022003I1 (el)	2022-03-24
CY2022003I2 (el)	2022-03-24
LT2958921T (lt)	2017-11-27
UY35337A (es)	2014-09-30
TR201902525T4 (tr)	2019-03-21
BR112015019634A2 (pt)	2019-12-17
AR094857A1 (es)	2015-09-02
HRP20190152T1 (hr)	2019-03-22
CR20150395A (es)	2015-09-23
HRP20171599T2 (hr)	2018-11-16
EP2958921A1 (fr)	2015-12-30
PL3290421T3 (pl)	2019-05-31
FR22C1006I2 (fr)	2023-01-27
KR20150109434A (ko)	2015-10-01
LUC00261I2 (fr)	2025-04-25
ES2647525T3 (es)	2017-12-22
PH12015501779B1 (en)	2015-12-02
TW201443055A (zh)	2014-11-16
PL2958921T3 (pl)	2018-01-31
AU2014220357A1 (en)	2015-08-06
ZA201505454B (en)	2016-07-27
JP2017165762A (ja)	2017-09-21
NO3052752T3 (fr)	2018-06-16
CN105008362B (zh)	2017-06-06
JP6145179B2 (ja)	2017-06-07
EA027879B1 (ru)	2017-09-29
MD4735C1 (ro)	2021-07-31
NL301155I1 (fr)	2021-12-22
PT3290421T (pt)	2019-03-01
CN107089985A (zh)	2017-08-25
TN2015000355A1 (fr)	2017-01-03
RS58245B1 (sr)	2019-03-29

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