CY2050B1 - 7-Piperazinyl-or 7-morpholino-4-oxo-quinoline-3-carboxylic acid derivatives their preparation and their use as antimicrobial agents - Google Patents

7-Piperazinyl-or 7-morpholino-4-oxo-quinoline-3-carboxylic acid derivatives their preparation and their use as antimicrobial agents

Info

Publication number: CY2050B1
Authority: CY; Cyprus
Prior art keywords: piperazinyl; morpholino; quinoline; oxo; preparation
Prior art date: 1987-04-16

Application number

CY9802050A

Other languages

English (en)

Original Assignee

Otsuka Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-16

Filing date

1998-04-30

Publication date

1998-04-30

1998-04-30 Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd

1998-04-30 Publication of CY2050B1 publication Critical patent/CY2050B1/xx

Links

VGCDBVUNQNEGMQ-UHFFFAOYSA-N 7-morpholin-4-yl-4-oxo-3h-quinoline-3-carboxylic acid Chemical class C=1C=C2C(=O)C(C(=O)O)C=NC2=CC=1N1CCOCC1 VGCDBVUNQNEGMQ-UHFFFAOYSA-N 0.000 title 1
239000004599 antimicrobial Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

CY9802050A 1987-04-16 1998-04-30 7-Piperazinyl-or 7-morpholino-4-oxo-quinoline-3-carboxylic acid derivatives their preparation and their use as antimicrobial agents CY2050B1 (en)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
JP9419887		1987-04-16
JP10235187		1987-04-24
JP10836187		1987-04-30
JP12659887		1987-05-22
JP14954487		1987-06-16
JP17612687		1987-07-14
JP28377687		1987-11-09
JP28710887		1987-11-12

Publications (1)

Publication Number	Publication Date
CY2050B1 true CY2050B1 (en)	1998-04-30

Family

ID=27572879

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY9802050A CY2050B1 (en)	1987-04-16	1998-04-30	7-Piperazinyl-or 7-morpholino-4-oxo-quinoline-3-carboxylic acid derivatives their preparation and their use as antimicrobial agents

Country Status (13)

Country	Link
US (5)	US5563138A (fr)
EP (3)	EP0287951B1 (fr)
JP (2)	JPH0696557B2 (fr)
KR (2)	KR940002113B1 (fr)
CN (1)	CN1053666C (fr)
CY (1)	CY2050B1 (fr)
DE (4)	DE19775083I2 (fr)
DK (2)	DK170640B1 (fr)
ES (3)	ES2172734T3 (fr)
HK (1)	HK128797A (fr)
NL (1)	NL980011I2 (fr)
SA (1)	SA97180461A (fr)
SG (3)	SG49836A1 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL88003A (en) *	1987-10-16	1992-11-15	Dainippon Pharmaceutical Co	Quinoline derivatives,their preparation and pharmaceutical compositions containing them
US5164392A (en) *	1987-10-16	1992-11-17	Dainippon Pharmaceutical Co., Ltd.	Quinoline derivatives and antibacterial agent containing them
EP0319906A3 (fr) *	1987-12-11	1990-05-02	Dainippon Pharmaceutical Co., Ltd.	Dérivés de la quinoléine, procédé de leur préparation et agent antibactérien les contenant
US4920120A (en) *	1988-01-25	1990-04-24	Warner-Lambert Company	Antibacterial agents
US5585491A (en) *	1988-01-25	1996-12-17	Otsuka Pharmaceutical Co., Ltd.	Antibacterial agents
AU5123690A (en) *	1989-03-13	1990-09-13	Bristol-Myers Squibb Company	5-substituted-1,4-dihydro-4-oxo-nephthyridine-3-carboxylate antibacterial agents
DE3910663A1 (de) *	1989-04-03	1990-10-04	Bayer Ag	5-alkylchinoloncarbonsaeuren
KR100204987B1 (ko)	1990-04-18	1999-06-15	제이코버스 코넬리스 레이서	항미생물성 퀴놀로닐 락탐
US5342846A (en) *	1990-12-05	1994-08-30	Synphar Laboratories, Inc.	7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
US5696132A (en) *	1991-05-28	1997-12-09	Daiichi Pharmaceutical Co., Ltd.	Pyridonecarboxylic acid derivatives
FR2692577B1 (fr) *	1992-05-26	1996-02-02	Bouchara Sa	Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
EP0688218B1 (fr) *	1993-03-10	1999-11-17	Otsuka Pharmaceutical Co., Ltd.	Inhibiteur de l'interleukine-1
DE4329600A1 (de) *	1993-09-02	1995-03-09	Bayer Ag	Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
ATE205209T1 (de) *	1993-10-28	2001-09-15	Kaken Pharma Co Ltd	Chinolincarbonsäurederivate und ihre salze
DE4408212A1 (de) *	1994-03-11	1995-09-14	Bayer Ag	5-Vinyl- und 5-Ethinyl-chinolon- und -naphthyridon-carbonsäuren
DE4431821A1 (de) *	1994-09-07	1996-03-14	Bayer Ag	Verfahren zur Herstellung von N-Arylaminoacrylsäurederivaten und die Verwendung so hergestellter N-Arylaminoacrylsäurederivate zur Herstellung von 4-Chinolon-3-carbonsäurederivaten
CA2210007A1 (fr) *	1995-01-24	1996-08-01	Yasuo Ito	Derives de l'acide quiloleine carboxylique
EP0945435B1 (fr) *	1996-11-28	2003-08-13	Wakunaga Pharmaceutical Co., Ltd.	Nouveaux derives d'acide pyridonecarboxylique ou leurs sels, et medicaments contenant ceux-ci en tant que principe actif
DE19652239A1 (de) *	1996-12-16	1998-06-18	Bayer Ag	Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
US6333431B1 (en) *	1998-09-14	2001-12-25	Otsuka Pharmaceutical Co., Ltd.	Processes for the preparation of fluorinated benzoic acids
CA2344050A1 (fr) *	1998-09-30	2000-04-06	Alcon Laboratories, Inc.	Compositions antibiotiques pour le traitement des yeux, des oreilles et du nez
US6509327B1 (en)	1998-09-30	2003-01-21	Alcon Manufacturing, Ltd.	Compositions and methods for treating otic, ophthalmic and nasal infections
US6716830B2 (en)	1998-09-30	2004-04-06	Alcon, Inc.	Ophthalmic antibiotic compositions containing moxifloxacin
US6395746B1 (en)	1998-09-30	2002-05-28	Alcon Manufacturing, Ltd.	Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
DE19850788A1 (de) *	1998-11-04	2000-05-11	Clariant Gmbh	Verfahren zur Herstellung von Trifluorbenzoesäuren
AU3192700A (en)	1999-03-17	2000-10-04	Daiichi Pharmaceutical Co., Ltd.	Medicinal compositions
DE19962470A1 (de) *	1999-12-22	2001-07-12	Schulz Hans Herrmann	Verwendung von Chemotherapeutika
US6608078B2 (en)	2000-05-08	2003-08-19	Wockhardt Limited	Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en)	2000-08-01	2006-08-29	Wockhart Limited	Inhibitors of cellular efflux pumps of microbes
WO2002041891A2 (fr) *	2000-11-01	2002-05-30	The Procter & Gamble Company	Traitement de l'infection par le vih
US6964966B2 (en)	2001-04-25	2005-11-15	Wockhardt Limited	Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en)	2001-04-25	2005-04-12	Wockhardt Limited	Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
JP2005521712A (ja) *	2002-03-26	2005-07-21	アリゾナボードオブリージェンツオンビハーフオブザユニバーシティーオブアリゾナ	弱塩基の可溶化
WO2003099815A1 (fr)	2002-05-28	2003-12-04	Wockhardt Limited	Forme cristalline de sel d'arginine de fluoroquinolone
EP2161258A3 (fr)	2002-11-20	2010-04-07	Japan Tabacco Inc.	Composé d'oxoquinoline 4 et utilisation associée en tant qu'inhibiteur contre l'intégrase du HIV
AU2003304460A1 (en)	2003-09-04	2005-03-29	Wockhardt Limited	Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
CN100410249C (zh) *	2003-09-10	2008-08-13	杏林制药株式会社	7-(4-取代-3-环丙基氨基甲基-1-吡咯烷基)喹诺酮羧酸衍生物
WO2005026145A2 (fr) *	2003-09-12	2005-03-24	Warner-Lambert Company Llc	Agents antibacteriens a base de quinolone
IN2014CN00532A (fr)	2006-03-06	2015-04-03	Japan Tobacco Inc
RS54047B1 (sr)	2006-03-06	2015-10-30	Japan Tobacco Inc.	Postupak za dobijanje jedinjenja 4-oksohinolina
JP5199263B2 (ja)	2006-09-29	2013-05-15	シプラ・リミテッド	テモゾロミドと類似体を調製するための改善された方法
CA2688008A1 (fr) *	2007-05-24	2008-11-27	Kyorin Pharmaceutical Co., Ltd.	Derive de la mutiline ayant une structure d'acide carboxylique a noyau aromatique heterocyclique en substituant a la position 14
WO2009064836A2 (fr) *	2007-11-15	2009-05-22	University Of Maryland, Baltimore	Inhibiteurs de la kynurénine-aminotransférase
US20090270379A1 (en) *	2008-04-23	2009-10-29	Macielag Mark J	Quinolone derivatives useful as antibacterial agents
CN106913569B (zh) *	2016-01-04	2022-04-22	广东工业大学	苯酞类化合物在制备抗耐药菌药物中的应用
CN112266326A (zh) *	2020-11-10	2021-01-26	杭州臻挚生物科技有限公司	二氯甲苯硝化物中间体的制备方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS604820B2 (ja) *	1979-02-26	1985-02-06	大塚製薬株式会社	キノリンカルボン酸誘導体
JPS5630964A (en) *	1979-08-22	1981-03-28	Kyorin Pharmaceut Co Ltd	Novel substituted quinolinecarboxylic acid and its preparation
DE3142854A1 (de) *	1981-10-29	1983-05-11	Bayer Ag, 5090 Leverkusen	1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3142856A1 (de) *	1981-10-29	1983-05-11	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoylchlorid
JPS58174367A (ja) *	1982-04-07	1983-10-13	Tanabe Seiyaku Co Ltd	キノリン誘導体及びその製法
DE3318145A1 (de) *	1983-05-18	1984-11-22	Bayer Ag, 5090 Leverkusen	7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4577473A (en) *	1983-10-17	1986-03-25	Hoshizaki Electric Co., Ltd.	Ice product making machine
JPS60123837A (ja) *	1983-12-09	1985-07-02	Mitsubishi Paper Mills Ltd	ハロゲン化銀写真乳剤
US4571396A (en) *	1984-04-16	1986-02-18	Warner-Lambert Company	Antibacterial agents
DE3420770A1 (de) *	1984-06-04	1985-12-05	Bayer Ag, 5090 Leverkusen	1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3502935A1 (de) *	1984-09-29	1986-04-10	Bayer Ag, 5090 Leverkusen	3-amino-2-benzoyl-acrylsaeurederivate und ein verfahren zu ihrer herstellung
JPS6191183A (ja) *	1984-10-11	1986-05-09	Kyorin Pharmaceut Co Ltd	キノロンカルボン酸誘導体
DE3441788A1 (de) *	1984-11-15	1986-05-15	Bayer Ag, 5090 Leverkusen	Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS61205258A (ja) *	1985-03-08	1986-09-11	Kyorin Pharmaceut Co Ltd	キノロンカルボン酸誘導体及びその製造方法
US4578473A (en) *	1985-04-15	1986-03-25	Warner-Lambert Company	Process for quinoline-3-carboxylic acid antibacterial agents
US4657913A (en) *	1985-04-18	1987-04-14	Warner-Lambert Company	Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
DE3522406A1 (de) *	1985-06-22	1987-01-02	Bayer Ag	Verfahren zur herstellung von 1,8-verbrueckten 4-chinolon-3-carbonsaeuren
JPS62469A (ja) *	1985-06-27	1987-01-06	Dainippon Pharmaceut Co Ltd	新規キノロン誘導体、そのエステルおよびその塩
AU594983B2 (en) *	1985-10-29	1990-03-22	Dainippon Pharmaceutical Co. Ltd.	Novel quinoline derivatives and processes for preparation thereof
US4668680A (en) *	1985-12-12	1987-05-26	Warner-Lambert Company	5-amino-6,8-difluoroquinolones as antibacterial agents
EP0230053A3 (fr) *	1986-01-17	1988-03-30	American Cyanamid Company	Acides 7-(substitué)pipérazinyl-1-éthyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoléine carboxyliques
JPH089597B2 (ja) *	1986-01-21	1996-01-31	杏林製薬株式会社	選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPS62215572A (ja) *	1986-03-17	1987-09-22	Kyorin Pharmaceut Co Ltd	キノロンカルボン酸誘導体
EP0242789A3 (fr) *	1986-04-25	1990-09-05	Dainippon Pharmaceutical Co., Ltd.	Dérivés de quinoléine et procédés pour leur préparation
GB8612137D0 (en) *	1986-05-19	1986-06-25	Fujisawa Pharmaceutical Co	Quinolone compounds
US4771055A (en) *	1986-07-28	1988-09-13	Warner-Lambert Company	7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
JPS63152318A (ja) *	1986-08-07	1988-06-24	Dainippon Pharmaceut Co Ltd	抗マイコプラズマ剤
GB8702508D0 (en) *	1987-02-04	1987-03-11	Fujisawa Pharmaceutical Co	Quinoline compound
DE3711193A1 (de) *	1987-04-02	1988-10-13	Bayer Ag	5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
SI8810667A8 (en) *	1987-04-08	1996-04-30	Chinoin Gyogyszer Es Vegyeszet	Anhydride of quinoline carboxylic acid of boron acid and process for their production.
US4766844A (en) *	1987-05-28	1988-08-30	Westinghouse Electric Corp.	Robotic tinning station for axial lead electronic components
US4929613A (en) *	1987-08-26	1990-05-29	Warner-Lambert Company	Antibacterial agents
DE3811341A1 (de) *	1987-10-09	1989-04-27	Bayer Ag	In 7-stellung c-verknuepfte chinolon- und 1,8-naphthyridin-4-on-carbonsaeure und ein verfahren zu ihrer herstellung
US4920120A (en) *	1988-01-25	1990-04-24	Warner-Lambert Company	Antibacterial agents
US4945160A (en) *	1988-11-22	1990-07-31	Warner-Lambert Company	Preparation of certain 7-substituted quinolones

1988
- 1988-04-08 US US07/179,239 patent/US5563138A/en not_active Expired - Lifetime
- 1988-04-08 US US07/179,300 patent/US5591744A/en not_active Expired - Fee Related
- 1988-04-13 JP JP63091121A patent/JPH0696557B2/ja not_active Expired - Lifetime
- 1988-04-14 SG SG1996007292A patent/SG49836A1/en unknown
- 1988-04-14 SG SG200203819A patent/SG101541A1/en unknown
- 1988-04-14 DE DE1997175083 patent/DE19775083I2/de active Active
- 1988-04-14 ES ES97120444T patent/ES2172734T3/es not_active Expired - Lifetime
- 1988-04-14 SG SG9900120A patent/SG97777A1/en unknown
- 1988-04-14 ES ES93107626T patent/ES2152936T3/es not_active Expired - Lifetime
- 1988-04-14 EP EP88105959A patent/EP0287951B1/fr not_active Expired - Lifetime
- 1988-04-14 DE DE3856515T patent/DE3856515T2/de not_active Expired - Lifetime
- 1988-04-14 EP EP97120444A patent/EP0823413B1/fr not_active Expired - Lifetime
- 1988-04-14 DE DE3856434T patent/DE3856434T2/de not_active Expired - Lifetime
- 1988-04-14 ES ES88105959T patent/ES2091180T3/es not_active Expired - Lifetime
- 1988-04-14 DE DE3855388T patent/DE3855388T2/de not_active Expired - Lifetime
- 1988-04-14 EP EP93107626A patent/EP0565132B1/fr not_active Expired - Lifetime
- 1988-04-15 DK DK207688A patent/DK170640B1/da not_active IP Right Cessation
- 1988-04-16 KR KR1019880004336A patent/KR940002113B1/ko not_active Expired - Lifetime
- 1988-04-16 CN CN88102360A patent/CN1053666C/zh not_active Expired - Lifetime
1990
- 1990-08-02 US US07/562,034 patent/US5495020A/en not_active Expired - Lifetime
1992
- 1992-08-13 DK DK101492A patent/DK171820B1/da not_active IP Right Cessation
1993
- 1993-07-26 KR KR1019930014139A patent/KR960006145B1/ko not_active Expired - Lifetime
1994
- 1994-04-25 JP JP6086368A patent/JP2654537B2/ja not_active Expired - Lifetime
1996
- 1996-07-05 US US08/676,034 patent/US5723648A/en not_active Expired - Fee Related
1997
- 1997-06-26 HK HK128797A patent/HK128797A/en not_active IP Right Cessation
- 1997-09-03 US US08/922,108 patent/US5811576A/en not_active Expired - Fee Related
- 1997-09-30 SA SA97180461A patent/SA97180461A/ar unknown
1998
- 1998-03-11 NL NL980011C patent/NL980011I2/nl unknown
- 1998-04-30 CY CY9802050A patent/CY2050B1/xx unknown

Also Published As

Publication number	Publication date
US5591744A (en)	1997-01-07
JPH0696557B2 (ja)	1994-11-30
KR880012506A (ko)	1988-11-28
US5723648A (en)	1998-03-03
DE19775083I2 (de)	2001-06-13
SG101541A1 (en)	2004-01-30
SA97180461A (ar)	2005-12-03
EP0565132A2 (fr)	1993-10-13
DK101492D0 (da)	1992-08-13
DE3855388T2 (de)	1997-02-13
DK170640B1 (da)	1995-11-20
SG49836A1 (en)	1998-06-15
HK128797A (en)	1997-09-19
KR940002113B1 (ko)	1994-03-17
CN1030237A (zh)	1989-01-11
NL980011I1 (nl)	1998-05-06
DK171820B1 (da)	1997-06-23
JPH01230558A (ja)	1989-09-14
EP0565132B1 (fr)	2000-10-25
CN1053666C (zh)	2000-06-21
KR960006145B1 (ko)	1996-05-09
JPH07138232A (ja)	1995-05-30
ES2152936T3 (es)	2001-02-16
US5563138A (en)	1996-10-08
SG97777A1 (en)	2003-08-20
DE3856515D1 (de)	2002-03-21
EP0287951B1 (fr)	1996-07-03
DK207688D0 (da)	1988-04-15
DE3855388D1 (de)	1996-08-08
ES2172734T3 (es)	2002-10-01
EP0287951A3 (en)	1990-06-13
EP0823413A2 (fr)	1998-02-11
EP0823413A3 (fr)	1998-12-09
JP2654537B2 (ja)	1997-09-17
EP0823413B1 (fr)	2002-02-13
DE3856434D1 (de)	2000-11-30
EP0287951A2 (fr)	1988-10-26
DK101492A (da)	1992-08-13
NL980011I2 (nl)	1998-10-01
DK207688A (da)	1988-10-17
DE3856434T2 (de)	2001-06-13
US5495020A (en)	1996-02-27
DE3856515T2 (de)	2002-08-14
US5811576A (en)	1998-09-22
EP0565132A3 (en)	1994-05-18
ES2091180T3 (es)	1996-11-01

Publication	Publication Date	Title
CY2050B1 (en)	1998-04-30	7-Piperazinyl-or 7-morpholino-4-oxo-quinoline-3-carboxylic acid derivatives their preparation and their use as antimicrobial agents
EP0237955A3 (en)	1987-11-25	Quinolonecarboxylic acid derivatives and their preparation
IL87866A0 (en)	1989-03-31	2-anilinopyrimidine derivatives,their preparation and their use as pesticides
IL86671A0 (en)	1988-11-30	Hyaluronic acid derivatives and their preparation
NZ223079A (en)	1989-12-21	1h-imidazole-5-carboxylic acid derivatives and herbicidal compositions
EP0264106A3 (en)	1990-02-07	5-substituted amino-4-hydroxy-pentanoic acid derivatives and their use
PH23770A (en)	1989-11-03	Trifluoro-quinoline-3-carboxylic acids and their use as antibacterial agents
HU906721D0 (en)	1991-07-29	Methylene-diphosphonic acid derivatives and inflammation-preventing preparations containing them as active agents
EG19184A (en)	1994-07-30	4-Nitro-n- phenylpyrazole derivatives and their use as pesticide
IL81674A0 (en)	1987-09-16	1h-imidazole-5-carboxylic acid derivatives,their preparation and their use as herbicides
AU2302288A (en)	1989-03-31	4-quinoline-3-carboxylic acid derivatives and their use as antibacterial agents
AU2171888A (en)	1989-03-09	4-oxo-3-quinolinecarboxylic acids useful as antibacterial agents and preparation thereof
IL87131A0 (en)	1988-12-30	Pyrazoline derivatives and their use as insecticides
NZ224923A (en)	1989-08-29	2-methoxymethyl-penem-3-carboxylic acid derivatives and pharmaceutical compositions
ZA932576B (en)	1993-10-28	1,2,4-benzothiadiazine-3-carboxylic acid derivatives, their preparation and their use
ZA886400B (en)	1989-04-26	4-oxo-3-quinolinecarboxylic acids useful as antibacterial agents and preparation thereof
GB2105329B (en)	1985-05-30	Penem-3-carboxylic acid derivatives their preparation and their use as antimicrobial agents
IL84978A0 (en)	1988-06-30	1-methyl-1h-imidazole-5-carboxylic acid derivatives,their preparation and their use as herbicides
IL88393A0 (en)	1989-06-30	Imidiates,their preparation and their use as insecticides
AR244042A1 (es)	1993-10-29	Derivados del tiadizabiciclononano y composiciones herbicidas que los contienen.
IL87022A0 (en)	1988-12-30	Hydroxyethylazole derivatives and their use as fungicides
ZA864514B (en)	1987-02-25	Benzoyltriazolylacetic or benzoyltriazolylthioacetic acid derivatives,their preparation and biocidal agents containing them
ZA911649B (en)	1992-11-25	5-phenyl-1h-pyrazol-4-propionic acid derivatives,their preparation and their use
IL84979A0 (en)	1988-06-30	Substituted 1h-imidazole-5-carboxylic acid derivatives,their preparation and their use as herbicides
IL83411A (en)	1991-05-12	Benzohydroxamic acid derivatives,their preparation and their use as herbicides