CY2476B1 - Benzonaphthyridines as bronchial therapeutics. - Google Patents

Benzonaphthyridines as bronchial therapeutics.

Info

Publication number
CY2476B1
CY2476B1 CY0400068A CY0400068A CY2476B1 CY 2476 B1 CY2476 B1 CY 2476B1 CY 0400068 A CY0400068 A CY 0400068A CY 0400068 A CY0400068 A CY 0400068A CY 2476 B1 CY2476 B1 CY 2476B1
Authority
CY
Cyprus
Prior art keywords
pct
benzonaphthyridines
bronchial therapeutics
date
sec
Prior art date
Application number
CY0400068A
Other languages
English (en)
Inventor
Beate Gutterer
Hermann Amschler
Wolf-Ruediger Ulrich
Thomas Martin
Thomas Baer
Armin Hatzelmann
Karl Sanders
Rolf Beume
Hildegard Boss
Dietrich Haefner
Hans-Peter Kley
Karl-Josef Goebel
Dieter Flockerzi
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of CY2476B1 publication Critical patent/CY2476B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CY0400068A 1996-11-11 2004-09-03 Benzonaphthyridines as bronchial therapeutics. CY2476B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19646298 1996-11-11
EP96118188 1996-11-13
DE19739056 1997-09-05

Publications (1)

Publication Number Publication Date
CY2476B1 true CY2476B1 (en) 2005-05-03

Family

ID=27216810

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0400068A CY2476B1 (en) 1996-11-11 2004-09-03 Benzonaphthyridines as bronchial therapeutics.

Country Status (30)

Country Link
US (1) US6008215A (id)
EP (1) EP0937074B1 (id)
JP (1) JP4223075B2 (id)
KR (1) KR100484045B1 (id)
CN (1) CN1090188C (id)
AT (1) ATE234300T1 (id)
AU (1) AU733129B2 (id)
BG (1) BG63695B1 (id)
BR (1) BR9713338B1 (id)
CA (1) CA2270964C (id)
CY (1) CY2476B1 (id)
CZ (1) CZ288752B6 (id)
DE (1) DE69719778T2 (id)
DK (1) DK0937074T3 (id)
EA (1) EA001551B1 (id)
EE (1) EE03829B1 (id)
ES (1) ES2195189T3 (id)
GE (1) GEP20012390B (id)
HU (1) HU226981B1 (id)
ID (1) ID22042A (id)
IL (1) IL129054A (id)
NO (1) NO312764B1 (id)
NZ (1) NZ334976A (id)
PL (1) PL189641B1 (id)
PT (1) PT937074E (id)
RS (1) RS49607B (id)
SI (1) SI0937074T1 (id)
SK (1) SK283269B6 (id)
TR (1) TR199900856T2 (id)
WO (1) WO1998021208A1 (id)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1075477T3 (da) 1998-05-05 2003-06-30 Altana Pharma Ag Nye benzonaphthyridin-N-oxider
AU5970199A (en) * 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity
IT1303272B1 (it) * 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
CA2360386A1 (en) 1999-01-15 2000-07-20 Beate Gutterer Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
DE60020079T2 (de) 1999-01-15 2006-01-19 Altana Pharma Ag Phenanthridin-N-oxide mit PDE-IV-hemmender Wirkung
ES2241571T3 (es) 1999-01-15 2005-11-01 Altana Pharma Ag N-oxidos de fenantrinida con actividad inhividora de pde-iv.
TR200501553T2 (tr) 1999-01-15 2005-06-21 Altana Pharma Ag PDE-IV inhibe edici aktivitesi olan fenilfenantridinler
CA2715683A1 (en) * 1999-08-21 2001-03-01 Nycomed Gmbh Synergistic combination
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
US6936622B2 (en) 2001-02-21 2005-08-30 Altana Pharma Ag 6-phenylbenzonaphthyridines
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
RS20050117A (sr) * 2002-08-17 2007-06-04 Altana Pharma Ag., Novi benzonaftiridini
HRP20050293A2 (en) 2002-09-04 2006-07-31 Altana Pharma Ag Novel benzonaphthyridines
PL373989A1 (en) * 2002-09-04 2005-09-19 Altana Pharma Ag Novel benzonaphthyridines
US7153824B2 (en) 2003-04-01 2006-12-26 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
PL2589599T4 (pl) 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
EP1725534A1 (en) * 2004-03-10 2006-11-29 Altana Pharma AG Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
US7671068B2 (en) 2004-03-17 2010-03-02 Nycomed Gmbh N-(alkoxyalkyl) carbamoyl-substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE ¾ inhibitors
EP1791847A2 (en) 2004-09-08 2007-06-06 Altana Pharma AG Novel 3-thia-10-aza-phenanthrene derivatives
ATE508130T1 (de) * 2004-09-08 2011-05-15 Nycomed Gmbh 3-oxa-10-aza-phenanthrene als pde4- oder pde3/4- inhibitoren
PL1856093T3 (pl) 2005-03-02 2010-05-31 Takeda Gmbh Chlorowodorek (2R,4aR,10bR)-6-(2,6-dimetoksy-pirydyn-3-ylo)-9-etoksy-8-metoksy-1,2,3,4,4a,10b-heksahydrofenantrydyn-2-olu
AU2006305619A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
BRPI0719123A2 (pt) * 2006-09-01 2013-12-17 Cylene Pharmaceuticals Inc Moduladores de serina-treonina proteína cinase e parp
BRPI0911681B8 (pt) 2008-04-23 2021-05-25 Rigel Pharmaceuticals Inc composto, composição farmacêutica, e, método para ativar a via de proteína quinase ativada por 5'-amp em uma célula in vitro
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) * 1990-05-16 1994-09-30 Byk Gulden Lomberg Chemische Fabrik New sulphonyl compounds

Also Published As

Publication number Publication date
PT937074E (pt) 2003-07-31
SK283269B6 (sk) 2003-04-01
CN1236367A (zh) 1999-11-24
TR199900856T2 (xx) 1999-07-21
BR9713338B1 (pt) 2009-12-01
EE03829B1 (et) 2002-08-15
NO312764B1 (no) 2002-07-01
HK1022151A1 (en) 2000-07-28
PL189641B1 (pl) 2005-09-30
JP4223075B2 (ja) 2009-02-12
CA2270964C (en) 2007-07-31
EE9900105A (et) 1999-10-15
KR20000053100A (ko) 2000-08-25
SK62399A3 (en) 1999-10-08
JP2001503442A (ja) 2001-03-13
RS49607B (sr) 2007-06-04
HU226981B1 (hu) 2010-04-28
ID22042A (id) 1999-08-26
NO992282D0 (no) 1999-05-11
DK0937074T3 (da) 2003-06-23
AU733129B2 (en) 2001-05-10
NO992282L (no) 1999-05-11
CZ288752B6 (cs) 2001-08-15
AU5317098A (en) 1998-06-03
WO1998021208A1 (en) 1998-05-22
IL129054A0 (en) 2000-02-17
GEP20012390B (en) 2001-03-25
DE69719778T2 (de) 2004-02-05
ATE234300T1 (de) 2003-03-15
HUP0000426A3 (en) 2001-04-28
EA001551B1 (ru) 2001-04-23
US6008215A (en) 1999-12-28
NZ334976A (en) 2000-10-27
YU19499A (sh) 2001-09-28
CZ167599A3 (cs) 1999-11-17
EP0937074B1 (en) 2003-03-12
BR9713338A (pt) 2000-05-09
HUP0000426A2 (hu) 2001-02-28
SI0937074T1 (en) 2003-08-31
BG103310A (en) 2000-05-31
BG63695B1 (bg) 2002-09-30
KR100484045B1 (ko) 2005-04-20
CA2270964A1 (en) 1998-05-22
IL129054A (en) 2002-07-25
PL333429A1 (en) 1999-12-06
DE69719778D1 (de) 2003-04-17
ES2195189T3 (es) 2003-12-01
EP0937074A1 (en) 1999-08-25
CN1090188C (zh) 2002-09-04
EA199900421A1 (ru) 1999-10-28

Similar Documents

Publication Publication Date Title
IL129054A0 (en) Benzonaphthyridines as bronchial therapeutics
CA2297911A1 (en) Substituted 6-phenylphenanthridines
GR3034991T3 (en) Dihydrobenzofuranes
PL338339A1 (en) Novel derivatives of tetrazole
AU2291097A (en) Novel phenanthridines substituted in the 6 position
BG105561A (en) Phenylphenanthridines with pde-iv inhibiting activity
CA2245142A1 (en) New phenanthridines
AU5648496A (en) Pyrazolo-(1,5a)pyrimidines, their preparation and their use
DE69719358D1 (de) Substituierte dihydrobenzofurane als pde-hemmstoffe
PT920426E (pt) Novos derivados de tiazole com efeito inibidor de fosfodiesterase
PL341239A1 (en) Dihydrobenzofuranes
SI1147088T1 (sl) 6-arilfenantridini s PDE-IV inhibirajoco aktivnostjo
DE59308187D1 (en) Substituierte ortho-ethenylphenylessigsäurederivate
DE69717277D1 (en) Imidazopyridine
MX9800053A (es) Herbicidas de cis-2,3-expoxicicloalcanol bencilado.
SI0937075T1 (en) New Imidazo- and Oxazolopyridines as Phosphodiesterase Inhibitors.
AU758194C (en) Novel benzimidazoles and benzoxazoles