EE9900105A - Bensonaftüridiinid bronhiaalravimitena - Google Patents

Bensonaftüridiinid bronhiaalravimitena

Info

Publication number: EE9900105A
Authority: EE; Estonia
Prior art keywords: pct; benzonaphthyridines; bronchodilators; date; sec
Prior art date: 1996-11-11

Application number

EEP199900105A

Other languages

English (en)

Other versions

EE03829B1 (et

Inventor

Gutterer Beate

Amschler Hermann

Ulrich Wolf-R�diger

Martin Thomas

B�r Thomas

Hatzelmann Armin

Sanders Karl

Beume Rolf

Boss Hildegard

H�fner Dietrich

Kley Hans-Peter

Goebel Karl-Josef

Original Assignee

Byk Gulden Lomberg Chemische Fabrik Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-11

Filing date

1997-11-05

Publication date

1999-10-15

1997-11-05 Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh

1999-10-15 Publication of EE9900105A publication Critical patent/EE9900105A/et

2002-08-15 Publication of EE03829B1 publication Critical patent/EE03829B1/et

Links

BJVCSICIEDHBNI-UHFFFAOYSA-N benzo[b][1,8]naphthyridine Chemical class N1=CC=CC2=CC3=CC=CC=C3N=C21 BJVCSICIEDHBNI-UHFFFAOYSA-N 0.000 title 1
229940124630 bronchodilator Drugs 0.000 title 1
239000000168 bronchodilator agent Substances 0.000 title 1
239000003814 drug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Immunology (AREA)
Hematology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

EEP199900105A 1996-11-11 1997-11-05 Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim EE03829B1 (et)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE19646298		1996-11-11
EP96118188		1996-11-13
DE19739056		1997-09-05
PCT/EP1997/006096 WO1998021208A1 (en)	1996-11-11	1997-11-05	Benzonaphthyridines as bronchial therapeutics

Publications (2)

Publication Number	Publication Date
EE9900105A true EE9900105A (et)	1999-10-15
EE03829B1 EE03829B1 (et)	2002-08-15

Family

ID=27216810

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900105A EE03829B1 (et)	1996-11-11	1997-11-05	Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim

Country Status (30)

Country	Link
US (1)	US6008215A (et)
EP (1)	EP0937074B1 (et)
JP (1)	JP4223075B2 (et)
KR (1)	KR100484045B1 (et)
CN (1)	CN1090188C (et)
AT (1)	ATE234300T1 (et)
AU (1)	AU733129B2 (et)
BG (1)	BG63695B1 (et)
BR (1)	BR9713338B1 (et)
CA (1)	CA2270964C (et)
CY (1)	CY2476B1 (et)
CZ (1)	CZ288752B6 (et)
DE (1)	DE69719778T2 (et)
DK (1)	DK0937074T3 (et)
EA (1)	EA001551B1 (et)
EE (1)	EE03829B1 (et)
ES (1)	ES2195189T3 (et)
GE (1)	GEP20012390B (et)
HU (1)	HU226981B1 (et)
ID (1)	ID22042A (et)
IL (1)	IL129054A (et)
NO (1)	NO312764B1 (et)
NZ (1)	NZ334976A (et)
PL (1)	PL189641B1 (et)
PT (1)	PT937074E (et)
RS (1)	RS49607B (et)
SI (1)	SI0937074T1 (et)
SK (1)	SK283269B6 (et)
TR (1)	TR199900856T2 (et)
WO (1)	WO1998021208A1 (et)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1075477T1 (en)	1998-05-05	2003-08-31	Altana Pharma Ag	Novel Benzonaphthyridine-N-oxides
JP2002523505A (ja) *	1998-08-31	2002-07-30	ビイクグルデンロンベルクヒエーミツシエフアブリークゲゼルシヤフトミツトベシユレンクテルハフツング	Ｐｄｅ３−及びｐｄｅ−４抑制作用を有するベンゾナフチリデン−ｎ−オキシド
IT1303272B1 (it) *	1998-10-29	2000-11-06	Zambon Spa	Derivati triciclici inibitori della fosfodiesterasi 4
DE60033918D1 (de)	1999-01-15	2007-04-26	Altana Pharma Ag	Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung
WO2000042017A1 (en) *	1999-01-15	2000-07-20	Byk Gulden Lomberg Chemische Fabrik Gmbh	Phenanthridine-n-oxides with pde-iv inhibiting activity
DE60024581T2 (de) *	1999-01-15	2006-08-10	Altana Pharma Ag	6-phenylphenanthridine mit pde-iv hemmender wirkung
CA2359449A1 (en)	1999-01-15	2000-07-20	Beate Gutterer	Phenanthridine-n-oxides with pde-iv inhibiting activity
CA2715683A1 (en) *	1999-08-21	2001-03-01	Nycomed Gmbh	Synergistic combination
NL1017973C2 (nl) *	2000-05-10	2002-11-08	Tristem Trading Cyprus Ltd	Inrichting.
CA2438717C (en) *	2001-02-21	2011-08-30	Altana Pharma Ag	6-phenylbenzonaphthyridines
US6479493B1 (en)	2001-08-23	2002-11-12	Cell Pathways, Inc.	Methods for treatment of type I diabetes
AU2003263216A1 (en) *	2002-08-17	2004-03-11	Nycomed Gmbh	Benzonaphthyridines with PDE 3/4 inhibiting activity
HRP20050293A2 (en)	2002-09-04	2006-07-31	Altana Pharma Ag	Novel benzonaphthyridines
JP4638736B2 (ja) *	2002-09-04	2011-02-23	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	新規のベンゾナフチリジン
EA200501548A1 (ru)	2003-04-01	2006-02-24	Апплайд Резеч Системз Арс Холдинг Н.В.	Ингибиторы фосфодиэстераз при бесплодии
SG182194A1 (en)	2004-03-03	2012-07-30	Nycomed Gmbh	Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors
AR049419A1 (es) *	2004-03-03	2006-08-02	Altana Pharma Ag	Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
NZ549254A (en) *	2004-03-10	2010-06-25	Nycomed Gmbh	Amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
US7671068B2 (en)	2004-03-17	2010-03-02	Nycomed Gmbh	N-(alkoxyalkyl) carbamoyl-substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE ¾ inhibitors
JP5009799B2 (ja) *	2004-09-08	2012-08-22	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	新規の３−オキサ−１０−アザ−フェナントレン
WO2006027345A2 (en) *	2004-09-08	2006-03-16	Altana Pharma Ag	Novel 3-thia-10-aza-phenanthrene derivatives
SI1856093T1 (sl)	2005-03-02	2010-03-31	Nycomed Gmbh	Hidrokloridna sol R aR bR dimetoksipiridin il etoksi metoksi a b heksahidrofenantridin ola
WO2007045979A1 (en)	2005-10-19	2007-04-26	Ranbaxy Laboratories Limited	Pharmaceutical compositions of muscarinic receptor antagonists
TW200808695A (en) *	2006-06-08	2008-02-16	Amgen Inc	Benzamide derivatives and uses related thereto
US7956064B2 (en) *	2006-09-01	2011-06-07	Cylene Pharmaceuticals, Inc.	Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators
JP5658138B2 (ja)	2008-04-23	2015-01-21	ライジェルファーマシューティカルズ，インコーポレイテッド	代謝障害の処置のためのカルボキサミド化合物
AR079451A1 (es)	2009-12-18	2012-01-25	Nycomed Gmbh	Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) *	2018-04-09	2021-10-08	中南大学	一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3899494A (en) *	1970-05-13	1975-08-12	Sandoz Ltd	Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (en) *	1986-05-29	1990-01-17	Sandoz Ag	Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) *	1990-05-16	1994-09-30	Byk Gulden Lomberg Chemische Fabrik	New sulphonyl compounds

1997
- 1997-11-05 GE GEAP19974710A patent/GEP20012390B/en unknown
- 1997-11-05 CZ CZ19991675A patent/CZ288752B6/cs not_active IP Right Cessation
- 1997-11-05 SK SK623-99A patent/SK283269B6/sk not_active IP Right Cessation
- 1997-11-05 ES ES97950093T patent/ES2195189T3/es not_active Expired - Lifetime
- 1997-11-05 NZ NZ334976A patent/NZ334976A/xx not_active IP Right Cessation
- 1997-11-05 KR KR10-1999-7004024A patent/KR100484045B1/ko not_active Expired - Fee Related
- 1997-11-05 PT PT97950093T patent/PT937074E/pt unknown
- 1997-11-05 AU AU53170/98A patent/AU733129B2/en not_active Ceased
- 1997-11-05 DE DE69719778T patent/DE69719778T2/de not_active Expired - Lifetime
- 1997-11-05 US US09/284,458 patent/US6008215A/en not_active Expired - Lifetime
- 1997-11-05 WO PCT/EP1997/006096 patent/WO1998021208A1/en not_active Ceased
- 1997-11-05 DK DK97950093T patent/DK0937074T3/da active
- 1997-11-05 JP JP52212098A patent/JP4223075B2/ja not_active Expired - Fee Related
- 1997-11-05 ID IDW990180A patent/ID22042A/id unknown
- 1997-11-05 HU HU0000426A patent/HU226981B1/hu not_active IP Right Cessation
- 1997-11-05 EE EEP199900105A patent/EE03829B1/et not_active IP Right Cessation
- 1997-11-05 PL PL97333429A patent/PL189641B1/pl unknown
- 1997-11-05 EP EP97950093A patent/EP0937074B1/en not_active Expired - Lifetime
- 1997-11-05 SI SI9730535T patent/SI0937074T1/xx unknown
- 1997-11-05 TR TR1999/00856T patent/TR199900856T2/xx unknown
- 1997-11-05 EA EA199900421A patent/EA001551B1/ru not_active IP Right Cessation
- 1997-11-05 RS YUP-194/99A patent/RS49607B/sr unknown
- 1997-11-05 CN CN97199529A patent/CN1090188C/zh not_active Expired - Fee Related
- 1997-11-05 CA CA002270964A patent/CA2270964C/en not_active Expired - Fee Related
- 1997-11-05 AT AT97950093T patent/ATE234300T1/de active
- 1997-11-05 IL IL12905497A patent/IL129054A/en not_active IP Right Cessation
- 1997-11-05 BR BRPI9713338-8A patent/BR9713338B1/pt not_active IP Right Cessation
1999
- 1999-04-05 BG BG103310A patent/BG63695B1/bg unknown
- 1999-05-11 NO NO19992282A patent/NO312764B1/no not_active IP Right Cessation
2004
- 2004-09-03 CY CY0400068A patent/CY2476B1/xx unknown

Also Published As

Publication number	Publication date
HUP0000426A2 (hu)	2001-02-28
BG63695B1 (bg)	2002-09-30
SK283269B6 (sk)	2003-04-01
SK62399A3 (en)	1999-10-08
CZ288752B6 (cs)	2001-08-15
KR100484045B1 (ko)	2005-04-20
HUP0000426A3 (en)	2001-04-28
PT937074E (pt)	2003-07-31
EP0937074A1 (en)	1999-08-25
NO312764B1 (no)	2002-07-01
BR9713338B1 (pt)	2009-12-01
AU5317098A (en)	1998-06-03
BG103310A (en)	2000-05-31
DE69719778D1 (de)	2003-04-17
EE03829B1 (et)	2002-08-15
EA001551B1 (ru)	2001-04-23
ATE234300T1 (de)	2003-03-15
HU226981B1 (hu)	2010-04-28
NO992282D0 (no)	1999-05-11
BR9713338A (pt)	2000-05-09
PL189641B1 (pl)	2005-09-30
SI0937074T1 (en)	2003-08-31
JP4223075B2 (ja)	2009-02-12
DK0937074T3 (da)	2003-06-23
JP2001503442A (ja)	2001-03-13
CY2476B1 (en)	2005-05-03
CN1236367A (zh)	1999-11-24
AU733129B2 (en)	2001-05-10
WO1998021208A1 (en)	1998-05-22
PL333429A1 (en)	1999-12-06
IL129054A (en)	2002-07-25
CZ167599A3 (cs)	1999-11-17
EP0937074B1 (en)	2003-03-12
TR199900856T2 (xx)	1999-07-21
CA2270964A1 (en)	1998-05-22
NZ334976A (en)	2000-10-27
DE69719778T2 (de)	2004-02-05
YU19499A (sh)	2001-09-28
ID22042A (id)	1999-08-26
ES2195189T3 (es)	2003-12-01
US6008215A (en)	1999-12-28
CN1090188C (zh)	2002-09-04
EA199900421A1 (ru)	1999-10-28
RS49607B (sr)	2007-06-04
NO992282L (no)	1999-05-11
CA2270964C (en)	2007-07-31
KR20000053100A (ko)	2000-08-25
GEP20012390B (en)	2001-03-25
HK1022151A1 (en)	2000-07-28
IL129054A0 (en)	2000-02-17

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-12-15	HC1A	Change of owner name
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2016-07-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20151105

Publication	Publication Date	Title
DK0937074T3 (da)	2003-06-23	Benzonaphthyridiner som bronkiale terapeutiske midler
CA2297911A1 (en)	1999-02-04	Substituted 6-phenylphenanthridines
DK0772610T3 (da)	2001-01-29	Dihydrobenzofuraner
SI1070056T1 (en)	2004-12-31	Phthalazinone pde iii/iv inhibitors
ES2184077T3 (es)	2003-04-01	Nuevas fenantridinas sustituidas en la posicion 6.
DK0882021T3 (da)	2003-06-23	Nye phenanthridiner
EE200000033A (et)	2000-10-16	Uudsed tetrasoolderivaadid
ATE233252T1 (de)	2003-03-15	Substituierte dihydrobenzofurane als pde- hemmstoffe
PT920426E (pt)	2004-02-27	Novos derivados de tiazole com efeito inibidor de fosfodiesterase
ATE258930T1 (de)	2004-02-15	Dihydrobenzifurane
PT1086096E (pt)	2003-12-31	Benzamidas com substituintes etra-hidrofuraniloxi como inibidores da fosfodiesterase 4
DE60025327D1 (de)	2006-03-30	6-arylphenanthridine mit pde-iv hemmender wirkung
DK1204659T3 (da)	2004-04-05	Serotonerge benzofuraner
SI0937075T1 (en)	2004-06-30	New Imidazo- and Oxazolopyridines as Phosphodiesterase Inhibitors.
PL343848A1 (en)	2001-09-10	Novel benzimidazoles and benzoxazoles