DK0467331T3 - O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler - Google Patents

O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler

Info

Publication number: DK0467331T3
Authority: DK; Denmark
Prior art keywords: azithromycin; methyl derivatives; co2ch2c6h5; derivatives; methyl
Prior art date: 1990-07-18

Application number

DK91111948.5T

Other languages

Danish (da)

English (en)

Inventor

Gabrijela Kobrehel

Slobodan Djokic

Gorjana Lazarevski

Original Assignee

Pliva Pharm & Chem Works

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-18

Filing date

1991-07-17

Publication date

1996-02-05

1991-07-17 Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works

1996-02-05 Application granted granted Critical

1996-02-05 Publication of DK0467331T3 publication Critical patent/DK0467331T3/da

Links

229960004099 azithromycin Drugs 0.000 title abstract 2
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK91111948.5T 1990-07-18 1991-07-17 O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler DK0467331T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
YU140990		1990-07-18

Publications (1)

Publication Number	Publication Date
DK0467331T3 true DK0467331T3 (da)	1996-02-05

Family

ID=25554060

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91111948.5T DK0467331T3 (da)	1990-07-18	1991-07-17	O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler

Country Status (20)

Country	Link
US (1)	US5250518A (de)
EP (1)	EP0467331B1 (de)
JP (1)	JP2657132B2 (de)
CN (1)	CN1029738C (de)
AT (1)	ATE129715T1 (de)
BG (1)	BG60593B1 (de)
CA (1)	CA2046956C (de)
CZ (1)	CZ280640B6 (de)
DE (1)	DE69114198T2 (de)
DK (1)	DK0467331T3 (de)
ES (1)	ES2081397T3 (de)
GR (1)	GR3018330T3 (de)
HR (1)	HRP920491B1 (de)
HU (4)	HU221803B1 (de)
PL (1)	PL166379B1 (de)
RO (1)	RO109338B1 (de)
RU (1)	RU2045533C1 (de)
SI (1)	SI9011409A (de)
SK (1)	SK279075B6 (de)
UA (1)	UA27105A1 (de)

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US7056893B2 (en)	1999-03-31	2006-06-06	Insite Vision, Inc.	Topical treatment for prevention of ocular infections
US6239113B1 (en)	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
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KR100336447B1 (ko) *	1999-11-24	2002-05-15	민경윤	클라리스로마이신의 개선된 제조방법
US6787342B2 (en)	2000-02-16	2004-09-07	Merial Limited	Paste formulations
CN1193036C (zh) *	2000-03-15	2005-03-16	韩美药品工业株式会社	制备甲红霉素－克拉霉素ⅱ型晶体的方法
DE60114028T2 (de)	2000-08-23	2006-07-13	Wockhardt Ltd.	Verfahren zur herstellung von wasserfreiem azithromycin
RU2202619C2 (ru) *	2001-01-09	2003-04-20	Научно-исследовательский институт химии Нижегородского государственного университета им. Н.И. Лобачевского	Способ определения общей токсичности твердой, жидкой и газообразной сред
HRP20010301A2 (en) *	2001-04-27	2001-12-31	Pliva D D	New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
EP1483579A4 (de)	2002-02-15	2006-07-12	Merckle Gmbh	Konjugate biologisch aktiver verbindungen, verfahren zu ihrer herstellung und verwendung, formulierung und pharmazeutische anwendungen davon
WO2003070254A1 (en)	2002-02-15	2003-08-28	Sympore Gmbh	Antibiotic conjugates
WO2003070174A2 (en)	2002-02-15	2003-08-28	Sympore Gmbh	Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
ITMI20022292A1 (it) *	2002-10-29	2004-04-30	Zambon Spa	9a-azalidi ad attivita' antiinfiammatoria.
US7435805B2 (en) *	2003-05-30	2008-10-14	Glaxpsmithkline Istrazivacki	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2004106353A1 (en) *	2003-05-30	2004-12-09	Pliva - Istrazivacki Institut D.O.O.	Process for selective alkylation of macrolide and azalide derivatives
WO2005021567A1 (en) *	2003-09-02	2005-03-10	Pliva - Istrazivacki Institut D.O.O.	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
KR20070105993A (ko) *	2005-01-13	2007-10-31	글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오.	소염 활성을 갖는 마크로라이드
US8362086B2 (en)	2005-08-19	2013-01-29	Merial Limited	Long acting injectable formulations
JP2012516305A (ja)	2009-01-30	2012-07-19	グラクソグループリミテッド	好中球優位の炎症性疾患の治療のための９−デオキソ−９ａ−メチル−９ａ−アザ−９ａ−ホモエリスロマイシンａ誘導体
CN102378763A (zh)	2009-01-30	2012-03-14	葛兰素集团有限公司	消炎的大环内酯
CN101830949B (zh) *	2009-03-13	2012-05-23	上海医药工业研究院	一种阿奇霉素衍生物、其中间体及其制备方法和应用
WO2011131749A1 (en)	2010-04-23	2011-10-27	Glaxo Group Limited	New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CN102952166A (zh) *	2011-08-28	2013-03-06	山东方明药业集团股份有限公司	聚合物支载硼氢阴离子还原剂合成阿奇霉素中间体的方法
WO2013148874A1 (en) *	2012-03-27	2013-10-03	Burnet Michael W	Anti-inflammatory macrolides
GB201608236D0 (en)	2016-05-11	2016-06-22	Fidelta D O O	Seco macrolide compounds
EP3612543B1 (de)	2017-04-20	2022-11-23	Rising Tide Foundation	Ein phosphonium-ion enthaltende azithromycin-derivate als antikrebsmittel
US11427606B2 (en)	2017-04-20	2022-08-30	Rising Tide Foundation	Azithromycin derivatives containing a phosphonium ion as anticancer agents
WO2018195446A1 (en)	2017-04-21	2018-10-25	Lisanti Michael P	Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy
WO2018195434A1 (en)	2017-04-21	2018-10-25	Lisanti Michael P	Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
US11160821B2 (en)	2017-05-19	2021-11-02	Lunella Biotech, Inc.	Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
WO2018213764A1 (en)	2017-05-19	2018-11-22	Lunella Biotech, Inc.	Companion diagnostics for mitochondrial inhibitors
CU20190106A7 (es)	2017-06-26	2020-11-30	Lunella Biotech Inc	Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas

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JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
EP0184921A3 (de) *	1984-12-08	1986-10-29	Beecham Group Plc	Erythromycinderivate
JPS63107994A (ja) *	1986-05-02	1988-05-12	Taisho Pharmaceut Co Ltd	エリスロマイシン誘導体
WO1989002271A1 (en) *	1987-09-10	1989-03-23	Pfizer	Azithromycin and derivatives as antiprotozoal agents

1990
- 1990-07-18 SI SI9011409A patent/SI9011409A/sl not_active IP Right Cessation
1991
- 1991-07-06 SK SK2195-91A patent/SK279075B6/sk unknown
- 1991-07-12 CA CA002046956A patent/CA2046956C/en not_active Expired - Fee Related
- 1991-07-16 CZ CS912195A patent/CZ280640B6/cs not_active IP Right Cessation
- 1991-07-16 RO RO148016A patent/RO109338B1/ro unknown
- 1991-07-17 DK DK91111948.5T patent/DK0467331T3/da active
- 1991-07-17 ES ES91111948T patent/ES2081397T3/es not_active Expired - Lifetime
- 1991-07-17 BG BG94837A patent/BG60593B1/bg unknown
- 1991-07-17 EP EP91111948A patent/EP0467331B1/de not_active Expired - Lifetime
- 1991-07-17 AT AT91111948T patent/ATE129715T1/de not_active IP Right Cessation
- 1991-07-17 DE DE69114198T patent/DE69114198T2/de not_active Expired - Fee Related
- 1991-07-17 UA UA5001127A patent/UA27105A1/uk unknown
- 1991-07-17 RU SU915001127A patent/RU2045533C1/ru not_active IP Right Cessation
- 1991-07-18 US US07/731,781 patent/US5250518A/en not_active Expired - Lifetime
- 1991-07-18 HU HU9802439A patent/HU221803B1/hu not_active IP Right Cessation
- 1991-07-18 HU HU9202619A patent/HU215158B/hu unknown
- 1991-07-18 PL PL91291130A patent/PL166379B1/pl not_active IP Right Cessation
- 1991-07-18 CN CN91104907A patent/CN1029738C/zh not_active Expired - Fee Related
- 1991-07-18 HU HU912408A patent/HUT59935A/hu unknown
- 1991-07-18 JP JP3178514A patent/JP2657132B2/ja not_active Expired - Fee Related
1992
- 1992-09-25 HR HRP-1409/90A patent/HRP920491B1/xx not_active IP Right Cessation
1995
- 1995-07-03 HU HU95P/P00748P patent/HU211659A9/hu unknown
- 1995-12-07 GR GR950403439T patent/GR3018330T3/el unknown

Also Published As

Publication number	Publication date
HRP920491B1 (en)	1998-10-31
RU2045533C1 (ru)	1995-10-10
US5250518A (en)	1993-10-05
CA2046956C (en)	1999-01-05
JP2657132B2 (ja)	1997-09-24
ATE129715T1 (de)	1995-11-15
CS219591A3 (en)	1992-03-18
HU9802439D0 (en)	1998-12-28
JPH05132497A (ja)	1993-05-28
SI9011409A (en)	1995-10-31
HU215158B (hu)	1998-12-28
HU221803B1 (hu)	2003-01-28
HU912408D0 (en)	1991-12-30
DE69114198D1 (de)	1995-12-07
BG60593B1 (bg)	1995-09-29
CA2046956A1 (en)	1992-01-19
RO109338B1 (ro)	1995-01-30
HUT59935A (en)	1992-07-28
EP0467331B1 (de)	1995-11-02
CN1059728A (zh)	1992-03-25
HRP920491A2 (en)	1994-08-31
CN1029738C (zh)	1995-09-13
DE69114198T2 (de)	1996-06-27
PL166379B1 (en)	1995-05-31
HU9202619D0 (en)	1992-12-28
GR3018330T3 (en)	1996-03-31
HU211659A9 (en)	1995-12-28
EP0467331A1 (de)	1992-01-22
BG94837A (bg)	1993-12-24
CZ280640B6 (cs)	1996-03-13
SK279075B6 (sk)	1998-06-03
PL291130A1 (en)	1992-11-16
UA27105A1 (uk)	2000-02-28
ES2081397T3 (es)	1996-03-01
HUT62307A (en)	1993-04-28

Publication	Publication Date	Title
PL291130A1 (en)	1992-11-16	Method of obtaining novel o-methyl derivatives of azithromycine a
DK0732338T3 (da)	2002-06-17	2,2-difluor-3-carbamoylribosesulfonatforbindelser og fremgangsmåde til fremstilling af beta-nucleosider
DK0463488T4 (da)	2004-05-10	0-benzyloximethere og plantebeskyttelsesmidler indeholdende disse forbindelser
DK0879236T3 (da)	2010-01-18	Derivater af camptothecin til anvendelse ved behandling af cancer
ATE18902T1 (de)	1986-04-15	Aminosaeurederivate und ihre therapeutischen verwendungen.
DK0464465T3 (da)	1995-05-22	Substituerede aminoalkylbiphenylderivater, antimykotiske præparater indeholdende disse derivater og mellemprodukter til fremstilling deraf
BR8105103A (pt)	1982-04-27	Processo para preparar um composto e processo para tingir ou estampar substratos
DK0429627T3 (da)	1995-11-20	Derivater af quinolin-3-carboxanilider
FI864017A0 (fi)	1986-10-03	3-vinyl och 3-etynyl- -karbolinderivat, deras framstaellning och deras anvaendning som laekemedel.
DK0632805T3 (da)	1999-04-19	Melaminderivater til anvendelse i behandlingen af cancer
ES2152563T3 (es)	2001-02-01	Procedimiento para preparar derivados de dihidroxipirimidina.
EP1043312A4 (de)	2001-01-17	Heterocyclische verbindungen die nos-hemmende aktivitäten besitzen
DE68920717D1 (de)	1995-03-02	Reaktivfarbstoffe.
TR199802163T2 (xx)	1999-02-22	4'-Triflorometilbifenil-2-karboksilik asit
DK0781764T3 (da)	2000-07-10	Fremgangsmåde til fremstilling af alkoxyiminoacetamid-derivater
MX9700179A (es)	1997-12-31	Derivados de triazol y su utilizacion.
DK0975601T3 (da)	2003-06-16	Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derfor
CZ281393B6 (cs)	1996-09-11	Způsob výroby 6-(substituovaných amino)-propionyl derivátů forskolinu
DK383588A (da)	1989-01-12	Fremgangsmaade til fremstilling af substituerede pyridylketoner
DK0788472T3 (da)	2000-09-04	Fremgangsmåde til fremstilling af 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalenderivater
TW358114B (en)	1999-05-11	Diasazo dyestuffs for dyeing cellulosic materials
PT98389A (pt)	1992-05-29	Processo de preparacao de derivados de estreptogramina
IT1231765B (it)	1991-12-21	Malte aeree a presa autogena.
GR3002592T3 (en)	1993-01-25	Polyfunctional ethylenic monomers
DK0678515T3 (da)	1998-11-02	Fremgangsmåde og mellemprodukter til fremstilling af 5-oxaspiro[2.4]heptan-on