HRP920491B1 - O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals - Google Patents

O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Info

Publication number: HRP920491B1
Authority: HR; Croatia
Prior art keywords: preparation; azithromycin; pharmaceuticals; intermediates; methyl derivatives
Prior art date: 1990-07-18

Application number

HRP-1409/90A

Other languages

English (en)

Inventor

Slobodan Dokic

Original Assignee

Slobodan Dokic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-18

Filing date

1992-09-25

Publication date

1998-10-31

1992-09-25 Application filed by Slobodan Dokic filed Critical Slobodan Dokic

1992-09-25 Priority to HRP-1409/90A priority Critical patent/HRP920491B1/xx

1994-08-31 Publication of HRP920491A2 publication Critical patent/HRP920491A2/hr

1998-10-31 Publication of HRP920491B1 publication Critical patent/HRP920491B1/xx

Links

229960004099 azithromycin Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title 2
239000003814 drug Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

HRP-1409/90A 1990-07-18 1992-09-25 O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals HRP920491B1 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
HRP-1409/90A HRP920491B1 (en)	1990-07-18	1992-09-25	O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
YU140990		1990-07-18
HRP-1409/90A HRP920491B1 (en)	1990-07-18	1992-09-25	O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Publications (2)

Publication Number	Publication Date
HRP920491A2 HRP920491A2 (en)	1994-08-31
HRP920491B1 true HRP920491B1 (en)	1998-10-31

Family

ID=25554060

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HRP-1409/90A HRP920491B1 (en)	1990-07-18	1992-09-25	O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Country Status (20)

Country	Link
US (1)	US5250518A (de)
EP (1)	EP0467331B1 (de)
JP (1)	JP2657132B2 (de)
CN (1)	CN1029738C (de)
AT (1)	ATE129715T1 (de)
BG (1)	BG60593B1 (de)
CA (1)	CA2046956C (de)
CZ (1)	CZ280640B6 (de)
DE (1)	DE69114198T2 (de)
DK (1)	DK0467331T3 (de)
ES (1)	ES2081397T3 (de)
GR (1)	GR3018330T3 (de)
HR (1)	HRP920491B1 (de)
HU (4)	HU221803B1 (de)
PL (1)	PL166379B1 (de)
RO (1)	RO109338B1 (de)
RU (1)	RU2045533C1 (de)
SI (1)	SI9011409A (de)
SK (1)	SK279075B6 (de)
UA (1)	UA27105A1 (de)

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RU2122549C1 (ru) *	1997-12-29	1998-11-27	Закрытое акционерное общество "Фосфосорб"	Способ хроматографического выделения и очистки белков, пептидов и их комплексов
HRP970714B1 (en) *	1997-12-31	2003-08-31	Pliva Pharm & Chem Works	Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a
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UA70972C2 (uk)	1998-11-20	2004-11-15	Пфайзер Продактс Інк.	13-членні азаліди і їх застосування як антибіотиків
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US7056893B2 (en)	1999-03-31	2006-06-06	Insite Vision, Inc.	Topical treatment for prevention of ocular infections
US6239113B1 (en)	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
HRP990116B1 (en) *	1999-04-20	2007-10-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
US6465437B1 (en) *	1999-06-30	2002-10-15	Pfizer Inc.	Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
KR100336447B1 (ko) *	1999-11-24	2002-05-15	민경윤	클라리스로마이신의 개선된 제조방법
US6787342B2 (en)	2000-02-16	2004-09-07	Merial Limited	Paste formulations
CN1193036C (zh) *	2000-03-15	2005-03-16	韩美药品工业株式会社	制备甲红霉素－克拉霉素ⅱ型晶体的方法
DE60114028T2 (de)	2000-08-23	2006-07-13	Wockhardt Ltd.	Verfahren zur herstellung von wasserfreiem azithromycin
RU2202619C2 (ru) *	2001-01-09	2003-04-20	Научно-исследовательский институт химии Нижегородского государственного университета им. Н.И. Лобачевского	Способ определения общей токсичности твердой, жидкой и газообразной сред
HRP20010301A2 (en) *	2001-04-27	2001-12-31	Pliva D D	New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
EP1483579A4 (de)	2002-02-15	2006-07-12	Merckle Gmbh	Konjugate biologisch aktiver verbindungen, verfahren zu ihrer herstellung und verwendung, formulierung und pharmazeutische anwendungen davon
WO2003070254A1 (en)	2002-02-15	2003-08-28	Sympore Gmbh	Antibiotic conjugates
WO2003070174A2 (en)	2002-02-15	2003-08-28	Sympore Gmbh	Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
ITMI20022292A1 (it) *	2002-10-29	2004-04-30	Zambon Spa	9a-azalidi ad attivita' antiinfiammatoria.
US7435805B2 (en) *	2003-05-30	2008-10-14	Glaxpsmithkline Istrazivacki	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2004106353A1 (en) *	2003-05-30	2004-12-09	Pliva - Istrazivacki Institut D.O.O.	Process for selective alkylation of macrolide and azalide derivatives
WO2005021567A1 (en) *	2003-09-02	2005-03-10	Pliva - Istrazivacki Institut D.O.O.	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
KR20070105993A (ko) *	2005-01-13	2007-10-31	글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오.	소염 활성을 갖는 마크로라이드
US8362086B2 (en)	2005-08-19	2013-01-29	Merial Limited	Long acting injectable formulations
JP2012516305A (ja)	2009-01-30	2012-07-19	グラクソグループリミテッド	好中球優位の炎症性疾患の治療のための９−デオキソ−９ａ−メチル−９ａ−アザ−９ａ−ホモエリスロマイシンａ誘導体
CN102378763A (zh)	2009-01-30	2012-03-14	葛兰素集团有限公司	消炎的大环内酯
CN101830949B (zh) *	2009-03-13	2012-05-23	上海医药工业研究院	一种阿奇霉素衍生物、其中间体及其制备方法和应用
WO2011131749A1 (en)	2010-04-23	2011-10-27	Glaxo Group Limited	New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CN102952166A (zh) *	2011-08-28	2013-03-06	山东方明药业集团股份有限公司	聚合物支载硼氢阴离子还原剂合成阿奇霉素中间体的方法
WO2013148874A1 (en) *	2012-03-27	2013-10-03	Burnet Michael W	Anti-inflammatory macrolides
GB201608236D0 (en)	2016-05-11	2016-06-22	Fidelta D O O	Seco macrolide compounds
EP3612543B1 (de)	2017-04-20	2022-11-23	Rising Tide Foundation	Ein phosphonium-ion enthaltende azithromycin-derivate als antikrebsmittel
US11427606B2 (en)	2017-04-20	2022-08-30	Rising Tide Foundation	Azithromycin derivatives containing a phosphonium ion as anticancer agents
WO2018195446A1 (en)	2017-04-21	2018-10-25	Lisanti Michael P	Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy
WO2018195434A1 (en)	2017-04-21	2018-10-25	Lisanti Michael P	Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
US11160821B2 (en)	2017-05-19	2021-11-02	Lunella Biotech, Inc.	Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
WO2018213764A1 (en)	2017-05-19	2018-11-22	Lunella Biotech, Inc.	Companion diagnostics for mitochondrial inhibitors
CU20190106A7 (es)	2017-06-26	2020-11-30	Lunella Biotech Inc	Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas

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US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
EP0184921A3 (de) *	1984-12-08	1986-10-29	Beecham Group Plc	Erythromycinderivate
JPS63107994A (ja) *	1986-05-02	1988-05-12	Taisho Pharmaceut Co Ltd	エリスロマイシン誘導体
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1990
- 1990-07-18 SI SI9011409A patent/SI9011409A/sl not_active IP Right Cessation
1991
- 1991-07-06 SK SK2195-91A patent/SK279075B6/sk unknown
- 1991-07-12 CA CA002046956A patent/CA2046956C/en not_active Expired - Fee Related
- 1991-07-16 CZ CS912195A patent/CZ280640B6/cs not_active IP Right Cessation
- 1991-07-16 RO RO148016A patent/RO109338B1/ro unknown
- 1991-07-17 DK DK91111948.5T patent/DK0467331T3/da active
- 1991-07-17 ES ES91111948T patent/ES2081397T3/es not_active Expired - Lifetime
- 1991-07-17 BG BG94837A patent/BG60593B1/bg unknown
- 1991-07-17 EP EP91111948A patent/EP0467331B1/de not_active Expired - Lifetime
- 1991-07-17 AT AT91111948T patent/ATE129715T1/de not_active IP Right Cessation
- 1991-07-17 DE DE69114198T patent/DE69114198T2/de not_active Expired - Fee Related
- 1991-07-17 UA UA5001127A patent/UA27105A1/uk unknown
- 1991-07-17 RU SU915001127A patent/RU2045533C1/ru not_active IP Right Cessation
- 1991-07-18 US US07/731,781 patent/US5250518A/en not_active Expired - Lifetime
- 1991-07-18 HU HU9802439A patent/HU221803B1/hu not_active IP Right Cessation
- 1991-07-18 HU HU9202619A patent/HU215158B/hu unknown
- 1991-07-18 PL PL91291130A patent/PL166379B1/pl not_active IP Right Cessation
- 1991-07-18 CN CN91104907A patent/CN1029738C/zh not_active Expired - Fee Related
- 1991-07-18 HU HU912408A patent/HUT59935A/hu unknown
- 1991-07-18 JP JP3178514A patent/JP2657132B2/ja not_active Expired - Fee Related
1992
- 1992-09-25 HR HRP-1409/90A patent/HRP920491B1/xx not_active IP Right Cessation
1995
- 1995-07-03 HU HU95P/P00748P patent/HU211659A9/hu unknown
- 1995-12-07 GR GR950403439T patent/GR3018330T3/el unknown

Also Published As

Publication number	Publication date
RU2045533C1 (ru)	1995-10-10
US5250518A (en)	1993-10-05
CA2046956C (en)	1999-01-05
JP2657132B2 (ja)	1997-09-24
ATE129715T1 (de)	1995-11-15
CS219591A3 (en)	1992-03-18
HU9802439D0 (en)	1998-12-28
JPH05132497A (ja)	1993-05-28
SI9011409A (en)	1995-10-31
HU215158B (hu)	1998-12-28
HU221803B1 (hu)	2003-01-28
HU912408D0 (en)	1991-12-30
DE69114198D1 (de)	1995-12-07
BG60593B1 (bg)	1995-09-29
CA2046956A1 (en)	1992-01-19
RO109338B1 (ro)	1995-01-30
HUT59935A (en)	1992-07-28
DK0467331T3 (da)	1996-02-05
EP0467331B1 (de)	1995-11-02
CN1059728A (zh)	1992-03-25
HRP920491A2 (en)	1994-08-31
CN1029738C (zh)	1995-09-13
DE69114198T2 (de)	1996-06-27
PL166379B1 (en)	1995-05-31
HU9202619D0 (en)	1992-12-28
GR3018330T3 (en)	1996-03-31
HU211659A9 (en)	1995-12-28
EP0467331A1 (de)	1992-01-22
BG94837A (bg)	1993-12-24
CZ280640B6 (cs)	1996-03-13
SK279075B6 (sk)	1998-06-03
PL291130A1 (en)	1992-11-16
UA27105A1 (uk)	2000-02-28
ES2081397T3 (es)	1996-03-01
HUT62307A (en)	1993-04-28

Legal Events

Date	Code	Title	Description
1994-08-31	A1OB	Publication of a patent application
1994-10-06	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
1998-10-31	B1PR	Patent granted
2007-01-15	PNAN	Change of the applicant name, address/residence	Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.,
2007-01-15	PPPP	Transfer of rights	Owner name: PLIVA-ISTRAZIVACKI INSTITUT D.O.O., HR
2007-07-13	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20070713 Year of fee payment: 18
2009-01-19	PBON	Lapse due to non-payment of renewal fee	Effective date: 20080719

Publication	Publication Date	Title
GR3018330T3 (en)	1996-03-31	O-methyl derivatives of azithromycin A, process and intermediates for their preparation, and use thereof in the preparation of pharmaceuticals.
ZA892474B (en)	1989-12-27	Process for preparing derivatives of baccatine iii and of 10-deacetyl baccatine iii
DK0553202T3 (da)	1995-07-03	Fremgangsmåde til fremstilling af imidazo(4,5-c)quinolin-4-aminer
DE3270317D1 (en)	1986-05-07	Derivatives of amino acids and their therapeutic use
CA2146852A1 (en)	1994-04-28	New substituted pyrazole derivatives, processes for their preparation and their use as herbicides
FI111263B (fi)	2003-06-30	Uudet erytromysiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä sekä menetelmässä käytettävät välituoteamiinit
MX9805181A (es)	1998-10-31	Derivados de lactona a partir de derivados de 17.beta- carboxi, carbotio y amida androstano.
NZ233735A (en)	1992-10-28	Heterocyclic substituted aminophenol derivatives
NO890567D0 (no)	1989-02-09	Anthracyklin-derivater.
NO961356D0 (no)	1996-04-02	Antracyklinonderivater, samt anvendelse derav ved amyloidose
CA2148595A1 (en)	1994-05-11	Molecule labelling using 2-hydrazinopyridine derivatives
ES2145772T3 (es)	2000-07-16	Uso de un complejo de ibuprofeno-beta-ciclodextrina para administracion oral.
ATE63921T1 (de)	1991-06-15	6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung.
DE69025505D1 (de)	1996-04-04	Tylosin-Derivate
CZ281393B6 (cs)	1996-09-11	Způsob výroby 6-(substituovaných amino)-propionyl derivátů forskolinu
HUT58065A (en)	1992-01-28	Process for producing new 4'-epi-4'-aminoanthracyclines and pharmaceutical composiktions comprising same
PT86702A (pt)	1988-03-01	Process for preparing substituted methanesulphonamidophenethylamines
DK0424248T3 (da)	1996-03-04	20,21-dinoreburnamein med substitution i 15-stillingen, fremgangsmåde til deres fremstilling samt mellemprodukter til brug derved, deres anvendelse som lægemidler og præparater med indhold deraf
MY115291A (en)	2003-05-31	New substituted pyrazole derivatives, processes for their preparation nad their use as herbicides
HUT50127A (en)	1989-12-28	Process for producing compounds of antiarrythmic activity and pharmaceutical compositions containing
SE8305231D0 (sv)	1983-09-28	Aminoglycoside derivatives, processes for their production and their use
HUT57718A (en)	1991-12-30	Process for producing thiourea derivative
MX9802933A (es)	1998-11-29	Derivados novedosos de amina de 2", 3"-didesoxiglicosidos de epipodofilotoxina, metodo de preparacion de los mismos y uso de los mismos con un farmaco y para tratamientos anticancer.
FI102972B1 (fi)	1999-03-31	20-metyyli-5,7-pregneadieeni-3b,21-diolijohdannaisia
MY101624A (en)	1991-12-31	Novel compounds and prosesses.