DK0778263T3 - Benzenforbindelser og farmaceutisk anvendelse af disse - Google Patents

Benzenforbindelser og farmaceutisk anvendelse af disse

Info

Publication number: DK0778263T3
Authority: DK; Denmark
Prior art keywords: disease; syndrome; salt; useful; optically active
Prior art date: 1994-08-22

Application number

DK95928630T

Other languages

Danish (da)

English (en)

Inventor

Tetsuro Fujita

Kunitomo Yoshitomi Phar Adachi

Toshiyuki Yoshitomi Pha Kohara

Masatoshi Yoshitomi Pha Kiuchi

Kenji Yoshitomi Pharmace Chiba

Koji Yoshitomi Pharmac Teshima

Tadashi Yoshitomi Phar Mishina

Original Assignee

Mitsubishi Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-22

Filing date

1995-08-22

Publication date

2002-04-22

1995-08-22 Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp

2002-04-22 Application granted granted Critical

2002-04-22 Publication of DK0778263T3 publication Critical patent/DK0778263T3/da

Links

125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 1
208000032467 Aplastic anaemia Diseases 0.000 abstract 1
208000027496 Behcet disease Diseases 0.000 abstract 1
206010008909 Chronic Hepatitis Diseases 0.000 abstract 1
206010009900 Colitis ulcerative Diseases 0.000 abstract 1
208000011231 Crohn disease Diseases 0.000 abstract 1
201000004624 Dermatitis Diseases 0.000 abstract 1
206010012438 Dermatitis atopic Diseases 0.000 abstract 1
201000003066 Diffuse Scleroderma Diseases 0.000 abstract 1
206010060742 Endocrine ophthalmopathy Diseases 0.000 abstract 1
208000004332 Evans syndrome Diseases 0.000 abstract 1
201000003675 Evans' syndrome Diseases 0.000 abstract 1
206010016654 Fibrosis Diseases 0.000 abstract 1
206010018364 Glomerulonephritis Diseases 0.000 abstract 1
206010018691 Granuloma Diseases 0.000 abstract 1
208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 abstract 1
208000003250 Mixed connective tissue disease Diseases 0.000 abstract 1
241000721454 Pemphigus Species 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
206010048908 Seasonal allergy Diseases 0.000 abstract 1
208000021386 Sjogren Syndrome Diseases 0.000 abstract 1
201000009594 Systemic Scleroderma Diseases 0.000 abstract 1
206010042953 Systemic sclerosis Diseases 0.000 abstract 1
208000001106 Takayasu Arteritis Diseases 0.000 abstract 1
208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 abstract 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
208000027076 Uveal disease Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
229940121375 antifungal agent Drugs 0.000 abstract 1
239000003429 antifungal agent Substances 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
201000008937 atopic dermatitis Diseases 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
201000000448 autoimmune hemolytic anemia Diseases 0.000 abstract 1
201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 abstract 1
-1 benzene compound Chemical class 0.000 abstract 1
238000010322 bone marrow transplantation Methods 0.000 abstract 1
230000007882 cirrhosis Effects 0.000 abstract 1
208000019425 cirrhosis of liver Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000001981 dermatomyositis Diseases 0.000 abstract 1
229940124563 hair growth stimulant Drugs 0.000 abstract 1
208000006454 hepatitis Diseases 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
229960003444 immunosuppressant agent Drugs 0.000 abstract 1
230000001861 immunosuppressant effect Effects 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1
208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
206010028417 myasthenia gravis Diseases 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
201000006292 polyarteritis nodosa Diseases 0.000 abstract 1
208000005987 polymyositis Diseases 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
201000000306 sarcoidosis Diseases 0.000 abstract 1
201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/44—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/31—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK95928630T 1994-08-22 1995-08-22 Benzenforbindelser og farmaceutisk anvendelse af disse DK0778263T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP19688894		1994-08-22
JP8293495		1995-04-07
JP17254395		1995-07-07
PCT/JP1995/001654 WO1996006068A1 (en)	1994-08-22	1995-08-22	Benzene compound and medicinal use thereof

Publications (1)

Publication Number	Publication Date
DK0778263T3 true DK0778263T3 (da)	2002-04-22

Family

ID=27304053

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95928630T DK0778263T3 (da)	1994-08-22	1995-08-22	Benzenforbindelser og farmaceutisk anvendelse af disse

Country Status (9)

Country	Link
EP (1)	EP0778263B1 (de)
JP (1)	JP3870419B2 (de)
KR (1)	KR100358922B1 (de)
AT (1)	ATE211726T1 (de)
DE (2)	DE69524962T4 (de)
DK (1)	DK0778263T3 (de)
ES (1)	ES2171191T3 (de)
PT (1)	PT778263E (de)
WO (1)	WO1996006068A1 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002241272A (ja) *	1996-07-18	2002-08-28	Mitsubishi Pharma Corp	医薬処方組成物
US6476004B1 (en)	1996-07-18	2002-11-05	Mitsubishi Pharma Corporation	Pharmaceutical composition
JPH11209277A (ja) *	1998-01-19	1999-08-03	Yoshitomi Pharmaceut Ind Ltd	医薬組成物
DE69840169D1 (de) *	1997-02-27	2008-12-11	Novartis Ag	Arzneimittel zubereitung enthaltend 2-amino-2-ä2-(4-octylphenyl)ethylüpropane-1,3-diol, ein lecithin und ein saccharid
ES2312184T3 (es)	1997-03-21	2009-02-16	Chugai Seiyaku Kabushiki Kaisha	Agentes preventivos terapeuticos para el tratamiento de esclerosis multiple, que contienen anticuerpos anti-receptores de il-6 antagonistas.
CA2286315C (en) *	1997-04-04	2007-03-06	Yoshitomi Pharmaceutical Industries Ltd.	2-aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor
WO1999001420A1 (en) *	1997-07-03	1999-01-14	Taito Co., Ltd.	Process for the preparation of 2-aminomalonic acid derivatives and intermediates used in the process
JPH1180026A (ja)	1997-09-02	1999-03-23	Yoshitomi Pharmaceut Ind Ltd	新規免疫抑制剤、その使用方法およびその同定方法
ATE288414T1 (de)	1998-11-11	2005-02-15	Novartis Pharma Gmbh	Herstellung von 2-amino-2(2-(4- alkylphenyl)äthyl)propan-1,3-diolen
NZ533997A (en) *	2000-07-13	2005-11-25	Sankyo Co	Amino alcohol derivatives
RU2233839C1 (ru) *	2000-07-13	2004-08-10	Санкио Компани, Лимитед	Производные аминоспиртов, фармацевтическая композиция, способ профилактики или лечения, промежуточные соединения и способ получения промежуточных соединений
CN100415735C (zh) *	2000-07-13	2008-09-03	三共株式会社	氨基醇衍生物
US7326801B2 (en) *	2001-03-26	2008-02-05	Novartis Ag	2-amino-propanol derivatives
ATE463478T1 (de) *	2001-09-27	2010-04-15	Kyorin Seiyaku Kk	Diaryletherderivat, dessen additionssalz und immunosuppressivum
GB0125443D0 (en) *	2001-10-23	2001-12-12	Novartis Ag	Organic Compounds
RU2330839C2 (ru) *	2002-01-11	2008-08-10	Санкио Компани, Лимитед	Производные аминоспиртов или производные фосфорных кислот и фармацевтические композиции, содержащие указанные производные
JP2005531506A (ja)	2002-03-01	2005-10-20	メルク　エンド　カムパニー　インコーポレーテッド	Ｅｄｇ受容体作動薬としてのアミノアルキルホスホネートおよび関連化合物
CA2483594C (en)	2002-05-16	2011-02-15	Novartis Ag	Use of edg receptor binding agents in cancer
CN100351244C (zh)	2002-05-27	2007-11-28	诺瓦提斯公司	双芳族链烷醇
GB0217152D0 (en) *	2002-07-24	2002-09-04	Novartis Ag	Organic compounds
AU2003273865A1 (en) *	2002-09-13	2004-04-30	Novartis Ag	Amino-propanol derivatives
MXPA05003254A (es)	2002-09-24	2005-06-08	Novartis Ag	Agonistas del receptor de esfingosina-1-fosfato en el tratamiento de trastornos de desmielinacion.
DE202004021680U1 (de)	2003-04-08	2010-04-22	Novartis Ag	Feste pharmazeutische Zusammensetzung
ATE547395T1 (de) *	2003-04-30	2012-03-15	Novartis Pharma Gmbh	Aminopropanol-derivate als modulatoren des sphingosin-1-phosphat-rezeptors
GB0313612D0 (en) *	2003-06-12	2003-07-16	Novartis Ag	Organic compounds
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1995
- 1995-08-22 JP JP50794296A patent/JP3870419B2/ja not_active Expired - Lifetime
- 1995-08-22 ES ES95928630T patent/ES2171191T3/es not_active Expired - Lifetime
- 1995-08-22 DE DE69524962T patent/DE69524962T4/de not_active Expired - Lifetime
- 1995-08-22 DK DK95928630T patent/DK0778263T3/da active
- 1995-08-22 DE DE69524962A patent/DE69524962D1/de not_active Expired - Lifetime
- 1995-08-22 EP EP95928630A patent/EP0778263B1/de not_active Expired - Lifetime
- 1995-08-22 AT AT95928630T patent/ATE211726T1/de active
- 1995-08-22 WO PCT/JP1995/001654 patent/WO1996006068A1/ja not_active Ceased
- 1995-08-22 KR KR1019970701140A patent/KR100358922B1/ko not_active Expired - Lifetime
- 1995-08-22 PT PT95928630T patent/PT778263E/pt unknown

Also Published As

Publication number	Publication date
PT778263E (pt)	2002-06-28
ES2171191T3 (es)	2002-09-01
KR100358922B1 (ko)	2003-01-24
JP3870419B2 (ja)	2007-01-17
DE69524962T4 (de)	2003-08-28
DE69524962D1 (de)	2002-02-14
EP0778263A1 (de)	1997-06-11
ATE211726T1 (de)	2002-01-15
DE69524962T2 (de)	2002-10-31
EP0778263B1 (de)	2002-01-09
EP0778263A4 (de)	1997-10-22
WO1996006068A1 (en)	1996-02-29
KR970705534A (ko)	1997-10-09

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