DK0805853T3 - Afstamningsdirigeret induktion af differentiering af humane mesenkyme stamceller - Google Patents

Afstamningsdirigeret induktion af differentiering af humane mesenkyme stamceller

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Publication number
DK0805853T3
DK0805853T3 DK96903358T DK96903358T DK0805853T3 DK 0805853 T3 DK0805853 T3 DK 0805853T3 DK 96903358 T DK96903358 T DK 96903358T DK 96903358 T DK96903358 T DK 96903358T DK 0805853 T3 DK0805853 T3 DK 0805853T3
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Prior art keywords
stem cells
mesenchymal stem
differentiation
progeny
human mesenchymal
Prior art date
Application number
DK96903358T
Other languages
Danish (da)
English (en)
Inventor
Scott P Bruder
Arnold I Caplan
Stephen E Haynesworth
Original Assignee
Univ Case Western Reserve
Osiris Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve, Osiris Therapeutics Inc filed Critical Univ Case Western Reserve
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Publication of DK0805853T3 publication Critical patent/DK0805853T3/da

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
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DK96903358T 1995-01-24 1996-01-05 Afstamningsdirigeret induktion af differentiering af humane mesenkyme stamceller DK0805853T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/377,461 US5736396A (en) 1995-01-24 1995-01-24 Lineage-directed induction of human mesenchymal stem cell differentiation
PCT/US1996/000170 WO1996023059A1 (en) 1995-01-24 1996-01-05 Lineage-directed induction of human mesenchymal stem cell differentiation

Publications (1)

Publication Number Publication Date
DK0805853T3 true DK0805853T3 (da) 2007-07-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK96903358T DK0805853T3 (da) 1995-01-24 1996-01-05 Afstamningsdirigeret induktion af differentiering af humane mesenkyme stamceller

Country Status (11)

Country Link
US (2) US5736396A (de)
EP (2) EP0805853B1 (de)
JP (2) JP4454697B2 (de)
AT (1) ATE357508T1 (de)
AU (1) AU719098B2 (de)
CA (1) CA2211120C (de)
DE (1) DE69636979T2 (de)
DK (1) DK0805853T3 (de)
ES (1) ES2285710T3 (de)
PT (1) PT805853E (de)
WO (1) WO1996023059A1 (de)

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US7037717B1 (en) * 1997-03-07 2006-05-02 Chugai Seiyaku Kabushiki Kaisha Cell line and screening method with the use of the same
EP0989855A4 (de) * 1997-05-13 2002-06-12 Osiris Therapeutics Inc Regeneration von knorpel bei osteoarthritis mittels menschlicher mesenchymaler stammzellen
US6110209A (en) * 1997-08-07 2000-08-29 Stone; Kevin R. Method and paste for articular cartilage transplantation
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