ZA972990B - Isatin derivatives as acetylcholinesterase inhibitors and analgesics. - Google Patents

Isatin derivatives as acetylcholinesterase inhibitors and analgesics.

Info

Publication number: ZA972990B
Authority: ZA; South Africa
Prior art keywords: analgesics; acetylcholinesterase inhibitors; isatin derivatives; isatin; derivatives
Prior art date: 1996-04-12

Application number

ZA9702990A

Other languages

English (en)

Inventor

Stephen J Shimshock

Abdul E Mutlib

Susan M Chesson

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1997-04-08

Publication date

1997-11-03

1997-04-08 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1997-11-03 Publication of ZA972990B publication Critical patent/ZA972990B/xx

Links

229940035676 analgesics Drugs 0.000 title 1
239000000730 antalgic agent Substances 0.000 title 1
239000000544 cholinesterase inhibitor Substances 0.000 title 1
JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

ZA9702990A 1996-04-12 1997-04-08 Isatin derivatives as acetylcholinesterase inhibitors and analgesics. ZA972990B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US63187096A	1996-04-12	1996-04-12

Publications (1)

Publication Number	Publication Date
ZA972990B true ZA972990B (en)	1997-11-03

Family

ID=24533114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9702990A ZA972990B (en)	1996-04-12	1997-04-08	Isatin derivatives as acetylcholinesterase inhibitors and analgesics.

Country Status (19)

Country	Link
EP (1)	EP0892796B1 (da)
JP (1)	JP4109718B2 (da)
KR (1)	KR20000005379A (da)
CN (1)	CN1215399A (da)
AR (1)	AR006606A1 (da)
AT (1)	ATE207483T1 (da)
BR (1)	BR9708655A (da)
CA (1)	CA2252039C (da)
DE (1)	DE69707659T2 (da)
DK (1)	DK0892796T3 (da)
ES (1)	ES2165586T3 (da)
GR (1)	GR3037006T3 (da)
HU (1)	HUP9903473A3 (da)
IL (1)	IL126308A0 (da)
NO (1)	NO984740D0 (da)
PT (1)	PT892796E (da)
TW (1)	TW426678B (da)
WO (1)	WO1997038993A1 (da)
ZA (1)	ZA972990B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6218383B1 (en)	1998-08-07	2001-04-17	Targacept, Inc.	Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
ATE554085T1 (de)	2006-11-30	2012-05-15	Probiodrug Ag	Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja)	2007-03-01	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (en)	2007-04-18	2014-12-24	Probiodrug AG	Thiourea derivatives as glutaminyl cyclase inhibitors
JP5934645B2 (ja)	2009-09-11	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
AU2011215870B2 (en)	2010-02-09	2016-01-28	The Johns Hopkins University	Methods and compositions for improving cognitive function
CA2788656A1 (en)	2010-02-16	2011-08-25	Pfizer Inc.	(r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
NZ602312A (en)	2010-03-10	2014-02-28	Probiodrug Ag	Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
EP2686313B1 (en)	2011-03-16	2016-02-03	Probiodrug AG	Benzimidazole derivatives as inhibitors of glutaminyl cyclase
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
PL2931276T3 (pl)	2012-12-13	2018-06-29	H. Lundbeck A/S	Kompozycje zawierające wortioksetynę i donepezil
WO2014144663A1 (en)	2013-03-15	2014-09-18	The Johns Hopkins University	Methods and compositions for improving cognitive function
JP6433482B2 (ja)	2013-03-15	2018-12-05	エージンバイオ，インコーポレイテッド	認知機能を改善するための方法および組成物
US10537552B2 (en)	2015-05-05	2020-01-21	Carafe Drug Innovation, Llc	Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
WO2016191288A1 (en)	2015-05-22	2016-12-01	Agenebio, Inc.	Extended release pharmaceutical compositions of levetiracetam
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa
WO2023081800A1 (en) *	2021-11-05	2023-05-11	The Regents Of The University Of California	Alpha-2a adrenergic receptor modulators and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5296488A (en) *	1989-08-02	1994-03-22	Hoechst-Roussel Pharmaceuticals Inc.	Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory
US5006537A (en) *	1989-08-02	1991-04-09	Hoechst-Roussel Pharmaceuticals, Inc.	1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US4994472A (en) *	1989-08-02	1991-02-19	Hoechst-Roussel Pharmaceuticals Incorporated	1-(pyridinylamino)-2-pyrrolidinones as pain relievers

1997
- 1997-03-07 JP JP53708497A patent/JP4109718B2/ja not_active Expired - Fee Related
- 1997-03-07 EP EP97908942A patent/EP0892796B1/en not_active Expired - Lifetime
- 1997-03-07 AT AT97908942T patent/ATE207483T1/de not_active IP Right Cessation
- 1997-03-07 BR BR9708655A patent/BR9708655A/pt not_active Application Discontinuation
- 1997-03-07 ES ES97908942T patent/ES2165586T3/es not_active Expired - Lifetime
- 1997-03-07 CN CN97193728A patent/CN1215399A/zh active Pending
- 1997-03-07 DE DE69707659T patent/DE69707659T2/de not_active Expired - Fee Related
- 1997-03-07 CA CA002252039A patent/CA2252039C/en not_active Expired - Fee Related
- 1997-03-07 IL IL12630897A patent/IL126308A0/xx unknown
- 1997-03-07 PT PT97908942T patent/PT892796E/pt unknown
- 1997-03-07 HU HU9903473A patent/HUP9903473A3/hu unknown
- 1997-03-07 DK DK97908942T patent/DK0892796T3/da active
- 1997-03-07 WO PCT/US1997/003598 patent/WO1997038993A1/en not_active Ceased
- 1997-04-07 TW TW086104363A patent/TW426678B/zh active
- 1997-04-08 ZA ZA9702990A patent/ZA972990B/xx unknown
- 1997-04-11 AR ARP970101447A patent/AR006606A1/es unknown
1998
- 1998-10-09 NO NO984740A patent/NO984740D0/no unknown
- 1998-10-12 KR KR1019980708105A patent/KR20000005379A/ko not_active Abandoned
2001
- 2001-10-25 GR GR20010401584T patent/GR3037006T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1997038993A1 (en)	1997-10-23
DE69707659T2 (de)	2002-05-08
CA2252039A1 (en)	1997-10-23
IL126308A0 (en)	1999-05-09
AU716997B2 (en)	2000-03-16
NO984740L (no)	1998-10-09
EP0892796A1 (en)	1999-01-27
HUP9903473A3 (en)	2000-09-28
PT892796E (pt)	2002-03-28
JP2001508400A (ja)	2001-06-26
GR3037006T3 (en)	2002-01-31
AU2072597A (en)	1997-11-07
ES2165586T3 (es)	2002-03-16
EP0892796B1 (en)	2001-10-24
KR20000005379A (en)	2000-01-25
ATE207483T1 (de)	2001-11-15
DE69707659D1 (de)	2001-11-29
DK0892796T3 (da)	2001-11-19
TW426678B (en)	2001-03-21
JP4109718B2 (ja)	2008-07-02
BR9708655A (pt)	1999-08-03
AR006606A1 (es)	1999-09-08
HUP9903473A2 (hu)	2000-05-28
CA2252039C (en)	2002-12-24
CN1215399A (zh)	1999-04-28
NO984740D0 (no)	1998-10-09

Publication	Publication Date	Title
ZA972990B (en)	1997-11-03	Isatin derivatives as acetylcholinesterase inhibitors and analgesics.
ZA9711376B (en)	1998-07-21	Indole or dihydroindole derivatives
PL331338A1 (en)	1999-07-05	Thiosulphonamidic metaloprotease inhibitors
GB9607729D0 (en)	1996-06-19	Quinazoline derivatives
GB2317640B (en)	2000-08-30	Security devices
AU3100097A (en)	1998-01-07	Security device
PL331803A1 (en)	1999-08-02	Bidonoric metaloprotease inhibitors
AUPO242896A0 (en)	1996-10-10	Security device
IL120488A (en)	2000-07-16	Modifiers for water-setting inorganic compositions and modified water-setting inorganic compositions
SI0892796T1 (en)	2002-04-30	Isatin derivatives as acetylcholinesterase inhibitors and analgesics
GB9616563D0 (en)	1996-09-25	Compounds and methods
ZA97672B (en)	1997-08-04	Tetrahydroisoquinoline derivatives.
AU3779997A (en)	1998-02-25	Security device
GB2312920B (en)	1999-10-27	Security devices
GB9613375D0 (en)	1996-08-28	Security bracket
AU3870197A (en)	1998-03-06	Security device
AU3315797A (en)	1998-02-19	Security device
AU7065596A (en)	1997-05-22	Decorative security device
ZA978046B (en)	1998-04-01	Compounds and methods.
AUPN939796A0 (en)	1996-05-16	Baccarat-double-triple ties
GB9619255D0 (en)	1996-10-30	Security arrangements
ZA978998B (en)	1998-04-20	Indole derivatives.
GB9623742D0 (en)	1997-01-08	Inhibitors
GB9601787D0 (en)	1996-04-03	Inhibitors
ZA9711056B (en)	1998-06-15	3-pyridyl enantiomers and their use as analgesics.