DK0937456T3 - Liposomal dispersion af erytropoietin - Google Patents

Liposomal dispersion af erytropoietin

Info

Publication number: DK0937456T3
Authority: DK; Denmark
Prior art keywords: erythropoietin; cholesterol; cholesterols; lecithin; liposome based
Prior art date: 1998-02-23

Application number

DK98103111T

Other languages

English (en)

Inventor

Rainer Naeff

Sandro Delmenico

Andre Wetter

Frank-Ulrich Floether

Original Assignee

Cilag Ag Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-23

Filing date

1998-02-23

Publication date

2004-11-08

1998-02-23 Application filed by Cilag Ag Int filed Critical Cilag Ag Int

2004-11-08 Application granted granted Critical

2004-11-08 Publication of DK0937456T3 publication Critical patent/DK0937456T3/da

Links

102000003951 Erythropoietin Human genes 0.000 title abstract 3
108090000394 Erythropoietin Proteins 0.000 title abstract 3
229940105423 erythropoietin Drugs 0.000 title abstract 3
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title abstract 3
239000006185 dispersion Substances 0.000 title 1
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 3
235000012000 cholesterol Nutrition 0.000 abstract 3
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
239000002502 liposome Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
102000008100 Human Serum Albumin Human genes 0.000 abstract 1
108091006905 Human Serum Albumin Proteins 0.000 abstract 1
239000002202 Polyethylene glycol Chemical class 0.000 abstract 1
150000001840 cholesterol esters Chemical class 0.000 abstract 1
150000001841 cholesterols Chemical class 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
150000002334 glycols Chemical class 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
229940067606 lecithin Drugs 0.000 abstract 1
235000010445 lecithin Nutrition 0.000 abstract 1
239000000787 lecithin Substances 0.000 abstract 1
-1 lipid compound Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
239000006201 parenteral dosage form Substances 0.000 abstract 1
239000008363 phosphate buffer Substances 0.000 abstract 1
229920001223 polyethylene glycol Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Dispersion Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

DK98103111T 1998-02-23 1998-02-23 Liposomal dispersion af erytropoietin DK0937456T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP98103111A EP0937456B1 (en)	1998-02-23	1998-02-23	Erythropoietin liposomal dispersion

Publications (1)

Publication Number	Publication Date
DK0937456T3 true DK0937456T3 (da)	2004-11-08

Family

ID=8231466

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98103111T DK0937456T3 (da)	1998-02-23	1998-02-23	Liposomal dispersion af erytropoietin

Country Status (23)

Country	Link
US (2)	US6645522B2 (da)
EP (1)	EP0937456B1 (da)
JP (1)	JP4613294B2 (da)
KR (1)	KR100591871B1 (da)
CN (1)	CN1184958C (da)
AT (1)	ATE271376T1 (da)
AU (1)	AU750481B2 (da)
BR (1)	BR9908202A (da)
CA (1)	CA2320072C (da)
CZ (1)	CZ296415B6 (da)
DE (1)	DE69825137T2 (da)
DK (1)	DK0937456T3 (da)
ES (1)	ES2224299T3 (da)
HU (1)	HUP0101026A2 (da)
IL (2)	IL137808A0 (da)
NO (1)	NO20004186L (da)
NZ (1)	NZ506429A (da)
PL (1)	PL194502B1 (da)
PT (1)	PT937456E (da)
RU (1)	RU2218914C2 (da)
SI (1)	SI0937456T1 (da)
SK (1)	SK284036B6 (da)
WO (1)	WO1999042085A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0937456B1 (en) *	1998-02-23	2004-07-21	Cilag AG International	Erythropoietin liposomal dispersion
US7345019B1 (en) *	1999-04-13	2008-03-18	The Kenneth S. Warren Institute, Inc.	Modulation of excitable tissue function by peripherally administered erythropoietin
EP1111050B1 (de) *	1999-12-22	2007-03-14	Dade Behring Marburg GmbH	Lösungen von humanem Procalcitonin
US20030072737A1 (en)	2000-12-29	2003-04-17	Michael Brines	Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
US7767643B2 (en)	2000-12-29	2010-08-03	The Kenneth S. Warren Institute, Inc.	Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
DE10219545A1 (de) *	2002-04-26	2003-11-06	Lang Florian	Regulation der Apoptose
CA2498319A1 (en) *	2002-09-09	2004-03-18	Nautilus Biotech	Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
JP2004115397A (ja) *	2002-09-25	2004-04-15	Fuji Photo Film Co Ltd	血管疾患治療薬を含むリポソーム
EP1592416B1 (en) *	2003-02-07	2009-01-07	ProMetic BioSciences Inc.	Medium-chain length fatty acids, glycerides and analogues as stimulators of erythropoiesis
CN1822844B (zh) *	2003-07-17	2012-05-09	大塚制药株式会社	含配糖物的脂质体
JP2007517769A (ja) *	2003-09-29	2007-07-05	ウォーレンファーマシューティカルズ，インコーポレーテッド	敗血症および癒着形成の治療および予防のための組織保護性サイトカイン
EP1537876A1 (en) *	2003-12-01	2005-06-08	BioGeneriX AG	Erythropoietin solution formulation
CN100508953C (zh) *	2004-05-24	2009-07-08	波利门科学生物免疫研究有限公司	用于药物释放的过载脂质体
KR100684380B1 (ko)	2005-05-24	2007-02-20	한국화학연구원	빗살형 폴리에틸렌글리콜을 결합한 리포솜 및 이의 제조방법
US9119782B2 (en)	2006-03-20	2015-09-01	Mary P. McCourt	Drug delivery means
EP2120998B1 (en)	2006-11-28	2013-08-07	HanAll Biopharma Co., Ltd.	Modified erythropoietin polypeptides and uses thereof for treatment
US20100310636A1 (en) *	2007-05-09	2010-12-09	Gita Sharma	Stearically stabilized unilamilar vesicles, process for preparation thereof and use thereof
US20100003322A1 (en) *	2008-07-03	2010-01-07	Lai Felix S	Enteric coated hydrophobic matrix formulation
US20110070294A1 (en) *	2009-09-23	2011-03-24	Javeri Indu	Methods for the Administration of Drugs Using Liposomes
WO2011162818A2 (en) *	2010-06-23	2011-12-29	Controlled Nanovolumes, Inc.	Lecithin carrier vesicles and methods of making the same
EA018472B1 (ru) *	2010-09-15	2013-08-30	Открытое Акционерное Общество "Протек"	Частицы, содержащие эритропоэтин, для лечения и профилактики неврологических и гематологических заболеваний и нарушений
AU2014236559B2 (en)	2013-03-14	2020-03-12	Julie HUGHES	Cholestosome vesicles for incorporation of molecules into chylomicrons
CN103751214A (zh) *	2014-01-03	2014-04-30	广州市鼍龙生物技术开发有限公司	一种鳄鱼油纳米脂质体及其制备方法
WO2015166988A1 (ja) *	2014-04-30	2015-11-05	富士フイルム株式会社	リポソームの製造方法
US11198831B2 (en)	2019-01-31	2021-12-14	Kvi Llc	Lubricant for a device

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ210501A (en)	1983-12-13	1991-08-27	Kirin Amgen Inc	Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
JPS6197229A (ja) *	1984-10-18	1986-05-15	Chugai Pharmaceut Co Ltd	安定なエリトロポエチン製剤
AU598002B2 (en) *	1986-07-15	1990-06-14	Cilag Ltd.	Method of preparing single bilayered liposomes
JPH087219B2 (ja)	1992-04-27	1996-01-29	雪印乳業株式会社	リポソーム封入生理活性蛋白質の定量方法
JPH06228012A (ja)	1993-01-29	1994-08-16	Dai Ichi Seiyaku Co Ltd	リポソーム製剤
CA2120197A1 (en) *	1993-04-02	1994-10-03	Kenji Endo	Stable aqueous dispersions containing liposomes
HUT72326A (en) *	1993-10-06	1996-04-29	Amgen Inc	Stable protein phospholipid compositions and methods
US5874075A (en) *	1993-10-06	1999-02-23	Amgen Inc.	Stable protein: phospholipid compositions and methods
US6214388B1 (en) *	1994-11-09	2001-04-10	The Regents Of The University Of California	Immunoliposomes that optimize internalization into target cells
JP3850468B2 (ja) *	1994-12-28	2006-11-29	中外製薬株式会社	エリスロポエチンのリポソーム製剤
US5858397A (en) *	1995-10-11	1999-01-12	University Of British Columbia	Liposomal formulations of mitoxantrone
EP0937456B1 (en) *	1998-02-23	2004-07-21	Cilag AG International	Erythropoietin liposomal dispersion

1998
- 1998-02-23 EP EP98103111A patent/EP0937456B1/en not_active Expired - Lifetime
- 1998-02-23 DK DK98103111T patent/DK0937456T3/da active
- 1998-02-23 DE DE69825137T patent/DE69825137T2/de not_active Expired - Lifetime
- 1998-02-23 PT PT98103111T patent/PT937456E/pt unknown
- 1998-02-23 AT AT98103111T patent/ATE271376T1/de active
- 1998-02-23 ES ES98103111T patent/ES2224299T3/es not_active Expired - Lifetime
- 1998-02-23 SI SI9830684T patent/SI0937456T1/xx unknown
1999
- 1999-02-12 KR KR1020007009202A patent/KR100591871B1/ko not_active Expired - Fee Related
- 1999-02-12 CA CA002320072A patent/CA2320072C/en not_active Expired - Fee Related
- 1999-02-12 PL PL99342514A patent/PL194502B1/pl unknown
- 1999-02-12 JP JP2000532102A patent/JP4613294B2/ja not_active Expired - Fee Related
- 1999-02-12 CZ CZ20002959A patent/CZ296415B6/cs not_active IP Right Cessation
- 1999-02-12 BR BR9908202-0A patent/BR9908202A/pt not_active Application Discontinuation
- 1999-02-12 WO PCT/IB1999/000249 patent/WO1999042085A1/en not_active Ceased
- 1999-02-12 IL IL13780899A patent/IL137808A0/xx active IP Right Grant
- 1999-02-12 AU AU21808/99A patent/AU750481B2/en not_active Ceased
- 1999-02-12 NZ NZ506429A patent/NZ506429A/xx not_active IP Right Cessation
- 1999-02-12 SK SK1222-2000A patent/SK284036B6/sk not_active IP Right Cessation
- 1999-02-12 CN CNB998052590A patent/CN1184958C/zh not_active Expired - Fee Related
- 1999-02-12 RU RU2000124317/14A patent/RU2218914C2/ru not_active IP Right Cessation
- 1999-02-12 HU HU0101026A patent/HUP0101026A2/hu unknown
- 1999-02-18 US US09/252,563 patent/US6645522B2/en not_active Expired - Lifetime
2000
- 2000-08-10 IL IL137808A patent/IL137808A/en not_active IP Right Cessation
- 2000-08-22 NO NO20004186A patent/NO20004186L/no not_active Application Discontinuation
2003
- 2003-09-10 US US10/659,097 patent/US20040052838A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69825137D1 (de)	2004-08-26
CN1298296A (zh)	2001-06-06
SI0937456T1 (en)	2004-12-31
EP0937456B1 (en)	2004-07-21
KR100591871B1 (ko)	2006-06-23
US20040052838A1 (en)	2004-03-18
PT937456E (pt)	2004-10-29
RU2218914C2 (ru)	2003-12-20
IL137808A0 (en)	2001-10-31
NZ506429A (en)	2003-03-28
NO20004186D0 (no)	2000-08-22
AU2180899A (en)	1999-09-06
ES2224299T3 (es)	2005-03-01
ATE271376T1 (de)	2004-08-15
NO20004186L (no)	2000-08-22
BR9908202A (pt)	2000-10-24
JP2002503685A (ja)	2002-02-05
CA2320072A1 (en)	1999-08-26
CZ296415B6 (cs)	2006-03-15
US6645522B2 (en)	2003-11-11
IL137808A (en)	2007-07-24
CA2320072C (en)	2009-04-07
JP4613294B2 (ja)	2011-01-12
WO1999042085A1 (en)	1999-08-26
CN1184958C (zh)	2005-01-19
KR20010041152A (ko)	2001-05-15
DE69825137T2 (de)	2005-07-21
SK284036B6 (sk)	2004-08-03
SK12222000A3 (sk)	2001-11-06
CZ20002959A3 (cs)	2001-10-17
US20020028236A1 (en)	2002-03-07
AU750481B2 (en)	2002-07-18
HUP0101026A2 (hu)	2001-08-28
PL194502B1 (pl)	2007-06-29
EP0937456A1 (en)	1999-08-25
PL342514A1 (en)	2001-06-18

Publication	Publication Date	Title
ATE271376T1 (de)	2004-08-15	Liposomale erythropoietin-dispersion
MY111841A (en)	2001-01-31	Injectable liposomal pharmaceutical preparations
ATE308327T1 (de)	2005-11-15	Verwendung von 2-hydroxy-5-phenylazobenzoesäure- derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs
ATE301640T1 (de)	2005-08-15	Anellierte 4-carboxyamino-2-methyl-1,2,3,4- tetrahydrochinoline als cetp-hemmer
BR9911013A (pt)	2001-02-06	Derivados de pirazol como inibidores da p-38 map quinase
ATE244015T1 (de)	2003-07-15	Formulierungen fuer faktor ix
ATE178584T1 (de)	1999-04-15	Kationische lipide
JPS6118718A (ja)	1986-01-27	抗炎症製薬組成物
HRP20010779B1 (hr)	2011-02-28	Farmaceutski pripravak
ATA189395A (de)	2001-09-15	Orale pharmazeutische zubereitung
AU6044994A (en)	1994-09-14	Glycerol derivative, device and pharmaceutical composition
KR960016908A (ko)	1996-06-17	제약학상 담체
AR022230A1 (es)	2002-09-04	Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion
ATE268163T1 (de)	2004-06-15	Hochdosierte liposomale aerosolformulierung
RU2000124317A (ru)	2002-08-20	Эритропоэтиновая липосомальная дисперсия
AU1438699A (en)	1999-06-16	Fatty acid uninterrupted by a methylene as anti-inflammatory agents in superficial tissues of mammals
BR0009765B1 (pt)	2013-11-05	Compostos de ésteres de l-carnitina ou alcanoil l-carnitinase, uso dos mesmos, lipossomas contendo os referidos compostos e composições farmacêuticas e cosméticas contendo os ditos lipossomas.
CY1105318T1 (el)	2010-03-03	Φαρμακευτικες συνθεσεις για απο του στοματος και τοπικη χορηγηση
ATE301709T1 (de)	2005-08-15	Lipidabkömmlinge von pentaerythritol
ATE287289T1 (de)	2005-02-15	Rückfettende ester auf basis von capryl-alkohol und isostearinsäure
KR960037677A (ko)	1996-11-19	4-인돌릴피페라지닐 유도체
BR9811954A (pt)	2000-08-22	ácidos 3-aril-succinamido-hidroxâmicos, processos para sua produção e preparações farmacêuticas contendo estas substâncias
SE9604193L (sv)	1998-05-16	Terapeutiska och kosmetiska kompositioner, deras användning och metod för framställning därav
DE60035613D1 (de)	2007-08-30	Topische kosmetische und pharmazeutische Mittel enthaltend spezifische alkoxilierte Diester der Fumarsäure
DE69824855D1 (de)	2004-08-05	Macrozyklische laktone, zusammensetzungen und verfahren zur verwendung