DK1145002T4 - Bioluminescenstest for agonister eller antagonister til en calciumkoblet receptor - Google Patents
Bioluminescenstest for agonister eller antagonister til en calciumkoblet receptorInfo
- Publication number
- DK1145002T4 DK1145002T4 DK99930956T DK99930956T DK1145002T4 DK 1145002 T4 DK1145002 T4 DK 1145002T4 DK 99930956 T DK99930956 T DK 99930956T DK 99930956 T DK99930956 T DK 99930956T DK 1145002 T4 DK1145002 T4 DK 1145002T4
- Authority
- DK
- Denmark
- Prior art keywords
- calcium
- coupled receptor
- agonists
- antagonists
- bioluminescence test
- Prior art date
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title abstract 4
- 229910052791 calcium Inorganic materials 0.000 title abstract 4
- 239000011575 calcium Substances 0.000 title abstract 4
- 239000000556 agonist Substances 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 3
- 230000029918 bioluminescence Effects 0.000 title 1
- 238000005415 bioluminescence Methods 0.000 title 1
- YHIPILPTUVMWQT-UHFFFAOYSA-N Oplophorus luciferin Chemical compound C1=CC(O)=CC=C1CC(C(N1C=C(N2)C=3C=CC(O)=CC=3)=O)=NC1=C2CC1=CC=CC=C1 YHIPILPTUVMWQT-UHFFFAOYSA-N 0.000 abstract 2
- 108010000239 Aequorin Proteins 0.000 abstract 1
- 108010041089 apoaequorin Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98870149 | 1998-07-06 | ||
| PCT/BE1999/000087 WO2000002045A2 (en) | 1998-07-06 | 1999-07-06 | Bioluminescent assay for agonists or antagonists of a calcium-coupled receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK1145002T3 DK1145002T3 (da) | 2003-05-05 |
| DK1145002T4 true DK1145002T4 (da) | 2009-03-16 |
Family
ID=8237065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99930956T DK1145002T4 (da) | 1998-07-06 | 1999-07-06 | Bioluminescenstest for agonister eller antagonister til en calciumkoblet receptor |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6872538B1 (da) |
| EP (1) | EP1145002B2 (da) |
| JP (1) | JP3495987B2 (da) |
| AT (1) | ATE232298T1 (da) |
| CA (1) | CA2336929C (da) |
| DE (1) | DE69905291T3 (da) |
| DK (1) | DK1145002T4 (da) |
| ES (1) | ES2192060T5 (da) |
| WO (1) | WO2000002045A2 (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
| US6248542B1 (en) | 1997-12-09 | 2001-06-19 | Massachusetts Institute Of Technology | Optoelectronic sensor |
| DE10008373C2 (de) * | 2000-02-23 | 2002-11-28 | Helmut Adelsberger | Verfahren und Vorrichtung zur Bestimmung der Ionenkanalaktivität |
| US7422860B2 (en) * | 2001-02-07 | 2008-09-09 | Massachusetts Institute Of Technology | Optoelectronic detection system |
| US7214346B2 (en) | 2001-02-07 | 2007-05-08 | Massachusetts Institute Of Technology | Optoelectronic detection system |
| US8216797B2 (en) * | 2001-02-07 | 2012-07-10 | Massachusetts Institute Of Technology | Pathogen detection biosensor |
| US7175988B2 (en) | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
| WO2002075273A2 (en) * | 2001-03-20 | 2002-09-26 | Euroscreen S.A. | Screening, diagnostic and/or dosage method and device of an agonist and/or antagonist for a calcium-coupled receptor |
| GB0108143D0 (en) * | 2001-03-31 | 2001-05-23 | Univ Dundee | High-throughput screen |
| US7393934B2 (en) | 2001-12-21 | 2008-07-01 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
| JP4360915B2 (ja) | 2002-01-07 | 2009-11-11 | ユーロスクリーン・ソシエテ・アノニム | Ｇタンパク質共役受容体ｇｐｒ４３のリガンドおよびその使用 |
| EP1900753B1 (en) | 2002-11-08 | 2017-08-09 | Ablynx N.V. | Method of administering therapeutic polypeptides, and polypeptides therefor |
| GB0228139D0 (en) * | 2002-12-03 | 2003-01-08 | Kozlova Zwinderman Olga | Fungal biosensor for contaminant detection |
| JP2006517789A (ja) | 2003-01-10 | 2006-08-03 | アブリンクス エン．ヴェー． | 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用 |
| ATE485307T1 (de) | 2003-11-07 | 2010-11-15 | Ablynx Nv | Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung |
| EP1723178A4 (en) | 2004-03-12 | 2007-12-12 | Human Genome Sciences Inc | HUMAN G-PROTEIN CHEMOKIN RECEPTOR (CCR5) HDGNR10 |
| ITMI20040598A1 (it) * | 2004-03-26 | 2004-06-26 | Carlotta Giorgi | Metodo per la rilevazione di parametri intracellulari con sonde proteiche luminescenti per lo screening di molecole in grado di alterare detti parametri |
| CA2504920C (en) | 2004-05-14 | 2014-04-01 | Euroscreen S.A. | Ligand for g-protein coupled receptor fprl2 and uses thereof |
| US8188223B2 (en) | 2005-05-18 | 2012-05-29 | Ablynx N.V. | Serum albumin binding proteins |
| ES2694247T3 (es) | 2005-05-20 | 2018-12-19 | Ablynx N.V. | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| WO2007100618A2 (en) * | 2006-02-23 | 2007-09-07 | Atto Bioscience | Novel cell-based phosphodiesterase assays |
| US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
| JP2012533298A (ja) * | 2009-07-14 | 2012-12-27 | イー・エム・デイー・ミリポア・コーポレイシヨン | カルシウム親和性の増加と生物発光の増強を示す改変型発光蛋白質及びその使用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422266A (en) | 1984-12-31 | 1995-06-06 | University Of Georgia Research Foundation, Inc. | Recombinant DNA vectors capable of expressing apoaequorin |
| JPH01285196A (ja) | 1988-05-11 | 1989-11-16 | Chisso Corp | 発光蛋白エクオリンの製造法 |
| JPH02253162A (ja) † | 1989-03-27 | 1990-10-11 | Chisso Corp | 特異的結合能を有する物質と結合したエクオリンを用いる検出法 |
| DE68922971T2 (de) † | 1988-12-06 | 1995-10-19 | Chisso Corp | Mit einem Protein mit spezifischer Bindungsaktivität fusioniertes Aequorin, seine Herstellung, Reinigung und Nachweismethode. |
| JPH03153700A (ja) † | 1989-11-09 | 1991-07-01 | Chisso Corp | 物理吸着法により担体に固定化されたエクオリン活性を示す蛋白質 |
| US5714666A (en) † | 1993-02-09 | 1998-02-03 | Children's Hospital Of Philadelphia | Measurement of intracellular calcium using bioluminescent apoaequorin expressed in mammalian cells |
| US5744320A (en) † | 1995-06-07 | 1998-04-28 | Promega Corporation | Quenching reagents and assays for enzyme-mediated luminescence |
-
1999
- 1999-07-06 AT AT99930956T patent/ATE232298T1/de active
- 1999-07-06 US US09/743,405 patent/US6872538B1/en not_active Expired - Lifetime
- 1999-07-06 JP JP2000558390A patent/JP3495987B2/ja not_active Expired - Lifetime
- 1999-07-06 DK DK99930956T patent/DK1145002T4/da active
- 1999-07-06 CA CA002336929A patent/CA2336929C/en not_active Expired - Lifetime
- 1999-07-06 EP EP99930956A patent/EP1145002B2/en not_active Expired - Lifetime
- 1999-07-06 WO PCT/BE1999/000087 patent/WO2000002045A2/en not_active Ceased
- 1999-07-06 DE DE69905291T patent/DE69905291T3/de not_active Expired - Lifetime
- 1999-07-06 ES ES99930956T patent/ES2192060T5/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000002045A2 (en) | 2000-01-13 |
| DE69905291T3 (de) | 2009-06-25 |
| EP1145002B1 (en) | 2003-02-05 |
| CA2336929C (en) | 2005-10-04 |
| US6872538B1 (en) | 2005-03-29 |
| DE69905291T2 (de) | 2003-11-06 |
| ES2192060T5 (es) | 2009-05-01 |
| EP1145002A2 (en) | 2001-10-17 |
| DE69905291D1 (de) | 2003-03-13 |
| CA2336929A1 (en) | 2000-01-13 |
| EP1145002B2 (en) | 2008-12-10 |
| ATE232298T1 (de) | 2003-02-15 |
| JP2002519699A (ja) | 2002-07-02 |
| DK1145002T3 (da) | 2003-05-05 |
| WO2000002045A3 (en) | 2001-11-08 |
| ES2192060T3 (es) | 2003-09-16 |
| JP3495987B2 (ja) | 2004-02-09 |
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