ATE322513T1 - Milchsäurepolymer und verfahren zu dessen herstellung - Google Patents

Milchsäurepolymer und verfahren zu dessen herstellung

Info

Publication number
ATE322513T1
ATE322513T1 AT01954447T AT01954447T ATE322513T1 AT E322513 T1 ATE322513 T1 AT E322513T1 AT 01954447 T AT01954447 T AT 01954447T AT 01954447 T AT01954447 T AT 01954447T AT E322513 T1 ATE322513 T1 AT E322513T1
Authority
AT
Austria
Prior art keywords
weight
lactic acid
acid polymer
production
sustained
Prior art date
Application number
AT01954447T
Other languages
English (en)
Inventor
Kohei Yamamoto
Tsutomu Tani
Takashi Aoki
Yoshio Hata
Original Assignee
Wako Pure Chem Ind Ltd
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18729814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE322513(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wako Pure Chem Ind Ltd, Takeda Pharmaceutical filed Critical Wako Pure Chem Ind Ltd
Application granted granted Critical
Publication of ATE322513T1 publication Critical patent/ATE322513T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/89—Recovery of the polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01954447T 2000-08-07 2001-08-06 Milchsäurepolymer und verfahren zu dessen herstellung ATE322513T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000238051 2000-08-07

Publications (1)

Publication Number Publication Date
ATE322513T1 true ATE322513T1 (de) 2006-04-15

Family

ID=18729814

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01954447T ATE322513T1 (de) 2000-08-07 2001-08-06 Milchsäurepolymer und verfahren zu dessen herstellung

Country Status (14)

Country Link
US (3) US7019106B2 (de)
EP (2) EP1693054B1 (de)
JP (2) JP5046447B2 (de)
KR (1) KR100772950B1 (de)
CN (1) CN1269870C (de)
AT (1) ATE322513T1 (de)
AU (1) AU2001276733A1 (de)
CA (1) CA2419065C (de)
CY (1) CY1117889T1 (de)
DE (1) DE60118575T3 (de)
DK (1) DK1310517T4 (de)
ES (2) ES2256276T5 (de)
PT (2) PT1693054T (de)
WO (1) WO2002012369A1 (de)

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TW200526267A (en) 2001-06-29 2005-08-16 Takeda Chemical Industries Ltd Controlled release composition and method of producing the same
WO2004067756A1 (en) * 2003-01-29 2004-08-12 Biomatera Inc. Method for controlling molecular weight and distribution of biopolymers
JP4205497B2 (ja) * 2003-06-23 2009-01-07 帝人株式会社 リン脂質を含有するポリ乳酸樹脂組成物および成形体
US7767806B2 (en) 2003-09-08 2010-08-03 Chugai Seiyaku Kabushiki Kaisha Hyaluronic acid modification products and drug carriers using them
WO2005105886A1 (en) * 2004-04-23 2005-11-10 Amgen Inc. Low molecular weight polylactic acid polymers
US20070009606A1 (en) * 2004-05-12 2007-01-11 Serdy James G Manufacturing process, such as three dimensional printing, including binding of water-soluble material followed by softening and flowing and forming films of organic-solvent-soluble material
TW200613012A (en) * 2004-07-02 2006-05-01 Takeda Pharmaceuticals Co Sustained-release composition, process for producing the same and use of the same
US7342048B2 (en) 2005-04-28 2008-03-11 Nipro Corporation Bioabsorbable pharmaceutical formulation
CA2637569C (en) 2006-01-18 2013-01-08 Yuhua Li Pharmaceutical compositions with enhanced stability
US8076448B2 (en) 2006-10-11 2011-12-13 Tolmar Therapeutics, Inc. Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction
NL2000454C1 (nl) * 2006-11-28 2008-01-02 Purac Biochem Bv Stabiele lactidedeeltjes.
AU2007327592B9 (en) * 2006-11-28 2013-12-19 Purac Biochem Bv Stable lactide particles
US20080146822A1 (en) 2006-11-28 2008-06-19 Purac Biochem B.V. Stable lactide particles
MY148370A (en) 2006-12-18 2013-04-15 Takeda Pharmaceutical Sustained-release composition and method for producing the same
EP3202814B1 (de) 2007-02-15 2019-10-16 Tolmar Therapeutics, Inc. Poly-(lactid/glycolid) mit geringen burst-eigenschaften und verfahren zur herstellung von polymeren
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US8877225B2 (en) 2008-06-03 2014-11-04 Tolmar Therapeutics, Inc. Controlled release copolymer formulation with improved release kinetics
US9486531B2 (en) * 2008-06-03 2016-11-08 Indivior Uk Limited Dehydrated hydrogel inclusion complex of a bioactive agent with flowable drug delivery system
EP2585091B1 (de) * 2010-06-25 2014-09-10 Takeda Pharmaceutical Company Limited Formulierung mit verzögerter freisetzung enthaltend ein metastinderivat
US8834694B2 (en) * 2010-12-27 2014-09-16 Mo Bio Laboratories, Inc. Dry compositions and methods for gel electrophoresis
WO2014168134A1 (ja) 2013-04-11 2014-10-16 三井化学株式会社 乳酸―グリコール酸共重合体の製造法またはその塩の製造法
WO2015158823A1 (de) 2014-04-16 2015-10-22 Veyx-Pharma Gmbh Veterinärpharmazeutische zusammensetzung und deren verwendung
AU2016355236C1 (en) 2015-11-16 2022-09-22 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
KR102688314B1 (ko) * 2017-08-31 2024-07-26 에보닉 코포레이션 개선된 재흡수성 중합체 정제 방법
WO2022070010A1 (en) 2020-09-30 2022-04-07 Tolmar International Limited Biodegradable polymer delivery system for extended delivery of testosterone
WO2024168022A2 (en) 2023-02-10 2024-08-15 Tolmar, Inc. Degarelix polymeric formulations
JP2026523906A (ja) 2023-07-05 2026-07-16 トルマー インターナショナル リミテッド ポリマー状ロイプロリド酢酸塩製剤

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Also Published As

Publication number Publication date
EP1310517A1 (de) 2003-05-14
DK1310517T3 (da) 2006-07-24
WO2002012369A1 (en) 2002-02-14
DE60118575D1 (de) 2006-05-18
US20030153724A1 (en) 2003-08-14
HK1095526A1 (en) 2007-05-11
AU2001276733A1 (en) 2002-02-18
EP1693054B1 (de) 2016-05-25
EP1310517B1 (de) 2006-04-05
CN1269870C (zh) 2006-08-16
EP1693054A2 (de) 2006-08-23
DK1310517T4 (da) 2011-01-17
US7019106B2 (en) 2006-03-28
KR20030046405A (ko) 2003-06-12
PT1310517E (pt) 2006-05-31
CA2419065A1 (en) 2002-02-14
CY1117889T1 (el) 2017-05-17
EP1693054A3 (de) 2007-07-11
JP5622760B2 (ja) 2014-11-12
DE60118575T2 (de) 2006-08-24
US20070259036A1 (en) 2007-11-08
ES2256276T3 (es) 2006-07-16
CA2419065C (en) 2009-12-22
EP1310517A4 (de) 2005-01-05
JP5046447B2 (ja) 2012-10-10
ES2256276T5 (es) 2011-02-22
US20060128938A1 (en) 2006-06-15
PT1693054T (pt) 2016-07-07
CN1461321A (zh) 2003-12-10
WO2002012369A9 (en) 2003-04-24
US8092830B2 (en) 2012-01-10
JP2012107256A (ja) 2012-06-07
DE60118575T3 (de) 2011-05-19
JP2002121272A (ja) 2002-04-23
KR100772950B1 (ko) 2007-11-02
EP1310517B2 (de) 2010-11-17
ES2577389T3 (es) 2016-07-14

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