DK1604687T3 - Micellefremstilling indeholdende ringe vandopløseligt anticancermiddel og ny blokcopolymer - Google Patents

Micellefremstilling indeholdende ringe vandopløseligt anticancermiddel og ny blokcopolymer

Info

Publication number
DK1604687T3
DK1604687T3 DK04721673.4T DK04721673T DK1604687T3 DK 1604687 T3 DK1604687 T3 DK 1604687T3 DK 04721673 T DK04721673 T DK 04721673T DK 1604687 T3 DK1604687 T3 DK 1604687T3
Authority
DK
Denmark
Prior art keywords
anticancer agent
block copolymer
soluble anticancer
integer
low water
Prior art date
Application number
DK04721673.4T
Other languages
English (en)
Inventor
Kazuhisa Shimizu
Toshitaka Murata
Katsuhiko Sagawa
Original Assignee
Nippon Kayaku Kk
Nanocarrier Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Kk, Nanocarrier Kabushiki Kaisha filed Critical Nippon Kayaku Kk
Application granted granted Critical
Publication of DK1604687T3 publication Critical patent/DK1604687T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
DK04721673.4T 2003-03-20 2004-03-18 Micellefremstilling indeholdende ringe vandopløseligt anticancermiddel og ny blokcopolymer DK1604687T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003077607 2003-03-20
PCT/JP2004/003647 WO2004082718A1 (ja) 2003-03-20 2004-03-18 難水溶性抗癌剤と新規ブロック共重合体を含むミセル調製物

Publications (1)

Publication Number Publication Date
DK1604687T3 true DK1604687T3 (da) 2010-11-15

Family

ID=33027953

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04721673.4T DK1604687T3 (da) 2003-03-20 2004-03-18 Micellefremstilling indeholdende ringe vandopløseligt anticancermiddel og ny blokcopolymer

Country Status (14)

Country Link
US (3) US20060099265A1 (da)
EP (1) EP1604687B1 (da)
JP (1) JP4757633B2 (da)
KR (1) KR101064901B1 (da)
CN (1) CN1761485B (da)
AT (1) ATE483476T1 (da)
AU (1) AU2004222439B2 (da)
CA (1) CA2518964C (da)
DE (1) DE602004029449D1 (da)
DK (1) DK1604687T3 (da)
ES (1) ES2351338T3 (da)
PL (1) PL1604687T3 (da)
RU (1) RU2324701C2 (da)
WO (1) WO2004082718A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1604687B1 (en) * 2003-03-20 2010-10-06 Nippon Kayaku Kabushiki Kaisha Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer
JP4820758B2 (ja) 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
AU2006255938B2 (en) 2005-06-09 2011-05-12 Nanocarrier Co., Ltd. Process for production of polymerized coordination compound of platinum complex
WO2007111211A1 (ja) * 2006-03-28 2007-10-04 Nippon Kayaku Kabushiki Kaisha タキサン類の高分子結合体
RU2447095C2 (ru) 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся Высокомолекулярный конъюгат подофиллотоксинов
JPWO2007136134A1 (ja) * 2006-05-23 2009-10-01 ナノキャリア株式会社 疎水性薬物内包ポリマーミセルの製造方法
CA2664852A1 (en) * 2006-10-03 2008-04-10 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of resorcinol derivatives
WO2008056596A1 (fr) 2006-11-06 2008-05-15 Nippon Kayaku Kabushiki Kaisha Dérivé polymère d'un antagoniste métabolique d'acide nucléique
EP2090607B1 (en) 2006-11-08 2015-05-20 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
CN101808651B (zh) 2007-09-28 2013-03-27 日本化药株式会社 类固醇类的高分子结合物
CN101977631A (zh) 2008-03-18 2011-02-16 日本化药株式会社 生理活性物质的高分子量偶联物
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
DK2287230T3 (da) 2008-05-23 2012-12-10 Nanocarrier Co Ltd Docetaxel polymer derivative, method for producing same and use of same
JP2011162569A (ja) 2008-05-23 2011-08-25 Nano Career Kk カンプトテシン高分子誘導体及びその用途
MD3972C2 (ro) * 2009-03-11 2010-07-31 Ион МЕРЕУЦЭ Remediu şi metodă de tratament al stărilor precanceroase
US8808749B2 (en) 2009-05-15 2014-08-19 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of bioactive substance having hydroxy group
EP3150194A1 (en) * 2009-08-31 2017-04-05 NanoCarrier Co., Ltd. Particle composition and medicinal composition comprising same
JP5856069B2 (ja) 2010-11-17 2016-02-09 日本化薬株式会社 新規なシチジン系代謝拮抗剤の高分子誘導体
KR101849142B1 (ko) * 2011-09-11 2018-04-16 니폰 가야꾸 가부시끼가이샤 블록 공중합체의 제조방법
US10945997B2 (en) 2016-01-08 2021-03-16 Nippon Kayaku Kabushiki Kaisha Polymer derivative of macrolide immunosuppressant
CN109476841B (zh) 2016-07-30 2021-08-24 日本化药株式会社 新型高分子衍生物和使用其的新型高分子衍生物成像探针
JPWO2018025699A1 (ja) 2016-08-02 2019-05-30 日本化薬株式会社 アクティブターゲティング型高分子誘導体、その高分子誘導体を含む組成物、及びそれらの用途
EP4175966A1 (en) 2020-07-06 2023-05-10 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Polymeric micelles comprising glucuronide-prodrugs

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467587A (en) * 1974-07-11 1977-03-16 Nestle Sa Preparation of an asparagine or a glutamine
GB8500209D0 (en) * 1985-01-04 1985-02-13 Ceskoslovenska Akademie Ved Synthetic polymeric drugs
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
US4742113A (en) 1987-02-20 1988-05-03 Lord Corporation Structural adhesive compositions
US5182203A (en) * 1989-03-29 1993-01-26 E. I. Du Pont De Nemours And Company Bifunctional compounds useful in catalyzed reporter deposition
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
US5543390A (en) * 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
US5817321A (en) * 1992-10-08 1998-10-06 Supratek Pharma, Inc. Biological agent compositions
JP3270592B2 (ja) * 1992-10-26 2002-04-02 日本化薬株式会社 ブロック共重合体−抗癌剤複合体医薬製剤
JP3268913B2 (ja) * 1992-10-27 2002-03-25 日本化薬株式会社 高分子担体
JPH06206830A (ja) * 1992-10-27 1994-07-26 Nippon Kayaku Co Ltd ブロック共重合体−薬剤複合体及び高分子ブロック共重合体
US5985548A (en) * 1993-02-04 1999-11-16 E. I. Du Pont De Nemours And Company Amplification of assay reporters by nucleic acid replication
DE4307114A1 (de) * 1993-03-06 1994-09-08 Basf Ag Verfahren zur Herstellung von Umsetzungsprodukten aus Polyasparaginsäureamid und Aminosäuren und ihre Verwendung
US5552517A (en) * 1995-03-03 1996-09-03 Monsanto Company Production of polysuccinimide in an organic medium
JP2694923B2 (ja) * 1995-08-21 1997-12-24 科学技術振興事業団 水溶性高分子化医薬製剤
DE69735057T2 (de) * 1996-03-12 2006-08-31 PG-TXL Co., L.P., Houston Wasserlösliche paclitaxel-prodrogen
GB9625895D0 (en) * 1996-12-13 1997-01-29 Riley Patrick A Novel compound useful as therapeutic agents and assay reagents
ES2197265T3 (es) * 1997-05-09 2004-01-01 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Conjugado que comprende un anatagonista de aacido folico y un portador.
AU1825299A (en) * 1997-12-17 1999-07-05 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6824766B2 (en) * 1998-04-17 2004-11-30 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
JPH11335267A (ja) * 1998-05-27 1999-12-07 Nano Career Kk 水難溶性薬物を含有するポリマーミセル系
IN191203B (da) * 1999-02-17 2003-10-04 Amarnath Prof Maitra
US20030054977A1 (en) * 1999-10-12 2003-03-20 Cell Therapeutics, Inc. Manufacture of polyglutamate-therapeutic agent conjugates
JP3523821B2 (ja) 2000-02-09 2004-04-26 ナノキャリア株式会社 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物
DE60233137D1 (de) * 2001-02-16 2009-09-10 Univ R Transporter mit beabstandeten arginin-teilchen
ES2339934T3 (es) * 2002-03-01 2010-05-27 The Administrators Of The Tulane Educational Fund Conjugados de agentes citotoxicos y peptidos biologicamente activos.
MXPA04009324A (es) * 2002-03-26 2005-01-25 Banyu Pharma Co Ltd Uso de derivado de indolopirrolocarbazol y otro agente anticanceroso en combinacion.
JP2004010479A (ja) * 2002-06-03 2004-01-15 Japan Science & Technology Corp ブロック共重合体とアンスラサイクリン系抗癌剤を含む新規固型製剤及びその製造法
US7169892B2 (en) * 2003-01-10 2007-01-30 Astellas Pharma Inc. Lipid-peptide-polymer conjugates for long blood circulation and tumor specific drug delivery systems
EP1604687B1 (en) * 2003-03-20 2010-10-06 Nippon Kayaku Kabushiki Kaisha Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer
AU2004224530A1 (en) * 2003-03-26 2004-10-07 Ltt Bio-Pharma Co., Ltd. Intravenous nanoparticles for targenting drug delivery and sustained drug release
EP1680073B1 (en) * 2003-10-21 2013-01-02 IGF Oncology, LLC Compounds and method for treating cancer
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
US7176185B2 (en) * 2003-11-25 2007-02-13 Tsrl, Inc. Short peptide carrier system for cellular delivery of agent
JP4792294B2 (ja) * 2004-01-07 2011-10-12 生化学工業株式会社 ヒアルロン酸誘導体及びそれを含む薬剤
JP4820758B2 (ja) * 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
CA2600085A1 (en) * 2005-03-09 2006-09-14 Toray Industries, Inc. Microparticle and pharmaceutical preparation
US8399464B2 (en) * 2005-03-09 2013-03-19 Nippon Kayaku Kabushiki Kaisha HSP90 inhibitor
BRPI0609095A2 (pt) * 2005-05-11 2010-02-17 Nippon Kayaku Kk derivado polimérico de antagonista metabólico de citidina, agente antitumor e antiviral e método para produzir o referido derivado
US20080280937A1 (en) * 2005-08-19 2008-11-13 Christopher Paul Leamon Ligand Conjugates of Vinca Alkaloids, Analogs, and Derivatives
WO2007111211A1 (ja) * 2006-03-28 2007-10-04 Nippon Kayaku Kabushiki Kaisha タキサン類の高分子結合体
WO2008056596A1 (fr) * 2006-11-06 2008-05-15 Nippon Kayaku Kabushiki Kaisha Dérivé polymère d'un antagoniste métabolique d'acide nucléique
EP2090607B1 (en) * 2006-11-08 2015-05-20 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
CN101808651B (zh) * 2007-09-28 2013-03-27 日本化药株式会社 类固醇类的高分子结合物
CN101977631A (zh) * 2008-03-18 2011-02-16 日本化药株式会社 生理活性物质的高分子量偶联物
US9149540B2 (en) * 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
US8808749B2 (en) * 2009-05-15 2014-08-19 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of bioactive substance having hydroxy group

Also Published As

Publication number Publication date
RU2005132309A (ru) 2006-04-10
ES2351338T3 (es) 2011-02-03
CN1761485B (zh) 2010-04-28
AU2004222439A1 (en) 2004-09-30
US20140142167A1 (en) 2014-05-22
JP4757633B2 (ja) 2011-08-24
WO2004082718A1 (ja) 2004-09-30
EP1604687B1 (en) 2010-10-06
ATE483476T1 (de) 2010-10-15
AU2004222439B2 (en) 2008-08-21
DE602004029449D1 (de) 2010-11-18
PL1604687T3 (pl) 2011-04-29
CA2518964A1 (en) 2004-09-30
JPWO2004082718A1 (ja) 2006-06-22
EP1604687A1 (en) 2005-12-14
EP1604687A4 (en) 2009-03-18
US20090156742A1 (en) 2009-06-18
KR20050107800A (ko) 2005-11-15
US20060099265A1 (en) 2006-05-11
US7820759B2 (en) 2010-10-26
KR101064901B1 (ko) 2011-09-16
CA2518964C (en) 2011-09-13
CN1761485A (zh) 2006-04-19
RU2324701C2 (ru) 2008-05-20

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