DOP2017000205A - Composiciones y métodos para activar la señalización dependiente del "estimulador del gen de interferon" - Google Patents

Composiciones y métodos para activar la señalización dependiente del "estimulador del gen de interferon"

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Publication number
DOP2017000205A
DOP2017000205A DO2017000205A DO2017000205A DOP2017000205A DO P2017000205 A DOP2017000205 A DO P2017000205A DO 2017000205 A DO2017000205 A DO 2017000205A DO 2017000205 A DO2017000205 A DO 2017000205A DO P2017000205 A DOP2017000205 A DO P2017000205A
Authority
DO
Dominican Republic
Prior art keywords
interferon
stimulator
activate
cdns
gen
Prior art date
Application number
DO2017000205A
Other languages
English (en)
Inventor
Hix Glickman Laura
Kanne David
Sung Leonard
Gauthier Kelsey
Leong Justin
Edwin Katibah George
M Mcwhirter Sarah
W Dubensky Thomas Jr
Original Assignee
Aduro Biotech Inc
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Application filed by Aduro Biotech Inc filed Critical Aduro Biotech Inc
Publication of DOP2017000205A publication Critical patent/DOP2017000205A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona estimuladores inmunitarios di-nucleótidos-cíclicos- (CDN) de gran actividad que activan DC a través de un receptor citoplasmático descubierto recientemente conocido como STING (Estimulador de genes de interferón). En particular, los CDN de la presente invención se proporcionan en forma de una composición que comprende uno o más dinucleótidos cíclicos de purina que inducen la producción de interferón de tipo I dependiente de STING humano, donde los dinuclotidas cíclicos de purina presentes en la composición son CDN bis-3',5' 2'-fluoro sustituidos, y más preferiblemente uno o más CDN bis-3’,5’ 2’,2’’-diF-Rp,Rp.
DO2017000205A 2015-03-10 2017-09-06 Composiciones y métodos para activar la señalización dependiente del "estimulador del gen de interferon" DOP2017000205A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562131235P 2015-03-10 2015-03-10

Publications (1)

Publication Number Publication Date
DOP2017000205A true DOP2017000205A (es) 2017-11-15

Family

ID=56879700

Family Applications (1)

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DO2017000205A DOP2017000205A (es) 2015-03-10 2017-09-06 Composiciones y métodos para activar la señalización dependiente del "estimulador del gen de interferon"

Country Status (30)

Country Link
US (2) US10449211B2 (es)
EP (1) EP3268035A4 (es)
JP (1) JP6692826B2 (es)
KR (1) KR20170129802A (es)
CN (1) CN107530415A (es)
AR (1) AR103894A1 (es)
AU (1) AU2016229146A1 (es)
BR (1) BR112017018908A2 (es)
CA (1) CA2979215A1 (es)
CL (1) CL2017002272A1 (es)
CO (1) CO2017009104A2 (es)
CR (1) CR20170410A (es)
DO (1) DOP2017000205A (es)
EA (1) EA035817B1 (es)
EC (1) ECSP17064523A (es)
GT (1) GT201700200A (es)
HK (2) HK1247089A1 (es)
IL (1) IL254047A0 (es)
JO (1) JO3746B1 (es)
MA (1) MA42146A (es)
MX (1) MX2017011597A (es)
MY (1) MY190404A (es)
PE (1) PE20171448A1 (es)
PH (1) PH12017501506A1 (es)
SG (1) SG11201706756VA (es)
SV (1) SV2017005529A (es)
TN (1) TN2017000375A1 (es)
TW (1) TWI706958B (es)
UY (1) UY36579A (es)
WO (1) WO2016145102A1 (es)

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